GREMLIN Database
PDXJ - Pyridoxine 5'-phosphate synthase
UniProt: P0A794 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10693
Length: 243 (236)
Sequences: 1738 (966)
Seq/√Len: 62.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
59_R85_E4.9211.00
18_N54_T4.0521.00
142_K181_F3.6161.00
219_I227_L2.8841.00
183_A208_E2.8651.00
124_A150_P2.8061.00
56_R60_I2.7671.00
35_E67_T2.7261.00
40_D235_K2.6981.00
154_I175_I2.6811.00
171_E174_R2.6221.00
84_V122_R2.5591.00
44_V58_V2.4311.00
113_R146_E2.4181.00
160_A199_N2.3901.00
188_K210_H2.1841.00
229_D233_E2.1481.00
76_T79_M2.1471.00
80_L119_A1.9741.00
228_K232_A1.9191.00
138_E181_F1.8701.00
75_V116_M1.8171.00
225_T229_D1.8061.00
62_R89_H1.8021.00
181_F184_S1.7961.00
145_A185_L1.7931.00
225_T233_E1.7761.00
84_V126_A1.7691.00
142_K146_E1.7390.99
91_C123_L1.7310.99
100_E105_G1.7250.99
7_G213_N1.6980.99
4_L238_M1.6920.99
235_K239_L1.6790.99
75_V119_A1.6730.99
181_F185_L1.6660.99
120_C147_V1.6640.99
173_A177_K1.6290.99
108_D111_G1.6180.99
233_E236_R1.6170.99
16_L223_V1.5890.99
110_A139_E1.5870.99
159_Y202_A1.5860.99
139_E142_K1.5770.99
65_L69_M1.5750.99
33_I228_K1.5750.99
120_C124_A1.5360.99
41_G90_F1.5340.99
141_I152_I1.5300.99
182_A189_V1.5150.98
36_Q228_K1.5130.98
136_A178_A1.4890.98
18_N21_G1.4760.98
80_L122_R1.4670.98
221_R233_E1.4650.98
129_Q151_F1.4620.98
90_F129_Q1.4590.98
32_F64_T1.4500.98
121_K125_D1.4450.98
179_A208_E1.4340.98
31_A42_I1.4340.98
44_V61_L1.4280.98
154_I179_A1.4040.97
26_D60_I1.4020.97
80_L123_L1.3850.97
180_T208_E1.3740.97
229_D232_A1.3620.97
200_V212_L1.3600.97
59_R86_T1.3590.97
140_Q143_A1.3360.97
221_R225_T1.3260.96
44_V69_M1.3230.96
77_E81_A1.3110.96
74_A98_R1.3090.96
109_V143_A1.2890.96
84_V128_I1.2830.96
28_V64_T1.2740.96
77_E122_R1.2670.95
203_I212_L1.2640.95
90_F151_F1.2560.95
13_I223_V1.2480.95
136_A158_C1.2470.95
172_L202_A1.2460.95
101_V135_D1.2410.95
43_T70_N1.2390.95
41_G68_R1.2210.94
7_G43_T1.2070.94
177_K180_T1.2050.94
142_K185_L1.1970.94
143_A147_V1.1890.94
120_C130_V1.1870.93
201_K237_L1.1800.93
197_Y234_M1.1660.93
13_I30_A1.1640.93
112_Q115_K1.1590.93
37_A228_K1.1480.92
29_Q32_F1.1420.92
173_A176_A1.1380.92
119_A122_R1.1300.92
141_I178_A1.1280.92
175_I203_I1.1280.92
34_A42_I1.1270.92
59_R63_Q1.1260.92
172_L206_I1.1120.91
8_V218_I1.1080.91
134_I141_I1.1000.91
91_C128_I1.0930.90
50_R55_D1.0860.90
159_Y200_V1.0790.90
74_A79_M1.0780.90
58_V71_L1.0630.89
60_I64_T1.0600.89
113_R117_R1.0570.89
46_L55_D1.0560.89
116_M119_A1.0550.89
197_Y225_T1.0530.89
26_D29_Q1.0480.88
179_A182_A1.0460.88
