PROB - ECOLI - GREMLIN Contacts

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PROB - Glutamate 5-kinase

UniProt:	P0A7B5	Sequences: MSDSQTLVVKLGTSVLTGGSRRLNRAHIVELVRQCAQLHAAGHRIVIVTSGAIAAGREHLGYPELPATIASKQLLAAVGQSRLIQLWEQLFSIYGIHVGQMLLTRADMEDRERFLNARDTLRALLDNNIVPVINENDAVATAEIKVGDNDNLSALAAILAGADKLLLLTDQKGLYTADPRSNPQAELIKDVYGIDDALRAIAGDSVSGLGTGGMSTKLQAADVACRAGIDTIIAAGSKPGVIGDVMEGISVGTLFHAQATPLENRKRWIFGAPPAGEITVDEGATAAILERGSSLLPKGIKSVTGNFSRGEVIRICNLEGRDIAHGVSRYNSDALRRIAGHHSQEIDAILGYEYGPVAVHRDDMITR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10768
Length:	367 (362)
Sequences:	2447 (1510)
Seq/√Len:	79.4

ECOLI - PROB
BACSU - PROJ PROB

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
6_T	44_R	4.552	1.00
315_I	359_V	4.226	1.00
280_V	315_I	4.188	1.00
177_A	182_N	3.966	1.00
341_H	349_I	3.807	1.00
244_D	249_I	3.803	1.00
282_E	318_L	3.677	1.00
53_I	144_I	3.539	1.00
285_T	317_N	3.316	1.00
77_A	99_G	3.256	1.00
317_N	321_R	3.198	1.00
9_V	35_C	3.196	1.00
46_V	160_A	3.168	1.00
335_L	358_A	3.161	1.00
300_I	358_A	3.101	1.00
278_I	313_I	3.057	1.00
13_T	54_A	3.040	1.00
322_D	325_H	2.942	1.00
176_T	186_E	2.933	1.00
199_R	222_D	2.932	1.00
121_L	133_I	2.931	1.00
277_E	304_T	2.918	1.00
190_D	256_H	2.822	1.00
279_T	302_S	2.820	1.00
314_R	322_D	2.749	1.00
173_G	187_L	2.715	1.00
230_D	257_A	2.640	1.00
277_E	316_C	2.637	1.00
238_K	244_D	2.631	1.00
39_H	128_N	2.587	1.00
341_H	345_E	2.585	1.00
336_R	339_A	2.558	1.00
191_V	255_F	2.463	1.00
176_T	182_N	2.455	1.00
275_A	311_E	2.454	1.00
174_L	191_V	2.420	1.00
15_V	236_G	2.411	1.00
32_V	90_L	2.367	1.00
280_V	285_T	2.329	1.00
166_L	242_I	2.283	1.00
107_D	113_R	2.247	1.00
191_V	253_T	2.172	1.00
286_A	290_E	2.172	1.00
68_T	71_S	2.105	1.00
178_D	181_S	2.103	1.00
39_H	96_I	2.042	1.00
172_K	235_A	2.027	1.00
301_K	318_L	2.006	1.00
280_V	288_I	1.984	1.00
279_T	304_T	1.922	1.00
117_A	159_L	1.915	1.00
279_T	318_L	1.897	1.00
96_I	130_V	1.895	1.00
285_T	323_I	1.864	1.00
277_E	314_R	1.830	1.00
230_D	254_L	1.807	1.00
36_A	96_I	1.805	1.00
71_S	123_A	1.738	1.00
192_Y	256_H	1.712	1.00
35_C	45_I	1.670	1.00
329_R	363_D	1.662	1.00
177_A	184_Q	1.658	1.00
35_C	47_I	1.653	1.00
11_L	47_I	1.644	1.00
29_V	90_L	1.639	1.00
338_I	346_I	1.639	1.00
13_T	209_L	1.620	1.00
225_C	231_T	1.616	1.00
