GREMLIN Database
PEPE - Peptidase E
UniProt: P0A7C6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11920
Length: 229 (198)
Sequences: 1967 (1468)
Seq/√Len: 104.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
109_V114_A4.5031.00
35_V80_A3.9561.00
75_A79_N3.2361.00
83_V114_A2.9141.00
77_I102_L2.8891.00
32_R81_E2.8431.00
4_L7_S2.8371.00
74_V108_D2.6131.00
33_S63_S2.5561.00
78_E108_D2.5141.00
94_L146_A2.3261.00
193_G208_P2.2591.00
23_L26_E2.2471.00
110_V149_L2.2391.00
35_V76_A2.1981.00
40_A93_L2.1731.00
23_L204_T2.1491.00
7_S10_T2.0781.00
109_V112_R2.0381.00
120_S157_H2.0161.00
35_V67_I2.0051.00
94_L130_I1.9821.00
36_F49_Y1.8921.00
188_I213_V1.8651.00
33_S81_E1.8491.00
53_T57_L1.8101.00
107_T111_K1.8051.00
123_A154_I1.8051.00
35_V77_I1.7461.00
24_I82_I1.7051.00
71_V75_A1.7021.00
5_L126_A1.6831.00
85_V116_Y1.6821.00
34_A82_I1.6621.00
74_V105_P1.6581.00
95_K99_E1.6541.00
51_A55_A1.6481.00
65_T76_A1.6461.00
87_G120_S1.6211.00
23_L27_Q1.5641.00
108_D112_R1.5451.00
197_T206_G1.5381.00
33_S79_N1.5101.00
50_T66_G1.5001.00
24_I117_I1.4671.00
83_V106_I1.4621.00
72_D75_A1.4601.00
128_P152_L1.4511.00
34_A62_V1.4511.00
38_P66_G1.4291.00
69_S101_G1.4261.00
33_S65_T1.3681.00
188_I196_I1.3641.00
175_I187_I1.3560.99
199_S204_T1.3520.99
106_I110_V1.3310.99
130_I146_A1.3210.99
105_P108_D1.3190.99
101_G104_A1.3130.99
74_V78_E1.2970.99
29_Q32_R1.2950.99
122_G157_H1.2880.99
84_I119_W1.2810.99
98_R103_L1.2810.99
179_L187_I1.2640.99
36_F86_G1.2530.99
116_Y126_A1.2460.99
118_G122_G1.2420.99
6_L10_T1.2330.99
35_V83_V1.2240.99
197_T204_T1.2120.99
85_V93_L1.2060.99
84_I117_I1.1980.99
96_Q99_E1.1710.98
88_G157_H1.1680.98
39_F73_P1.1670.98
65_T80_A1.1590.98
119_W192_E1.1570.98
7_S11_L1.1470.98
98_R142_Q1.1250.98
124_N156_P1.1240.98
78_E109_V1.1220.98
88_G120_S1.1180.98
77_I105_P1.1080.98
160_N192_E1.1070.98
137_P141_P1.0780.97
110_V116_Y1.0760.97
150_F153_Q1.0750.97
49_Y86_G1.0560.97
196_I203_A1.0560.97
121_A157_H1.0550.97
53_T84_I1.0470.97
37_I93_L1.0380.97
78_E105_P1.0280.97
49_Y52_K1.0240.96
175_I179_L1.0220.96
171_R174_R1.0170.96
8_N11_L1.0110.96
77_I80_A1.0090.96
198_V203_A1.0080.96
35_V65_T1.0070.96
124_N130_I1.0030.96
47_D51_A0.9920.96
77_I109_V0.9920.96
101_G105_P0.9910.96
74_V101_G0.9790.95
91_F99_E0.9770.95
135_D138_I0.9760.95
82_I115_L0.9630.95
87_G157_H0.9600.95
172_E176_R0.9590.95
153_Q187_I0.9560.95
23_L197_T0.9520.95
148_N151_P0.9480.95
36_F90_T0.9470.95
54_A66_G0.9440.94
20_A27_Q0.9410.94
128_P151_P0.9360.94
38_P86_G0.9350.94
118_G157_H0.9280.94
97_C125_L0.9160.94
69_S72_D0.9120.93
26_E202_H0.9060.93
90_T156_P0.8820.92
76_A80_A0.8770.92
129_T144_F0.8750.92
115_L197_T0.8690.92
105_P114_A0.8620.91
153_Q175_I0.8590.91
137_P140_D0.8580.91
154_I190_L0.8480.91
108_D111_K0.8440.90
160_N191_P0.8350.90
128_P185_L0.8340.90
105_P109_V0.8330.90
52_K56_V0.8330.90
84_I195_W0.8320.90
20_A23_L0.8280.90
32_R37_I0.8230.89
110_V201_G0.8220.89
46_W192_E0.8180.89
22_P26_E0.8170.89
203_A213_V0.8130.89
20_A28_L0.8120.89
131_R178_L0.8110.89
103_L107_T0.8020.88
58_A61_G0.8010.88
78_E202_H0.7950.88
172_E214_F0.7920.87
25_A28_L0.7910.87
161_A192_E0.7900.87
158_F161_A0.7860.87
174_R178_L0.7840.87
57_L190_L0.7770.86
83_V109_V0.7760.86
191_P194_N0.7660.86
