GREMLIN Database
PURA - Adenylosuccinate synthetase
UniProt: P0A7D4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10790
Length: 432 (421)
Sequences: 3013 (1511)
Seq/√Len: 73.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
341_E375_T6.1631.00
349_R370_E5.8811.00
54_H301_T5.3681.00
340_K380_S4.3091.00
85_K197_I3.6821.00
394_Q398_N3.6341.00
388_D391_G3.6101.00
52_V300_A3.3691.00
374_E402_R3.3141.00
352_D368_G3.2971.00
49_E90_R3.1701.00
389_R397_L3.0521.00
330_L400_I3.0281.00
402_R406_L2.9901.00
289_E293_K2.9501.00
292_C305_R2.9291.00
85_K89_D2.7841.00
78_A190_D2.7271.00
290_F339_L2.7001.00
341_E377_P2.6771.00
311_L316_V2.6561.00
395_A398_N2.6401.00
93_P96_E2.5841.00
344_L402_R2.5391.00
313_T406_L2.5291.00
343_K375_T2.5261.00
262_Y327_G2.4651.00
183_D186_K2.4321.00
116_N131_G2.4191.00
290_F294_Q2.4161.00
344_L376_M2.4051.00
338_G381_E2.3791.00
29_K217_D2.3571.00
159_A163_K2.3131.00
30_Y212_A2.2941.00
76_S112_V2.2911.00
349_R355_E2.2731.00
106_L149_V2.2501.00
389_R401_K2.1971.00
110_Y165_V2.1691.00
337_D383_T2.1621.00
293_K298_F2.1381.00
126_A276_A2.1141.00
328_F407_T2.0951.00
174_V181_A2.0811.00
211_Q215_R2.0691.00
228_L315_A2.0551.00
185_Q189_D2.0501.00
350_M369_V2.0461.00
153_F202_V2.0031.00
32_V253_S1.9991.00
350_M356_V1.9781.00
75_L104_C1.9641.00
69_I73_V1.9581.00
377_P395_A1.9521.00
327_G412_D1.9351.00
402_R405_E1.9011.00
394_Q397_L1.8891.00
397_L401_K1.8571.00
99_L203_V1.8511.00
99_L208_L1.8311.00
350_M368_G1.8251.00
376_M402_R1.8041.00
344_L406_L1.7901.00
81_M197_I1.7761.00
214_Q408_G1.7561.00
184_Y188_L1.7291.00
10_T325_L1.7121.00
338_G380_S1.6651.00
381_E395_A1.6651.00
85_K88_E1.6621.00
75_L80_L1.6511.00
398_N401_K1.6381.00
347_A355_E1.6341.00
311_L403_I1.6321.00
196_D199_T1.6010.99
75_L149_V1.5830.99
186_K190_D1.5800.99
401_K426_L1.5710.99
294_Q338_G1.5670.99
377_P398_N1.5640.99
69_I75_L1.5580.99
158_F162_L1.5560.99
292_C298_F1.5530.99
149_V202_V1.5520.99
386_V391_G1.5500.99
38_H76_S1.5420.99
404_E426_L1.5330.99
66_T99_L1.5320.99
48_G419_D1.5250.99
162_L184_Y1.5230.99
163_K184_Y1.4990.99
78_A194_V1.4980.99
387_K391_G1.4970.99
153_F199_T1.4960.99
401_K404_E1.4950.99
46_I61_L1.4910.99
159_A188_L1.4900.99
213_R219_V1.4880.99
158_F191_T1.4800.99
38_H107_I1.4740.99
105_P146_G1.4740.99
350_M365_D1.4690.99
80_L84_M1.4630.99
210_D214_Q1.4590.99
38_H79_A1.4590.99
155_K192_M1.4550.99
389_R426_L1.4460.99
345_C371_P1.4350.99
288_G308_T1.4270.99
337_D382_S1.4100.99
400_I411_I1.4000.99
104_C149_V1.3990.98
6_V249_V1.3940.98
320_V325_L1.3910.98
203_V208_L1.3820.98
401_K405_E1.3750.98
346_V355_E1.3690.98
68_I205_V1.3580.98
285_D288_G1.3530.98
71_N233_H1.3440.98
139_E143_A1.3390.98
