GREMLIN Database
PGK - Phosphoglycerate kinase
UniProt: P0A799 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10703
Length: 387 (379)
Sequences: 3700 (1879)
Seq/√Len: 96.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
186_V301_A3.9461.00
374_V379_A3.7701.00
34_D38_R3.5551.00
228_D279_A3.5111.00
17_F57_T3.3231.00
27_K30_K2.9641.00
289_A292_Q2.9221.00
231_K280_D2.8551.00
80_Y83_D2.7301.00
255_S293_E2.7141.00
168_A172_D2.6731.00
47_A52_A2.6541.00
18_I47_A2.6421.00
9_L162_C2.5411.00
34_D80_Y2.4811.00
316_P349_L2.4511.00
125_L129_Y2.3341.00
46_L165_P2.2811.00
261_T268_P2.2581.00
45_E49_K2.2311.00
182_A302_K2.2281.00
329_I336_S2.2161.00
101_V105_E2.2041.00
53_K103_E2.1831.00
101_V107_V2.1761.00
17_F154_I2.1591.00
219_N283_I2.1591.00
22_L40_S2.1561.00
152_H156_K2.1501.00
214_G310_V2.1421.00
273_S289_A2.1081.00
102_A105_E2.0371.00
252_P297_I2.0361.00
263_F315_F2.0271.00
223_A236_A2.0091.00
80_Y84_K2.0061.00
246_L251_I1.9851.00
95_Y115_N1.9771.00
206_K248_T1.9771.00
202_D244_R1.9331.00
323_E350_F1.9291.00
291_A295_A1.9221.00
323_E327_N1.9021.00
260_A267_A1.8991.00
90_R105_E1.8891.00
208_A211_L1.8841.00
15_R55_M1.8821.00
57_T133_C1.8571.00
270_T281_E1.8551.00
127_K157_F1.8541.00
202_D248_T1.8401.00
46_L50_Q1.8391.00
223_A239_V1.8171.00
255_S289_A1.8121.00
327_N331_D1.8041.00
75_L79_N1.7911.00
292_Q296_E1.7831.00
69_N72_F1.7801.00
320_K323_E1.7711.00
7_T165_P1.7671.00
298_L332_S1.7661.00
291_A324_I1.7631.00
177_A337_I1.7521.00
322_T346_A1.7371.00
143_T151_T1.7081.00
82_K88_P1.6941.00
123_E156_K1.6761.00
271_L288_D1.6701.00
239_V243_K1.6671.00
225_Q246_L1.6481.00
189_V201_L1.6471.00
250_N297_I1.6161.00
11_L47_A1.6081.00
48_L53_K1.6011.00
7_T168_A1.6001.00
163_A381_L1.5981.00
210_Q252_P1.5811.00
265_E317_N1.5701.00
55_M133_C1.5591.00
257_V274_V1.5561.00
212_I294_L1.5491.00
186_V210_Q1.5481.00
305_L370_V1.5301.00
85_L106_L1.5181.00
186_V298_L1.5161.00
261_T280_D1.5131.00
73_S91_L1.5031.00
13_G103_E1.4931.00
259_V272_K1.4841.00
198_L238_L1.4761.00
171_L378_V1.4731.00
41_L84_K1.4611.00
127_K131_A1.4511.00
137_V162_C1.4511.00
290_S294_L1.4451.00
261_T281_E1.4431.00
277_V283_I1.4391.00
45_E87_N1.4371.00
278_K281_E1.4371.00
244_R248_T1.4130.99
219_N257_V1.4080.99
57_T112_V1.4000.99
195_S235_E1.3940.99
26_V60_L1.3920.99
15_R53_K1.3890.99
155_G380_M1.3870.99
7_T46_L1.3640.99
167_L378_V1.3520.99
18_I44_I1.3480.99
38_R84_K1.3410.99
