GREMLIN Database
PYRB - Aspartate carbamoyltransferase catalytic chain
UniProt: P0A786 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10805
Length: 311 (288)
Sequences: 7154 (3792)
Seq/√Len: 223.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
252_A277_D4.1421.00
157_H184_R3.8381.00
38_E41_K3.5771.00
157_H186_Y3.4041.00
159_A223_V3.1351.00
264_V274_I3.1021.00
217_E257_N3.0981.00
32_K148_E2.8291.00
27_T302_A2.7741.00
146_I225_I2.7551.00
224_D259_K2.6151.00
149_T285_W2.6111.00
263_K285_W2.5671.00
98_T288_Q2.5491.00
215_S218_E2.5201.00
29_A147_Q2.4871.00
97_S122_N2.4491.00
46_A100_V2.3311.00
12_S134_Q2.3081.00
90_A115_L2.2881.00
26_A147_Q2.2821.00
265_L285_W2.1891.00
64_M69_A2.1721.00
29_A144_F2.1161.00
22_N147_Q2.1131.00
45_I64_M2.1101.00
102_A301_L2.0481.00
139_T176_A2.0421.00
191_D214_S2.0081.00
143_L176_A1.9481.00
188_I219_V1.9171.00
194_A214_S1.9091.00
150_Q261_N1.8851.00
66_R298_Q1.8551.00
149_T288_Q1.8511.00
220_M226_L1.8451.00
252_A256_H1.8381.00
177_L185_F1.8171.00
65_H70_S1.8031.00
18_R22_N1.7891.00
255_L262_M1.7541.00
98_T291_G1.7381.00
184_R211_S1.7311.00
17_S20_D1.6951.00
213_H218_E1.6791.00
23_L303_L1.6761.00
186_Y213_H1.6641.00
58_L96_I1.6311.00
109_Q112_A1.6281.00
240_E244_V1.6001.00
31_L302_A1.5991.00
45_I102_A1.5931.00
137_T300_L1.5861.00
262_M283_H1.5841.00
253_S256_H1.5651.00
150_Q156_L1.5651.00
258_A262_M1.5601.00
75_S79_N1.5411.00
24_V303_L1.5301.00
184_R209_A1.5291.00
27_T303_L1.4991.00
18_R179_K1.4971.00
134_Q175_Q1.4931.00
173_L227_Y1.4891.00
8_K20_D1.4881.00
18_R154_D1.4721.00
159_A188_I1.4661.00
191_D194_A1.4471.00
50_F112_A1.4421.00
225_I263_K1.4081.00
10_I140_L1.4061.00
137_T297_R1.3941.00
39_L302_A1.3941.00
28_A144_F1.3891.00
242_A245_K1.3771.00
217_E254_D1.3761.00
102_A305_L1.3621.00
227_Y289_Q1.3611.00
222_E259_K1.3581.00
161_V220_M1.3461.00
94_S280_K1.3381.00
93_I116_A1.3341.00
159_A186_Y1.3281.00
216_I254_D1.3231.00
25_L144_F1.3091.00
189_A194_A1.2991.00
251_R275_A1.2871.00
226_L250_L1.2841.00
25_L147_Q1.2801.00
241_Y245_K1.2681.00
14_N175_Q1.2661.00
94_S287_F1.2591.00
152_R156_L1.2551.00
27_T30_K1.2531.00
249_V275_A1.2351.00
54_T92_T1.2341.00
144_F296_A1.2341.00
13_I176_A1.2331.00
10_I300_L1.2291.00
221_A257_N1.2221.00
295_F298_Q1.2191.00
255_L264_V1.2101.00
186_Y211_S1.2081.00
228_M250_L1.2061.00
22_N180_F1.2021.00
9_H117_T1.1931.00
45_I104_V1.1811.00
271_V276_T1.1801.00
213_H219_V1.1741.00
57_R61_E1.1701.00
177_L183_N1.1691.00
54_T86_G1.1651.00
103_I123_V1.1621.00
114_R118_E1.1621.00
240_E243_N1.1581.00
200_L212_L1.1551.00
90_A119_F1.1491.00
255_L283_H1.1481.00
140_L300_L1.1461.00
103_I116_A1.1251.00
156_L225_I1.1211.00
54_T81_S1.1211.00
65_H71_V1.1081.00
220_M254_D1.0971.00
270_R280_K1.0941.00
63_S301_L1.0891.00
52_A83_G1.0811.00
29_A148_E1.0761.00
150_Q224_D1.0681.00
111_G115_L1.0681.00
12_S15_D1.0671.00
64_M71_V1.0571.00
250_L264_V1.0551.00
10_I16_L1.0541.00
22_N26_A1.0511.00
174_T187_F1.0491.00
95_V290_A1.0421.00
291_G295_F1.0391.00
150_Q263_K1.0361.00
281_T284_A1.0361.00
32_K292_N1.0261.00
139_T173_L1.0191.00
241_Y244_V1.0181.00
