GREMLIN Database
LEXA - LexA repressor
UniProt: P0A7C2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10533
Length: 202 (181)
Sequences: 4858 (3424)
Seq/√Len: 254.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
19_I47_L3.9921.00
157_R170_E3.8241.00
18_H22_T2.7991.00
82_V146_V2.7681.00
131_L155_V2.6591.00
118_M174_F2.5901.00
84_A115_V2.5771.00
126_M129_D2.3981.00
164_K178_V2.3841.00
122_D172_S2.2951.00
112_L130_L2.2871.00
11_V15_I2.1981.00
159_K168_L2.1541.00
29_A40_P2.1211.00
143_Q191_L2.1071.00
29_A33_Q2.0701.00
112_L132_A2.0421.00
46_H53_K2.0071.00
75_G99_Q1.9541.00
109_A135_K1.9511.00
139_V145_V1.9351.00
81_R116_S1.9321.00
123_I170_E1.8971.00
76_L112_L1.8551.00
148_R187_T1.8461.00
161_Q166_E1.7621.00
9_Q13_D1.7541.00
133_V192_A1.7511.00
159_K166_E1.7471.00
168_L176_P1.6961.00
154_T169_P1.6611.00
17_D21_Q1.6421.00
114_R130_L1.6041.00
155_V192_A1.5981.00
179_V186_F1.5721.00
44_E48_K1.5641.00
18_H21_Q1.5491.00
150_D185_S1.5331.00
14_L18_H1.5201.00
38_R41_N1.5021.00
125_I144_V1.4691.00
118_M173_E1.4501.00
31_I43_A1.4361.00
124_G170_E1.4121.00
133_V146_V1.3861.00
147_A158_L1.3811.00
115_V155_V1.3711.00
78_L96_G1.3671.00
45_E50_L1.3571.00
12_F47_L1.3461.00
115_V131_L1.3431.00
40_P44_E1.3201.00
37_F43_A1.3181.00
28_R47_L1.3171.00
164_K180_D1.2571.00
30_E34_R1.2511.00
144_V157_R1.2491.00
53_K56_I1.2351.00
131_L192_A1.2151.00
37_F42_A1.1941.00
123_I144_V1.1871.00
148_R189_E1.1851.00
27_T30_E1.1781.00
28_R40_P1.1681.00
145_V158_L1.1631.00
150_D184_Q1.1591.00
62_A66_I1.1581.00
12_F19_I1.1511.00
59_V63_S1.1481.00
45_E51_A1.1461.00
28_R44_E1.1431.00
98_Y112_L1.1391.00
16_R47_L1.1271.00
37_F46_H1.1261.00
32_A35_L1.1221.00
85_G156_K1.1131.00
129_D197_R1.1021.00
12_F49_A1.0921.00
51_A56_I1.0801.00
59_V62_A1.0781.00
110_D193_V1.0751.00
42_A46_H1.0661.00
43_A46_H1.0641.00
41_N44_E1.0611.00
32_A40_P1.0551.00
108_N134_H1.0501.00
126_M197_R1.0441.00
83_A87_P1.0411.00
42_A45_E1.0231.00
111_F135_K1.0211.00
166_E176_P1.0201.00
119_S156_K1.0161.00
146_V155_V1.0051.00
110_D132_A1.0011.00
125_I155_V1.0011.00
30_E33_Q0.9951.00
115_V125_I0.9881.00
122_D170_E0.9871.00
169_P176_P0.9781.00
87_P154_T0.9711.00
157_R168_L0.9551.00
57_E67_R0.9521.00
147_A167_L0.9321.00
82_V155_V0.9321.00
10_E13_D0.9281.00
123_I157_R0.9221.00
51_A54_G0.9201.00
146_V192_A0.9161.00
28_R45_E0.9121.00
76_L110_D0.9101.00
139_V191_L0.9101.00
117_G127_D0.9021.00
28_R43_A0.9001.00
113_L146_V0.8991.00
80_G113_L0.8931.00
45_E49_A0.8881.00
78_L112_L0.8771.00
132_A194_G0.8771.00
37_F41_N0.8701.00
82_V113_L0.8681.00
63_S68_L0.8631.00
166_E178_V0.8631.00
50_L54_G0.8621.00
31_I34_R0.8621.00
63_S66_I0.8610.99
62_A65_G0.8540.99
140_R143_Q0.8410.99
85_G117_G0.8390.99
160_K165_V0.8340.99
13_D17_D0.8330.99
107_P134_H0.8320.99
145_V191_L0.8310.99
81_R114_R0.8290.99
83_A88_L0.8280.99
110_D135_K0.8270.99
46_H51_A0.8270.99
122_D126_M0.8230.99
117_G156_K0.8230.99
60_S63_S0.8160.99
41_N45_E0.8140.99
29_A32_A0.8110.99
11_V46_H0.8110.99
161_Q164_K0.8100.99