18_I56_V1.3410.99
17_F133_C1.3360.99
335_F357_S1.3330.99
3_V383_E1.3200.99
299_K331_D1.3170.99
147_A152_H1.3060.99
260_A284_L1.3010.99
210_Q297_I1.2980.99
238_L241_E1.2960.99
295_A328_A1.2910.99
231_K282_Q1.2840.99
126_S153_G1.2810.99
87_N105_E1.2770.99
44_I56_V1.2760.99
240_D243_K1.2730.99
121_D153_G1.2620.99
47_A54_V1.2550.99
266_T315_F1.2550.99
348_D353_A1.2480.99
175_G369_F1.2470.99
144_A167_L1.2390.99
20_A56_V1.2370.99
117_G125_L1.2350.99
140_A143_T1.2230.99
210_Q250_N1.2210.99
112_V125_L1.2160.98
177_A305_L1.2160.98
324_I327_N1.2100.98
210_Q301_A1.2080.98
293_E297_I1.2080.98
115_N125_L1.2020.98
58_S74_L1.1940.98
176_K182_A1.1900.98
295_A299_K1.1820.98
78_V82_K1.1820.98
265_E316_P1.1800.98
296_E299_K1.1780.98
273_S276_D1.1540.98
212_I290_S1.1520.98
9_L135_V1.1490.98
272_K278_K1.1430.98
4_I382_E1.1410.98
123_E157_F1.1380.98
174_L369_F1.1380.98
115_N128_K1.1370.98
96_L115_N1.1340.98
79_N82_K1.1340.98
18_I43_T1.1200.97
258_R271_L1.1150.97
298_L328_A1.1100.97
57_T154_I1.1080.97
310_V325_V1.1060.97
229_V234_Y1.1040.97
173_A335_F1.1030.97
243_K247_T1.1020.97
12_A103_E1.0990.97
94_D97_D1.0920.97
123_E127_K1.0910.97
332_S336_S1.0890.97
126_S157_F1.0790.97
320_K324_I1.0750.97
222_I227_H1.0730.97
35_A348_D1.0720.97
223_A228_D1.0660.96
12_A51_G1.0610.96
210_Q300_N1.0520.96
144_A151_T1.0510.96
20_A40_S1.0490.96
126_S149_A1.0460.96
121_D152_H1.0440.96
352_I356_I1.0400.96
175_G179_K1.0360.96
48_L87_N1.0350.96
257_V283_I1.0300.96
286_I310_V1.0130.95
6_M47_A1.0100.95
227_H275_N1.0080.95
75_L91_L1.0070.95
96_L125_L1.0060.95
5_K168_A1.0040.95
33_S348_D1.0030.95
133_C158_A1.0020.95
223_A234_Y1.0000.95
222_I253_V0.9990.95
234_Y239_V0.9990.95
272_K281_E0.9980.95
252_P294_L0.9940.95
216_G233_L0.9940.95
74_L91_L0.9920.95
96_L128_K0.9910.95
66_G69_N0.9900.95
304_I334_A0.9850.95
297_I300_N0.9730.94
88_P105_E0.9710.94
79_N83_D0.9690.94
263_F284_L0.9670.94
256_D287_G0.9670.94
124_T128_K0.9650.94
338_A347_I0.9640.94
261_T270_T0.9590.94
172_D176_K0.9570.94
316_P319_R0.9570.94
296_E300_N0.9560.94
27_K32_T0.9560.94
92_V107_V0.9550.94
319_R350_F0.9450.93
244_R247_T0.9450.93
198_L241_E0.9410.93
67_E116_K0.9360.93
216_G229_V0.9330.93
44_I106_L0.9330.93
38_R80_Y0.9250.92
269_A317_N0.9250.92
338_A343_T0.9230.92
259_V281_E0.9200.92
261_T267_A0.9160.92
82_K108_V0.9150.92
183_R209_D0.9130.92
73_S110_E0.9110.92
48_L106_L0.9080.92
48_L105_E0.9070.92