227_T323_N1.3370.98
267_L316_V1.3300.98
80_L98_L1.3260.98
221_F255_L1.3190.98
188_L192_M1.3010.98
284_F287_T1.2840.97
362_A365_D1.2800.97
77_P198_L1.2800.97
78_A82_K1.2750.97
320_V409_V1.2730.97
30_Y209_L1.2710.97
120_K179_A1.2630.97
189_D193_A1.2630.97
387_K421_T1.2620.97
283_L288_G1.2610.97
212_A217_D1.2600.97
258_R326_S1.2570.97
374_E406_L1.2480.97
313_T402_R1.2210.96
343_K373_Y1.2200.96
159_A184_Y1.1970.96
350_M354_R1.1910.96
30_Y208_L1.1850.96
355_E370_E1.1770.96
416_T422_E1.1650.95
387_K422_E1.1640.95
4_N221_F1.1600.95
210_D259_Y1.1570.95
31_V65_V1.1500.95
210_D321_Q1.1460.95
34_Y244_T1.1450.95
22_D420_R1.1400.95
258_R324_S1.1390.95
159_A185_Q1.1370.95
117_A173_L1.1310.95
155_K159_A1.1270.94
337_D381_E1.1250.94
314_V347_A1.1250.94
403_I411_I1.1250.94
154_D364_D1.1210.94
162_L188_L1.1150.94
86_E89_D1.1130.94
313_T344_L1.1120.94
120_K131_G1.1000.94
384_F422_E1.0970.94
66_T208_L1.0940.93
256_G324_S1.0930.93
157_T161_K1.0910.93
346_V374_E1.0910.93
214_Q259_Y1.0900.93
81_M198_L1.0830.93
113_A116_N1.0820.93
103_A361_L1.0810.93
163_K167_E1.0800.93
147_L158_F1.0780.93
206_S321_Q1.0750.93
207_D321_Q1.0710.93
289_E305_R1.0650.93
359_T366_W1.0610.92
337_D380_S1.0590.92
227_T319_A1.0540.92
102_E361_L1.0510.92
9_G15_E1.0500.92
243_N251_T1.0500.92
209_L219_V1.0420.92
189_D192_M1.0300.91
26_E62_R1.0280.91
207_D211_Q1.0260.91
349_R353_G1.0220.91
108_L191_T1.0210.91
286_E289_E1.0180.91
171_F176_Y1.0180.91
319_A323_N1.0130.91
100_L149_V1.0030.90
355_E372_I0.9990.90
117_A179_A0.9960.90
75_L100_L0.9930.90
376_M398_N0.9850.89
290_F293_K0.9790.89
4_N213_R0.9770.89
191_T194_V0.9770.89
289_E292_C0.9760.89
414_I424_M0.9680.88
293_K296_N0.9660.88
313_T316_V0.9640.88
212_A215_R0.9580.88
205_V208_L0.9560.88
271_S315_A0.9550.88
311_L407_T0.9530.88
166_M170_N0.9530.88
141_K232_D0.9510.88
386_V389_R0.9450.87
182_V187_V0.9400.87
404_E411_I0.9290.86
209_L253_S0.9280.86
195_A199_T0.9260.86
213_R255_L0.9230.86
282_E307_R0.9230.86
313_T403_I0.9230.86
250_A257_P0.9200.86
225_Q229_L0.9160.86
349_R352_D0.9160.86
125_K238_Y0.9120.85
262_Y412_D0.9110.85
160_E164_E0.9060.85
265_G325_L0.8940.84
159_A192_M0.8900.84
107_I137_A0.8890.84
272_T332_K0.8850.84
291_L331_T0.8850.84
262_Y326_S0.8850.84
113_A182_V0.8820.83
333_L396_A0.8790.83
228_L318_R0.8790.83
139_E145_R0.8760.83
63_E97_R0.8740.83
125_K160_E0.8720.83
199_T202_V0.8710.83
365_D368_G0.8680.82
68_I208_L0.8660.82
193_A196_D0.8640.82
287_T339_L0.8600.82
229_L273_R0.8570.81
385_G416_T0.8550.81
349_R354_R0.8510.81
113_A179_A0.8490.81
387_K416_T0.8450.81
6_V260_V0.8440.80
413_I423_T0.8440.80
287_T290_F0.8430.80
86_E90_R0.8430.80
129_T135_G0.8410.80
247_G251_T0.8360.80