33_R	94_Y	1.600	1.00
34_Q	240_G	1.591	1.00
41_A	247_E	1.574	1.00
7_L	43_H	1.573	1.00
234_A	241_V	1.571	1.00
313_I	328_S	1.562	1.00
283_G	287_A	1.546	0.99
85_Q	89_Q	1.534	0.99
33_R	93_I	1.532	0.99
11_L	31_L	1.514	0.99
91_F	98_V	1.487	0.99
282_E	319_E	1.486	0.99
283_G	299_G	1.467	0.99
101_M	138_A	1.452	0.99
308_S	331_N	1.445	0.99
334_A	352_Y	1.445	0.99
177_A	185_A	1.435	0.99
153_S	165_L	1.428	0.99
32_V	91_F	1.424	0.99
9_V	242_I	1.419	0.99
312_V	327_V	1.394	0.99
28_I	86_L	1.388	0.99
8_V	162_A	1.376	0.99
37_Q	243_G	1.376	0.99
179_P	185_A	1.372	0.99
353_E	356_P	1.369	0.99
81_S	84_I	1.351	0.99
29_V	93_I	1.349	0.99
188_I	201_I	1.332	0.98
285_T	289_L	1.311	0.98
65_L	72_K	1.300	0.98
151_N	219_Q	1.294	0.98
111_R	115_L	1.292	0.98
334_A	337_R	1.249	0.98
23_L	55_A	1.243	0.97
91_F	130_V	1.231	0.97
120_T	124_L	1.228	0.97
35_C	130_V	1.225	0.97
47_I	87_W	1.213	0.97
282_E	285_T	1.210	0.97
193_G	196_D	1.203	0.97
151_N	223_V	1.200	0.97
157_A	229_I	1.194	0.97
175_Y	179_P	1.191	0.97
168_L	234_A	1.187	0.97
283_G	296_L	1.179	0.96
289_L	292_G	1.171	0.96
326_G	359_V	1.166	0.96
39_H	130_V	1.152	0.96
4_S	43_H	1.149	0.96
324_A	364_M	1.148	0.96
188_I	191_V	1.144	0.96
282_E	286_A	1.139	0.96
303_V	335_L	1.137	0.96
29_V	33_R	1.135	0.96
123_A	126_D	1.133	0.96
232_I	245_V	1.131	0.96
165_L	231_T	1.129	0.96
274_P	314_R	1.128	0.95
284_A	295_L	1.123	0.95
22_R	58_E	1.118	0.95
60_L	75_L	1.115	0.95
240_G	244_D	1.113	0.95
106_A	110_D	1.112	0.95
281_D	299_G	1.104	0.95
25_R	89_Q	1.104	0.95
199_R	218_L	1.103	0.95
279_T	316_C	1.100	0.95
90_L	93_I	1.089	0.95
302_S	339_A	1.086	0.94
101_M	121_L	1.083	0.94
234_A	245_V	1.079	0.94
106_A	113_R	1.078	0.94
332_S	336_R	1.077	0.94
297_P	346_I	1.074	0.94
316_C	322_D	1.071	0.94
345_E	348_A	1.070	0.94
347_D	353_E	1.069	0.94
219_Q	223_V	1.063	0.94
284_A	299_G	1.060	0.94
34_Q	241_V	1.057	0.94
57_R	66_P	1.050	0.93
224_A	231_T	1.048	0.93
198_L	201_I	1.040	0.93
37_Q	40_A	1.039	0.93
174_L	188_I	1.036	0.93
303_V	307_F	1.035	0.93
141_T	145_K	1.028	0.93
300_I	335_L	1.026	0.93
306_N	332_S	1.021	0.92
187_L	251_V	1.020	0.92
240_G	243_G	1.018	0.92
178_D	203_G	1.017	0.92
59_H	88_E	1.013	0.92
172_K	238_K	1.008	0.92
13_T	153_S	1.008	0.92
30_E	33_R	1.008	0.92
166_L	245_V	1.007	0.92
172_K	175_Y	1.006	0.92
