GREMLIN Database
PYRD - Dihydroorotate dehydrogenase (quinone)
UniProt: P0A7E1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10807
Length: 336 (273)
Sequences: 5152 (2921)
Seq/√Len: 176.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
48_N53_T3.8371.00
121_D161_K3.6741.00
324_K331_E3.3801.00
46_P53_T3.1341.00
160_E200_K3.0681.00
50_M215_A3.0651.00
191_D236_R2.8351.00
54_F314_L2.7601.00
228_I285_E2.6971.00
275_S307_K2.5571.00
283_S313_S2.5241.00
191_D237_H2.5161.00
299_D303_A2.5111.00
244_A282_L2.4541.00
87_V123_L2.4261.00
272_Q306_E2.3851.00
276_T307_K2.2911.00
215_A241_G2.2671.00
198_K240_D2.2591.00
300_S303_A2.2401.00
279_I292_I2.2061.00
56_N80_G2.1411.00
198_K214_I2.0461.00
272_Q303_A2.0321.00
283_S292_I2.0231.00
67_D118_L2.0101.00
235_V290_L1.9971.00
190_L234_L1.9751.00
298_I315_V1.8901.00
137_G168_Y1.8591.00
159_M169_I1.8541.00
56_N333_V1.7571.00
45_K57_P1.7521.00
235_V289_R1.7491.00
243_I295_V1.7321.00
223_S226_E1.7321.00
272_Q307_K1.7221.00
231_A282_L1.7211.00
298_I307_K1.6891.00
302_I306_E1.6851.00
118_L122_N1.6761.00
52_L168_Y1.6651.00
59_G83_E1.6621.00
305_R309_A1.6571.00
120_V161_K1.6551.00
107_E269_R1.6521.00
232_D236_R1.6381.00
156_L200_K1.5801.00
90_R145_D1.5701.00
173_I190_L1.5421.00
187_G229_Q1.5321.00
228_I281_R1.5171.00
291_P313_S1.5071.00
59_G81_S1.4991.00
245_T248_T1.4931.00
88_T141_G1.4881.00
279_I294_G1.4821.00
120_V162_I1.4791.00
304_A315_V1.4681.00
188_E192_D1.4681.00
140_I158_C1.4651.00
163_Y210_K1.4641.00
286_L290_L1.4551.00
131_H167_G1.4531.00
191_D195_T1.4441.00
140_I159_M1.4441.00
215_A293_I1.4351.00
163_Y211_Y1.4321.00
248_T274_K1.4301.00
226_E229_Q1.4181.00
138_I166_A1.4131.00
48_N51_G1.4091.00
86_T139_N1.4031.00
250_D274_K1.3961.00
317_I332_I1.3871.00
121_D125_E1.3541.00
49_C314_L1.3491.00
122_N126_N1.3471.00
242_V286_L1.3381.00
108_G270_P1.3361.00
58_L333_V1.3291.00
304_A332_I1.3281.00
294_G307_K1.3281.00
84_I138_I1.3011.00
157_I160_E1.3001.00
171_I197_I1.2991.00
86_T141_G1.2951.00
100_L113_M1.2871.00
301_V305_R1.2821.00
75_G134_G1.2811.00
83_E316_Q1.2761.00
61_A318_Y1.2761.00
106_A257_M1.2751.00
58_L298_I1.2741.00
159_M197_I1.2681.00
89_P143_N1.2641.00
157_I161_K1.2561.00
197_I214_I1.2551.00
320_G328_L1.2371.00
233_S237_H1.2361.00
272_Q276_T1.2311.00
156_L196_A1.2231.00
277_E281_R1.2171.00
152_K156_L1.2101.00
107_E324_K1.2031.00
120_V158_C1.1891.00
195_T237_H1.1831.00
89_P158_C1.1791.00
293_I314_L1.1771.00
84_I123_L1.1631.00
222_L230_V1.1601.00
59_G316_Q1.1541.00
186_Y189_A1.1511.00
232_D285_E1.1471.00
295_V316_Q1.1351.00
58_L332_I1.1331.00
248_T271_L1.1271.00
300_S328_L1.1211.00
299_D320_G1.1171.00
162_I169_I1.1111.00
124_V161_K1.1091.00
55_K133_D1.1081.00
72_D130_A1.0971.00
330_K334_T1.0881.00
169_I212_V1.0851.00
196_A199_N1.0851.00
50_M241_G1.0851.00
125_E128_K1.0771.00
106_A254_V1.0691.00
279_I307_K1.0661.00
269_R299_D1.0631.00
194_L216_V1.0601.00
276_T310_A1.0591.00
317_I328_L1.0581.00
218_I282_L1.0531.00
88_T92_Q1.0501.00
227_L282_L1.0491.00