281_T373_Y0.8350.80
109_D190_D0.8320.80
207_D358_T0.8310.79
166_M182_V0.8310.79
88_E93_P0.8310.79
122_R164_E0.8290.79
384_F416_T0.8290.79
211_Q357_T0.8280.79
419_D422_E0.8270.79
43_T50_K0.8230.79
47_N421_T0.8180.78
50_K296_N0.8140.78
221_F253_S0.8080.78
382_S416_T0.8080.78
80_L201_M0.8050.77
400_I414_I0.8040.77
191_T195_A0.8040.77
87_L92_I0.8030.77
30_Y66_T0.8030.77
64_N93_P0.8020.77
206_S233_H0.8010.77
45_V50_K0.8010.77
175_N178_K0.7990.77
20_I413_I0.7990.77
245_T248_G0.7950.76
150_G361_L0.7940.76
101_S205_V0.7930.76
316_V407_T0.7930.76
171_F175_N0.7900.76
88_E197_I0.7900.76
349_R372_I0.7900.76
34_Y248_G0.7900.76
298_F305_R0.7890.76
205_V209_L0.7880.76
7_V28_A0.7880.76
366_W369_V0.7840.75
149_V198_L0.7820.75
142_V231_I0.7810.75
68_I203_V0.7790.75
155_K188_L0.7770.75
245_T251_T0.7770.75
283_L287_T0.7760.75
327_G410_P0.7720.74
286_E290_F0.7720.74
400_I404_E0.7720.74
56_I226_G0.7720.74
76_S79_A0.7710.74
417_G422_E0.7700.74
389_R400_I0.7690.74
105_P137_A0.7690.74
141_K148_R0.7690.74
400_I426_L0.7690.74
193_A197_I0.7670.74
77_P81_M0.7660.74
71_N252_G0.7650.74
82_K86_E0.7640.73
398_N405_E0.7630.73
156_E160_E0.7620.73
29_K218_F0.7620.73
356_V369_V0.7600.73
247_G256_G0.7590.73
382_S385_G0.7590.73
50_K300_A0.7580.73
267_L328_F0.7570.73
113_A117_A0.7560.73
55_L73_V0.7550.73
291_L332_K0.7550.73
318_R321_Q0.7530.72
54_H86_E0.7500.72
117_A131_G0.7470.72
71_N243_N0.7460.72
224_A229_L0.7450.72
317_R406_L0.7450.72
56_I87_L0.7450.72
356_V365_D0.7450.72
267_L330_L0.7380.71
192_M195_A0.7380.71
270_Y335_V0.7350.71
147_L165_V0.7330.70
84_M94_V0.7320.70
338_G342_V0.7310.70
350_M353_G0.7300.70
386_V397_L0.7270.70
342_V380_S0.7240.69
33_R224_A0.7230.69
390_S397_L0.7230.69
347_A372_I0.7220.69
219_V255_L0.7210.69
235_T273_R0.7210.69
225_Q273_R0.7200.69
246_A250_A0.7200.69
294_Q339_L0.7190.69
332_K335_V0.7190.69
35_Q226_G0.7180.69
355_E374_E0.7170.69
325_L409_V0.7160.69
30_Y68_I0.7160.69
112_V116_N0.7150.68
88_E94_V0.7140.68
339_L342_V0.7130.68
102_E202_V0.7100.68
74_V138_Y0.7090.68
140_D169_H0.7080.68
342_V399_Y0.7080.68
329_C413_I0.7050.67
79_A107_I0.7040.67
8_L249_V0.7010.67
113_A131_G0.7000.67
54_H79_A0.7000.67
293_K305_R0.6990.67
63_E93_P0.6990.67
272_T308_T0.6970.67
102_E150_G0.6970.67
60_I67_S0.6970.67
364_D367_K0.6950.66
110_Y169_H0.6930.66
81_M85_K0.6920.66
382_S422_E0.6910.66
376_M406_L0.6900.66
81_M84_M0.6890.66
283_L308_T0.6860.65
51_T90_R0.6850.65
81_M194_V0.6840.65
317_R357_T0.6840.65
10_T267_L0.6830.65
135_G144_R0.6810.65
221_F249_V0.6780.64
363_A367_K0.6770.64
374_E398_N0.6750.64
190_D193_A0.6750.64
295_G335_V0.6750.64
69_I80_L0.6740.64
287_T291_L0.6690.63
62_R65_V0.6690.63