37_Q	41_A	1.004	0.92
296_L	299_G	0.999	0.92
235_A	238_K	0.995	0.91
313_I	359_V	0.995	0.91
294_S	360_H	0.987	0.91
315_I	324_A	0.985	0.91
14_S	210_G	0.978	0.91
11_L	16_L	0.977	0.91
9_V	168_L	0.975	0.91
151_N	216_T	0.972	0.90
111_R	268_W	0.969	0.90
28_I	32_V	0.969	0.90
31_L	87_W	0.961	0.90
72_K	211_T	0.958	0.90
243_G	247_E	0.957	0.90
16_L	23_L	0.955	0.90
47_I	130_V	0.952	0.89
103_L	117_A	0.937	0.89
197_A	200_A	0.936	0.89
99_G	124_L	0.936	0.89
284_A	287_A	0.935	0.89
17_T	24_N	0.933	0.89
7_L	246_M	0.931	0.88
196_D	200_A	0.924	0.88
5_Q	43_H	0.921	0.88
53_I	72_K	0.914	0.87
177_A	183_P	0.908	0.87
288_I	295_L	0.907	0.87
11_L	35_C	0.906	0.87
171_Q	175_Y	0.903	0.87
340_G	343_S	0.887	0.86
120_T	138_A	0.883	0.86
13_T	22_R	0.878	0.85
4_S	164_K	0.878	0.85
57_R	75_L	0.878	0.85
197_A	202_A	0.876	0.85
60_L	78_V	0.875	0.85
329_R	357_V	0.874	0.85
55_A	82_R	0.872	0.85
169_T	255_F	0.870	0.85
125_L	131_P	0.869	0.85
46_V	133_I	0.868	0.85
314_R	325_H	0.868	0.85
187_L	250_S	0.865	0.84
164_K	230_D	0.864	0.84
338_I	350_L	0.863	0.84
67_A	132_V	0.857	0.84
196_D	199_R	0.855	0.84
281_D	296_L	0.852	0.84
283_G	294_S	0.851	0.83
297_P	343_S	0.849	0.83
233_I	255_F	0.848	0.83
86_L	90_L	0.847	0.83
17_T	55_A	0.847	0.83
24_N	237_S	0.839	0.83
73_Q	116_N	0.837	0.82
278_I	339_A	0.832	0.82
330_Y	338_I	0.829	0.82
158_I	229_I	0.829	0.82
57_R	65_L	0.827	0.82
32_V	36_A	0.823	0.81
225_C	255_F	0.823	0.81
146_V	216_T	0.822	0.81
274_P	325_H	0.821	0.81
28_I	90_L	0.814	0.81
173_G	233_I	0.810	0.80
306_N	336_R	0.810	0.80
277_E	313_I	0.803	0.80
62_Y	75_L	0.802	0.80
14_S	170_D	0.799	0.79
39_H	45_I	0.799	0.79
331_N	334_A	0.793	0.79
40_A	96_I	0.791	0.79
94_Y	98_V	0.790	0.79
145_K	211_T	0.788	0.78
103_L	156_A	0.787	0.78
121_L	125_L	0.786	0.78
44_R	126_D	0.782	0.78
232_I	254_L	0.779	0.78
256_H	311_E	0.778	0.78
53_I	69_I	0.776	0.77
280_V	323_I	0.775	0.77
308_S	311_E	0.773	0.77
36_A	94_Y	0.772	0.77
297_P	340_G	0.772	0.77
77_A	138_A	0.772	0.77
297_P	354_Y	0.771	0.77
294_S	299_G	0.768	0.77
292_G	361_R	0.766	0.77
74_L	124_L	0.758	0.76
215_S	219_Q	0.758	0.76
71_S	127_N	0.756	0.76
234_A	238_K	0.756	0.76
38_L	43_H	0.755	0.75
286_A	291_R	0.754	0.75
182_N	186_E	0.749	0.75
180_R	206_V	0.749	0.75
205_S	210_G	0.747	0.75
68_T	123_A	0.745	0.75
303_V	336_R	0.742	0.74
178_D	185_A	0.740	0.74