164_L189_A1.0181.00
158_V177_L1.0171.00
188_I213_H1.0141.00
25_L29_A1.0031.00
66_R294_I0.9861.00
143_L180_F0.9831.00
279_D286_Y0.9801.00
214_S248_F0.9791.00
61_E73_G0.9791.00
158_V173_L0.9781.00
45_I69_A0.9741.00
21_L180_F0.9721.00
139_T169_T0.9681.00
94_S119_F0.9641.00
12_S175_Q0.9581.00
148_E292_N0.9571.00
58_L74_F0.9541.00
126_L300_L0.9431.00
32_K144_F0.9421.00
81_S85_K0.9391.00
104_V129_G0.9381.00
146_I156_L0.9361.00
25_L296_A0.9231.00
21_L179_K0.9231.00
302_A306_N0.9221.00
110_E114_R0.9210.99
9_H97_S0.9130.99
90_A280_K0.9120.99
253_S257_N0.9100.99
44_V66_R0.9030.99
218_E221_A0.9030.99
61_E65_H0.9020.99
107_H131_G0.9000.99
102_A126_L0.8980.99
90_A94_S0.8860.99
105_M116_A0.8830.99
44_V70_S0.8830.99
133_N196_P0.8800.99
38_E68_G0.8780.99
75_S78_A0.8770.99
150_Q285_W0.8760.99
38_E42_H0.8730.99
188_I223_V0.8690.99
140_L296_A0.8680.99
157_H222_E0.8660.99
161_V226_L0.8640.99
81_S92_T0.8620.99
13_I139_T0.8600.99
153_L180_F0.8580.99
81_S86_G0.8580.99
134_Q172_S0.8550.99
61_E71_V0.8540.99
144_F148_E0.8530.99
217_E221_A0.8530.99
252_A281_T0.8460.99
26_A30_K0.8430.99
186_Y223_V0.8410.99
64_M301_L0.8400.99
276_T280_K0.8390.99
195_M200_L0.8360.99
60_F137_T0.8330.99
288_Q291_G0.8310.99
270_R279_D0.8270.99
29_A33_A0.8270.99
188_I216_I0.8220.99
186_Y222_E0.8110.99
114_R117_T0.8070.99
255_L278_V0.8050.99
200_L204_D0.8040.99
164_L170_V0.8030.99
76_D79_N0.8010.99
30_K33_A0.8000.99
145_T285_W0.7970.99
211_S218_E0.7940.99
219_V223_V0.7920.98
174_T185_F0.7910.98
299_A303_L0.7880.98
278_V281_T0.7860.98
189_A195_M0.7840.98
43_K101_D0.7830.98
217_E253_S0.7760.98
115_L119_F0.7760.98
105_M112_A0.7750.98
23_L27_T0.7700.98
161_V254_D0.7700.98
171_H199_I0.7680.98
90_A276_T0.7670.98
44_V62_T0.7630.98
97_S123_V0.7620.98
28_A299_A0.7520.98
255_L258_A0.7520.98
146_I153_L0.7500.98
146_I150_Q0.7490.98
24_V296_A0.7490.98
21_L176_A0.7480.98
170_V187_F0.7460.98
11_I117_T0.7460.98
276_T279_D0.7450.98
251_R254_D0.7430.98
145_T292_N0.7420.98
150_Q225_I0.7420.98
86_G92_T0.7420.98
285_W288_Q0.7400.98
151_G155_N0.7390.98
13_I21_L0.7390.98
204_D210_W0.7350.98
226_L262_M0.7350.98
18_R206_K0.7340.98
100_V123_V0.7330.97
59_S99_Y0.7320.97
16_L24_V0.7270.97
10_I304_V0.7260.97
195_M212_L0.7210.97
107_H112_A0.7200.97
50_F82_L0.7200.97
113_A131_G0.7180.97
27_T31_L0.7170.97
157_H223_V0.7140.97
146_I177_L0.7130.97
59_S297_R0.7060.97
46_A103_I0.7010.97
252_A275_A0.7000.97
250_L274_I0.6970.97
63_S297_R0.6960.97
111_G114_R0.6950.97
8_K303_L0.6940.97
220_M257_N0.6920.96
28_A296_A0.6920.96
40_L69_A0.6890.96
115_L118_E0.6890.96
173_L177_L0.6890.96
174_T195_M0.6860.96
246_A249_V0.6840.96
244_V272_D0.6830.96
232_Q240_E0.6830.96
102_A304_V0.6770.96
40_L102_A0.6740.96
270_R276_T0.6740.96
255_L274_I0.6740.96
54_T85_K0.6740.96
19_D22_N0.6730.96
256_H283_H0.6720.96
254_D257_N0.6700.96
47_S64_M0.6680.96
13_I16_L0.6680.96
230_R234_E0.6670.96
24_V299_A0.6660.96
161_V216_I0.6660.96
89_L112_A0.6610.95
45_I301_L0.6580.95
149_T263_K0.6540.95
194_A212_L0.6530.95
36_Q41_K0.6530.95
216_I220_M0.6500.95
227_Y265_L0.6500.95
281_T286_Y0.6480.95
109_Q132_S0.6470.95
