GREMLIN Database
NADK - NAD kinase
UniProt: P0A7B3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12192
Length: 292 (274)
Sequences: 4024 (2733)
Seq/√Len: 165.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
125_K268_N4.2621.00
228_T261_R3.8381.00
230_R257_D3.7521.00
167_D227_S3.6351.00
163_E232_R3.2991.00
115_D120_H3.1031.00
130_E261_R3.0801.00
232_R257_D3.0241.00
33_K114_A3.0091.00
204_D225_S3.0041.00
230_R259_L2.9761.00
191_S209_V2.9481.00
135_Q256_E2.9021.00
13_H16_H2.7901.00
162_F231_L2.7261.00
130_E142_I2.7131.00
76_M269_L2.5401.00
199_L207_T2.5211.00
125_K266_H2.5031.00
132_Q259_L2.4301.00
25_M110_Q2.4251.00
168_E230_R2.3211.00
126_R185_T2.2691.00
108_N111_Q2.2351.00
29_W114_A2.2331.00
228_T259_L2.2281.00
165_Y170_F2.2121.00
114_A118_E2.1851.00
208_L223_I2.1211.00
131_A149_V2.0371.00
165_Y232_R2.0221.00
164_V208_L1.9871.00
165_Y230_R1.9171.00
132_Q261_R1.9131.00
124_E271_H1.8741.00
169_I276_S1.8741.00
149_V242_I1.8341.00
67_A83_L1.8301.00
128_L267_L1.8121.00
132_Q142_I1.7751.00
123_S268_N1.7651.00
168_E228_T1.7501.00
166_I229_I1.7461.00
163_E234_S1.7301.00
19_A23_H1.7291.00
144_T263_C1.7161.00
70_V95_R1.6991.00
12_G23_H1.6611.00
160_I240_L1.6481.00
81_R247_Q1.6471.00
29_W33_K1.6421.00
28_R32_T1.6321.00
151_L231_L1.6251.00
76_M92_G1.6211.00
194_A209_V1.6101.00
170_F173_S1.5921.00
134_C139_Q1.5781.00
26_L70_V1.5711.00
194_A212_F1.5581.00
130_E263_C1.4751.00
197_P222_V1.4511.00
76_M102_T1.4181.00
166_I227_S1.3971.00
29_W110_Q1.3911.00
164_V179_L1.3871.00
128_L263_C1.3841.00
181_I231_L1.3751.00
129_L206_I1.3691.00
134_C259_L1.3651.00
11_V67_A1.3491.00
26_L113_L1.3491.00
188_T198_I1.3421.00
134_C257_D1.3371.00
197_P207_T1.3071.00
66_L116_V1.2981.00
163_E173_S1.2971.00
145_A244_C1.2861.00
103_D271_H1.2801.00
169_I279_N1.2761.00
104_L112_Q1.2681.00
87_D265_Y1.2631.00
148_E180_I1.2571.00
120_H273_K1.2401.00
277_Y281_L1.2381.00
149_V260_I1.2371.00
204_D266_H1.2311.00
199_L205_A1.2311.00
80_A90_V1.2171.00
87_D268_N1.2151.00
24_E28_R1.2081.00
100_F278_F1.2021.00
91_I270_I1.1951.00
38_I64_A1.1841.00
94_N284_K1.1721.00
149_V244_C1.1671.00
182_S207_T1.1661.00
11_V79_A1.1581.00
131_A244_C1.1521.00
21_T25_M1.1511.00
80_A267_L1.1491.00
200_T278_F1.1471.00
98_L214_H1.1461.00
40_E43_I1.1461.00
180_I194_A1.1361.00
130_E264_D1.1241.00
216_L219_R1.1191.00
91_I116_V1.1141.00
128_L266_H1.1101.00
181_I260_I1.1031.00
20_L23_H1.1001.00
199_L222_V1.0981.00
27_Y31_C1.0911.00
223_I229_I1.0821.00
22_T25_M1.0811.00
126_R201_P1.0700.99
56_T59_E1.0610.99
66_L270_I1.0540.99
253_Q256_E1.0370.99
127_F262_R1.0350.99
192_L216_L1.0350.99
44_A47_L1.0350.99
233_F240_L1.0260.99
239_D253_Q1.0240.99
231_L260_I1.0230.99
68_V113_L1.0080.99
165_Y168_E1.0060.99
29_W113_L1.0030.99
21_T24_E0.9950.99
279_N283_T0.9930.99
56_T60_I0.9830.99
85_R265_Y0.9790.99
162_F176_S0.9790.99
111_Q115_D0.9760.99
33_K118_E0.9620.99
200_T224_N0.9600.99
177_D190_Y0.9580.99