53_K101_V0.9070.92
75_L93_K0.9030.92
187_A208_A0.9030.92
379_A382_E0.8980.91
291_A320_K0.8970.91
196_T199_T0.8940.91
188_I329_I0.8930.91
212_I297_I0.8920.91
142_G362_G0.8910.91
240_D244_R0.8900.91
41_L85_L0.8850.91
319_R323_E0.8850.91
304_I329_I0.8820.91
291_A325_V0.8810.91
56_V108_V0.8810.91
269_A315_F0.8810.91
70_E73_S0.8800.90
26_V29_G0.8780.90
90_R100_D0.8780.90
124_T127_K0.8750.90
286_I290_S0.8750.90
344_L348_D0.8740.90
34_D84_K0.8740.90
292_Q295_A0.8710.90
95_Y129_Y0.8700.90
293_E296_E0.8630.90
112_V129_Y0.8620.90
35_A344_L0.8620.90
236_A239_V0.8600.89
155_G161_A0.8600.89
46_L49_K0.8600.89
295_A324_I0.8590.89
261_T278_K0.8560.89
258_R291_A0.8550.89
298_L325_V0.8530.89
173_A357_S0.8530.89
10_D50_Q0.8520.89
262_E282_Q0.8500.89
219_N274_V0.8410.88
31_V80_Y0.8400.88
26_V32_T0.8370.88
70_E114_F0.8350.88
117_G128_K0.8300.88
110_E114_F0.8300.88
138_M144_A0.8280.88
58_S143_T0.8260.87
45_E86_S0.8210.87
143_T148_Q0.8210.87
223_A229_V0.8170.87
35_A39_A0.8130.87
77_V108_V0.8110.87
31_V81_L0.8080.86
151_T155_G0.8070.86
90_R101_V0.8060.86
222_I257_V0.8060.86
112_V150_S0.8040.86
259_V270_T0.8030.86
286_I321_G0.8020.86
68_Y115_N0.8020.86
138_M143_T0.7990.86
18_I54_V0.7970.86
224_A242_A0.7950.85
176_K335_F0.7940.85
329_I356_I0.7930.85
229_V283_I0.7910.85
328_A332_S0.7880.85
135_V162_C0.7880.85
222_I274_V0.7880.85
205_S249_C0.7820.84
48_L54_V0.7810.84
10_D14_K0.7810.84
44_I54_V0.7800.84
69_N119_K0.7760.84
347_I356_I0.7740.84
269_A281_E0.7710.84
199_T202_D0.7680.83
95_Y125_L0.7670.83
374_V382_E0.7660.83
216_G234_Y0.7650.83
338_A356_I0.7650.83
241_E244_R0.7640.83
284_L312_V0.7610.83
90_R107_V0.7600.83
265_E315_F0.7600.83
138_M148_Q0.7540.82
22_L56_V0.7520.82
227_H273_S0.7510.82
174_L178_L0.7460.82
181_P303_T0.7450.82
368_E373_K0.7440.81
65_E119_K0.7400.81
233_L282_Q0.7400.81
264_S315_F0.7390.81
252_P293_E0.7390.81
163_A167_L0.7380.81
11_L50_Q0.7360.81
312_V315_F0.7350.81
154_I158_A0.7350.81
91_L112_V0.7300.80
235_E238_L0.7300.80
11_L16_V0.7260.80
7_T50_Q0.7240.80
95_Y112_V0.7220.79
128_K131_A0.7220.79
119_K148_Q0.7210.79
255_S290_S0.7200.79
152_H380_M0.7200.79
186_V297_I0.7200.79
201_L205_S0.7180.79
37_I80_Y0.7180.79
358_Y366_F0.7170.79
263_F282_Q0.7140.79
261_T264_S0.7110.78
338_A344_L0.7090.78
82_K87_N0.7080.78
326_A347_I0.7070.78
264_S267_A0.7060.78
272_K277_V0.7060.78
284_L315_F0.7050.78
75_L78_V0.7050.78
55_M107_V0.7020.78
