GREMLIN Database
PROB - Glutamate 5-kinase
UniProt: P0A7B5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10768
Length: 367 (362)
Sequences: 2447 (1510)
Seq/√Len: 79.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
6_T44_R4.5521.00
315_I359_V4.2261.00
280_V315_I4.1881.00
177_A182_N3.9661.00
341_H349_I3.8071.00
244_D249_I3.8031.00
282_E318_L3.6771.00
53_I144_I3.5391.00
285_T317_N3.3161.00
77_A99_G3.2561.00
317_N321_R3.1981.00
9_V35_C3.1961.00
46_V160_A3.1681.00
335_L358_A3.1611.00
300_I358_A3.1011.00
278_I313_I3.0571.00
13_T54_A3.0401.00
322_D325_H2.9421.00
176_T186_E2.9331.00
199_R222_D2.9321.00
121_L133_I2.9311.00
277_E304_T2.9181.00
190_D256_H2.8221.00
279_T302_S2.8201.00
314_R322_D2.7491.00
173_G187_L2.7151.00
230_D257_A2.6401.00
277_E316_C2.6371.00
238_K244_D2.6311.00
39_H128_N2.5871.00
341_H345_E2.5851.00
336_R339_A2.5581.00
191_V255_F2.4631.00
176_T182_N2.4551.00
275_A311_E2.4541.00
174_L191_V2.4201.00
15_V236_G2.4111.00
32_V90_L2.3671.00
280_V285_T2.3291.00
166_L242_I2.2831.00
107_D113_R2.2471.00
191_V253_T2.1721.00
286_A290_E2.1721.00
68_T71_S2.1051.00
178_D181_S2.1031.00
39_H96_I2.0421.00
172_K235_A2.0271.00
301_K318_L2.0061.00
280_V288_I1.9841.00
279_T304_T1.9221.00
117_A159_L1.9151.00
279_T318_L1.8971.00
96_I130_V1.8951.00
285_T323_I1.8641.00
277_E314_R1.8301.00
230_D254_L1.8071.00
36_A96_I1.8051.00
71_S123_A1.7381.00
192_Y256_H1.7121.00
35_C45_I1.6701.00
329_R363_D1.6621.00
177_A184_Q1.6581.00
35_C47_I1.6531.00
11_L47_I1.6441.00
29_V90_L1.6391.00
338_I346_I1.6391.00
13_T209_L1.6201.00
225_C231_T1.6161.00
33_R94_Y1.6001.00
34_Q240_G1.5911.00
41_A247_E1.5741.00
7_L43_H1.5731.00
234_A241_V1.5711.00
313_I328_S1.5621.00
283_G287_A1.5460.99
85_Q89_Q1.5340.99
33_R93_I1.5320.99
11_L31_L1.5140.99
91_F98_V1.4870.99
282_E319_E1.4860.99
283_G299_G1.4670.99
101_M138_A1.4520.99
308_S331_N1.4450.99
334_A352_Y1.4450.99
177_A185_A1.4350.99
153_S165_L1.4280.99
32_V91_F1.4240.99
9_V242_I1.4190.99
312_V327_V1.3940.99
28_I86_L1.3880.99
8_V162_A1.3760.99
37_Q243_G1.3760.99
179_P185_A1.3720.99
353_E356_P1.3690.99
81_S84_I1.3510.99
29_V93_I1.3490.99
188_I201_I1.3320.98
285_T289_L1.3110.98
65_L72_K1.3000.98
151_N219_Q1.2940.98
111_R115_L1.2920.98
334_A337_R1.2490.98
23_L55_A1.2430.97
91_F130_V1.2310.97
120_T124_L1.2280.97
35_C130_V1.2250.97
47_I87_W1.2130.97
282_E285_T1.2100.97
193_G196_D1.2030.97
151_N223_V1.2000.97
157_A229_I1.1940.97
175_Y179_P1.1910.97
168_L234_A1.1870.97
283_G296_L1.1790.96
289_L292_G1.1710.96
326_G359_V1.1660.96
39_H130_V1.1520.96
4_S43_H1.1490.96
324_A364_M1.1480.96
188_I191_V1.1440.96
282_E286_A1.1390.96
303_V335_L1.1370.96
29_V33_R1.1350.96
123_A126_D1.1330.96
232_I245_V1.1310.96
165_L231_T1.1290.96
274_P314_R1.1280.95
284_A295_L1.1230.95
22_R58_E1.1180.95
60_L75_L1.1150.95
240_G244_D1.1130.95
106_A110_D1.1120.95
281_D299_G1.1040.95
25_R89_Q1.1040.95
