GREMLIN Database
GPMB - Probable phosphoglycerate mutase GpmB
UniProt: P0A7A2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12164
Length: 215 (186)
Sequences: 14074 (9941)
Seq/√Len: 728.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
79_R135_S3.0361.00
55_D81_R2.8781.00
33_E61_R2.8161.00
60_R76_F2.7711.00
3_Q181_R2.7241.00
87_V118_E2.7061.00
3_Q144_R2.4641.00
130_N160_T2.4631.00
129_V153_A2.3461.00
11_E31_K2.3391.00
79_R131_A2.2631.00
79_R132_A2.1971.00
50_H75_I2.1551.00
149_S153_A1.9821.00
80_L132_A1.9721.00
7_V39_V1.9631.00
3_Q183_D1.9301.00
27_P61_R1.9271.00
37_M65_I1.9261.00
11_E29_T1.8231.00
61_R64_E1.8121.00
33_E65_I1.7991.00
91_R99_E1.7951.00
23_Q81_R1.7831.00
48_I146_L1.7511.00
13_Q29_T1.7501.00
27_P57_G1.7041.00
51_I67_A1.6931.00
115_R124_E1.6891.00
5_Y48_I1.6221.00
7_V66_I1.6091.00
23_Q84_N1.5821.00
60_R64_E1.5811.00
51_I63_A1.5771.00
49_T143_S1.5711.00
53_S76_F1.5631.00
77_D135_S1.5631.00
77_D132_A1.5571.00
149_S154_L1.5551.00
7_V146_L1.5541.00
121_S124_E1.5291.00
120_E128_R1.5281.00
41_T69_A1.5181.00
34_Q37_M1.5041.00
55_D78_S1.4971.00
34_Q38_Q1.4941.00
13_Q17_E1.4761.00
5_Y144_R1.4691.00
154_L174_L1.4691.00
110_G113_D1.4401.00
49_T144_R1.4331.00
66_I148_V1.4321.00
5_Y181_R1.4071.00
30_A33_E1.4051.00
130_N134_E1.3771.00
31_K35_Q1.3721.00
11_E16_A1.3701.00
33_E37_M1.3551.00
31_K34_Q1.3301.00
36_A62_T1.3121.00
129_V157_L1.3041.00
14_W26_S1.3021.00
52_I132_A1.2921.00
92_H95_S1.2861.00
123_Q127_D1.2581.00
14_W21_Q1.2491.00
100_E103_W1.2161.00
50_H143_S1.2141.00
91_R95_S1.2101.00
64_E68_Q1.2041.00
57_G61_R1.2021.00
14_W19_R1.1921.00
124_E127_D1.1731.00
105_R109_N1.1531.00
54_S150_H1.1491.00
15_N176_N1.1471.00
67_A74_I1.1431.00
125_L153_A1.1371.00
53_S74_I1.1361.00
41_T44_K1.1361.00
54_S59_T1.1341.00
6_L154_L1.1291.00
38_Q41_T1.1261.00
168_A171_R1.1111.00
87_V117_P1.0981.00
113_D123_Q1.0921.00
126_S130_N1.0831.00
84_N89_E1.0831.00
63_A148_V1.0681.00
52_I77_D1.0521.00
48_I144_R1.0431.00
37_M68_Q1.0401.00
29_T32_G1.0211.00
6_L157_L1.0141.00
78_S81_R1.0121.00
185_Q188_L1.0061.00
53_S60_R1.0021.00
56_L81_R0.9991.00
63_A74_I0.9961.00
24_S89_E0.9931.00
59_T150_H0.9891.00
140_P143_S0.9801.00
132_A147_L0.9791.00
88_L96_L0.9761.00
25_D57_G0.9751.00
125_L156_C0.9711.00
91_R96_L0.9631.00
11_E35_Q0.9611.00
133_L157_L0.9571.00
50_H145_P0.9541.00
5_Y46_L0.9421.00
55_D76_F0.9411.00
44_K69_A0.9411.00
40_A65_I0.9391.00
127_D131_A0.9391.00
174_L180_S0.9371.00
64_E74_I0.9351.00
26_S29_T0.9291.00
23_Q55_D0.9271.00
65_I68_Q0.9181.00
158_V162_L0.9171.00
165_P168_A0.9091.00
132_A136_C0.9041.00
80_L147_L0.9031.00
52_I140_P0.9011.00
125_L129_V0.8991.00
30_A34_Q0.8991.00
19_R92_H0.8981.00
175_R178_S0.8891.00
12_T176_N0.8881.00
126_S160_T0.8821.00
53_S59_T0.8811.00
174_L178_S0.8791.00
82_E151_G0.8691.00
126_S156_C0.8671.00
134_E137_R0.8671.00
21_Q26_S0.8621.00
52_I75_I0.8521.00
39_V177_C0.8521.00
162_L182_V0.8441.00
57_G60_R0.8391.00
51_I72_C0.8351.00
12_T21_Q0.8321.00
158_V180_S0.8311.00
37_M69_A0.8291.00
5_Y179_I0.8281.00
15_N21_Q0.8251.00