30_K79_N0.7010.77
258_R320_K0.7010.77
79_N88_P0.7000.77
161_A381_L0.7000.77
344_L347_I0.6970.77
270_T278_K0.6970.77
268_P281_E0.6930.77
245_L251_I0.6930.77
47_A137_V0.6900.76
123_E153_G0.6900.76
333_E336_S0.6860.76
319_R349_L0.6860.76
20_A31_V0.6830.76
189_V344_L0.6800.75
41_L45_E0.6740.75
291_A328_A0.6730.75
199_T373_K0.6730.75
109_L129_Y0.6720.74
12_A50_Q0.6700.74
304_I332_S0.6680.74
142_G166_L0.6660.74
202_D241_E0.6660.74
72_F112_V0.6640.74
94_D115_N0.6640.74
15_R99_V0.6620.73
58_S112_V0.6610.73
43_T165_P0.6610.73
55_M132_L0.6610.73
138_M380_M0.6600.73
68_Y114_F0.6590.73
236_A240_D0.6570.73
49_K87_N0.6550.73
295_A331_D0.6550.73
343_T366_F0.6530.72
219_N282_Q0.6530.72
169_A173_A0.6520.72
196_T201_L0.6510.72
26_V76_P0.6480.72
171_L175_G0.6480.72
282_Q315_F0.6450.71
212_I252_P0.6450.71
250_N293_E0.6450.71
68_Y93_K0.6450.71
140_A148_Q0.6450.71
184_P303_T0.6440.71
63_P66_G0.6430.71
331_D355_K0.6410.71
162_C382_E0.6400.71
95_Y117_G0.6400.71
323_E349_L0.6400.71
57_T109_L0.6380.71
261_T269_A0.6360.70
99_V107_V0.6340.70
263_F312_V0.6340.70
356_I359_I0.6340.70
203_S206_K0.6330.70
56_V106_L0.6330.70
165_P168_A0.6320.70
192_S196_T0.6320.70
309_P313_F0.6310.70
306_W326_A0.6300.70
289_A293_E0.6290.69
316_P320_K0.6290.69
227_H257_V0.6290.69
216_G312_V0.6280.69
264_S317_N0.6270.69
240_D247_T0.6260.69
195_S217_I0.6250.69
298_L301_A0.6250.69
218_A257_V0.6250.69
27_K265_E0.6230.69
158_A161_A0.6230.69
112_V151_T0.6220.69
4_I9_L0.6220.69
195_S237_D0.6220.69
136_F155_G0.6220.69
66_G72_F0.6210.69
32_T345_A0.6200.68
270_T276_D0.6200.68
29_G76_P0.6180.68
48_L103_E0.6160.68
20_A57_T0.6150.68
263_F267_A0.6140.68
44_I81_L0.6070.67
286_I291_A0.6060.67
241_E245_L0.6050.67
272_K276_D0.6040.66
40_S142_G0.6010.66
11_L52_A0.6010.66
187_A212_I0.5990.66
97_D107_V0.5980.66
317_N320_K0.5970.65
126_S154_I0.5960.65
5_K172_D0.5940.65
186_V300_N0.5930.65
91_L95_Y0.5920.65
129_Y150_S0.5920.65
184_P209_D0.5920.65
380_M383_E0.5910.65
203_S372_G0.5900.65
94_D109_L0.5890.64
121_D151_T0.5890.64
68_Y73_S0.5890.64
202_D245_L0.5880.64
92_V95_Y0.5850.64
227_H274_V0.5840.64
286_I325_V0.5840.64
185_M305_L0.5840.64
16_V162_C0.5830.64
263_F266_T0.5810.63
224_A239_V0.5810.63
169_A358_Y0.5790.63
189_V196_T0.5790.63
4_I162_C0.5780.63
54_V106_L0.5780.63
133_C154_I0.5780.63
41_L78_V0.5770.63
136_F148_Q0.5770.63
95_Y128_K0.5760.63
238_L358_Y0.5750.63
3_V382_E0.5750.63
65_E68_Y0.5740.62