15_V	27_H	0.735	0.74
244_D	251_V	0.735	0.74
289_L	321_R	0.735	0.74
64_E	67_A	0.732	0.73
5_Q	163_D	0.731	0.73
44_R	128_N	0.730	0.73
116_N	141_T	0.729	0.73
204_D	215_S	0.727	0.73
70_A	119_D	0.726	0.73
25_R	29_V	0.725	0.72
359_V	364_M	0.723	0.72
281_D	284_A	0.722	0.72
360_H	364_M	0.722	0.72
231_T	255_F	0.721	0.72
158_I	267_R	0.718	0.72
170_D	179_P	0.718	0.72
283_G	298_K	0.717	0.72
189_K	250_S	0.715	0.71
333_D	336_R	0.714	0.71
106_A	112_E	0.713	0.71
105_R	155_L	0.711	0.71
190_D	254_L	0.710	0.71
198_L	202_A	0.709	0.71
14_S	211_T	0.708	0.71
194_I	198_L	0.708	0.71
287_A	299_G	0.704	0.70
357_V	360_H	0.704	0.70
255_F	271_G	0.704	0.70
57_R	72_K	0.703	0.70
288_I	314_R	0.703	0.70
24_N	27_H	0.701	0.70
75_L	78_V	0.700	0.70
157_A	165_L	0.694	0.69
9_V	47_I	0.694	0.69
300_I	347_D	0.690	0.69
99_G	158_I	0.689	0.69
285_T	318_L	0.688	0.69
145_K	151_N	0.686	0.68
223_V	231_T	0.681	0.68
85_Q	88_E	0.680	0.68
164_K	254_L	0.680	0.68
90_L	98_V	0.680	0.68
279_T	301_K	0.678	0.67
272_A	312_V	0.677	0.67
26_A	29_V	0.674	0.67
343_S	346_I	0.674	0.67
301_K	316_C	0.672	0.67
329_R	355_G	0.670	0.66
281_D	294_S	0.667	0.66
158_I	227_A	0.666	0.66
45_I	186_E	0.665	0.66
141_T	224_A	0.665	0.66
285_T	315_I	0.664	0.66
287_A	295_L	0.660	0.65
279_T	303_V	0.660	0.65
303_V	332_S	0.660	0.65
218_L	233_I	0.659	0.65
118_R	122_R	0.659	0.65
54_A	209_L	0.659	0.65
108_M	155_L	0.658	0.65
118_R	161_G	0.658	0.65
338_I	343_S	0.657	0.65
347_D	352_Y	0.656	0.65
244_D	248_G	0.656	0.65
279_T	313_I	0.656	0.65
279_T	282_E	0.655	0.65
47_I	269_I	0.654	0.65
17_T	54_A	0.653	0.64
117_A	156_A	0.653	0.64
298_K	340_G	0.652	0.64
7_L	38_L	0.650	0.64
343_S	356_P	0.650	0.64
16_L	169_T	0.646	0.64
164_K	232_I	0.645	0.64
30_E	240_G	0.644	0.63
23_L	130_V	0.641	0.63
142_A	145_K	0.641	0.63
203_G	207_S	0.641	0.63
280_V	295_L	0.641	0.63
304_T	364_M	0.640	0.63
108_M	117_A	0.638	0.63
335_L	339_A	0.638	0.63
6_T	122_R	0.638	0.63
36_A	40_A	0.637	0.63
108_M	146_V	0.637	0.63
339_A	343_S	0.636	0.62
282_E	317_N	0.635	0.62
266_K	360_H	0.635	0.62
219_Q	222_D	0.634	0.62
302_S	336_R	0.632	0.62
8_V	48_V	0.630	0.62
170_D	175_Y	0.626	0.61
18_G	24_N	0.626	0.61
23_L	86_L	0.626	0.61
81_S	88_E	0.622	0.61
328_S	331_N	0.622	0.61
24_N	55_A	0.621	0.61
337_R	349_I	0.621	0.61
330_Y	352_Y	0.620	0.61
