GREMLIN Database
HSLV - ATP-dependent protease subunit HslV
UniProt: P0A7B8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11676
Length: 176 (171)
Sequences: 1188 (472)
Seq/√Len: 36.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
146_R150_E4.2101.00
144_S147_E4.1331.00
16_A149_A3.8271.00
140_N151_K3.8031.00
158_D165_H3.5141.00
146_R171_E3.4871.00
51_T112_D3.3171.00
4_I17_G3.2231.00
106_I121_I2.9681.00
131_Q135_R2.7391.00
12_H171_E2.5481.00
21_A32_V2.4401.00
139_E151_K2.3551.00
60_L82_D2.2560.99
37_R170_E2.0670.99
6_S104_S2.0410.99
97_A121_I1.9850.98
44_I172_L1.9690.98
139_E158_D1.9330.98
8_R104_S1.9300.98
97_A104_S1.8420.97
104_S121_I1.8150.97
157_G165_H1.8150.97
45_A58_F1.8020.97
150_E154_D1.7850.97
40_N66_E1.7720.97
16_A167_H1.7670.96
61_F98_V1.7490.96
118_N135_R1.7470.96
22_T161_I1.7250.96
23_L95_L1.6990.96
97_A120_L1.6660.95
28_M114_V1.6210.94
76_A107_I1.6070.94
16_A153_L1.5870.94
39_Y70_G1.5650.93
87_R91_K1.5530.93
51_T54_A1.5510.93
154_D165_H1.5420.93
9_R138_L1.5120.92
5_V153_L1.4750.91
9_R141_T1.4660.91
45_A98_V1.4530.90
151_K154_D1.4510.90
76_A105_L1.4330.90
35_V168_T1.4290.89
23_L28_M1.4280.89
22_T26_T1.4140.89
122_A127_G1.3940.88
13_V104_S1.3720.87
5_V134_A1.3450.86
42_K100_D1.3190.85
25_N161_I1.2990.84
13_V99_A1.2810.83
30_G117_E1.2450.82
108_T114_V1.2410.81
12_H144_S1.2320.81
95_L114_V1.2220.80
26_T159_I1.2010.79
136_A155_I1.1870.78
26_T162_Y1.1840.78
31_N117_E1.1810.78
64_K82_D1.1580.77
64_K67_M1.1530.76
58_F98_V1.1490.76
154_D157_G1.1200.74
43_V65_L1.1010.73
73_V103_A1.0990.73
38_L45_A1.0950.73
11_G145_A1.0900.72
97_A106_I1.0540.70
135_R158_D1.0320.68
56_T59_E1.0300.68
7_V145_A1.0170.67
42_K101_E1.0160.67
13_V172_L1.0150.67
60_L88_M1.0140.67
118_N131_Q1.0080.66
15_I44_I1.0060.66
157_G167_H0.9970.65
10_N145_A0.9950.65
128_P161_I0.9740.63
4_I161_I0.9710.63
120_L138_L0.9630.62
81_K89_L0.9560.62
43_V75_A0.9560.62
118_N139_E0.9520.62
25_N162_Y0.9380.60
68_H78_E0.9370.60
149_A152_A0.9330.60
60_L63_R0.9320.60
112_D161_I0.9180.59
61_F76_A0.9090.58
38_L58_F0.9070.58
8_R13_V0.8950.57
67_M117_E0.8930.57
132_A159_I0.8820.56
59_E116_P0.8710.55
138_L148_I0.8620.54
85_T88_M0.8610.54
71_H117_E0.8590.54
129_Y132_A0.8520.53
7_V14_V0.8370.52
14_V61_F0.8340.52
98_V107_I0.8310.51
122_A160_C0.8300.51
30_G153_L0.8170.50
43_V87_R0.8070.49
58_F77_V0.8030.49
14_V146_R0.8020.49
85_T162_Y0.7990.48
30_G166_F0.7770.47
43_V103_A0.7730.46
146_R169_I0.7720.46
133_A152_A0.7690.46
14_V171_E0.7680.46
28_M106_I0.7550.45
50_G131_Q0.7540.45
45_A135_R0.7530.44
28_M91_K0.7490.44
150_E169_I0.7480.44
106_I128_P0.7470.44
73_V105_L0.7420.44
6_S97_A0.7410.43
147_E150_E0.7400.43
22_T30_G0.7380.43
33_K170_E0.7340.43
21_A55_F0.7310.43
115_Q160_C0.7300.43
119_D135_R0.7290.42
41_D50_G0.7250.42
69_Q108_T0.7240.42
81_K96_L0.7210.42
86_D90_R0.7210.42
35_V167_H0.7200.42
