GREMLIN Database
PAND - Aspartate 1-decarboxylase
UniProt: P0A790 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11747
Length: 126 (117)
Sequences: 1734 (849)
Seq/√Len: 78.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
38_I59_A3.4371.00
45_D56_S3.2481.00
53_K78_C2.9771.00
30_Q61_A2.8221.00
34_D64_R2.6061.00
109_E113_E2.5011.00
47_W88_A2.4601.00
30_Q64_R2.4201.00
31_D65_G2.3661.00
28_I69_I2.1471.00
26_C46_I2.0931.00
43_A56_S2.0461.00
27_A62_A2.0311.00
35_A114_M2.0141.00
10_L108_F2.0131.00
7_Q42_E1.9741.00
48_N79_A1.8441.00
49_V84_I1.7891.00
33_L59_A1.7781.00
77_H80_S1.7241.00
31_D64_R1.7151.00
26_C44_I1.7041.00
2_I92_T1.7001.00
36_A106_A1.6981.00
4_T92_T1.6611.00
3_R95_D1.6031.00
67_R113_E1.5751.00
55_F79_A1.5700.99
93_M98_A1.5390.99
17_H70_S1.4650.99
50_T77_H1.4460.99
37_G104_N1.4320.99
4_T43_A1.3970.99
10_L13_V1.3890.99
7_Q91_V1.3420.98
38_I89_S1.3330.98
3_R37_G1.3250.98
40_E61_A1.2830.98
28_I87_I1.2780.98
30_Q34_D1.2670.98
32_F108_F1.2490.97
69_I87_I1.2450.97
13_V108_F1.2440.97
93_M101_W1.2370.97
47_W90_F1.1920.97
50_T84_I1.1920.97
33_L38_I1.1860.96
6_L88_A1.1550.96
84_I110_G1.1500.96
39_L99_R1.1050.95
13_V85_V1.0950.95
14_K84_I1.0670.94
45_D90_F1.0610.94
28_I59_A1.0290.92
6_L41_N1.0070.92
93_M97_E0.9950.91
39_L98_A0.9890.91
94_P97_E0.9770.90
31_D34_D0.9740.90
49_V74_A0.9630.90
15_V79_A0.9600.90
69_I85_V0.9600.90
12_R84_I0.9590.90
5_M39_L0.9450.89
23_E47_W0.9380.89
16_T68_I0.9360.88
23_E107_Y0.9250.88
33_L36_A0.9240.88
27_A70_S0.9230.88
35_A106_A0.9160.87
8_G38_I0.8950.86
8_G37_G0.8900.86
26_C79_A0.8810.85
28_I33_L0.8780.85
5_M93_M0.8760.85
71_V77_H0.8730.85
48_N53_K0.8730.85
98_A101_W0.8680.84
3_R7_Q0.8520.83
3_R98_A0.8410.82
33_L61_A0.8400.82
7_Q89_S0.8260.81
29_D66_S0.8220.81
4_T42_E0.8110.80
47_W74_A0.8010.79
32_F67_R0.7950.79
74_A90_F0.7780.77
71_V79_A0.7690.76
26_C85_V0.7690.76
2_I94_P0.7650.76
41_N103_P0.7570.75
8_G104_N0.7480.74
21_H84_I0.7460.74
40_E49_V0.7440.74
50_T83_D0.7400.74
55_F78_C0.7330.73
15_V85_V0.7320.73
8_G89_S0.7320.73
39_L95_D0.7250.72
18_A80_S0.7220.72
36_A107_Y0.7120.71
78_C81_V0.7080.70
31_D35_A0.7020.70
62_A68_I0.6990.69
77_H83_D0.6920.69
17_H68_I0.6750.67
95_D99_R0.6580.65
37_G95_D0.6560.64
55_F71_V0.6540.64
20_L77_H0.6540.64
74_A86_I0.6530.64
46_I56_S0.6470.63
31_D67_R0.6460.63
7_Q37_G0.6380.62
12_R21_H0.6380.62
13_V69_I0.6350.62
5_M98_A0.6330.62
21_H77_H0.6310.61
36_A104_N0.6300.61
108_F114_M0.6260.61
5_M95_D0.6240.61
91_V101_W0.6220.60
62_A72_N0.6180.60
51_N83_D0.6130.59
12_R23_E0.6100.59
96_E100_T0.6100.59
48_N83_D0.6070.58
55_F75_A0.6030.58
3_R39_L0.5970.57
43_A90_F0.5960.57
27_A72_N0.5940.57
63_E66_S0.5920.57
20_L35_A0.5910.56
62_A66_S0.5880.56
23_E115_K0.5880.56
36_A117_T0.5810.55
44_I87_I0.5800.55
17_H71_V0.5730.54
21_H50_T0.5670.53
5_M101_W0.5660.53
18_A70_S0.5660.53
100_T111_D0.5620.53
19_D70_S0.5610.53
109_E115_K0.5610.53
48_N51_N0.5580.52
10_L28_I0.5570.52
41_N88_A0.5570.52
41_N101_W0.5530.52
54_R75_A0.5520.51
3_R42_E0.5510.51
107_Y116_R0.5490.51
51_N90_F0.5480.51
42_E45_D0.5470.51
3_R91_V0.5460.51
8_G106_A0.5450.51
7_Q101_W0.5440.50
67_R108_F0.5440.50
106_A117_T0.5440.50
45_D88_A0.5410.50
23_E40_E0.5410.50
46_I79_A0.5380.50
36_A108_F0.5380.50
34_D37_G0.5350.49
13_V112_N0.5310.49
53_K77_H0.5270.48
18_A46_I0.5220.48
14_K110_G0.5190.47
26_C70_S0.5190.47
42_E89_S0.5110.46
2_I41_N0.5100.46
18_A23_E0.5100.46
32_F109_E0.5080.46
74_A88_A0.5040.45
104_N117_T0.5020.45
111_D115_K0.5010.45
30_Q63_E0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pqhA 3 0.9206 100 0.009 Contact Map
2c45A 3 0.8968 100 0.041 Contact Map
3ougA 5 0.8492 100 0.08 Contact Map
1vc3B 3 0.754 100 0.279 Contact Map
3plxB 3 0.7937 100 0.282 Contact Map
1uheA 5 0.7698 100 0.315 Contact Map
3plxA 3 0.1905 99 0.792 Contact Map
1vc3A 1 0.1905 99 0.792 Contact Map
1uheB 2 0.1905 99 0.792 Contact Map
1cz4A 1 0.9206 83.1 0.92 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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