239_D251_P0.9560.99
167_D228_T0.9500.99
17_P20_L0.9440.99
166_I223_I0.9370.99
94_N99_G0.9360.99
185_T201_P0.9340.99
135_Q138_C0.9310.99
91_I104_L0.9270.99
202_S224_N0.9270.99
10_I27_Y0.9260.98
204_D262_R0.9240.98
132_Q139_Q0.9210.98
207_T222_V0.9210.98
115_D272_P0.9190.98
206_I229_I0.9170.98
171_A278_F0.9170.98
181_I206_I0.9150.98
223_I227_S0.9110.98
225_S262_R0.9050.98
43_I46_E0.9010.98
20_L24_E0.8980.98
166_I171_A0.8970.98
179_L208_L0.8950.98
127_F205_A0.8930.98
150_V180_I0.8910.98
192_L214_H0.8890.98
26_L68_V0.8850.98
122_I274_D0.8850.98
135_Q140_K0.8840.98
153_P158_H0.8820.98
27_Y39_V0.8790.98
134_C256_E0.8720.98
144_T265_Y0.8710.98
93_I109_A0.8710.98
28_R31_C0.8670.98
136_Q139_Q0.8640.98
143_S244_C0.8610.98
127_F225_S0.8610.98
41_Q45_H0.8600.98
127_F184_P0.8600.98
181_I208_L0.8590.98
116_V121_Y0.8580.98
27_Y37_V0.8570.98
80_A146_I0.8560.97
131_A258_V0.8560.97
127_F204_D0.8500.97
32_T110_Q0.8490.97
62_Q86_Y0.8450.97
76_M90_V0.8400.97
59_E62_Q0.8400.97
84_A263_C0.8360.97
69_V79_A0.8350.97
153_P157_A0.8340.97
128_L146_I0.8290.97
200_T277_Y0.8290.97
116_V119_G0.8200.97
74_G96_G0.8120.97
103_D275_Y0.8100.97
35_Y117_L0.8100.97
146_I185_T0.8070.96
135_Q253_Q0.8040.96
200_T227_S0.8030.96
139_Q142_I0.7990.96
262_R266_H0.7950.96
60_I64_A0.7910.96
241_E251_P0.7900.96
140_K143_S0.7890.96
146_I267_L0.7880.96
121_Y270_I0.7850.96
161_E175_R0.7820.96
154_G239_D0.7810.96
158_H247_Q0.7790.96
30_L37_V0.7780.96
93_I104_L0.7760.96
204_D226_S0.7760.96
171_A223_I0.7750.96
131_A242_I0.7720.95
44_A48_Q0.7690.95
130_E144_T0.7690.95
83_L88_I0.7680.95
224_N227_S0.7660.95
112_Q272_P0.7660.95
61_G64_A0.7620.95
41_Q56_T0.7540.95
23_H27_Y0.7530.95
148_E152_H0.7520.95
164_V231_L0.7480.95
21_T32_T0.7440.94
276_S280_T0.7380.94
36_E53_K0.7350.94
215_T246_S0.7330.94
67_A90_V0.7310.94
10_I26_L0.7280.94
277_Y280_T0.7240.94
25_M28_R0.7220.93
181_I229_I0.7210.93
18_T151_L0.7200.93
13_H200_T0.7190.93
127_F206_I0.7170.93
122_I271_H0.7150.93
14_P46_E0.7130.93
192_L285_L0.7130.93
10_I30_L0.7120.93
31_C35_Y0.7120.93
217_S285_L0.7070.93
161_E173_S0.7050.93
66_L91_I0.7020.93
61_G83_L0.7000.92
31_C36_E0.6940.92
26_L109_A0.6940.92
12_G43_I0.6920.92
118_E139_Q0.6910.92
19_A22_T0.6900.92
22_T106_P0.6900.92
111_Q114_A0.6880.92
116_V272_P0.6870.92
106_P179_L0.6860.92
64_A88_I0.6850.92
69_V76_M0.6850.92
90_V267_L0.6830.91
103_D189_A0.6800.91
209_V220_P0.6790.91
84_A128_L0.6780.91
241_E249_A0.6780.91
163_E170_F0.6780.91
24_E31_C0.6780.91
126_R277_Y0.6770.91
44_A49_L0.6770.91
192_L197_P0.6770.91
194_A211_M0.6750.91
45_H49_L0.6690.91
108_N112_Q0.6690.91
133_V252_I0.6680.91
12_G40_E0.6670.90
54_T58_A0.6640.90
278_F281_L0.6620.90
157_A243_S0.6610.90
205_A222_V0.6600.90
205_A220_P0.6590.90
124_E202_S0.6570.90
97_N175_R0.6560.90
61_G86_Y0.6560.90
148_E266_H0.6530.90
33_K117_L0.6490.89
39_V43_I0.6450.89
24_E32_T0.6430.89
148_E247_Q0.6430.89
31_C34_G0.6400.89
33_K110_Q0.6400.89