183_T226_E1.0451.00
152_K196_A1.0320.99
111_N247_T1.0200.99
327_P331_E1.0190.99
192_D196_A1.0150.99
156_L160_E1.0140.99
52_L135_V1.0130.99
216_V239_I1.0060.99
115_F141_G0.9950.99
103_L106_A0.9900.99
163_Y212_V0.9900.99
144_K154_D0.9870.99
55_K134_G0.9810.99
118_L126_N0.9780.99
47_V313_S0.9750.99
192_D195_T0.9730.99
195_T199_N0.9690.99
305_R308_I0.9660.99
74_L82_I0.9570.99
49_C215_A0.9560.99
79_F329_I0.9520.99
244_A278_I0.9480.99
188_E191_D0.9470.99
269_R272_Q0.9450.99
153_D157_I0.9430.99
124_V165_Y0.9380.99
250_D253_L0.9300.99
215_A243_I0.9260.99
152_K192_D0.9250.99
245_T275_S0.9250.99
59_G314_L0.9100.99
301_V332_I0.9070.99
105_D257_M0.9060.99
49_C293_I0.9030.99
175_S182_R0.8990.99
183_T186_Y0.8960.99
68_G123_L0.8940.98
113_M117_N0.8930.98
245_T271_L0.8900.98
109_L319_S0.8830.98
253_L256_G0.8720.98
247_T267_S0.8690.98
273_L277_E0.8670.98
58_L304_A0.8650.98
92_Q143_N0.8640.98
144_K179_P0.8620.98
60_L79_F0.8550.98
43_P46_P0.8480.98
187_G233_S0.8450.98
175_S178_T0.8420.98
142_K170_A0.8410.98
187_G191_D0.8380.98
171_I216_V0.8360.98
83_E243_I0.8310.98
86_T140_I0.8280.98
89_P157_I0.8240.97
122_N125_E0.8200.97
283_S289_R0.8180.97
228_I282_L0.8140.97
143_N158_C0.8120.97
228_I232_D0.8100.97
254_V305_R0.8070.97
234_L242_V0.8030.97
118_L123_L0.8000.97
175_S181_L0.8000.97
49_C291_P0.7970.97
124_V162_I0.7970.97
242_V282_L0.7970.97
281_R285_E0.7930.97
274_K277_E0.7890.97
227_L278_I0.7880.97
176_P265_G0.7860.97
90_R143_N0.7850.97
232_D235_V0.7840.97
163_Y169_I0.7820.97
189_A192_D0.7810.96
162_I165_Y0.7800.96
58_L317_I0.7790.96
61_A316_Q0.7780.96
231_A286_L0.7770.96
317_I320_G0.7740.96
304_A308_I0.7680.96
140_I171_I0.7670.96
120_V124_V0.7590.96
245_T278_I0.7580.96
89_P154_D0.7570.96
196_A200_K0.7560.96
275_S294_G0.7530.96
186_Y226_E0.7530.96
198_K237_H0.7490.96
269_R303_A0.7470.95
58_L315_V0.7450.95
263_T280_R0.7440.95
279_I310_A0.7390.95
235_V286_L0.7390.95
54_F168_Y0.7370.95
94_G119_G0.7330.95
70_C74_L0.7330.95
277_E280_R0.7310.95
218_I242_V0.7310.95
104_V107_E0.7310.95
249_L281_R0.7300.95
81_S316_Q0.7300.95
83_E139_N0.7290.95
70_C73_A0.7270.95
127_V130_A0.7260.95
45_K305_R0.7250.95
324_K327_P0.7240.95
135_V167_G0.7220.95
95_N99_R0.7220.95
168_Y316_Q0.7210.95
282_L286_L0.7180.94
166_A169_I0.7170.94
54_F81_S0.7140.94
62_A85_G0.7100.94
173_I216_V0.7040.94
100_L109_L0.6990.94
229_Q233_S0.6970.93
218_I278_I0.6960.93
214_I240_D0.6920.93
121_D157_I0.6920.93
153_D156_L0.6920.93
156_L199_N0.6900.93
88_T117_N0.6880.93
247_T265_G0.6870.93
50_M168_Y0.6870.93
54_F59_G0.6860.93
49_C313_S0.6850.93
321_F329_I0.6830.93
47_V57_P0.6810.93
43_P57_P0.6810.93
257_M309_A0.6790.93
227_L285_E0.6780.93
242_V292_I0.6770.92
328_L332_I0.6760.92
243_I316_Q0.6750.92
190_L193_L0.6730.92
272_Q279_I0.6730.92
281_R284_L0.6700.92
152_K189_A0.6690.92
161_K164_A0.6660.92
92_Q141_G0.6650.92
128_K131_H0.6650.92
49_C54_F0.6610.92
159_M163_Y0.6580.91
129_K132_Y0.6550.91
65_D71_I0.6550.91
114_G117_N0.6540.91
156_L197_I0.6530.91