199_R218_L1.1030.95
279_T316_C1.1000.95
90_L93_I1.0890.95
302_S339_A1.0860.94
101_M121_L1.0830.94
234_A245_V1.0790.94
106_A113_R1.0780.94
332_S336_R1.0770.94
297_P346_I1.0740.94
316_C322_D1.0710.94
345_E348_A1.0700.94
347_D353_E1.0690.94
219_Q223_V1.0630.94
284_A299_G1.0600.94
34_Q241_V1.0570.94
57_R66_P1.0500.93
224_A231_T1.0480.93
198_L201_I1.0400.93
37_Q40_A1.0390.93
174_L188_I1.0360.93
303_V307_F1.0350.93
141_T145_K1.0280.93
300_I335_L1.0260.93
306_N332_S1.0210.92
187_L251_V1.0200.92
240_G243_G1.0180.92
178_D203_G1.0170.92
59_H88_E1.0130.92
172_K238_K1.0080.92
13_T153_S1.0080.92
30_E33_R1.0080.92
166_L245_V1.0070.92
172_K175_Y1.0060.92
37_Q41_A1.0040.92
296_L299_G0.9990.92
235_A238_K0.9950.91
313_I359_V0.9950.91
294_S360_H0.9870.91
315_I324_A0.9850.91
14_S210_G0.9780.91
11_L16_L0.9770.91
9_V168_L0.9750.91
151_N216_T0.9720.90
111_R268_W0.9690.90
28_I32_V0.9690.90
31_L87_W0.9610.90
72_K211_T0.9580.90
243_G247_E0.9570.90
16_L23_L0.9550.90
47_I130_V0.9520.89
103_L117_A0.9370.89
197_A200_A0.9360.89
99_G124_L0.9360.89
284_A287_A0.9350.89
17_T24_N0.9330.89
7_L246_M0.9310.88
196_D200_A0.9240.88
5_Q43_H0.9210.88
53_I72_K0.9140.87
177_A183_P0.9080.87
288_I295_L0.9070.87
11_L35_C0.9060.87
171_Q175_Y0.9030.87
340_G343_S0.8870.86
120_T138_A0.8830.86
13_T22_R0.8780.85
4_S164_K0.8780.85
57_R75_L0.8780.85
197_A202_A0.8760.85
60_L78_V0.8750.85
329_R357_V0.8740.85
55_A82_R0.8720.85
169_T255_F0.8700.85
125_L131_P0.8690.85
46_V133_I0.8680.85
314_R325_H0.8680.85
187_L250_S0.8650.84
164_K230_D0.8640.84
338_I350_L0.8630.84
67_A132_V0.8570.84
196_D199_R0.8550.84
281_D296_L0.8520.84
283_G294_S0.8510.83
297_P343_S0.8490.83
233_I255_F0.8480.83
86_L90_L0.8470.83
17_T55_A0.8470.83
24_N237_S0.8390.83
73_Q116_N0.8370.82
278_I339_A0.8320.82
330_Y338_I0.8290.82
158_I229_I0.8290.82
57_R65_L0.8270.82
32_V36_A0.8230.81
225_C255_F0.8230.81
146_V216_T0.8220.81
274_P325_H0.8210.81
28_I90_L0.8140.81
173_G233_I0.8100.80
306_N336_R0.8100.80
277_E313_I0.8030.80
62_Y75_L0.8020.80
14_S170_D0.7990.79
39_H45_I0.7990.79
331_N334_A0.7930.79
40_A96_I0.7910.79
94_Y98_V0.7900.79
145_K211_T0.7880.78
103_L156_A0.7870.78
121_L125_L0.7860.78
44_R126_D0.7820.78
232_I254_L0.7790.78
256_H311_E0.7780.78
53_I69_I0.7760.77
280_V323_I0.7750.77
308_S311_E0.7730.77
36_A94_Y0.7720.77
297_P340_G0.7720.77
77_A138_A0.7720.77
297_P354_Y0.7710.77
294_S299_G0.7680.77
292_G361_R0.7660.77
74_L124_L0.7580.76
215_S219_Q0.7580.76
71_S127_N0.7560.76
234_A238_K0.7560.76
38_L43_H0.7550.75
286_A291_R0.7540.75
182_N186_E0.7490.75
180_R206_V0.7490.75
205_S210_G0.7470.75
68_T123_A0.7450.75
303_V336_R0.7420.74
178_D185_A0.7400.74
15_V27_H0.7350.74
244_D251_V0.7350.74
289_L321_R0.7350.74
64_E67_A0.7320.73
5_Q163_D0.7310.73
44_R128_N0.7300.73
116_N141_T0.7290.73
204_D215_S0.7270.73
70_A119_D0.7260.73
25_R29_V0.7250.72
359_V364_M0.7230.72
