GREMLIN Database
PUR7 - Phosphoribosylaminoimidazole-succinocarboxamide synthase
UniProt: P0A7D7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10791
Length: 237 (213)
Sequences: 3330 (1668)
Seq/√Len: 114.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
92_V121_F3.9071.00
147_N182_L3.7961.00
167_D203_K3.2941.00
86_M190_G2.7901.00
5_A17_S2.7821.00
183_Y186_E2.6501.00
67_P186_E2.5971.00
134_E152_K2.4591.00
93_V155_T2.4331.00
60_K161_V2.3861.00
23_L71_E2.3751.00
145_K149_A2.3331.00
84_L190_G2.3051.00
36_D128_H2.2361.00
75_S78_E2.1781.00
82_K183_Y2.1311.00
138_E145_K2.0511.00
170_G204_E2.0301.00
55_Y73_L2.0051.00
60_K165_L1.9961.00
87_V187_V1.9821.00
150_R153_E1.9741.00
20_N23_L1.9521.00
172_I206_L1.9501.00
17_S83_K1.9421.00
64_A161_V1.9201.00
59_S63_E1.8881.00
164_K168_D1.7991.00
108_E111_I1.7701.00
96_R174_V1.7531.00
150_R186_E1.6601.00
57_I166_F1.5951.00
14_T27_E1.5531.00
96_R112_E1.5441.00
153_E157_K1.5361.00
150_R154_L1.4661.00
35_G219_G1.4621.00
6_E14_T1.4471.00
35_G38_A1.4381.00
118_F137_C1.4371.00
31_D42_Q1.4091.00
55_Y70_M1.4021.00
38_A128_H1.3931.00
96_R172_I1.3901.00
24_L81_V1.3881.00
182_L187_V1.3851.00
45_R48_M1.3831.00
41_E214_F1.3791.00
97_A111_I1.3791.00
84_L183_Y1.3771.00
18_T80_L1.3471.00
48_M76_D1.3381.00
64_A164_K1.3341.00
39_R214_F1.3251.00
173_L200_L1.3141.00
98_A109_E1.3111.00
55_Y79_C1.2750.99
95_N159_N1.2750.99
112_E163_K1.2730.99
183_Y188_V1.2720.99
112_E167_D1.2700.99
147_N187_V1.2700.99
9_R14_T1.2680.99
91_C155_T1.2600.99
91_C151_M1.2570.99
101_L113_L1.2550.99
89_V137_C1.2510.99
48_M52_K1.2400.99
212_D216_Q1.2390.99
158_A178_L1.2380.99
166_F200_L1.2260.99
163_K167_D1.2080.99
93_V156_Y1.2060.99
171_L200_L1.2060.99
136_Y141_G1.2040.99
120_L137_C1.1980.99
54_N58_M1.1830.99
87_V147_N1.1770.99
28_F51_N1.1770.99
149_A153_E1.1760.99
32_T214_F1.1740.99
18_T21_P1.1730.99
217_S221_L1.1700.99
160_D164_K1.1540.99
165_L169_A1.1540.99
144_S147_N1.1470.99
56_F60_K1.1440.99
121_F131_M1.1390.99
157_K161_V1.1390.99
27_E77_T1.1350.99
154_L157_K1.1260.99
134_E148_L1.1210.99
15_V26_L1.1170.98
107_I111_I1.1160.98
87_V151_M1.1150.98
89_V132_V1.0930.98
49_V53_F1.0900.98
23_L80_L1.0880.98
101_L107_I1.0820.98
48_M77_T1.0810.98
85_D182_L1.0810.98
103_K219_G1.0760.98
67_P154_L1.0760.98
114_N141_G1.0610.98
135_S152_K1.0610.98
160_D163_K1.0580.98
202_D205_T1.0540.98
6_E9_R1.0530.98
51_N79_C1.0390.98
115_P160_D1.0380.98
52_K76_D1.0210.97
18_T23_L1.0140.97
138_E148_L1.0140.97
189_L193_F1.0140.97
60_K64_A1.0120.97
56_F165_L1.0100.97
27_E78_E1.0060.97
24_L83_K1.0020.97
91_C118_F0.9990.97
55_Y59_S0.9950.97
9_R29_R0.9910.97
150_R187_V0.9860.97
70_M73_L0.9840.97
98_A110_G0.9800.97
14_T29_R0.9750.96
52_K73_L0.9720.96
61_L65_G0.9710.96
132_V142_W0.9660.96
52_K55_Y0.9640.96
154_L158_A0.9580.96
71_E82_K0.9560.96
172_I203_K0.9540.96
87_V182_L0.9520.96
97_A113_L0.9490.96
82_K188_V0.9430.96
30_N44_D0.9390.96
59_S70_M0.9290.95
157_K160_D0.9230.95
97_A102_V0.9160.95
165_L168_D0.9110.95
114_N163_K0.9100.95
102_V107_I0.9040.95
67_P188_V0.9000.94
26_L81_V0.8980.94
152_K156_Y0.8970.94
72_R80_L0.8940.94
193_F197_G0.8930.94
74_L78_E0.8870.94
70_M79_C0.8830.94
15_V24_L0.8820.94
154_L187_V0.8760.94
120_L148_L0.8720.93
134_E149_A0.8690.93
107_I113_L0.8690.93
91_C180_F0.8680.93
137_C148_L0.8620.93
104_R136_Y0.8620.93
17_S21_P0.8530.93
100_S131_M0.8490.93
27_E75_S0.8480.92
143_V151_M0.8450.92
53_F195_P0.8420.92
25_V74_L0.8410.92
19_E23_L0.8390.92
135_S138_E0.8380.92
34_A218_L0.8360.92
124_N128_H0.8310.92