5_V28_A0.6690.63
48_G421_T0.6660.63
166_M184_Y0.6660.63
376_M395_A0.6650.63
224_A273_R0.6640.63
4_N255_L0.6630.63
93_P97_R0.6620.63
192_M196_D0.6580.62
150_G362_A0.6550.62
248_G252_G0.6550.62
113_A173_L0.6540.62
161_K164_E0.6540.62
118_R139_E0.6530.61
186_K189_D0.6520.61
35_Q244_T0.6500.61
5_V264_L0.6480.61
347_A357_T0.6480.61
229_L235_T0.6470.61
10_T265_G0.6460.61
67_S300_A0.6460.61
129_T239_V0.6460.61
290_F338_G0.6450.61
213_R259_Y0.6450.61
82_K85_K0.6410.60
38_H416_T0.6410.60
228_L359_T0.6400.60
311_L406_L0.6400.60
8_L246_A0.6380.60
103_A150_G0.6380.60
68_I209_L0.6370.60
207_D357_T0.6360.59
170_N181_A0.6350.59
413_I425_I0.6350.59
170_N182_V0.6340.59
263_V325_L0.6320.59
81_M100_L0.6320.59
52_V67_S0.6310.59
146_G236_Y0.6310.59
38_H292_C0.6300.59
30_Y219_V0.6280.58
235_T271_S0.6280.58
295_G308_T0.6280.58
105_P148_R0.6270.58
123_G276_A0.6240.58
170_N177_Y0.6230.58
30_Y217_D0.6230.58
21_V267_L0.6230.58
102_E204_D0.6220.58
264_L327_G0.6220.58
34_Y415_S0.6210.58
56_I60_I0.6210.58
328_F400_I0.6200.58
286_E340_K0.6190.57
60_I98_L0.6180.57
364_D368_G0.6170.57
151_D161_K0.6140.57
190_D194_V0.6120.57
32_V70_G0.6110.56
102_E362_A0.6070.56
194_V198_L0.6060.56
129_T144_R0.6060.56
328_F403_I0.6040.56
407_T411_I0.6030.55
112_V190_D0.6020.55
111_H140_D0.6000.55
291_L342_V0.5970.55
342_V376_M0.5960.55
53_L60_I0.5960.55
127_I144_R0.5960.55
383_T396_A0.5940.54
210_D256_G0.5940.54
114_L173_L0.5940.54
71_N232_D0.5940.54
346_V349_R0.5920.54
70_G252_G0.5920.54
82_K89_D0.5920.54
374_E377_P0.5920.54
345_C373_Y0.5910.54
320_V407_T0.5910.54
35_Q111_H0.5910.54
20_I415_S0.5880.54
23_L415_S0.5880.54
156_E159_A0.5880.54
392_L396_A0.5870.53
157_T160_E0.5860.53
84_M201_M0.5860.53
344_L403_I0.5860.53
54_H82_K0.5840.53
309_G312_D0.5840.53
163_K189_D0.5840.53
208_L212_A0.5830.53
78_A191_T0.5830.53
180_E183_D0.5830.53
117_A120_K0.5830.53
337_D416_T0.5830.53
415_S423_T0.5810.53
51_T300_A0.5810.53
344_L405_E0.5800.53
238_Y276_A0.5800.53
164_E167_E0.5800.53
399_Y403_I0.5790.52
411_I414_I0.5790.52
344_L374_E0.5780.52
25_T28_A0.5770.52
394_Q401_K0.5770.52
173_L179_A0.5760.52
60_I92_I0.5760.52
111_H223_G0.5750.52
337_D384_F0.5750.52
38_H169_H0.5740.52
35_Q53_L0.5740.52
416_T423_T0.5740.52
149_V199_T0.5730.52
7_V122_R0.5710.51
260_V263_V0.5690.51
11_Q144_R0.5690.51
150_G202_V0.5680.51
183_D192_M0.5680.51
311_L344_L0.5680.51
56_I279_F0.5650.51
313_T407_T0.5630.50
102_E153_F0.5630.50
168_Y172_Q0.5630.50
121_A171_F0.5630.50
274_V304_R0.5620.50
111_H137_A0.5610.50
132_R301_T0.5610.50
20_I329_C0.5610.50
142_V145_R0.5610.50
154_D362_A0.5600.50
112_V132_R0.5590.50
13_G17_K0.5580.50
10_T226_G0.5580.50
341_E398_N0.5570.50
232_D243_N0.5570.50
