GREMLIN Database
PIMT - Protein-L-isoaspartate O-methyltransferase
UniProt: P0A7A5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10689
Length: 208 (198)
Sequences: 4419 (3171)
Seq/√Len: 225.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
110_Q129_H2.5761.00
84_T102_S2.5591.00
29_A95_H2.5331.00
104_E110_Q2.4821.00
156_T160_T2.4591.00
164_E186_G2.4181.00
167_I183_R2.3481.00
102_S127_T2.3081.00
167_I181_R2.2691.00
135_G161_Q2.2381.00
112_Q116_R2.1981.00
19_Q69_E2.1961.00
110_Q127_T2.1641.00
77_S144_A2.1301.00
159_M189_F2.0841.00
95_H122_L2.0771.00
70_L194_V2.0141.00
99_H126_S2.0021.00
136_W142_F1.9811.00
25_N29_A1.9781.00
147_V170_L1.9711.00
34_K119_N1.9571.00
71_L144_A1.8721.00
143_D163_D1.8561.00
147_V158_L1.8351.00
128_R136_W1.8341.00
7_Q28_A1.8121.00
107_K111_W1.8051.00
178_Y193_T1.7581.00
54_Q108_G1.7471.00
184_R189_F1.7311.00
107_K129_H1.7201.00
117_L127_T1.7111.00
185_R188_E1.7111.00
183_R192_D1.6751.00
54_Q106_I1.6571.00
145_I162_L1.6391.00
24_L28_A1.6051.00
68_T92_I1.5841.00
14_R24_L1.5501.00
181_R192_D1.5221.00
139_R142_F1.4851.00
144_A167_I1.4651.00
20_D69_E1.4571.00
13_L16_Q1.4281.00
13_L17_G1.4281.00
117_L125_V1.4121.00
9_L27_L1.4061.00
116_R120_L1.4001.00
180_K191_I1.3921.00
12_Q15_A1.3841.00
78_R99_H1.3831.00
164_E185_R1.3831.00
141_P161_Q1.3711.00
68_T89_Q1.3701.00
33_E45_W1.3661.00
7_Q11_D1.3491.00
73_L144_A1.3451.00
135_G141_P1.3421.00
73_L93_L1.3321.00
105_R203_V1.3181.00
27_L65_A1.3091.00
63_M197_V1.3051.00
101_C139_R1.3041.00
79_V93_L1.2861.00
78_R139_R1.2441.00
13_L18_I1.2401.00
6_V10_L1.2391.00
47_N62_Y1.2351.00
162_L168_L1.2341.00
34_K120_L1.2251.00
73_L97_V1.2191.00
21_E25_N1.2141.00
111_W114_R1.2131.00
27_L92_I1.2111.00
154_I182_V1.2081.00
181_R194_V1.2071.00
135_G140_A1.1961.00
90_T125_V1.1701.00
67_M199_F1.1661.00
81_E148_T1.1591.00
22_Q75_P1.1511.00
136_W139_R1.1501.00
20_D72_E1.1431.00
66_R195_E1.1431.00
151_P170_L1.1361.00
89_Q146_I1.1321.00
164_E187_G1.1311.00
97_V124_N1.1301.00
91_A117_L1.1261.00
162_L166_G1.1241.00
140_A161_Q1.1221.00
89_Q148_T1.1211.00
81_E102_S1.1161.00
36_V50_L1.1121.00
133_W202_L1.1071.00
88_Y92_I1.1021.00
58_I64_V1.0841.00
179_L197_V1.0831.00
74_T77_S1.0701.00
149_A202_L1.0601.00
94_A124_N1.0571.00
182_V189_F1.0561.00
90_T127_T1.0531.00
31_P34_K1.0401.00
180_K193_T1.0401.00
90_T94_A1.0391.00
30_V95_H1.0371.00
114_R118_K1.0351.00
67_M146_I1.0301.00
126_S139_R1.0161.00
22_Q96_L1.0121.00
110_Q114_R1.0091.00
101_C136_W1.0021.00
12_Q16_Q0.9921.00
151_P202_L0.9911.00
11_D15_A0.9891.00
101_C128_R0.9831.00
18_I69_E0.9781.00
115_R119_N0.9691.00
81_E89_Q0.9591.00
184_R187_G0.9591.00
11_D14_R0.9521.00
159_M182_V0.9401.00
26_A95_H0.9391.00
70_L169_V0.9351.00
36_V58_I0.9291.00
183_R190_I0.9241.00
122_L125_V0.9150.99
64_V89_Q0.9120.99
59_S63_M0.9120.99
6_V9_L0.9100.99
94_A125_V0.9030.99
76_Q98_Q0.8880.99
81_E84_T0.8880.99
103_V130_G0.8850.99
26_A92_I0.8850.99
12_Q47_N0.8790.99
157_A160_T0.8730.99
14_R21_E0.8670.99
133_W203_V0.8630.99
162_L184_R0.8580.99
94_A122_L0.8540.99
134_Q157_A0.8510.99
153_E156_T0.8450.99
23_V69_E0.8450.99
102_S148_T0.8370.99
173_G177_Q0.8360.99
156_T159_M0.8310.99
76_Q97_V0.8270.99
10_L28_A0.8260.99
90_T102_S0.8260.99
67_M89_Q0.8230.99