55_A59_P0.7650.86
46_W49_Y0.7630.85
195_W206_G0.7610.85
104_A107_T0.7610.85
30_G82_I0.7590.85
124_N174_R0.7570.85
98_R143_G0.7540.85
22_P60_L0.7520.85
16_W26_E0.7390.84
128_P148_N0.7380.83
92_Q95_K0.7380.83
57_L84_I0.7360.83
41_G49_Y0.7350.83
73_P77_I0.7270.83
86_G93_L0.7240.82
159_T162_L0.7240.82
194_N205_L0.7190.82
45_T48_D0.7180.82
90_T124_N0.7130.81
94_L125_L0.7120.81
19_H24_I0.7080.81
77_I83_V0.7060.81
86_G94_L0.7000.80
126_A149_L0.6990.80
75_A78_E0.6950.80
92_Q96_Q0.6930.79
125_L194_N0.6870.79
21_L60_L0.6850.79
5_L11_L0.6840.79
65_T79_N0.6830.78
91_F95_K0.6810.78
171_R187_I0.6780.78
173_Q176_R0.6740.78
63_S104_A0.6660.77
57_L119_W0.6650.77
88_G118_G0.6640.76
171_R179_L0.6640.76
194_N211_T0.6610.76
119_W161_A0.6610.76
171_R175_I0.6600.76
45_T51_A0.6600.76
87_G121_A0.6600.76
210_T215_K0.6590.76
80_A83_V0.6540.75
55_A79_N0.6530.75
30_G81_E0.6530.75
124_N133_T0.6520.75
67_I77_I0.6510.75
135_D141_P0.6460.74
123_A190_L0.6420.74
5_L10_T0.6410.74
67_I203_A0.6400.74
131_R134_N0.6370.73
81_E114_A0.6350.73
4_L117_I0.6330.73
21_L57_L0.6300.73
127_C154_I0.6290.73
8_N195_W0.6290.73
41_G119_W0.6280.72
41_G53_T0.6270.72
61_G97_C0.6250.72
149_L198_V0.6240.72
37_I67_I0.6240.72
88_G122_G0.6210.72
33_S54_A0.6210.72
55_A71_V0.6150.71
39_F96_Q0.6140.71
28_L32_R0.6130.71
26_E55_A0.6120.70
110_V126_A0.6110.70
93_L125_L0.6110.70
111_K148_N0.6100.70
103_L147_L0.6070.70
4_L9_S0.6070.70
48_D51_A0.6060.70
91_F143_G0.6000.69
81_E115_L0.5970.69
53_T86_G0.5970.69
18_E60_L0.5910.68
36_F50_T0.5900.68
84_I115_L0.5820.67
6_L20_A0.5750.66
19_H149_L0.5730.65
98_R101_G0.5730.65
101_G128_P0.5730.65
26_E65_T0.5730.65
129_T153_Q0.5730.65
15_A24_I0.5720.65
36_F134_N0.5710.65
210_T213_V0.5670.65
17_L34_A0.5660.65
93_L156_P0.5650.64
94_L113_G0.5640.64
125_L199_S0.5640.64
68_H154_I0.5610.64
37_I106_I0.5580.63
103_L210_T0.5580.63
171_R178_L0.5570.63
11_L190_L0.5570.63
102_L135_D0.5550.63
50_T89_N0.5530.63
57_L86_G0.5530.63
15_A18_E0.5520.63
199_S202_H0.5490.62
65_T78_E0.5470.62
127_C153_Q0.5470.62
20_A25_A0.5460.62
51_A72_D0.5440.61
88_G121_A0.5440.61
63_S75_A0.5420.61
91_F144_F0.5410.61
97_C102_L0.5410.61
178_L185_L0.5400.61
194_N207_G0.5400.61
146_A211_T0.5400.61
161_A173_Q0.5400.61
86_G124_N0.5390.61
143_G178_L0.5380.61
136_M139_V0.5370.60
34_A208_P0.5330.60
85_V94_L0.5310.60
158_F171_R0.5300.60
44_Q125_L0.5260.59
128_P184_E0.5250.59
126_A150_F0.5240.59
125_L139_V0.5240.59
129_T185_L0.5230.58
174_R177_E0.5230.58
95_K123_A0.5200.58
34_A64_V0.5200.58
131_R146_A0.5170.58
152_L155_N0.5160.57
38_P53_T0.5160.57
125_L152_L0.5100.57
190_L195_W0.5090.56
159_T212_Y0.5090.56
6_L9_S0.5090.56
26_E197_T0.5090.56
22_P47_D0.5070.56
47_D50_T0.5020.55
91_F129_T0.5000.55
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3en0A 2 0.9389 100 0.333 Contact Map
1fy2A 1 0.9607 100 0.342 Contact Map
3l4eA 1 0.8384 100 0.444 Contact Map
1ka9H 1 0.7598 97.8 0.84 Contact Map
1jvnA 1 0.7642 97.8 0.841 Contact Map
2nv0A 1 0.7249 97.6 0.847 Contact Map
2issD 1 0.7205 97.6 0.849 Contact Map
1gpwB 1 0.7162 97.4 0.853 Contact Map
2ywdA 1 0.7293 97.3 0.856 Contact Map
1q7rA 1 0.7555 97 0.862 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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