GREMLIN Database
PTH - Peptidyl-tRNA hydrolase
UniProt: P0A7D1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10785
Length: 194 (185)
Sequences: 4110 (2814)
Seq/√Len: 206.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
76_A80_S3.3631.00
121_I130_F3.1611.00
79_A89_I2.8411.00
93_H117_L2.7431.00
29_D63_V2.6851.00
4_K88_E2.6201.00
51_R58_D2.5031.00
19_T153_K2.4721.00
75_V120_I2.4291.00
70_L73_K2.3801.00
96_L137_I2.3611.00
47_G62_L2.3501.00
62_L78_M2.2801.00
115_N118_K2.2101.00
37_A50_S2.1401.00
46_F73_K2.1361.00
47_G74_A2.0901.00
30_L33_E2.0371.00
37_A52_V2.0331.00
96_L146_V1.9761.00
28_V61_L1.8321.00
7_V75_V1.8211.00
14_A17_A1.8051.00
34_R171_R1.7391.00
18_A26_W1.7371.00
119_D123_K1.7331.00
111_H118_K1.7201.00
48_Y65_T1.6581.00
175_M184_A1.6011.00
34_R174_E1.6001.00
111_H121_I1.5991.00
39_L50_S1.5921.00
32_A61_L1.5771.00
30_L167_D1.5501.00
28_V39_L1.5291.00
90_L133_L1.5151.00
62_L74_A1.4521.00
91_V120_I1.4331.00
79_A124_L1.4321.00
76_A123_K1.4261.00
23_A135_I1.4251.00
180_G183_K1.4201.00
179_D183_K1.3911.00
180_G184_A1.3801.00
25_A63_V1.3701.00
66_T74_A1.3571.00
35_L174_E1.3451.00
131_H181_L1.3341.00
175_M179_D1.3311.00
107_L182_T1.3301.00
175_M188_L1.3301.00
70_L119_D1.3171.00
30_L34_R1.2861.00
119_D122_S1.2751.00
100_P165_A1.2731.00
27_F166_I1.2681.00
147_V152_G1.2591.00
141_G144_N1.2581.00
159_Q163_D1.2501.00
183_K187_R1.2461.00
86_P126_N1.2451.00
117_L130_F1.2411.00
156_V160_K1.2361.00
73_K123_K1.2071.00
30_L170_A1.2001.00
32_A39_L1.1971.00
90_L176_W1.1951.00
27_F92_A1.1901.00
100_P138_G1.1821.00
5_L84_I1.1681.00
46_F77_A1.1661.00
107_L131_H1.1631.00
26_W159_Q1.1591.00
85_N88_E1.1551.00
139_H146_V1.1511.00
144_N148_G1.1471.00
161_L164_E1.1391.00
12_P65_T1.1301.00
105_F181_L1.1241.00
155_P158_E1.1241.00
9_L68_M1.1231.00
145_K148_G1.1191.00
18_A159_Q1.1121.00
135_I165_A1.1031.00
34_R170_A1.0931.00
35_L52_V1.0871.00
20_R158_E1.0781.00
179_D187_R1.0531.00
27_F135_I1.0501.00
92_A173_T1.0481.00
5_L62_L1.0411.00
27_F169_A1.0381.00
31_L173_T1.0271.00
97_D134_R1.0221.00
99_P102_V1.0161.00
6_I92_A1.0051.00
175_M180_G1.0011.00
160_K163_D0.9981.00
39_L63_V0.9961.00
100_P161_L0.9931.00
162_I166_I0.9861.00
26_W154_P0.9821.00
53_T58_D0.9751.00
30_L166_I0.9751.00
90_L173_T0.9751.00
126_N129_N0.9691.00
79_A84_I0.9681.00
26_W166_I0.9570.99
97_D139_H0.9560.99
105_F133_L0.9510.99
32_A37_A0.9500.99
54_L59_V0.9450.99
32_A50_S0.9420.99
172_C188_L0.9370.99
35_L54_L0.9330.99
164_E167_D0.9320.99
157_S160_K0.9310.99
108_G129_N0.9230.99
95_E112_G0.9090.99
31_L35_L0.9070.99
164_E168_E0.9030.99
30_L163_D0.9020.99
90_L131_H0.8930.99
100_P162_I0.8930.99
183_K186_N0.8850.99
140_P146_V0.8840.99
23_A26_W0.8820.99
25_A64_P0.8790.99
68_M114_H0.8700.99
20_R152_G0.8680.99
27_F173_T0.8660.99
25_A65_T0.8590.99
45_F81_F0.8580.99
118_K122_S0.8560.99
160_K164_E0.8550.99
3_I57_E0.8540.99
59_V177_F0.8490.99
55_G178_T0.8470.99
42_E51_R0.8410.99
7_V89_I0.8370.99
3_I88_E0.8360.99
165_A169_A0.8340.99
174_E178_T0.8340.99
18_A153_K0.8330.99
34_R167_D0.8310.99
6_I173_T0.8310.99
47_G65_T0.8230.98