158_C162_A1.0380.88
29_Q33_I1.0280.87
117_R146_E1.0250.87
116_M120_C1.0180.87
44_V90_F1.0120.86
23_A26_D1.0110.86
32_F36_Q1.0100.86
33_I37_A1.0100.86
151_F188_K1.0020.86
141_I181_F0.9960.86
132_L147_V0.9940.85
138_E142_K0.9910.85
110_A143_A0.9830.85
8_V39_A0.9820.85
113_R147_V0.9810.85
30_A224_M0.9740.84
35_E66_D0.9720.84
5_L68_R0.9660.84
179_A206_I0.9640.84
27_P34_A0.9630.84
225_T230_A0.9630.84
182_A187_L0.9610.84
24_Y220_G0.9590.83
59_R82_I0.9580.83
10_I42_I0.9570.83
221_R230_A0.9500.83
74_A97_K0.9490.83
71_L83_A0.9480.83
129_Q210_H0.9310.82
221_R237_L0.9220.81
132_L144_A0.9100.80
44_V53_I0.9090.80
24_Y196_T0.9070.80
142_K145_A0.9050.80
138_E177_K0.9040.80
169_A173_A0.9000.79
81_A85_E0.8950.79
58_V86_T0.8920.79
175_I209_M0.8880.78
87_K126_A0.8840.78
159_Y172_L0.8820.78
109_V147_V0.8810.78
179_A209_M0.8600.76
46_L53_I0.8500.75
59_R62_R0.8490.75
43_T213_N0.8490.75
44_V151_F0.8470.75
98_R107_L0.8470.75
44_V71_L0.8420.75
152_I189_V0.8420.75
232_A236_R0.8390.74
81_A84_V0.8310.74
110_A113_R0.8200.73
179_A189_V0.8160.72
46_L82_I0.8140.72
164_T168_Q0.8110.72
183_A210_H0.8030.71
87_K128_I0.8030.71
200_V203_I0.8030.71
229_D236_R0.8010.71
68_R90_F0.8000.71
164_T167_E0.7970.70
35_E68_R0.7950.70
191_A209_M0.7840.69
197_Y237_L0.7810.69
34_A227_L0.7760.68
136_A175_I0.7740.68
62_R86_T0.7710.68
92_C150_P0.7690.68
170_Q173_A0.7660.67
117_R121_K0.7650.67
55_D82_I0.7630.67
78_E81_A0.7590.67
141_I185_L0.7560.66
28_V60_I0.7440.65
109_V140_Q0.7390.65
83_A128_I0.7360.64
197_Y221_R0.7350.64
178_A181_F0.7320.64
115_K119_A0.7320.64
62_R69_M0.7310.64
136_A154_I0.7290.64
172_L176_A0.7250.63
41_G182_A0.7210.63
134_I140_Q0.7210.63
93_L123_L0.7210.63
96_E100_E0.7180.62
46_L50_R0.7170.62
199_N217_A0.7160.62
100_E104_E0.7140.62
203_I213_N0.7130.62
196_T217_A0.7100.61
84_V119_A0.7100.61
29_Q221_R0.7020.61
200_V237_L0.7000.60
48_E96_E0.6990.60
84_V91_C0.6950.60
143_A146_E0.6920.60
158_C175_I0.6920.60
129_Q188_K0.6890.59
131_S190_N0.6890.59
41_G190_N0.6890.59
30_A223_V0.6840.59
34_A221_R0.6840.59
141_I182_A0.6770.58
48_E74_A0.6760.58
116_M147_V0.6730.57
110_A140_Q0.6710.57
206_I209_M0.6690.57
53_I58_V0.6690.57
31_A61_L0.6690.57
44_V190_N0.6690.57
183_A206_I0.6680.57
183_A189_V0.6680.57
114_D118_D0.6670.57
56_R63_Q0.6660.57
28_V61_L0.6640.56
151_F190_N0.6630.56
48_E98_R0.6630.56
30_A227_L0.6630.56
137_D140_Q0.6620.56
118_D121_K0.6620.56
29_Q36_Q0.6610.56
79_M91_C0.6590.56
33_I227_L0.6580.56
74_A96_E0.6570.56
180_T184_S0.6570.56
134_I144_A0.6530.55
61_L65_L0.6480.55
120_C150_P0.6460.54
233_E237_L0.6440.54