171_Q	180_R	0.620	0.61
346_I	352_Y	0.618	0.60
274_P	322_D	0.615	0.60
42_G	95_G	0.614	0.60
203_G	206_V	0.614	0.60
116_N	119_D	0.611	0.59
265_R	363_D	0.610	0.59
128_N	161_G	0.609	0.59
28_I	87_W	0.608	0.59
144_I	234_A	0.607	0.59
284_A	296_L	0.607	0.59
342_H	345_E	0.606	0.59
15_V	245_V	0.604	0.59
27_H	169_T	0.602	0.58
304_T	316_C	0.602	0.58
194_I	218_L	0.600	0.58
284_A	293_S	0.600	0.58
241_V	251_V	0.598	0.58
32_V	87_W	0.597	0.58
278_I	328_S	0.595	0.57
282_E	348_A	0.594	0.57
169_T	231_T	0.594	0.57
101_M	117_A	0.593	0.57
110_D	113_R	0.593	0.57
345_E	349_I	0.592	0.57
105_R	151_N	0.592	0.57
278_I	315_I	0.589	0.57
84_I	153_S	0.586	0.56
198_L	210_G	0.586	0.56
327_V	351_G	0.585	0.56
73_Q	143_E	0.584	0.56
62_Y	66_P	0.583	0.56
175_Y	185_A	0.583	0.56
284_A	294_S	0.583	0.56
87_W	207_S	0.582	0.56
311_E	335_L	0.582	0.56
33_R	37_Q	0.580	0.55
143_E	296_L	0.579	0.55
216_T	245_V	0.579	0.55
174_L	218_L	0.578	0.55
174_L	233_I	0.578	0.55
70_A	112_E	0.578	0.55
286_A	300_I	0.577	0.55
40_A	186_E	0.577	0.55
62_Y	71_S	0.576	0.55
174_L	255_F	0.574	0.55
298_K	342_H	0.574	0.55
66_P	325_H	0.573	0.55
176_T	188_I	0.570	0.54
281_D	287_A	0.570	0.54
109_E	155_L	0.569	0.54
197_A	201_I	0.569	0.54
175_Y	187_L	0.569	0.54
240_G	247_E	0.569	0.54
13_T	210_G	0.567	0.54
229_I	335_L	0.567	0.54
186_E	247_E	0.565	0.54
266_K	326_G	0.564	0.53
153_S	269_I	0.563	0.53
266_K	292_G	0.563	0.53
339_A	345_E	0.562	0.53
351_G	354_Y	0.560	0.53
26_A	239_P	0.560	0.53
267_R	270_F	0.559	0.53
346_I	353_E	0.559	0.53
65_L	159_L	0.558	0.53
287_A	296_L	0.558	0.53
117_A	178_D	0.557	0.53
22_R	139_V	0.557	0.53
168_L	241_V	0.557	0.53
49_T	225_C	0.556	0.52
57_R	63_P	0.556	0.52
34_Q	38_L	0.555	0.52
115_L	118_R	0.554	0.52
88_E	98_V	0.553	0.52
172_K	187_L	0.551	0.52
14_S	52_A	0.550	0.52
117_A	224_A	0.549	0.51
13_T	138_A	0.548	0.51
303_V	339_A	0.547	0.51
114_F	158_I	0.546	0.51
57_R	67_A	0.546	0.51
187_L	190_D	0.545	0.51
206_V	211_T	0.544	0.51
110_D	208_G	0.543	0.51
43_H	169_T	0.543	0.51
302_S	319_E	0.542	0.51
105_R	271_G	0.542	0.51
241_V	244_D	0.542	0.51
265_R	327_V	0.541	0.50
15_V	170_D	0.540	0.50
132_V	331_N	0.540	0.50
77_A	97_H	0.540	0.50
109_E	114_F	0.538	0.50
35_C	49_T	0.537	0.50
292_G	326_G	0.537	0.50
41_A	286_A	0.537	0.50
49_T	87_W	0.536	0.50
24_N	218_L	0.535	0.50