168_E171_R0.8210.98
133_L176_W0.8140.98
39_L49_T0.8130.98
73_K119_D0.8080.98
98_L102_V0.8070.98
111_H127_N0.8020.98
45_F77_A0.7940.98
8_G28_V0.7930.98
77_A80_S0.7910.98
171_R174_E0.7880.98
25_A29_D0.7860.98
55_G174_E0.7850.98
173_T177_F0.7790.98
5_L78_M0.7740.98
23_A162_I0.7680.98
4_K57_E0.7680.98
95_E134_R0.7650.98
96_L139_H0.7630.98
49_T78_M0.7610.97
158_E161_L0.7550.97
87_D107_L0.7540.97
87_D129_N0.7470.97
175_M187_R0.7470.97
172_C184_A0.7450.97
175_M178_T0.7410.97
16_Y19_T0.7370.97
154_P162_I0.7330.97
49_T60_R0.7320.97
106_K109_G0.7310.97
93_H97_D0.7310.97
80_S123_K0.7300.97
48_Y63_V0.7300.97
92_A135_I0.7290.97
89_I124_L0.7250.97
100_P154_P0.7170.96
156_V159_Q0.7110.96
53_T56_G0.7100.96
113_G117_L0.7020.96
167_D171_R0.7000.96
170_A174_E0.6990.96
60_R78_M0.6970.96
98_L134_R0.6920.96
39_L48_Y0.6920.96
105_F172_C0.6910.96
121_I127_N0.6900.96
144_N149_F0.6890.95
52_V59_V0.6860.95
93_H134_R0.6840.95
163_D167_D0.6760.95
98_L104_K0.6670.95
75_V89_I0.6660.95
138_G149_F0.6630.94
109_G132_R0.6600.94
113_G121_I0.6580.94
44_K81_F0.6560.94
111_H117_L0.6540.94
133_L173_T0.6530.94
3_I60_R0.6530.94
26_W162_I0.6520.94
40_R50_S0.6450.94
7_V62_L0.6430.93
170_A173_T0.6430.93
137_I150_V0.6420.93
45_F82_F0.6390.93
86_P124_L0.6320.93
109_G117_L0.6250.93
122_S125_G0.6250.93
10_A25_A0.6180.92
166_I170_A0.6180.92
92_A169_A0.6170.92
6_I90_L0.6130.92
32_A38_P0.6080.91
184_A188_L0.6070.91
5_L79_A0.6060.91
44_K49_T0.6060.91
141_G149_F0.6050.91
54_L57_E0.6040.91
13_G67_F0.5970.91
103_A165_A0.5960.91
176_W184_A0.5930.90
49_T82_F0.5880.90
79_A86_P0.5880.90
95_E98_L0.5840.90
103_A188_L0.5810.90
105_F131_H0.5810.90
182_T186_N0.5800.89
23_A154_P0.5770.89
100_P163_D0.5740.89
133_L169_A0.5720.89
106_K110_G0.5690.89
4_K90_L0.5650.88
26_W153_K0.5630.88
4_K85_N0.5630.88
54_L177_F0.5620.88
51_R60_R0.5580.88
97_D146_V0.5560.87
114_H119_D0.5550.87
111_H119_D0.5540.87
45_F62_L0.5510.87
186_N189_H0.5510.87
117_L134_R0.5490.87
38_P50_S0.5450.86
28_V63_V0.5440.86
70_L123_K0.5440.86
27_F170_A0.5410.86
185_T189_H0.5380.86
115_N130_F0.5370.86
110_G127_N0.5360.85
168_E187_R0.5350.85
103_A189_H0.5350.85
80_S83_R0.5320.85
100_P158_E0.5290.85
15_E153_K0.5270.85
96_L140_P0.5270.85
67_F70_L0.5260.84
13_G17_A0.5220.84
153_K159_Q0.5220.84
93_H108_G0.5210.84
33_E38_P0.5210.84
112_G134_R0.5200.84
6_I28_V0.5190.84
20_R153_K0.5180.84
162_I165_A0.5160.83
60_R82_F0.5140.83
103_A168_E0.5130.83
93_H106_K0.5080.82
39_L42_E0.5050.82
107_L181_L0.5030.82
96_L147_V0.5010.81
120_I124_L0.5000.81
135_I169_A0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3v2iA 1 0.933 100 0.012 Contact Map
2mjlA 1 0.9948 100 0.013 Contact Map
2pthA 1 0.9897 100 0.014 Contact Map
4qajA 1 0.9948 100 0.014 Contact Map
2z2iA 1 0.9175 100 0.021 Contact Map
4lwrA 1 0.9897 100 0.021 Contact Map
4qt4A 1 0.9691 100 0.022 Contact Map
1rybA 1 0.9536 100 0.024 Contact Map
3neaA 1 0.9639 100 0.024 Contact Map
1cfzA 1 0.7629 54.2 0.945 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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