81_A121_K0.6380.53
146_E181_F0.6370.53
122_R126_A0.6340.53
78_E98_R0.6280.52
236_R239_L0.6270.52
176_A205_A0.6240.52
7_G70_N0.6220.52
159_Y205_A0.6200.51
80_L84_V0.6200.51
158_C171_E0.6180.51
113_R120_C0.6150.51
176_A206_I0.6150.51
135_D140_Q0.6150.51
75_V93_L0.6140.51
34_A39_A0.6140.51
22_T196_T0.6120.50
48_E100_E0.6100.50
50_R78_E0.6080.50
70_N213_N0.6070.50
76_T98_R0.6050.50
122_R125_D0.6020.49
200_V234_M0.6010.49
7_G41_G0.6010.49
150_P188_K0.5970.49
189_V208_E0.5950.48
4_L203_I0.5940.48
149_A152_I0.5940.48
167_E170_Q0.5940.48
219_I223_V0.5940.48
217_A221_R0.5940.48
87_K124_A0.5940.48
124_A130_V0.5930.48
78_E82_I0.5920.48
73_M83_A0.5920.48
27_P30_A0.5900.48
118_D125_D0.5860.47
217_A220_G0.5830.47
169_A202_A0.5820.47
108_D191_A0.5810.47
90_F150_P0.5790.47
196_T199_N0.5780.47
31_A34_A0.5760.46
135_D161_D0.5760.46
117_R147_V0.5730.46
136_A140_Q0.5720.46
7_G10_I0.5690.45
157_G161_D0.5680.45
152_I182_A0.5660.45
92_C190_N0.5640.45
97_K135_D0.5630.45
84_V125_D0.5630.45
32_F65_L0.5630.45
36_Q66_D0.5620.45
219_I228_K0.5600.44
12_H15_T0.5580.44
55_D78_E0.5580.44
151_F210_H0.5580.44
42_I61_L0.5570.44
4_L212_L0.5550.44
37_A231_V0.5540.44
35_E64_T0.5540.44
56_R64_T0.5520.44
146_E180_T0.5520.44
70_N212_L0.5500.43
169_A176_A0.5460.43
104_E155_H0.5430.43
10_I213_N0.5420.42
119_A159_Y0.5400.42
123_L130_V0.5390.42
37_A235_K0.5380.42
82_I86_T0.5380.42
161_D168_Q0.5360.42
58_V69_M0.5340.42
34_A197_Y0.5330.41
61_L64_T0.5320.41
202_A205_A0.5310.41
65_L92_C0.5300.41
90_F188_K0.5300.41
67_T190_N0.5300.41
209_M238_M0.5290.41
36_Q225_T0.5280.41
90_F213_N0.5270.41
109_V134_I0.5250.41
138_E178_A0.5240.40
230_A234_M0.5210.40
109_V144_A0.5190.40
77_E115_K0.5170.40
157_G175_I0.5170.40
23_A66_D0.5160.40
113_R143_A0.5150.39
176_A180_T0.5150.39
16_L28_V0.5140.39
41_G213_N0.5140.39
15_T30_A0.5130.39
135_D199_N0.5130.39
44_V65_L0.5130.39
15_T19_A0.5120.39
7_G235_K0.5120.39
48_E155_H0.5080.39
4_L92_C0.5080.39
158_C161_D0.5060.38
121_K181_F0.5040.38
27_P44_V0.5010.38
98_R155_H0.5010.38
56_R59_R0.5000.38
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1m5wA 5 0.9959 100 0.004 Contact Map
3gk0A 3 1 100 0.011 Contact Map
3o6cA 2 0.9712 100 0.037 Contact Map
1h1yA 2 0.8395 98.3 0.904 Contact Map
4nu7A 5 0.8807 98.2 0.906 Contact Map
4u28A 1 0.8683 98.2 0.907 Contact Map
1tqjA 4 0.8477 98.2 0.907 Contact Map
2ekcA 1 0.8683 98.2 0.907 Contact Map
4ml9A 2 0.893 98.1 0.908 Contact Map
1xm3A 4 0.9012 98.1 0.908 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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