133_V242_I0.6400.89
201_P277_Y0.6370.88
164_V174_Q0.6340.88
23_H42_Q0.6340.88
191_S207_T0.6330.88
103_D124_E0.6320.88
99_G102_T0.6310.88
226_S262_R0.6300.88
129_L145_A0.6270.88
128_L144_T0.6270.88
177_D212_F0.6250.87
133_V256_E0.6220.87
22_T42_Q0.6190.87
30_L35_Y0.6170.87
41_Q44_A0.6160.87
67_A91_I0.6150.87
29_W109_A0.6140.87
103_D272_P0.6140.87
90_V198_I0.6130.86
173_S234_S0.6130.86
103_D280_T0.6110.86
22_T26_L0.6110.86
68_V91_I0.6100.86
89_K210_P0.6080.86
151_L240_L0.6080.86
171_A174_Q0.6080.86
21_T28_R0.6080.86
14_P36_E0.6070.86
31_C38_I0.6030.86
243_S249_A0.6030.86
133_V258_V0.6030.86
129_L185_T0.6000.85
30_L34_G0.5990.85
137_D257_D0.5950.85
174_Q210_P0.5940.85
67_A88_I0.5890.84
158_H243_S0.5820.83
17_P21_T0.5810.83
150_V246_S0.5800.83
276_S279_N0.5800.83
84_A265_Y0.5790.83
42_Q45_H0.5780.83
205_A233_F0.5770.83
45_H48_Q0.5750.83
78_G81_R0.5740.83
42_Q48_Q0.5740.83
105_D277_Y0.5740.83
150_V176_S0.5730.83
15_R23_H0.5720.82
109_A206_I0.5700.82
18_T31_C0.5690.82
77_L191_S0.5670.82
64_A83_L0.5660.82
31_C41_Q0.5650.82
182_S263_C0.5610.81
202_S226_S0.5600.81
17_P45_H0.5590.81
28_R33_K0.5590.81
81_R84_A0.5580.81
17_P35_Y0.5570.81
150_V243_S0.5570.81
167_D226_S0.5570.81
174_Q198_I0.5560.81
97_N277_Y0.5560.81
59_E63_L0.5530.80
158_H246_S0.5520.80
157_A212_F0.5490.80
75_N126_R0.5480.80
190_Y211_M0.5480.80
148_E193_S0.5460.79
111_Q118_E0.5450.79
270_I280_T0.5440.79
169_I282_S0.5430.79
242_I252_I0.5420.79
87_D128_L0.5420.79
263_C266_H0.5420.79
148_E243_S0.5420.79
30_L109_A0.5410.79
10_I233_F0.5410.79
25_M41_Q0.5400.79
95_R98_L0.5400.79
97_N148_E0.5390.79
31_C37_V0.5380.78
106_P211_M0.5380.78
14_P43_I0.5380.78
110_Q114_A0.5380.78
28_R47_L0.5370.78
10_I32_T0.5370.78
152_H241_E0.5360.78
115_D261_R0.5340.78
105_D272_P0.5320.78
31_C49_L0.5310.78
134_C182_S0.5300.77
22_T70_V0.5280.77
235_H239_D0.5270.77
275_Y280_T0.5260.77
26_L29_W0.5220.76
41_Q48_Q0.5210.76
58_A86_Y0.5210.76
162_F233_F0.5200.76
25_M29_W0.5190.76
170_F282_S0.5180.76
10_I37_V0.5180.76
150_V181_I0.5170.76
25_M32_T0.5170.76
215_T260_I0.5150.75
197_P284_K0.5140.75
159_M194_A0.5140.75
80_A215_T0.5140.75
14_P21_T0.5130.75
28_R49_L0.5130.75
15_R45_H0.5120.75
151_L274_D0.5120.75
206_I227_S0.5110.75
36_E39_V0.5100.75
134_C140_K0.5100.75
136_Q256_E0.5100.75
125_K204_D0.5090.75
84_A144_T0.5060.74
101_L246_S0.5050.74
95_R207_T0.5040.74
150_V157_A0.5040.74
150_V194_A0.5020.74
67_A79_A0.5020.74
153_P243_S0.5010.73
36_E44_A0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pfnA 4 0.9829 100 0.131 Contact Map
3afoA 4 1 100 0.164 Contact Map
2an1A 4 0.9658 100 0.282 Contact Map
1u0tA 4 0.9281 100 0.318 Contact Map
1yt5A 4 0.8664 100 0.364 Contact Map
1z0sA 4 0.8493 100 0.378 Contact Map
2i2cA 3 0.8767 100 0.378 Contact Map
2qv7A 2 0.9007 100 0.644 Contact Map
3s40A 3 0.8562 100 0.657 Contact Map
4werA 2 0.8459 100 0.69 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0099 seconds.