56_Q109_L0.8150.99
26_A96_L0.8130.99
25_N28_A0.8090.99
56_Q200_V0.8060.99
59_S171_P0.7990.99
14_R28_A0.7950.99
106_I203_V0.7950.99
49_A59_S0.7940.99
18_I24_L0.7920.99
68_T148_T0.7900.99
37_D112_Q0.7900.99
53_G106_I0.7890.98
73_L77_S0.7850.98
182_V191_I0.7820.98
154_I170_L0.7820.98
169_V181_R0.7810.98
40_F50_L0.7750.98
72_E144_A0.7740.98
23_V96_L0.7720.98
73_L79_V0.7710.98
72_E167_I0.7680.98
30_V122_L0.7680.98
14_R17_G0.7590.98
79_V97_V0.7550.98
80_L142_F0.7550.98
79_V100_V0.7520.98
116_R119_N0.7500.98
71_L169_V0.7470.98
138_A141_P0.7460.98
82_I132_G0.7450.98
164_E184_R0.7420.98
101_C126_S0.7400.98
113_A116_R0.7320.98
72_E181_R0.7320.98
18_I65_A0.7300.98
16_Q47_N0.7260.97
172_V180_K0.7180.97
60_Q63_M0.7160.97
185_R190_I0.7130.97
77_S143_D0.7050.97
22_Q25_N0.7020.97
58_I86_S0.6990.97
78_R163_D0.6930.97
27_L61_P0.6930.97
164_E188_E0.6920.97
73_L76_Q0.6860.96
22_Q74_T0.6860.96
81_E93_L0.6820.96
177_Q197_V0.6820.96
147_V151_P0.6800.96
84_T148_T0.6800.96
68_T93_L0.6770.96
43_K46_D0.6720.96
154_I172_V0.6710.96
6_V33_E0.6710.96
10_L14_R0.6700.96
8_A11_D0.6670.96
78_R101_C0.6640.96
158_L168_L0.6630.96
11_D28_A0.6620.96
47_N60_Q0.6600.95
147_V150_A0.6560.95
102_S117_L0.6540.95
133_W151_P0.6510.95
172_V182_V0.6450.95
64_V148_T0.6430.95
168_L182_V0.6430.95
38_E41_E0.6420.95
44_A58_I0.6400.95
151_P158_L0.6390.95
110_Q113_A0.6360.95
101_C142_F0.6340.94
86_S109_L0.6340.94
9_L47_N0.6340.94
84_T113_A0.6320.94
131_D134_Q0.6300.94
194_V197_V0.6280.94
164_E189_F0.6240.94
130_G134_Q0.6210.94
136_W140_A0.6200.94
128_R138_A0.6160.94
115_R118_K0.6110.93
105_R133_W0.6070.93
93_L146_I0.6060.93
176_H196_A0.6040.93
135_G142_F0.6030.93
63_M66_R0.6000.93
59_S67_M0.5980.93
104_E129_H0.5970.92
178_Y196_A0.5930.92
49_A63_M0.5930.92
56_Q105_R0.5900.92
30_V88_Y0.5850.92
22_Q26_A0.5840.92
27_L88_Y0.5830.92
49_A60_Q0.5810.91
132_G161_Q0.5800.91
67_M169_V0.5790.91
173_G197_V0.5740.91
111_W115_R0.5700.91
43_K48_I0.5680.90
59_S64_V0.5670.90
171_P199_F0.5660.90
133_W152_P0.5640.90
20_D24_L0.5630.90
165_G183_R0.5620.90
56_Q106_I0.5620.90
36_V44_A0.5590.90
21_E24_L0.5590.90
90_T100_V0.5550.89
82_I149_A0.5530.89
179_L195_E0.5510.89
20_D73_L0.5510.89
67_M179_L0.5490.89
101_C138_A0.5460.89
68_T146_I0.5440.89
68_T96_L0.5430.88
10_L27_L0.5410.88
36_V43_K0.5300.87
154_I159_M0.5290.87
147_V202_L0.5290.87
64_V92_I0.5280.87
82_I202_L0.5260.87
40_F51_P0.5250.87
59_S148_T0.5250.87
52_I56_Q0.5250.87
176_H198_R0.5230.87
81_E90_T0.5220.86
137_Q141_P0.5150.86
37_D40_F0.5140.86
23_V97_V0.5120.85
71_L93_L0.5120.85
89_Q92_I0.5100.85
37_D50_L0.5090.85
61_P65_A0.5090.85
34_K41_E0.5050.85
64_V146_I0.5050.85
53_G104_E0.5030.84
149_A199_F0.5020.84
175_E197_V0.5010.84
66_R70_L0.5010.84
107_K110_Q0.5010.84
10_L65_A0.5010.84
81_E146_I0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4l7vA 1 0.8942 100 0.436 Contact Map
4o29A 1 0.9663 100 0.444 Contact Map
1jg1A 1 1 100 0.449 Contact Map
1r18A 2 0.9519 100 0.494 Contact Map
2pbfA 1 0.9519 100 0.497 Contact Map
3lbfA 1 0.9952 100 0.501 Contact Map
2yxeA 2 1 100 0.506 Contact Map
1i1nA 1 0.9808 100 0.507 Contact Map
1dl5A 2 0.976 100 0.531 Contact Map
1vbfA 5 0.9567 100 0.537 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0079 seconds.