208_K216_Q0.8300.92
147_N150_R0.8260.91
6_E16_Y0.8220.91
101_L104_R0.8190.91
136_Y142_W0.8160.91
117_L133_N0.8150.91
102_V216_Q0.8130.91
138_E141_G0.8120.91
58_M79_C0.8050.90
164_K167_D0.8040.90
57_I200_L0.8030.90
30_N42_Q0.7960.90
84_L188_V0.7940.90
133_N136_Y0.7910.90
59_S72_R0.7900.90
118_F155_T0.7820.89
35_G128_H0.7770.89
32_T43_F0.7760.89
97_A107_I0.7740.89
60_K63_E0.7670.88
158_A193_F0.7620.88
124_N130_P0.7600.88
66_I154_L0.7570.88
149_A152_K0.7550.87
105_L136_Y0.7550.87
17_S24_L0.7540.87
85_D185_G0.7450.87
74_L80_L0.7410.86
101_L105_L0.7390.86
178_L197_G0.7370.86
120_L152_K0.7310.86
88_P125_D0.7300.86
102_V111_I0.7250.85
213_R221_L0.7220.85
71_E80_L0.7210.85
118_F156_Y0.7200.85
134_E145_K0.7090.84
132_V136_Y0.7080.84
59_S73_L0.7040.83
103_K212_D0.7030.83
202_D207_E0.7000.83
98_A102_V0.6990.83
94_R175_D0.6990.83
118_F151_M0.6980.83
110_G201_W0.6960.83
89_V142_W0.6940.83
7_L24_L0.6940.83
18_T25_V0.6890.82
102_V108_E0.6890.82
85_D183_Y0.6890.82
134_E137_C0.6880.82
35_G39_R0.6850.82
109_E208_K0.6850.82
148_L152_K0.6840.82
143_V147_N0.6840.82
30_N77_T0.6790.81
58_M69_Q0.6780.81
68_T188_V0.6760.81
135_S156_Y0.6720.81
113_L116_P0.6720.81
88_P190_G0.6590.79
8_Y15_V0.6550.79
93_V118_F0.6550.79
159_N163_K0.6500.78
117_L135_S0.6480.78
118_F152_K0.6470.78
57_I162_L0.6470.78
85_D147_N0.6430.78
143_V148_L0.6420.77
104_R119_D0.6390.77
105_L132_V0.6380.77
180_F187_V0.6380.77
67_P82_K0.6370.77
39_R217_S0.6350.77
65_G157_K0.6350.77
146_E149_A0.6340.77
41_E221_L0.6330.76
202_D209_M0.6310.76
6_E15_V0.6260.76
120_L151_M0.6240.75
90_E129_D0.6200.75
92_V151_M0.6180.75
51_N55_Y0.6170.75
54_N192_E0.6160.75
109_E216_Q0.6130.74
151_M187_V0.6130.74
120_L138_E0.6110.74
134_E138_E0.6090.74
25_V78_E0.6030.73
170_G203_K0.6000.73
130_P136_Y0.5980.72
132_V137_C0.5910.71
104_R131_M0.5880.71
161_V165_L0.5860.71
61_L158_A0.5860.71
208_K213_R0.5840.71
218_L221_L0.5830.70
208_K218_L0.5830.70
171_L209_M0.5820.70
20_N83_K0.5820.70
158_A189_L0.5800.70
6_E17_S0.5790.70
211_K215_R0.5790.70
61_L68_T0.5780.70
51_N78_E0.5770.70
116_P156_Y0.5770.70
97_A101_L0.5760.70
110_G206_L0.5760.70
73_L79_C0.5740.69
26_L79_C0.5730.69
57_I201_W0.5730.69
178_L193_F0.5720.69
169_A200_L0.5720.69
61_L161_V0.5710.69
103_K216_Q0.5650.68
217_S220_G0.5600.67
46_K196_D0.5580.67
192_E195_P0.5570.67
141_G164_K0.5540.67
100_S103_K0.5530.66
112_E150_R0.5490.66
98_A216_Q0.5490.66
12_A197_G0.5490.66
212_D219_G0.5480.66
176_F198_S0.5470.66
115_P135_S0.5460.65
57_I165_L0.5430.65
69_Q81_V0.5430.65
167_D172_I0.5420.65
96_R198_S0.5390.64
194_S198_S0.5340.64
71_E184_K0.5280.63
8_Y125_D0.5280.63
98_A219_G0.5250.62
12_A50_N0.5230.62
124_N127_M0.5230.62
174_V201_W0.5230.62
37_G40_I0.5220.62
98_A104_R0.5210.62
61_L193_F0.5160.61
117_L131_M0.5150.61
201_W210_D0.5140.61
17_S23_L0.5140.61
57_I193_F0.5100.60
90_E123_K0.5090.60
41_E49_V0.5070.60
138_E149_A0.5070.60
150_R157_K0.5060.60
14_T31_D0.5050.59
51_N58_M0.5030.59
138_E152_K0.5020.59
90_E177_K0.5000.59
78_E81_V0.5000.59
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3kreA 2 0.9831 100 0.018 Contact Map
2gqrA 2 1 100 0.023 Contact Map
3nuaA 2 0.9873 100 0.023 Contact Map
2ywvA 2 0.9916 100 0.031 Contact Map
2z02A 2 0.9873 100 0.033 Contact Map
4fe2A 2 0.9831 100 0.042 Contact Map
1kutA 2 0.9367 100 0.065 Contact Map
2h31A 6 0.8819 100 0.066 Contact Map
3u55A 2 0.9451 100 0.068 Contact Map
4ja0A 6 0.962 100 0.074 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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