GREMLIN Database
IPYR - Inorganic pyrophosphatase
UniProt: P0A7A9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10755
Length: 176 (163)
Sequences: 2291 (1168)
Seq/√Len: 91.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
72_V108_A4.0591.00
157_E161_A3.1021.00
164_A168_A3.0801.00
159_A163_K2.6261.00
167_V171_E2.5371.00
95_K157_E2.4871.00
15_D87_R2.4721.00
65_L102_E2.4401.00
129_E133_A2.4331.00
18_V72_V2.3361.00
123_D158_N2.2781.00
136_A140_E2.2531.00
80_L84_S2.2351.00
141_H144_D2.1011.00
112_S119_D2.0651.00
11_D14_E2.0241.00
97_T154_E1.9511.00
20_I74_V1.9351.00
29_I42_V1.8951.00
70_V169_S1.8751.00
93_V157_E1.8741.00
123_D159_A1.8731.00
65_L172_R1.8651.00
89_R122_K1.8621.00
87_R111_H1.8491.00
14_E163_K1.8291.00
122_K126_D1.8051.00
15_D111_H1.7331.00
95_K104_A1.7081.00
158_N161_A1.6551.00
133_A136_A1.6471.00
80_L86_I1.6221.00
104_A165_E1.6051.00
16_I90_P1.5851.00
168_A172_R1.5761.00
9_G13_P1.5581.00
91_V121_I1.5471.00
59_I166_I1.5281.00
81_Q84_S1.5161.00
12_L170_F1.4510.99
93_V165_E1.4310.99
171_E174_K1.4270.99
163_K167_V1.4220.99
164_A167_V1.3970.99
17_Y41_F1.3780.99
33_I58_Y1.3660.99
16_I88_C1.3580.99
16_I72_V1.3520.99
34_D37_S1.3500.99
137_H144_D1.3400.99
137_H141_H1.3330.99
90_P166_I1.3320.99
18_V88_C1.3310.99
90_P106_L1.3180.99
64_S169_S1.2850.99
16_I59_I1.2690.99
86_I110_P1.2480.98
39_A85_V1.2280.98
124_V127_L1.2250.98
11_D15_D1.2180.98
93_V162_A1.2040.98
47_S116_K1.2030.98
161_A164_A1.1750.98
107_V132_K1.1400.97
33_I37_S1.1280.97
136_A155_G1.1200.97
29_I55_N1.1100.97
97_T101_G1.1090.97
97_T102_E1.1010.97
8_A59_I1.0910.96
95_K154_E1.0820.96
17_Y87_R1.0820.96
95_K161_A1.0770.96
54_C73_L1.0710.96
40_L82_P1.0520.96
41_F87_R1.0500.96
88_C108_A1.0470.95
61_H173_A1.0450.95
130_L134_Q1.0390.95
160_E164_A1.0310.95
42_V45_F1.0290.95
33_I40_L1.0150.95
93_V106_L1.0120.95
50_M141_H1.0060.94
97_T152_K0.9840.94
17_Y60_N0.9820.94
165_E168_A0.9770.93
125_N158_N0.9770.93
106_L166_I0.9720.93
64_S165_E0.9690.93
64_S102_E0.9650.93
120_H129_E0.9590.93
160_E163_K0.9570.93
93_V104_A0.9490.92
32_E56_Y0.9370.92
9_G12_L0.9340.92
123_D160_E0.9340.92
64_S172_R0.9180.91
170_F174_K0.9120.91
24_A76_T0.8890.90
165_E169_S0.8870.90
45_F76_T0.8830.89
56_Y143_K0.8830.89
50_M137_H0.8810.89
59_I70_V0.8740.89
56_Y105_K0.8710.89
75_P127_L0.8710.89
8_A170_F0.8700.89
107_V124_V0.8660.88
55_N80_L0.8390.87
146_E149_K0.8390.87
32_E143_K0.8340.87
117_E131_L0.8310.86
48_T137_H0.8260.86
29_I81_Q0.8200.86
77_P115_S0.8190.86
46_M138_F0.8150.85
20_I86_I0.8080.85
92_G124_V0.8020.84
56_Y98_D0.8020.84
32_E98_D0.7880.83
158_N164_A0.7860.83
77_P117_E0.7830.83
98_D105_K0.7770.82
68_D71_D0.7710.82
136_A156_W0.7700.82
136_A153_V0.7670.82
131_L135_I0.7670.82
34_D41_F0.7670.82