264_V278_V0.6460.95
66_R101_D0.6460.95
47_S73_G0.6450.95
227_Y230_R0.6440.95
226_L255_L0.6390.95
110_E132_S0.6390.95
47_S71_V0.6360.94
21_L140_L0.6350.94
143_L147_Q0.6350.94
146_I263_K0.6350.94
161_V228_M0.6330.94
95_V99_Y0.6300.94
31_L39_L0.6290.94
52_A79_N0.6270.94
126_L304_V0.6270.94
9_H122_N0.6260.94
158_V227_Y0.6250.94
80_T85_K0.6240.94
194_A197_Q0.6210.94
139_T289_Q0.6210.94
52_A86_G0.6200.94
146_I158_V0.6170.93
111_G130_D0.6170.93
51_E235_R0.6170.93
180_F183_N0.6150.93
11_I114_R0.6150.93
60_F297_R0.6130.93
160_M167_G0.6130.93
126_L301_L0.6120.93
175_Q199_I0.6120.93
62_T72_V0.6120.93
237_D240_E0.6120.93
44_V65_H0.6100.93
239_S243_N0.6100.93
59_S137_T0.6100.93
200_L210_W0.6090.93
95_V98_T0.6080.93
88_T280_K0.6070.93
159_A226_L0.6060.93
13_I134_Q0.6060.93
197_Q200_L0.6040.93
240_E245_K0.6000.92
93_I103_I0.5960.92
36_Q39_L0.5960.92
271_V277_D0.5950.92
54_T80_T0.5940.92
52_A81_S0.5930.92
92_T96_I0.5930.92
60_F104_V0.5920.92
252_A283_H0.5920.92
239_S242_A0.5900.92
240_E272_D0.5890.92
279_D284_A0.5880.92
80_T86_G0.5860.92
147_Q152_R0.5850.92
139_T143_L0.5850.92
49_F53_S0.5840.91
24_V300_L0.5830.91
214_S218_E0.5830.91
178_A185_F0.5820.91
148_E288_Q0.5760.91
19_D23_L0.5750.91
23_L26_A0.5740.91
34_N37_P0.5720.91
53_S56_T0.5700.90
59_S95_V0.5670.90
279_D287_F0.5660.90
62_T66_R0.5630.90
179_K206_K0.5630.90
159_A219_V0.5630.90
50_F107_H0.5620.90
176_A180_F0.5610.90
26_A29_A0.5600.90
62_T294_I0.5590.90
159_A213_H0.5580.90
14_N134_Q0.5570.89
27_T299_A0.5560.89
53_S57_R0.5550.89
111_G133_N0.5530.89
10_I21_L0.5530.89
169_T227_Y0.5520.89
257_N260_A0.5520.89
37_P41_K0.5500.89
130_D133_N0.5500.89
15_D179_K0.5440.88
143_L153_L0.5440.88
189_A214_S0.5440.88
184_R208_I0.5430.88
178_A208_I0.5430.88
25_L28_A0.5380.88
37_P42_H0.5380.88
20_D23_L0.5350.87
49_F56_T0.5350.87
108_P112_A0.5340.87
32_K295_F0.5340.87
197_Q204_D0.5340.87
161_V247_Q0.5330.87
225_I265_L0.5330.87
51_E234_E0.5320.87
178_A206_K0.5310.87
220_M258_A0.5290.87
156_L224_D0.5280.87
36_Q67_L0.5280.87
187_F210_W0.5280.87
151_G263_K0.5270.87
213_H216_I0.5260.87
79_N82_L0.5260.87
51_E108_P0.5230.86
87_E91_D0.5230.86
95_V287_F0.5230.86
160_M227_Y0.5220.86
250_L255_L0.5220.86
211_S222_E0.5210.86
60_F129_G0.5200.86
169_T173_L0.5190.86
12_S114_R0.5190.86
89_L105_M0.5160.86
104_V130_D0.5150.85
21_L143_L0.5140.85
98_T290_A0.5140.85
153_L183_N0.5140.85
301_L305_L0.5100.85
281_T285_W0.5080.85
225_I285_W0.5070.85
40_L301_L0.5060.84
182_G209_A0.5060.84
22_N154_D0.5050.84
152_R155_N0.5040.84
264_V284_A0.5040.84
268_L287_F0.5020.84
167_G229_T0.5020.84
52_A73_G0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3csuA 3 0.9904 100 0.021 Contact Map
1ml4A 3 0.9711 100 0.03 Contact Map
4oh7A 3 0.9486 100 0.042 Contact Map
4iv5A 4 0.9357 100 0.042 Contact Map
1pg5A 4 0.9293 100 0.049 Contact Map
1pvvA 6 0.9678 100 0.05 Contact Map
4nf2A 3 0.955 100 0.052 Contact Map
3gd5A 4 0.8971 100 0.055 Contact Map
4eknB 5 0.9582 100 0.061 Contact Map
2i6uA 3 0.955 100 0.062 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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