GREMLIN Database
PSIE - Protein PsiE
UniProt: P0A7C8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11209
Length: 136 (123)
Sequences: 187 (127)
Seq/√Len: 11.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
116_A120_L4.8671.00
29_L33_V2.9420.94
73_L125_L2.7740.92
24_L85_P2.5140.88
73_L80_S2.3850.85
59_E122_V2.2860.82
78_F91_Y2.2640.82
97_I121_L2.2270.81
45_V58_V2.2120.80
77_Y92_I2.1040.77
42_L114_Y2.0790.76
69_E105_H2.0420.74
67_Y101_I1.9810.72
17_Q129_N1.9200.69
39_T73_L1.8780.68
85_P88_Y1.8310.66
70_F118_I1.8260.65
84_F102_I1.8240.65
78_F103_V1.7680.63
77_Y91_Y1.6990.60
13_S16_L1.6280.56
67_Y76_K1.6130.56
103_V111_V1.5760.54
64_Y68_F1.5740.54
67_Y88_Y1.5250.51
55_Y117_A1.4150.46
40_V122_V1.3930.45
54_K62_V1.3880.45
17_Q20_L1.3880.45
124_T130_S1.3490.43
39_T64_Y1.3420.42
97_I125_L1.3400.42
20_L68_F1.3270.42
22_L123_I1.3250.41
90_V98_V1.3040.40
60_G114_Y1.2930.40
90_V97_I1.2880.40
29_L44_D1.2780.39
119_L129_N1.2590.38
28_G49_P1.2370.37
81_G120_L1.2320.37
100_L114_Y1.2310.37
77_Y84_F1.1980.36
84_F101_I1.1870.35
24_L112_L1.1840.35
67_Y84_F1.1810.35
21_N78_F1.1730.34
31_L102_I1.1700.34
20_L111_V1.1670.34
43_A62_V1.1590.34
15_I115_S1.1430.33
117_A125_L1.1380.33
90_V125_L1.1200.32
76_K84_F1.1150.32
11_F127_L1.1140.32
87_R119_L1.1090.32
24_L74_I1.1060.32
34_F60_G1.1060.32
84_F91_Y1.1030.31
49_P61_L1.0900.31
78_F82_F1.0900.31
97_I128_C1.0860.31
52_T120_L1.0450.29
78_F84_F1.0390.29
29_L109_L0.9830.27
26_C112_L0.9830.27
53_S114_Y0.9710.26
77_Y88_Y0.9600.26
76_K85_P0.9580.26
57_L64_Y0.9410.25
65_F96_A0.9390.25
29_L56_E0.9210.24
33_V40_V0.9200.24
112_L127_L0.9040.24
72_A119_L0.8920.23
62_V81_G0.8900.23
66_L102_I0.8900.23
24_L88_Y0.8840.23
78_F101_I0.8770.23
23_G113_I0.8760.23
73_L89_F0.8650.22
56_E115_S0.8630.22
84_F88_Y0.8620.22
76_K92_I0.8590.22
15_I29_L0.8510.22
21_N84_F0.8430.22
106_K123_I0.8380.21
53_S121_L0.8290.21
85_P95_T0.8240.21
12_I33_V0.8210.21
36_G57_L0.8200.21
98_V124_T0.8090.20
78_F89_F0.8070.20
37_K100_L0.8030.20
58_V125_L0.7970.20
26_C52_T0.7970.20
61_L71_I0.7950.20
16_L28_G0.7950.20
107_S112_L0.7920.20
32_V106_K0.7910.20
77_Y85_P0.7810.20
42_L60_G0.7700.19
26_C43_A0.7700.19
38_E63_V0.7620.19
55_Y80_S0.7590.19
97_I117_A0.7570.19
27_L39_T0.7530.19
14_T22_L0.7480.19
19_V103_V0.7430.18
22_L109_L0.7430.18
32_V107_S0.7420.18
41_H124_T0.7290.18
76_K91_Y0.7260.18
68_F72_A0.7220.18
119_L123_I0.7220.18
47_F61_L0.7200.18
9_V115_S0.7190.18
16_L104_D0.7110.18
76_K82_F0.7040.17
30_I39_T0.7030.17
79_Q116_A0.7020.17
10_E29_L0.6920.17
108_P114_Y0.6870.17
123_I128_C0.6870.17
90_V128_C0.6840.17
18_T22_L0.6830.17
69_E76_K0.6750.17
99_R118_I0.6730.16
35_L63_V0.6660.16
69_E96_A0.6540.16
83_H99_R0.6520.16
52_T56_E0.6500.16
27_L114_Y0.6480.16
29_L120_L0.6420.16
36_G40_V0.6400.16
10_E43_A0.6380.16
56_E127_L0.6350.15
19_V109_L0.6310.15
89_F111_V0.6240.15
80_S125_L0.6210.15
73_L86_L0.6190.15
39_T80_S0.6170.15
114_Y121_L0.6120.15
34_F127_L0.6050.15
22_L27_L0.6020.15
69_E97_I0.5990.15
15_I19_V0.5940.14
77_Y103_V0.5900.14
46_L79_Q0.5860.14
16_L82_F0.5860.14
51_Q109_L0.5790.14
82_F91_Y0.5750.14
34_F46_L0.5680.14
91_Y101_I0.5680.14
21_N124_T0.5670.14
22_L53_S0.5660.14
45_V50_E0.5620.14
77_Y82_F0.5560.14
82_F103_V0.5550.14
42_L113_I0.5530.13
89_F105_H0.5500.13
27_L131_K0.5460.13
106_K131_K0.5440.13
34_F64_Y0.5440.13
45_V60_G0.5410.13
67_Y78_F0.5410.13
74_I102_I0.5390.13
81_G127_L0.5350.13
22_L43_A0.5350.13
27_L36_G0.5330.13
86_L93_G0.5270.13
80_S85_P0.5240.13
75_V103_V0.5220.13
73_L128_C0.5160.13
18_T57_L0.5160.13
39_T60_G0.5150.13
40_V43_A0.5120.13
33_V79_Q0.5100.13
36_G126_W0.5090.13
52_T116_A0.5030.12
88_Y92_I0.5020.12
32_V36_G0.5020.12
64_Y73_L0.5010.12
33_V57_L0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4hw9A 3 0.6765 9.9 0.946 Contact Map
1rklA 1 0.2647 9.3 0.947 Contact Map
3l1lA 2 0.9118 7.2 0.95 Contact Map
2latA 1 0.2647 7 0.95 Contact Map
3m73A 3 0.4485 5.4 0.953 Contact Map
2kluA 1 0.2426 3.4 0.957 Contact Map
2ww9B 1 0.4412 3.1 0.958 Contact Map
3j2wE 1 0.3382 2.9 0.959 Contact Map
3j5pB 3 0.9265 2.7 0.959 Contact Map
2mfrA 1 0.2941 2.4 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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