136_C145_P0.8211.00
164_L168_A0.8201.00
94_D98_E0.8201.00
16_A31_K0.8061.00
14_W24_S0.8031.00
95_S98_E0.7901.00
162_L172_L0.7871.00
10_G28_L0.7831.00
12_T29_T0.7801.00
136_C147_L0.7751.00
35_Q176_N0.7731.00
52_I145_P0.7671.00
13_Q27_P0.7661.00
36_A40_A0.7621.00
46_L144_R0.7611.00
37_M41_T0.7451.00
4_V133_L0.7431.00
23_Q56_L0.7411.00
158_V182_V0.7411.00
40_A69_A0.7371.00
85_M89_E0.7351.00
10_G62_T0.7341.00
94_D97_T0.7341.00
61_R65_I0.7301.00
83_L125_L0.7261.00
7_V179_I0.7231.00
65_I69_A0.7151.00
107_L111_T0.7141.00
95_S99_E0.7131.00
22_G89_E0.7121.00
52_I136_C0.7101.00
36_A177_C0.7071.00
42_R179_I0.7041.00
154_L180_S0.7031.00
135_S139_L0.7021.00
108_V111_T0.6991.00
53_S63_A0.6991.00
7_V148_V0.6951.00
13_Q16_A0.6931.00
12_T15_N0.6931.00
6_L182_V0.6841.00
137_R184_Y0.6711.00
22_G56_L0.6701.00
111_T114_G0.6551.00
36_A65_I0.6551.00
102_N106_Q0.6541.00
47_G144_R0.6481.00
159_S169_E0.6481.00
132_A135_S0.6461.00
67_A72_C0.6421.00
103_W106_Q0.6411.00
37_M40_A0.6391.00
122_M156_C0.6351.00
40_A44_K0.6311.00
27_P33_E0.6311.00
56_L59_T0.6291.00
32_G35_Q0.6291.00
39_V179_I0.6261.00
88_L116_I0.6261.00
139_L143_S0.6241.00
16_A29_T0.6231.00
129_V160_T0.6211.00
48_I70_C0.6211.00
51_I70_C0.6171.00
161_I182_V0.6171.00
13_Q26_S0.6101.00
134_E138_D0.6091.00
6_L147_L0.6081.00
28_L32_G0.6041.00
127_D130_N0.6031.00
102_N105_R0.6021.00
50_H140_P0.6011.00
107_L114_G0.6001.00
67_A70_C0.5991.00
130_N157_L0.5991.00
91_R100_E0.5991.00
131_A135_S0.5941.00
10_G32_G0.5931.00
159_S166_A0.5891.00
97_T105_R0.5891.00
51_I146_L0.5861.00
46_L70_C0.5831.00
125_L152_I0.5821.00
67_A71_G0.5821.00
169_E172_L0.5801.00
25_D56_L0.5801.00
18_R93_I0.5781.00
82_E152_I0.5771.00
101_E105_R0.5751.00
32_G36_A0.5711.00
134_E160_T0.5701.00
112_V123_Q0.5651.00
97_T104_R0.5641.00
28_L36_A0.5581.00
159_S164_L0.5571.00
97_T102_N0.5571.00
157_L161_I0.5521.00
80_L136_C0.5511.00
104_R108_V0.5501.00
112_V167_W0.5471.00
18_R94_D0.5461.00
12_T26_S0.5421.00
42_R45_E0.5411.00
63_A67_A0.5411.00
97_T101_E0.5391.00
10_G177_C0.5381.00
55_D77_D0.5381.00
24_S90_K0.5331.00
40_A66_I0.5311.00
122_M169_E0.5291.00
9_H82_E0.5261.00
46_L181_R0.5231.00
115_R121_S0.5231.00
4_V184_Y0.5211.00
18_R21_Q0.5211.00
47_G70_C0.5201.00
45_E70_C0.5181.00
5_Y43_A0.5171.00
49_T146_L0.5141.00
64_E76_F0.5141.00
21_Q151_G0.5121.00
83_L122_M0.5111.00
149_S174_L0.5101.00
26_S57_G0.5091.00
51_I74_I0.5081.00
154_L158_V0.5061.00
35_Q38_Q0.5061.00
140_P145_P0.5061.00
35_Q177_C0.5051.00
8_R58_R0.5030.99
21_Q176_N0.5010.99
107_L110_G0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1h2eA 1 0.9581 100 0.136 Contact Map
4ij5A 2 0.9767 100 0.139 Contact Map
4pzaA 2 0.9488 100 0.149 Contact Map
3gp3A 1 0.9163 100 0.159 Contact Map
1e58A 2 0.9767 100 0.162 Contact Map
3kkkA 3 0.9163 100 0.165 Contact Map
3d8hA 2 0.9209 100 0.167 Contact Map
4embA 2 0.986 100 0.176 Contact Map
3dcyA 1 0.9349 100 0.184 Contact Map
4odiA 3 0.9767 100 0.185 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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