GREMLIN Database
ORN - Oligoribonuclease
UniProt: P0A784 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12480
Length: 181 (175)
Sequences: 1487 (834)
Seq/√Len: 63.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
73_E77_A4.1861.00
34_D38_N3.6761.00
67_T72_V3.5631.00
52_D76_K3.4101.00
52_D56_A2.9841.00
137_L179_I2.9741.00
26_I75_V2.6151.00
64_R68_A2.5221.00
30_T89_T2.5181.00
109_I131_Y2.4821.00
8_L132_L2.3011.00
13_L25_I2.2541.00
86_E122_E2.1081.00
31_L165_R2.1061.00
159_Q162_D2.0511.00
24_R82_D2.0081.00
21_E118_K2.0051.00
46_I80_M1.9591.00
23_D54_Q1.9171.00
141_A178_F1.9141.00
87_L91_E1.9101.00
31_L168_V1.9061.00
47_A74_R1.8961.00
59_D63_V1.8831.00
151_G173_Y1.8361.00
169_A172_A1.8031.00
93_L123_L1.7991.00
139_E143_R1.7651.00
63_V72_V1.7300.99
60_D63_V1.7110.99
104_I127_F1.6920.99
60_D64_R1.6670.99
87_L122_E1.6310.99
19_D22_R1.6200.99
148_I173_Y1.6050.99
110_G131_Y1.5960.99
84_E88_A1.5940.99
28_I89_T1.5390.99
81_G84_E1.5370.99
83_R86_E1.5360.99
162_D166_E1.5220.99
46_I88_A1.4930.98
8_L105_C1.4890.98
54_Q57_L1.4680.98
42_E165_R1.4680.98
113_R124_E1.4410.98
31_L39_I1.4340.98
139_E142_R1.4260.98
16_T26_I1.3930.97
90_L94_K1.3530.97
41_A95_Q1.3510.97
88_A91_E1.3440.97
40_L96_W1.3180.96
80_M85_A1.3160.96
157_T162_D1.3070.96
65_T166_E1.3050.96
41_A92_F1.2910.96
13_L116_L1.2800.96
80_M88_A1.2760.96
44_P92_F1.2380.95
62_N72_V1.2310.95
65_T68_A1.2160.94
97_V126_Y1.2120.94
24_R119_Y1.2120.94
61_W65_T1.1970.94
65_T159_Q1.1870.94
20_P119_Y1.1800.93
46_I85_A1.1790.93
80_M84_E1.1240.92
94_K122_E1.1210.91
137_L178_F1.1210.91
156_G166_E1.0910.90
138_K170_E1.0910.90
84_E87_L1.0850.90
142_R149_L1.0760.90
22_R57_L1.0630.89
25_I48_V1.0610.89
65_T69_S1.0570.89
26_I55_L1.0400.88
56_A63_V1.0160.87
93_L126_Y1.0140.87
41_A44_P1.0080.86
26_I54_Q1.0070.86
145_K148_I1.0040.86
49_H78_S0.9940.86
11_I123_L0.9860.85
172_A176_E0.9650.84
155_Q166_E0.9570.83
83_R87_L0.9560.83
82_D119_Y0.9550.83
110_G119_Y0.9470.83
5_E101_K0.9450.83
86_E120_M0.9410.82
59_D62_N0.9400.82
55_L76_K0.9350.82
7_N35_A0.9330.82
44_P89_T0.9220.81
32_V93_L0.9180.81
145_K178_F0.9130.80
73_E76_K0.9110.80
6_N142_R0.9080.80
140_L171_L0.9070.80
111_Q114_R0.8870.78
49_H52_D0.8870.78
23_D57_L0.8740.77
21_E119_Y0.8720.77
28_I123_L0.8720.77
145_K179_I0.8690.77
93_L100_G0.8670.77
24_R54_Q0.8560.76
5_E98_P0.8550.76
155_Q162_D0.8510.75
25_I86_E0.8500.75
50_Q82_D0.8480.75
91_E95_Q0.8390.74
98_P126_Y0.8380.74
48_V85_A0.8380.74
104_I131_Y0.8340.74
152_F173_Y0.8230.73
62_N159_Q0.8040.71
62_N65_T0.8030.71
30_T43_G0.8010.71
43_G85_A0.8000.71
113_R131_Y0.7980.71
29_A161_M0.7970.71
51_S54_Q0.7920.70
66_H69_S0.7890.70
117_F124_E0.7870.70
108_S131_Y0.7840.69
110_G117_F0.7800.69
91_E94_K0.7800.69
59_D64_R0.7790.69
137_L140_L0.7770.69
94_K126_Y0.7690.68
86_E90_L0.7680.68
10_W14_E0.7650.67
136_T140_L0.7620.67
109_I124_E0.7610.67
132_L140_L0.7610.67