10_E14_L0.8090.99
38_R42_A0.7970.99
66_I69_L0.7930.99
134_H137_Q0.7870.99
109_A136_T0.7850.99
57_E61_G0.7850.99
38_R45_E0.7800.99
149_I179_V0.7790.99
65_G68_L0.7790.99
18_H66_I0.7750.99
48_K52_R0.7700.99
82_V85_G0.7680.99
180_D184_Q0.7670.99
144_V155_V0.7630.99
40_P46_H0.7610.99
14_L17_D0.7590.99
141_N160_K0.7580.99
32_A43_A0.7570.99
51_A55_V0.7560.99
149_I152_E0.7560.99
77_P97_H0.7530.99
78_L130_L0.7500.99
125_I195_V0.7440.99
94_I97_H0.7440.99
16_R20_S0.7410.98
141_N159_K0.7390.98
148_R151_D0.7370.98
14_L31_I0.7240.98
27_T31_I0.7220.98
37_F55_V0.7200.98
163_N180_D0.7130.98
95_E114_R0.7070.98
35_L65_G0.7050.98
46_H54_G0.7040.98
139_V147_A0.7020.98
167_L177_I0.7000.98
62_A69_L0.7000.98
12_F55_V0.6960.98
132_A196_I0.6930.98
19_I27_T0.6880.98
110_D134_H0.6740.97
60_S64_R0.6730.97
42_A51_A0.6720.97
28_R53_K0.6650.97
116_S127_D0.6640.97
75_G97_H0.6600.97
63_S69_L0.6580.97
76_L132_A0.6580.97
113_L153_V0.6550.97
169_P174_F0.6520.97
19_I31_I0.6510.97
46_H49_A0.6440.96
79_V94_I0.6420.96
139_V158_L0.6410.96
100_V104_L0.6410.96
144_V170_E0.6350.96
22_T67_R0.6330.96
19_I24_M0.6310.96
133_V155_V0.6300.96
10_E49_A0.6280.96
165_V186_F0.6230.96
51_A57_E0.6230.96
101_D104_L0.6220.96
83_A86_E0.6200.95
118_M171_N0.6170.95
192_A195_V0.6140.95
41_N48_K0.6100.95
118_M127_D0.6090.95
24_M31_I0.6050.95
14_L34_R0.6050.95
37_F54_G0.6020.95
131_L146_V0.5990.95
41_N54_G0.5930.94
45_E53_K0.5920.94
59_V68_L0.5900.94
90_A153_V0.5890.94
50_L56_I0.5870.94
169_P177_I0.5860.94
11_V53_K0.5860.94
13_D16_R0.5850.94
147_A188_I0.5830.94
19_I28_R0.5820.94
46_H52_R0.5820.94
35_L53_K0.5790.94
45_E55_V0.5780.93
47_L51_A0.5780.93
193_V196_I0.5760.93
137_Q187_T0.5760.93
142_G159_K0.5740.93
124_G129_D0.5670.93
156_K169_P0.5630.93
59_V66_I0.5630.93
148_R153_V0.5630.93
24_M47_L0.5610.92
83_A154_T0.5580.92
29_A50_L0.5570.92
35_L41_N0.5560.92
35_L46_H0.5560.92
83_A127_D0.5520.92
18_H24_M0.5520.92
45_E54_G0.5510.92
62_A68_L0.5510.92
61_G64_R0.5510.92
100_V105_F0.5510.92
40_P45_E0.5510.92
78_L114_R0.5500.92
11_V31_I0.5470.92
62_A67_R0.5470.92
144_V174_F0.5450.91
11_V14_L0.5440.91
123_I171_N0.5390.91
90_A148_R0.5380.91
73_E99_Q0.5330.90
35_L42_A0.5300.90
28_R32_A0.5290.90
154_T177_I0.5290.90
129_D195_V0.5280.90
158_L165_V0.5260.90
43_A47_L0.5250.90
28_R38_R0.5190.89
46_H56_I0.5180.89
44_E53_K0.5160.89
44_E51_A0.5140.89
37_F51_A0.5100.88
169_P175_K0.5090.88
35_L55_V0.5080.88
46_H55_V0.5040.88
41_N55_V0.5000.87
87_P169_P0.5000.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1jhfA 2 0.9802 100 0.24 Contact Map
3bdnA 2 0.9406 100 0.29 Contact Map
3k2zA 2 0.9604 100 0.31 Contact Map
2fjrA 4 0.8416 100 0.419 Contact Map
2hnfA 1 0.599 99.9 0.496 Contact Map
1umuA 2 0.5149 99.9 0.511 Contact Map
1kcaA 6 0.4604 99.9 0.57 Contact Map
2bnmA 3 0.8713 99.8 0.623 Contact Map
1dw9A 6 0.6881 99.6 0.668 Contact Map
4y42A 6 0.6832 99.4 0.706 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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