HSLV - ECOLI - GREMLIN Contacts

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HSLV - ATP-dependent protease subunit HslV

UniProt:	P0A7B8	Sequences: MTTIVSVRRNGHVVIAGDGQATLGNTVMKGNVKKVRRLYNDKVIAGFAGGTADAFTLFELFERKLEMHQGHLVKAAVELAKDWRTDRMLRKLEALLAVADETASLIITGNGDVVQPENDLIAIGSGGPYAQAAARALLENTELSAREIAEKALDIAGDICIYTNHFHTIEELSYKA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11676
Length:	176 (171)
Sequences:	1188 (472)
Seq/√Len:	36.1

ECOLI - HSLV
BACSU - CLPQ

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
146_R	150_E	4.210	1.00
144_S	147_E	4.133	1.00
16_A	149_A	3.827	1.00
140_N	151_K	3.803	1.00
158_D	165_H	3.514	1.00
146_R	171_E	3.487	1.00
51_T	112_D	3.317	1.00
4_I	17_G	3.223	1.00
106_I	121_I	2.968	1.00
131_Q	135_R	2.739	1.00
12_H	171_E	2.548	1.00
21_A	32_V	2.440	1.00
139_E	151_K	2.355	1.00
60_L	82_D	2.256	0.99
37_R	170_E	2.067	0.99
6_S	104_S	2.041	0.99
97_A	121_I	1.985	0.98
44_I	172_L	1.969	0.98
139_E	158_D	1.933	0.98
8_R	104_S	1.930	0.98
97_A	104_S	1.842	0.97
104_S	121_I	1.815	0.97
157_G	165_H	1.815	0.97
45_A	58_F	1.802	0.97
150_E	154_D	1.785	0.97
40_N	66_E	1.772	0.97
16_A	167_H	1.767	0.96
61_F	98_V	1.749	0.96
118_N	135_R	1.747	0.96
22_T	161_I	1.725	0.96
23_L	95_L	1.699	0.96
97_A	120_L	1.666	0.95
28_M	114_V	1.621	0.94
76_A	107_I	1.607	0.94
16_A	153_L	1.587	0.94
39_Y	70_G	1.565	0.93
87_R	91_K	1.553	0.93
51_T	54_A	1.551	0.93
154_D	165_H	1.542	0.93
9_R	138_L	1.512	0.92
5_V	153_L	1.475	0.91
9_R	141_T	1.466	0.91
45_A	98_V	1.453	0.90
151_K	154_D	1.451	0.90
76_A	105_L	1.433	0.90
35_V	168_T	1.429	0.89
23_L	28_M	1.428	0.89
22_T	26_T	1.414	0.89
122_A	127_G	1.394	0.88
13_V	104_S	1.372	0.87
5_V	134_A	1.345	0.86
42_K	100_D	1.319	0.85
25_N	161_I	1.299	0.84
13_V	99_A	1.281	0.83
30_G	117_E	1.245	0.82
108_T	114_V	1.241	0.81
12_H	144_S	1.232	0.81
95_L	114_V	1.222	0.80
26_T	159_I	1.201	0.79
136_A	155_I	1.187	0.78
26_T	162_Y	1.184	0.78
31_N	117_E	1.181	0.78
64_K	82_D	1.158	0.77
64_K	67_M	1.153	0.76
58_F	98_V	1.149	0.76
154_D	157_G	1.120	0.74
43_V	65_L	1.101	0.73
73_V	103_A	1.099	0.73
38_L	45_A	1.095	0.73
11_G	145_A	1.090	0.72
97_A	106_I	1.054	0.70
135_R	158_D	1.032	0.68
56_T	59_E	1.030	0.68
7_V	145_A	1.017	0.67
42_K	101_E	1.016	0.67
13_V	172_L	1.015	0.67
60_L	88_M	1.014	0.67