298_I304_A0.6510.91
78_G330_K0.6470.91
234_L292_I0.6420.90
252_S272_Q0.6420.90
103_L108_G0.6400.90
138_I162_I0.6390.90
111_N265_G0.6370.90
327_P330_K0.6370.90
128_K164_A0.6350.90
168_Y243_I0.6340.90
123_L162_I0.6340.90
90_R157_I0.6330.90
113_M116_N0.6320.90
280_R284_L0.6310.90
124_V128_K0.6310.90
156_L193_L0.6310.90
308_I315_V0.6300.90
159_M193_L0.6300.90
103_L266_L0.6270.89
46_P55_K0.6260.89
86_T168_Y0.6240.89
272_Q275_S0.6230.89
159_M200_K0.6210.89
87_V138_I0.6190.89
60_L329_I0.6180.89
69_E118_L0.6170.89
190_L194_L0.6160.88
81_S135_V0.6160.88
259_N264_G0.6150.88
139_N170_A0.6140.88
60_L74_L0.6130.88
301_V331_E0.6120.88
249_L263_T0.6100.88
109_L322_I0.6100.88
127_V165_Y0.6100.88
128_K132_Y0.6100.88
159_M212_V0.6090.88
64_L322_I0.6040.88
255_Q302_I0.6030.87
123_L138_I0.6020.87
44_A47_V0.5980.87
71_I321_F0.5970.87
276_T294_G0.5960.87
111_N174_S0.5920.86
179_P182_R0.5920.86
174_S177_N0.5910.86
127_V136_L0.5900.86
128_K165_Y0.5890.86
210_K214_I0.5890.86
69_E122_N0.5860.86
191_D233_S0.5840.86
178_T181_L0.5840.86
59_G137_G0.5810.85
276_T279_I0.5810.85
111_N115_F0.5800.85
230_V234_L0.5790.85
278_I282_L0.5760.85
242_V290_L0.5760.85
229_Q232_D0.5750.85
132_Y167_G0.5750.85
170_A243_I0.5750.85
280_R306_E0.5750.85
90_R121_D0.5740.85
135_V168_Y0.5730.85
324_K328_L0.5720.85
299_D324_K0.5720.85
294_G310_A0.5710.84
194_L239_I0.5700.84
75_G82_I0.5690.84
178_T182_R0.5680.84
301_V328_L0.5680.84
168_Y215_A0.5650.84
252_S306_E0.5650.84
276_T280_R0.5620.84
193_L196_A0.5590.83
115_F175_S0.5540.83
240_D291_P0.5540.83
111_N117_N0.5520.82
50_M291_P0.5520.82
65_D85_G0.5510.82
218_I244_A0.5490.82
54_F135_V0.5480.82
71_I127_V0.5480.82
174_S265_G0.5460.82
60_L65_D0.5430.81
181_L185_Q0.5430.81
159_M210_K0.5420.81
171_I214_I0.5420.81
81_S314_L0.5420.81
115_F181_L0.5410.81
108_G271_L0.5410.81
120_V123_L0.5400.81
220_P246_N0.5400.81
198_K239_I0.5390.81
110_I250_D0.5390.81
69_E129_K0.5370.81
219_A222_L0.5370.81
187_G232_D0.5330.80
112_R261_D0.5320.80
329_I333_V0.5320.80
51_G213_P0.5320.80
71_I84_I0.5300.80
144_K175_S0.5270.79
114_G172_N0.5250.79
72_D76_A0.5230.79
71_I82_I0.5210.79
114_G265_G0.5200.79
115_F178_T0.5200.79
265_G268_G0.5190.78
223_S227_L0.5190.78
99_R102_R0.5180.78
59_G293_I0.5150.78
328_L331_E0.5130.78
218_I230_V0.5130.78
45_K333_V0.5120.78
84_I87_V0.5090.77
112_R262_Q0.5080.77
83_E137_G0.5050.77
301_V315_V0.5040.76
50_M314_L0.5030.76
234_L237_H0.5030.76
80_G291_P0.5010.76
52_L167_G0.5010.76
47_V314_L0.5000.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4cq8A 1 0.9792 100 0.312 Contact Map
1tv5A 3 0.9702 100 0.324 Contact Map
4oqvA 1 0.9524 100 0.362 Contact Map
1f76A 1 0.997 100 0.392 Contact Map
4ef8A 2 0.8244 100 0.468 Contact Map
1ep3A 2 0.8185 100 0.515 Contact Map
2e6fA 2 0.8185 100 0.529 Contact Map
1jubA 2 0.8185 100 0.532 Contact Map
1gteA 4 0.9435 100 0.532 Contact Map
3oixA 3 0.7976 100 0.545 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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