281_D284_A0.7220.72
360_H364_M0.7220.72
231_T255_F0.7210.72
158_I267_R0.7180.72
170_D179_P0.7180.72
283_G298_K0.7170.72
189_K250_S0.7150.71
333_D336_R0.7140.71
106_A112_E0.7130.71
105_R155_L0.7110.71
190_D254_L0.7100.71
198_L202_A0.7090.71
14_S211_T0.7080.71
194_I198_L0.7080.71
287_A299_G0.7040.70
357_V360_H0.7040.70
255_F271_G0.7040.70
57_R72_K0.7030.70
288_I314_R0.7030.70
24_N27_H0.7010.70
75_L78_V0.7000.70
157_A165_L0.6940.69
9_V47_I0.6940.69
300_I347_D0.6900.69
99_G158_I0.6890.69
285_T318_L0.6880.69
145_K151_N0.6860.68
223_V231_T0.6810.68
85_Q88_E0.6800.68
164_K254_L0.6800.68
90_L98_V0.6800.68
279_T301_K0.6780.67
272_A312_V0.6770.67
26_A29_V0.6740.67
343_S346_I0.6740.67
301_K316_C0.6720.67
329_R355_G0.6700.66
281_D294_S0.6670.66
158_I227_A0.6660.66
45_I186_E0.6650.66
141_T224_A0.6650.66
285_T315_I0.6640.66
287_A295_L0.6600.65
279_T303_V0.6600.65
303_V332_S0.6600.65
218_L233_I0.6590.65
118_R122_R0.6590.65
54_A209_L0.6590.65
108_M155_L0.6580.65
118_R161_G0.6580.65
338_I343_S0.6570.65
347_D352_Y0.6560.65
244_D248_G0.6560.65
279_T313_I0.6560.65
279_T282_E0.6550.65
47_I269_I0.6540.65
17_T54_A0.6530.64
117_A156_A0.6530.64
298_K340_G0.6520.64
7_L38_L0.6500.64
343_S356_P0.6500.64
16_L169_T0.6460.64
164_K232_I0.6450.64
30_E240_G0.6440.63
23_L130_V0.6410.63
142_A145_K0.6410.63
203_G207_S0.6410.63
280_V295_L0.6410.63
304_T364_M0.6400.63
108_M117_A0.6380.63
335_L339_A0.6380.63
6_T122_R0.6380.63
36_A40_A0.6370.63
108_M146_V0.6370.63
339_A343_S0.6360.62
282_E317_N0.6350.62
266_K360_H0.6350.62
219_Q222_D0.6340.62
302_S336_R0.6320.62
8_V48_V0.6300.62
170_D175_Y0.6260.61
18_G24_N0.6260.61
23_L86_L0.6260.61
81_S88_E0.6220.61
328_S331_N0.6220.61
24_N55_A0.6210.61
337_R349_I0.6210.61
330_Y352_Y0.6200.61
171_Q180_R0.6200.61
346_I352_Y0.6180.60
274_P322_D0.6150.60
42_G95_G0.6140.60
203_G206_V0.6140.60
116_N119_D0.6110.59
265_R363_D0.6100.59
128_N161_G0.6090.59
28_I87_W0.6080.59
144_I234_A0.6070.59
284_A296_L0.6070.59
342_H345_E0.6060.59
15_V245_V0.6040.59
27_H169_T0.6020.58
304_T316_C0.6020.58
194_I218_L0.6000.58
284_A293_S0.6000.58
241_V251_V0.5980.58
32_V87_W0.5970.58
278_I328_S0.5950.57
282_E348_A0.5940.57
169_T231_T0.5940.57
101_M117_A0.5930.57
110_D113_R0.5930.57
345_E349_I0.5920.57
105_R151_N0.5920.57
278_I315_I0.5890.57
84_I153_S0.5860.56
198_L210_G0.5860.56
327_V351_G0.5850.56
73_Q143_E0.5840.56
62_Y66_P0.5830.56
175_Y185_A0.5830.56
284_A294_S0.5830.56
87_W207_S0.5820.56
311_E335_L0.5820.56
33_R37_Q0.5800.55
143_E296_L0.5790.55
216_T245_V0.5790.55
174_L218_L0.5780.55
174_L233_I0.5780.55
70_A112_E0.5780.55
286_A300_I0.5770.55
40_A186_E0.5770.55
62_Y71_S0.5760.55
174_L255_F0.5740.55
298_K342_H0.5740.55
66_P325_H0.5730.55
176_T188_I0.5700.54
281_D287_A0.5700.54
109_E155_L0.5690.54
197_A201_I0.5690.54
175_Y187_L0.5690.54
240_G247_E0.5690.54
13_T210_G0.5670.54
229_I335_L0.5670.54