51_S56_A0.7600.67
113_R117_F0.7570.67
25_I119_Y0.7520.66
53_E56_A0.7510.66
7_N40_L0.7500.66
68_A125_A0.7480.66
145_K149_L0.7460.65
99_A126_Y0.7440.65
148_I178_F0.7440.65
20_P114_R0.7420.65
148_I177_H0.7400.65
19_D23_D0.7380.65
20_P117_F0.7360.64
107_N154_K0.7200.63
74_R159_Q0.7120.62
31_L161_M0.7070.61
35_A40_L0.7070.61
173_Y177_H0.7010.61
166_E169_A0.7010.61
124_E127_F0.6980.60
63_V67_T0.6980.60
11_I164_I0.6970.60
20_P111_Q0.6960.60
75_V78_S0.6950.60
49_H79_T0.6950.60
47_A80_M0.6930.60
138_K174_Y0.6840.59
25_I120_M0.6830.59
29_A160_A0.6810.58
102_S127_F0.6730.58
54_Q59_D0.6730.58
160_A163_D0.6730.58
45_T159_Q0.6660.57
163_D167_S0.6600.56
13_L28_I0.6570.56
82_D127_F0.6550.55
154_K166_E0.6540.55
26_I119_Y0.6540.55
23_D118_K0.6520.55
79_T84_E0.6520.55
22_R54_Q0.6490.55
105_C109_I0.6450.54
11_I104_I0.6420.54
90_L93_L0.6380.54
103_P124_E0.6350.53
15_M111_Q0.6340.53
20_P26_I0.6310.53
104_I116_L0.6300.53
39_I165_R0.6290.52
162_D165_R0.6290.52
94_K99_A0.6240.52
13_L89_T0.6210.52
120_M123_L0.6200.51
130_R139_E0.6190.51
36_N122_E0.6180.51
15_M58_M0.6150.51
72_V75_V0.6150.51
86_E123_L0.6150.51
7_N102_S0.6070.50
11_I28_I0.6050.50
60_D72_V0.6040.50
120_M140_L0.6030.50
50_Q75_V0.6030.50
47_A159_Q0.6020.49
13_L92_F0.6000.49
50_Q119_Y0.6000.49
9_I32_V0.5850.47
32_V40_L0.5850.47
124_E131_Y0.5840.47
46_I89_T0.5840.47
94_K176_E0.5820.47
116_L124_E0.5800.47
9_I97_V0.5780.47
140_L144_W0.5730.46
152_F166_E0.5730.46
19_D142_R0.5670.45
28_I75_V0.5660.45
135_S139_E0.5640.45
103_P113_R0.5620.45
9_I127_F0.5580.44
102_S105_C0.5570.44
32_V100_G0.5560.44
43_G89_T0.5550.44
26_I50_Q0.5550.44
49_H91_E0.5540.44
109_I129_Y0.5530.44
100_G125_A0.5490.43
93_L99_A0.5470.43
6_N35_A0.5460.43
34_D40_L0.5440.43
102_S132_L0.5420.43
10_W33_T0.5370.42
132_L150_D0.5360.42
90_L126_Y0.5320.41
11_I116_L0.5300.41
24_R50_Q0.5280.41
20_P118_K0.5280.41
41_A165_R0.5270.41
128_H138_K0.5270.41
45_T81_G0.5260.41
160_A164_I0.5250.41
173_Y176_E0.5250.41
11_I43_G0.5240.41
92_F96_W0.5230.40
57_L63_V0.5220.40
17_G66_H0.5210.40
51_S57_L0.5180.40
9_I104_I0.5160.40
50_Q54_Q0.5150.40
11_I30_T0.5150.40
30_T123_L0.5110.39
144_W175_R0.5100.39
8_L24_R0.5100.39
79_T85_A0.5090.39
148_I151_G0.5090.39
53_E153_T0.5080.39
28_I159_Q0.5080.39
87_L94_K0.5060.39
72_V76_K0.5060.39
142_R165_R0.5050.38
158_H163_D0.5010.38
45_T84_E0.5000.38
159_Q165_R0.5000.38
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2gbzA 2 0.9779 100 0.581 Contact Map
3tr8A 2 1 100 0.589 Contact Map
2igiA 2 0.9945 100 0.602 Contact Map
3u3yB 2 0.9337 99.9 0.69 Contact Map
3mxmB 2 0.9282 99.9 0.698 Contact Map
1w0hA 1 0.9503 99.8 0.706 Contact Map
4qozB 1 0.9392 99.8 0.714 Contact Map
1zbuA 1 0.9503 99.8 0.718 Contact Map
4rg8A 1 0.9061 99.8 0.718 Contact Map
2xriA 1 0.9171 99.8 0.719 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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