96_L129_Y0.5700.62
213_V217_I0.5700.62
92_V115_N0.5690.62
196_T344_L0.5690.62
53_K102_A0.5680.62
267_A315_F0.5660.61
195_S303_T0.5660.61
345_A349_L0.5650.61
60_L77_V0.5650.61
14_K134_D0.5640.61
379_A383_E0.5630.61
219_N233_L0.5620.61
112_V115_N0.5620.61
58_S140_A0.5610.61
96_L132_L0.5610.61
138_M155_G0.5610.61
205_S211_L0.5600.61
47_A158_A0.5600.61
297_I301_A0.5590.60
173_A337_I0.5590.60
353_A359_I0.5570.60
97_D128_K0.5560.60
260_A318_F0.5560.60
109_L115_N0.5560.60
147_A153_G0.5550.60
20_A58_S0.5520.59
231_K262_E0.5520.59
193_K341_G0.5500.59
313_F346_A0.5490.59
22_L58_S0.5470.59
151_T377_A0.5460.59
18_I137_V0.5450.59
117_G129_Y0.5440.58
305_L337_I0.5440.58
72_F114_F0.5430.58
173_A177_A0.5420.58
61_G198_L0.5420.58
324_I328_A0.5410.58
262_E266_T0.5400.58
299_K328_A0.5400.58
199_T371_E0.5390.58
341_G364_G0.5390.58
60_L72_F0.5380.58
6_M137_V0.5360.57
129_Y136_F0.5360.57
68_Y72_F0.5350.57
310_V350_F0.5350.57
290_S293_E0.5340.57
112_V136_F0.5340.57
330_A355_K0.5330.57
219_N223_A0.5320.57
167_L381_L0.5320.57
202_D206_K0.5290.56
175_G178_L0.5280.56
66_G116_K0.5280.56
257_V275_N0.5270.56
70_E75_L0.5270.56
122_D126_S0.5250.56
68_Y95_Y0.5250.56
203_S305_L0.5240.56
256_D290_S0.5210.55
336_S357_S0.5210.55
53_K105_E0.5210.55
203_S373_K0.5200.55
81_L89_V0.5200.55
219_N277_V0.5170.55
182_A335_F0.5170.55
22_L54_V0.5150.54
196_T238_L0.5150.54
82_K90_R0.5150.54
3_V171_L0.5150.54
217_I303_T0.5140.54
101_V104_G0.5140.54
199_T238_L0.5130.54
218_A254_P0.5120.54
196_T358_Y0.5120.54
328_A331_D0.5120.54
344_L359_I0.5120.54
63_P72_F0.5120.54
262_E267_A0.5110.54
136_F140_A0.5100.54
136_F380_M0.5100.54
201_L245_L0.5070.53
143_T377_A0.5070.53
185_M196_T0.5070.53
41_L56_V0.5060.53
95_Y109_L0.5050.53
286_I294_L0.5050.53
320_K327_N0.5040.53
38_R348_D0.5030.53
40_S44_I0.5030.53
22_L44_I0.5000.52
11_L135_V0.5000.52
48_L51_G0.5000.52
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ng4A 1 0.9948 100 -0.03 Contact Map
1zmrA 1 0.9948 100 -0.027 Contact Map
1phpA 1 0.9871 100 -0.025 Contact Map
3q3vA 1 0.9819 100 -0.019 Contact Map
1vpeA 1 0.9897 100 -0.018 Contact Map
4feyA 1 0.9948 100 -0.018 Contact Map
3zlbA 1 0.9897 100 -0.016 Contact Map
5bt8A 1 0.9948 100 -0.013 Contact Map
1qpgA 1 0.9871 100 -0.01 Contact Map
16pkA 1 0.9871 100 -0.009 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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