186_E247_E0.5650.54
266_K326_G0.5640.53
153_S269_I0.5630.53
266_K292_G0.5630.53
339_A345_E0.5620.53
351_G354_Y0.5600.53
26_A239_P0.5600.53
267_R270_F0.5590.53
346_I353_E0.5590.53
65_L159_L0.5580.53
287_A296_L0.5580.53
117_A178_D0.5570.53
22_R139_V0.5570.53
168_L241_V0.5570.53
49_T225_C0.5560.52
57_R63_P0.5560.52
34_Q38_L0.5550.52
115_L118_R0.5540.52
88_E98_V0.5530.52
172_K187_L0.5510.52
14_S52_A0.5500.52
117_A224_A0.5490.51
13_T138_A0.5480.51
303_V339_A0.5470.51
114_F158_I0.5460.51
57_R67_A0.5460.51
187_L190_D0.5450.51
206_V211_T0.5440.51
110_D208_G0.5430.51
43_H169_T0.5430.51
302_S319_E0.5420.51
105_R271_G0.5420.51
241_V244_D0.5420.51
265_R327_V0.5410.50
15_V170_D0.5400.50
132_V331_N0.5400.50
77_A97_H0.5400.50
109_E114_F0.5380.50
35_C49_T0.5370.50
292_G326_G0.5370.50
41_A286_A0.5370.50
49_T87_W0.5360.50
24_N218_L0.5350.50
82_R88_E0.5340.50
81_S311_E0.5340.50
191_V198_L0.5340.50
157_A216_T0.5330.49
332_S344_Q0.5330.49
170_D206_V0.5330.49
147_G220_A0.5330.49
27_H30_E0.5320.49
74_L120_T0.5320.49
17_T23_L0.5310.49
36_A39_H0.5280.49
52_A132_V0.5280.49
16_L58_E0.5280.49
27_H167_L0.5260.49
37_Q237_S0.5260.49
266_K294_S0.5260.49
165_L224_A0.5250.48
49_T305_G0.5250.48
224_A229_I0.5250.48
189_K323_I0.5240.48
9_V286_A0.5220.48
337_R341_H0.5220.48
292_G360_H0.5220.48
146_V215_S0.5210.48
112_E309_R0.5210.48
216_T231_T0.5210.48
246_M291_R0.5210.48
181_S184_Q0.5210.48
361_R364_M0.5200.48
201_I218_L0.5200.48
306_N333_D0.5190.48
208_G218_L0.5190.48
330_Y351_G0.5190.48
4_S7_L0.5190.48
218_L255_F0.5180.47
40_A94_Y0.5180.47
237_S328_S0.5170.47
122_R126_D0.5170.47
103_L221_A0.5170.47
14_S206_V0.5170.47
258_Q261_P0.5160.47
34_Q243_G0.5150.47
277_E322_D0.5150.47
343_S357_V0.5150.47
188_I205_S0.5150.47
169_T198_L0.5150.47
114_F207_S0.5150.47
64_E208_G0.5140.47
293_S298_K0.5140.47
21_R207_S0.5140.47
26_A33_R0.5130.47
87_W90_L0.5130.47
298_K353_E0.5120.47
281_D292_G0.5120.47
118_R280_V0.5110.47
154_A223_V0.5110.47
154_A170_D0.5100.46
57_R209_L0.5100.46
223_V270_F0.5100.46
23_L47_I0.5090.46
52_A75_L0.5090.46
194_I199_R0.5080.46
25_R86_L0.5080.46
62_Y78_V0.5070.46
355_G363_D0.5060.46
31_L218_L0.5060.46
178_D201_I0.5060.46
44_R125_L0.5060.46
170_D185_A0.5050.46
40_A89_Q0.5040.46
94_Y132_V0.5040.46
207_S215_S0.5040.46
263_E266_K0.5030.46
290_E293_S0.5030.46
147_G211_T0.5010.45
86_L89_Q0.5010.45
66_P72_K0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2j5vA 2 0.8856 100 0.247 Contact Map
4q1tA 4 0.951 100 0.268 Contact Map
2akoA 2 0.654 100 0.606 Contact Map
3ll9A 2 0.6267 100 0.66 Contact Map
3d40A 2 0.6431 100 0.661 Contact Map
1e19A 2 0.6621 100 0.67 Contact Map
2e9yA 2 0.6649 100 0.67 Contact Map
1z9dA 5 0.624 100 0.672 Contact Map
3ll5A 2 0.6158 100 0.678 Contact Map
4jz8A 2 0.6703 100 0.681 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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