55_F61_F0.7070.41
140_N155_I0.7050.40
100_D103_A0.7050.40
8_R119_D0.7040.40
96_L159_I0.7030.40
55_F112_D0.7030.40
68_H74_K0.7010.40
38_L128_P0.6990.40
55_F96_L0.6990.40
17_G35_V0.6980.40
6_S15_I0.6960.40
66_E75_A0.6930.39
54_A95_L0.6910.39
25_N129_Y0.6800.38
16_A169_I0.6780.38
137_L140_N0.6780.38
87_R165_H0.6780.38
51_T56_T0.6760.38
149_A169_I0.6700.38
15_I35_V0.6700.38
97_A101_E0.6680.37
6_S13_V0.6650.37
39_Y42_K0.6610.37
141_T151_K0.6550.36
6_S99_A0.6540.36
28_M35_V0.6530.36
150_E167_H0.6500.36
15_I134_A0.6490.36
88_M157_G0.6460.36
33_K168_T0.6390.35
95_L107_I0.6360.35
5_V99_A0.6260.34
108_T167_H0.6210.34
58_F81_K0.6210.34
14_V169_I0.6180.33
27_V164_N0.6180.33
22_T128_P0.6170.33
73_V115_Q0.6130.33
10_N13_V0.6130.33
71_H108_T0.6120.33
87_R154_D0.6110.33
132_A152_A0.6100.33
108_T159_I0.6100.33
70_G163_T0.6050.32
95_L123_I0.6050.32
5_V138_L0.6040.32
26_T128_P0.6020.32
39_Y66_E0.6010.32
142_E147_E0.5990.32
68_H79_L0.5960.32
139_E155_I0.5960.32
138_L141_T0.5940.32
6_S108_T0.5910.31
50_G110_N0.5890.31
45_A96_L0.5880.31
100_D153_L0.5880.31
137_L141_T0.5860.31
27_V32_V0.5860.31
35_V161_I0.5860.31
79_L107_I0.5850.31
4_I95_L0.5830.31
45_A50_G0.5820.31
40_N45_A0.5790.30
17_G32_V0.5780.30
132_A138_L0.5770.30
22_T116_P0.5740.30
119_D155_I0.5730.30
66_E161_I0.5710.30
44_I61_F0.5700.30
8_R11_G0.5690.30
108_T117_E0.5680.30
11_G102_T0.5680.30
157_G166_F0.5670.30
123_I127_G0.5670.30
68_H71_H0.5670.30
60_L77_V0.5650.29
156_A163_T0.5630.29
151_K155_I0.5620.29
55_F122_A0.5610.29
60_L108_T0.5610.29
66_E148_I0.5580.29
38_L41_D0.5570.29
35_V158_D0.5570.29
128_P132_A0.5560.29
72_L100_D0.5550.29
26_T112_D0.5550.29
128_P131_Q0.5550.29
28_M127_G0.5540.29
7_V148_I0.5530.29
154_D167_H0.5530.29
74_K88_M0.5520.28
37_R129_Y0.5500.28
150_E171_E0.5490.28
22_T96_L0.5480.28
35_V56_T0.5460.28
64_K80_A0.5450.28
45_A82_D0.5450.28
64_K79_L0.5450.28
25_N160_C0.5450.28
54_A61_F0.5420.28
16_A117_E0.5310.27
140_N143_L0.5270.27
134_A155_I0.5270.27
59_E157_G0.5240.27
4_I127_G0.5210.26
85_T91_K0.5180.26
63_R81_K0.5170.26
24_G95_L0.5150.26
37_R74_K0.5150.26
76_A88_M0.5110.26
43_V104_S0.5110.26
137_L143_L0.5100.26
63_R69_Q0.5100.26
15_I99_A0.5090.26
37_R172_L0.5070.25
23_L112_D0.5040.25
77_V156_A0.5040.25
10_N142_E0.5030.25
44_I87_R0.5000.25
33_K123_I0.5000.25
107_I168_T0.5000.25
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1g3kA 5 0.9773 100 0.643 Contact Map
1m4yA 5 0.9716 100 0.664 Contact Map
2z3bA 5 0.983 100 0.672 Contact Map
4hnzA 5 0.9773 100 0.686 Contact Map
3wxrK 2 0.9773 99.9 0.733 Contact Map
1rypJ 1 0.9773 99.9 0.739 Contact Map
4r3oJ 1 0.983 99.9 0.739 Contact Map
1rypK 2 0.9773 99.9 0.741 Contact Map
4r3oN 1 0.983 99.9 0.742 Contact Map
1g0uM 1 0.983 99.9 0.742 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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