118_N	131_Q	1.008	0.66
15_I	44_I	1.006	0.66
157_G	167_H	0.997	0.65
10_N	145_A	0.995	0.65
128_P	161_I	0.974	0.63
4_I	161_I	0.971	0.63
120_L	138_L	0.963	0.62
81_K	89_L	0.956	0.62
43_V	75_A	0.956	0.62
118_N	139_E	0.952	0.62
25_N	162_Y	0.938	0.60
68_H	78_E	0.937	0.60
149_A	152_A	0.933	0.60
60_L	63_R	0.932	0.60
112_D	161_I	0.918	0.59
61_F	76_A	0.909	0.58
38_L	58_F	0.907	0.58
8_R	13_V	0.895	0.57
67_M	117_E	0.893	0.57
132_A	159_I	0.882	0.56
59_E	116_P	0.871	0.55
138_L	148_I	0.862	0.54
85_T	88_M	0.861	0.54
71_H	117_E	0.859	0.54
129_Y	132_A	0.852	0.53
7_V	14_V	0.837	0.52
14_V	61_F	0.834	0.52
98_V	107_I	0.831	0.51
122_A	160_C	0.830	0.51
30_G	153_L	0.817	0.50
43_V	87_R	0.807	0.49
58_F	77_V	0.803	0.49
14_V	146_R	0.802	0.49
85_T	162_Y	0.799	0.48
30_G	166_F	0.777	0.47
43_V	103_A	0.773	0.46
146_R	169_I	0.772	0.46
133_A	152_A	0.769	0.46
14_V	171_E	0.768	0.46
28_M	106_I	0.755	0.45
50_G	131_Q	0.754	0.45
45_A	135_R	0.753	0.44
28_M	91_K	0.749	0.44
150_E	169_I	0.748	0.44
106_I	128_P	0.747	0.44
73_V	105_L	0.742	0.44
6_S	97_A	0.741	0.43
147_E	150_E	0.740	0.43
22_T	30_G	0.738	0.43
33_K	170_E	0.734	0.43
21_A	55_F	0.731	0.43
115_Q	160_C	0.730	0.43
119_D	135_R	0.729	0.42
41_D	50_G	0.725	0.42
69_Q	108_T	0.724	0.42
81_K	96_L	0.721	0.42
86_D	90_R	0.721	0.42
35_V	167_H	0.720	0.42
55_F	61_F	0.707	0.41
140_N	155_I	0.705	0.40
100_D	103_A	0.705	0.40
8_R	119_D	0.704	0.40
96_L	159_I	0.703	0.40
55_F	112_D	0.703	0.40
68_H	74_K	0.701	0.40
38_L	128_P	0.699	0.40
55_F	96_L	0.699	0.40
17_G	35_V	0.698	0.40
6_S	15_I	0.696	0.40
66_E	75_A	0.693	0.39
54_A	95_L	0.691	0.39
25_N	129_Y	0.680	0.38
16_A	169_I	0.678	0.38
137_L	140_N	0.678	0.38
87_R	165_H	0.678	0.38
51_T	56_T	0.676	0.38
149_A	169_I	0.670	0.38
15_I	35_V	0.670	0.38
97_A	101_E	0.668	0.37
6_S	13_V	0.665	0.37
39_Y	42_K	0.661	0.37
141_T	151_K	0.655	0.36
6_S	99_A	0.654	0.36
28_M	35_V	0.653	0.36
150_E	167_H	0.650	0.36
15_I	134_A	0.649	0.36
88_M	157_G	0.646	0.36
33_K	168_T	0.639	0.35
95_L	107_I	0.636	0.35
5_V	99_A	0.626	0.34
108_T	167_H	0.621	0.34
58_F	81_K	0.621	0.34
14_V	169_I	0.618	0.33
27_V	164_N	0.618	0.33
22_T	128_P	0.617	0.33
73_V	115_Q	0.613	0.33
10_N	13_V	0.613	0.33
71_H	108_T	0.612	0.33
87_R	154_D	0.611	0.33
132_A	152_A	0.610	0.33
108_T	159_I	0.610	0.33