82_R	88_E	0.534	0.50
81_S	311_E	0.534	0.50
191_V	198_L	0.534	0.50
157_A	216_T	0.533	0.49
332_S	344_Q	0.533	0.49
170_D	206_V	0.533	0.49
147_G	220_A	0.533	0.49
27_H	30_E	0.532	0.49
74_L	120_T	0.532	0.49
17_T	23_L	0.531	0.49
36_A	39_H	0.528	0.49
52_A	132_V	0.528	0.49
16_L	58_E	0.528	0.49
27_H	167_L	0.526	0.49
37_Q	237_S	0.526	0.49
266_K	294_S	0.526	0.49
165_L	224_A	0.525	0.48
49_T	305_G	0.525	0.48
224_A	229_I	0.525	0.48
189_K	323_I	0.524	0.48
9_V	286_A	0.522	0.48
337_R	341_H	0.522	0.48
292_G	360_H	0.522	0.48
146_V	215_S	0.521	0.48
112_E	309_R	0.521	0.48
216_T	231_T	0.521	0.48
246_M	291_R	0.521	0.48
181_S	184_Q	0.521	0.48
361_R	364_M	0.520	0.48
201_I	218_L	0.520	0.48
306_N	333_D	0.519	0.48
208_G	218_L	0.519	0.48
330_Y	351_G	0.519	0.48
4_S	7_L	0.519	0.48
218_L	255_F	0.518	0.47
40_A	94_Y	0.518	0.47
237_S	328_S	0.517	0.47
122_R	126_D	0.517	0.47
103_L	221_A	0.517	0.47
14_S	206_V	0.517	0.47
258_Q	261_P	0.516	0.47
34_Q	243_G	0.515	0.47
277_E	322_D	0.515	0.47
343_S	357_V	0.515	0.47
188_I	205_S	0.515	0.47
169_T	198_L	0.515	0.47
114_F	207_S	0.515	0.47
64_E	208_G	0.514	0.47
293_S	298_K	0.514	0.47
21_R	207_S	0.514	0.47
26_A	33_R	0.513	0.47
87_W	90_L	0.513	0.47
298_K	353_E	0.512	0.47
281_D	292_G	0.512	0.47
118_R	280_V	0.511	0.47
154_A	223_V	0.511	0.47
154_A	170_D	0.510	0.46
57_R	209_L	0.510	0.46
223_V	270_F	0.510	0.46
23_L	47_I	0.509	0.46
52_A	75_L	0.509	0.46
194_I	199_R	0.508	0.46
25_R	86_L	0.508	0.46
62_Y	78_V	0.507	0.46
355_G	363_D	0.506	0.46
31_L	218_L	0.506	0.46
178_D	201_I	0.506	0.46
44_R	125_L	0.506	0.46
170_D	185_A	0.505	0.46
40_A	89_Q	0.504	0.46
94_Y	132_V	0.504	0.46
207_S	215_S	0.504	0.46
263_E	266_K	0.503	0.46
290_E	293_S	0.503	0.46
147_G	211_T	0.501	0.45
86_L	89_Q	0.501	0.45
66_P	72_K	0.500	0.45

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2j5vA	2	0.8856	100	0.247	Contact Map
4q1tA	4	0.951	100	0.268	Contact Map
2akoA	2	0.654	100	0.606	Contact Map
3ll9A	2	0.6267	100	0.66	Contact Map
3d40A	2	0.6431	100	0.661	Contact Map
1e19A	2	0.6621	100	0.67	Contact Map
2e9yA	2	0.6649	100	0.67	Contact Map
1z9dA	5	0.624	100	0.672	Contact Map
3ll5A	2	0.6158	100	0.678	Contact Map
4jz8A	2	0.6703	100	0.681	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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