125_N132_K0.7580.81
94_L153_V0.7570.81
47_S115_S0.7550.81
98_D103_D0.7510.80
40_L81_Q0.7480.80
28_P134_Q0.7400.79
68_D98_D0.7370.79
75_P131_L0.7350.79
132_K156_W0.7330.79
54_C135_I0.7310.78
64_S104_A0.7250.78
51_F78_Y0.7250.78
31_Y43_D0.7240.78
46_M52_Y0.7220.78
66_D71_D0.7150.77
61_H170_F0.7130.77
55_N81_Q0.7070.76
87_R112_S0.7050.76
39_A60_N0.7050.76
94_L135_I0.6990.75
116_K119_D0.6980.75
145_L149_K0.6960.75
117_E121_I0.6920.75
70_V100_A0.6890.74
94_L156_W0.6840.74
119_D164_A0.6840.74
42_V55_N0.6790.73
91_V127_L0.6780.73
96_M151_V0.6730.72
133_A147_K0.6710.72
31_Y82_P0.6640.71
35_K173_A0.6620.71
64_S70_V0.6610.71
45_F55_N0.6600.71
14_E167_V0.6590.71
105_K143_K0.6520.70
22_I32_E0.6510.70
107_V127_L0.6470.70
9_G16_I0.6460.69
129_E132_K0.6450.69
49_A137_H0.6440.69
23_P81_Q0.6420.69
54_C75_P0.6400.69
56_Y103_D0.6400.69
121_I128_P0.6390.69
8_A61_H0.6370.68
19_V139_F0.6370.68
29_I79_P0.6360.68
166_I170_F0.6320.68
124_V132_K0.6250.67
161_A165_E0.6250.67
98_D143_K0.6240.67
140_E152_K0.6160.66
76_T80_L0.6100.65
32_E43_D0.6090.65
40_L83_G0.6060.64
107_V156_W0.6000.64
91_V123_D0.5990.64
78_Y116_K0.5990.64
62_T69_P0.5960.63
95_K102_E0.5950.63
26_A78_Y0.5930.63
90_P163_K0.5910.63
140_E153_V0.5910.63
35_K169_S0.5900.62
32_E105_K0.5820.61
8_A12_L0.5820.61
161_A168_A0.5810.61
73_L139_F0.5800.61
28_P55_N0.5780.61
126_D132_K0.5750.60
45_F80_L0.5740.60
106_L162_A0.5730.60
21_E30_K0.5720.60
18_V108_A0.5710.60
48_T52_Y0.5640.59
91_V125_N0.5620.59
46_M49_A0.5600.58
59_I106_L0.5590.58
25_N130_L0.5570.58
55_N76_T0.5570.58
34_D43_D0.5570.58
22_I105_K0.5520.57
74_V88_C0.5510.57
168_A171_E0.5500.57
19_V60_N0.5490.57
63_L67_G0.5470.57
80_L88_C0.5440.56
125_N129_E0.5430.56
153_V157_E0.5400.56
18_V74_V0.5380.55
70_V165_E0.5370.55
45_F110_P0.5330.55
62_T166_I0.5300.54
16_I163_K0.5290.54
89_R119_D0.5280.54
74_V86_I0.5280.54
75_P135_I0.5240.54
164_A171_E0.5220.53
120_H168_A0.5210.53
16_I111_H0.5170.53
25_N78_Y0.5160.52
79_P134_Q0.5160.52
59_I88_C0.5160.52
22_I143_K0.5160.52
14_E159_A0.5130.52
34_D73_L0.5110.52
32_E103_D0.5080.51
41_F85_V0.5080.51
159_A162_A0.5070.51
142_Y145_L0.5050.51
34_D38_G0.5050.51
42_V84_S0.5020.50
46_M141_H0.5020.50
105_K115_S0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3fq3A 6 0.9773 100 0.069 Contact Map
3gvfA 5 0.983 100 0.075 Contact Map
3ld3A 5 0.9716 100 0.076 Contact Map
2au7A 5 0.9886 100 0.077 Contact Map
2bqxA 5 0.9432 100 0.079 Contact Map
3q46A 5 0.9716 100 0.079 Contact Map
3tr4A 5 0.9659 100 0.079 Contact Map
4lugA 3 0.9773 100 0.082 Contact Map
2prdA 5 0.9773 100 0.082 Contact Map
4xelA 3 0.9716 100 0.088 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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