70_G	163_T	0.605	0.32
95_L	123_I	0.605	0.32
5_V	138_L	0.604	0.32
26_T	128_P	0.602	0.32
39_Y	66_E	0.601	0.32
142_E	147_E	0.599	0.32
68_H	79_L	0.596	0.32
139_E	155_I	0.596	0.32
138_L	141_T	0.594	0.32
6_S	108_T	0.591	0.31
50_G	110_N	0.589	0.31
45_A	96_L	0.588	0.31
100_D	153_L	0.588	0.31
137_L	141_T	0.586	0.31
27_V	32_V	0.586	0.31
35_V	161_I	0.586	0.31
79_L	107_I	0.585	0.31
4_I	95_L	0.583	0.31
45_A	50_G	0.582	0.31
40_N	45_A	0.579	0.30
17_G	32_V	0.578	0.30
132_A	138_L	0.577	0.30
22_T	116_P	0.574	0.30
119_D	155_I	0.573	0.30
66_E	161_I	0.571	0.30
44_I	61_F	0.570	0.30
8_R	11_G	0.569	0.30
108_T	117_E	0.568	0.30
11_G	102_T	0.568	0.30
157_G	166_F	0.567	0.30
123_I	127_G	0.567	0.30
68_H	71_H	0.567	0.30
60_L	77_V	0.565	0.29
156_A	163_T	0.563	0.29
151_K	155_I	0.562	0.29
55_F	122_A	0.561	0.29
60_L	108_T	0.561	0.29
66_E	148_I	0.558	0.29
38_L	41_D	0.557	0.29
35_V	158_D	0.557	0.29
128_P	132_A	0.556	0.29
72_L	100_D	0.555	0.29
26_T	112_D	0.555	0.29
128_P	131_Q	0.555	0.29
28_M	127_G	0.554	0.29
7_V	148_I	0.553	0.29
154_D	167_H	0.553	0.29
74_K	88_M	0.552	0.28
37_R	129_Y	0.550	0.28
150_E	171_E	0.549	0.28
22_T	96_L	0.548	0.28
35_V	56_T	0.546	0.28
64_K	80_A	0.545	0.28
45_A	82_D	0.545	0.28
64_K	79_L	0.545	0.28
25_N	160_C	0.545	0.28
54_A	61_F	0.542	0.28
16_A	117_E	0.531	0.27
140_N	143_L	0.527	0.27
134_A	155_I	0.527	0.27
59_E	157_G	0.524	0.27
4_I	127_G	0.521	0.26
85_T	91_K	0.518	0.26
63_R	81_K	0.517	0.26
24_G	95_L	0.515	0.26
37_R	74_K	0.515	0.26
76_A	88_M	0.511	0.26
43_V	104_S	0.511	0.26
137_L	143_L	0.510	0.26
63_R	69_Q	0.510	0.26
15_I	99_A	0.509	0.26
37_R	172_L	0.507	0.25
23_L	112_D	0.504	0.25
77_V	156_A	0.504	0.25
10_N	142_E	0.503	0.25
44_I	87_R	0.500	0.25
33_K	123_I	0.500	0.25
107_I	168_T	0.500	0.25

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1g3kA	5	0.9773	100	0.643	Contact Map
1m4yA	5	0.9716	100	0.664	Contact Map
2z3bA	5	0.983	100	0.672	Contact Map
4hnzA	5	0.9773	100	0.686	Contact Map
3wxrK	2	0.9773	99.9	0.733	Contact Map
1rypJ	1	0.9773	99.9	0.739	Contact Map
4r3oJ	1	0.983	99.9	0.739	Contact Map
1rypK	2	0.9773	99.9	0.741	Contact Map
4r3oN	1	0.983	99.9	0.742	Contact Map
1g0uM	1	0.983	99.9	0.742	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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