44_L51_T0.5560.50
352_D365_D0.5560.50
122_R367_K0.5560.50
25_T62_R0.5550.49
126_A131_G0.5530.49
270_Y295_G0.5530.49
10_T316_V0.5500.49
68_I99_L0.5500.49
118_R168_Y0.5500.49
213_R290_F0.5480.49
130_T136_P0.5480.49
71_N101_S0.5480.49
167_E171_F0.5470.48
54_H300_A0.5470.48
268_K297_E0.5470.48
314_V359_T0.5460.48
157_T364_D0.5460.48
281_T345_C0.5450.48
109_D187_V0.5450.48
170_N174_V0.5430.48
207_D210_D0.5410.48
296_N305_R0.5410.48
37_G42_H0.5400.48
6_V246_A0.5400.48
274_V302_T0.5390.47
383_T416_T0.5390.47
54_H132_R0.5380.47
153_F195_A0.5370.47
46_I49_E0.5370.47
45_V419_D0.5350.47
64_N97_R0.5350.47
9_G13_G0.5340.47
226_G415_S0.5330.47
156_E355_E0.5320.47
332_K336_L0.5310.46
44_L52_V0.5310.46
393_P396_A0.5310.46
349_R374_E0.5310.46
78_A193_A0.5300.46
68_I150_G0.5280.46
396_A416_T0.5280.46
66_T217_D0.5270.46
108_L165_V0.5270.46
155_K195_A0.5250.46
352_D362_A0.5250.46
386_V426_L0.5250.46
26_E397_L0.5240.46
283_L310_W0.5240.46
44_L53_L0.5240.46
7_V79_A0.5240.46
145_R168_Y0.5230.46
398_N402_R0.5230.46
38_H112_V0.5230.46
106_L147_L0.5220.45
20_I23_L0.5220.45
354_R370_E0.5220.45
135_G273_R0.5200.45
44_L245_T0.5200.45
389_R414_I0.5180.45
268_K274_V0.5180.45
245_T250_A0.5170.45
211_Q358_T0.5160.45
405_E408_G0.5160.45
116_N120_K0.5160.45
33_R111_H0.5160.45
328_F411_I0.5150.45
297_E304_R0.5150.45
208_L211_Q0.5150.45
32_V209_L0.5140.44
125_K164_E0.5130.44
386_V405_E0.5130.44
5_V262_Y0.5120.44
162_L187_V0.5120.44
248_G251_T0.5110.44
122_R145_R0.5110.44
113_A180_E0.5110.44
77_P225_Q0.5100.44
272_T331_T0.5100.44
147_L151_D0.5090.44
157_T365_D0.5080.44
21_V31_V0.5080.44
349_R368_G0.5080.44
62_R139_E0.5080.44
255_L259_Y0.5070.44
7_V24_L0.5070.44
174_V177_Y0.5070.44
11_Q135_G0.5070.44
404_E410_P0.5070.44
250_A260_V0.5070.44
117_A178_K0.5060.43
38_H123_G0.5060.43
365_D369_V0.5060.43
211_Q214_Q0.5050.43
44_L50_K0.5050.43
77_P194_V0.5050.43
201_M330_L0.5050.43
235_T272_T0.5050.43
315_A325_L0.5040.43
174_V180_E0.5030.43
35_Q223_G0.5030.43
224_A235_T0.5030.43
250_A253_S0.5020.43
330_L403_I0.5020.43
245_T359_T0.5020.43
337_D342_V0.5010.43
55_L74_V0.5000.43
388_D424_M0.5000.43
250_A255_L0.5000.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3hidA 2 0.9815 100 0.003 Contact Map
4m9dA 2 0.9931 100 0.006 Contact Map
3ue9A 2 0.9722 100 0.012 Contact Map
2v40A 2 0.956 100 0.026 Contact Map
1dj2A 2 0.9815 100 0.027 Contact Map
3r7tA 4 0.9444 100 0.029 Contact Map
1p9bA 2 0.9699 100 0.03 Contact Map
2d7uA 2 0.7384 100 0.208 Contact Map
1f8mA 4 0.6227 34.6 0.981 Contact Map
2a3lA 3 0.1644 14.6 0.984 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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