GREMLIN Database
MNTH - Divalent metal cation transporter MntH
UniProt: P0A769 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14157
Length: 412 (390)
Sequences: 4040 (2608)
Seq/√Len: 132.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
79_K87_D9.5821.00
178_N181_Q5.4701.00
372_S387_K4.4831.00
384_K388_Q3.6721.00
88_H373_D3.5351.00
371_T382_N3.4891.00
277_L280_Q3.4131.00
384_K387_K3.3571.00
365_V398_V3.3041.00
374_S381_V3.1791.00
368_L390_G3.1781.00
328_R331_T2.9081.00
382_N387_K2.8951.00
65_L393_I2.8401.00
95_W99_V2.8291.00
365_V394_V2.7411.00
280_Q285_H2.6631.00
76_A380_L2.6561.00
68_I72_K2.5801.00
186_M251_L2.5681.00
383_S386_V2.4601.00
365_V369_I2.4491.00
43_Q47_S2.4441.00
402_I406_V2.4241.00
182_L255_A2.4131.00
73_L371_T2.3511.00
89_Y369_I2.3401.00
323_P326_V2.3351.00
218_S312_V2.3271.00
53_L251_L2.3071.00
119_G296_V2.2851.00
62_M393_I2.2261.00
179_L182_L2.2261.00
251_L255_A2.2111.00
40_T202_G2.1841.00
280_Q288_A2.1191.00
64_M240_A2.0811.00
274_E277_L2.0591.00
192_P196_A2.0381.00
92_P96_F2.0181.00
369_I373_D1.9621.00
120_F124_L1.9511.00
65_L386_V1.9101.00
68_I236_K1.8961.00
127_S130_Q1.8771.00
69_L382_N1.8641.00
162_L166_A1.8591.00
372_S382_N1.8541.00
80_N83_E1.8511.00
135_T296_V1.8501.00
403_W407_G1.8241.00
90_P93_V1.8231.00
151_K155_K1.7941.00
233_S237_W1.7871.00
73_L84_Q1.7171.00
364_L394_V1.7171.00
395_V399_A1.7101.00
79_K84_Q1.6941.00
171_E256_T1.6811.00
388_Q391_W1.6801.00
198_F351_M1.6211.00
18_R237_W1.6051.00
66_I364_L1.6011.00
138_A141_L1.5921.00
76_A232_Y1.5851.00
244_T248_F1.5851.00
48_F196_A1.5791.00
181_Q185_G1.5691.00
91_R95_W1.5531.00
72_K382_N1.5501.00
116_A135_T1.5351.00
333_L336_F1.5191.00
26_F242_A1.5191.00
373_D376_L1.5101.00
69_L390_G1.5021.00
368_L394_V1.4881.00
54_W189_P1.4781.00
391_W395_V1.4761.00
237_W241_I1.4711.00
372_S391_W1.4671.00
335_S339_I1.4631.00
50_Y259_A1.4521.00
154_E223_L1.4461.00
99_V103_I1.4421.00
57_V247_G1.4281.00
271_D274_E1.4161.00
48_F195_E1.4131.00
178_N182_L1.3921.00
117_A128_L1.3901.00
86_R94_V1.3871.00
198_F354_V1.3841.00
71_A235_T1.3741.00
126_V130_Q1.3691.00
179_L183_G1.3661.00
270_A274_E1.3601.00
32_Y246_A1.3481.00
180_A183_G1.3461.00
169_I252_A1.3451.00
289_T293_L1.3441.00
370_F376_L1.3431.00
56_V254_M1.3241.00
381_V384_K1.3141.00
138_A300_L1.3131.00
163_F293_L1.3101.00
120_F296_V1.3061.00
343_L348_I1.3061.00
184_K190_S1.2991.00
332_M335_S1.2941.00
184_K188_I1.2931.00
183_G187_V1.2871.00
177_P182_L1.2851.00
39_A275_A1.2831.00
163_F297_A1.2801.00
31_G305_V1.2791.00
369_I391_W1.2751.00
82_A313_V1.2741.00
41_N250_N1.2701.00
105_A313_V1.2541.00
322_I326_V1.2541.00
100_Q359_G1.2531.00
332_M339_I1.2501.00
385_R388_Q1.2471.00
344_D347_R1.2461.00
59_A207_T1.2421.00
368_L372_S1.2391.00
286_A290_V1.2361.00
29_A33_I1.2331.00
175_S283_L1.2311.00
85_I97_Y1.2091.00
107_A352_S1.2061.00
333_L339_I1.1980.99
173_I177_P1.1950.99
44_A203_V1.1920.99
191_L196_A1.1840.99
104_I359_G1.1800.99
307_T311_Q1.1770.99
382_N386_V1.1650.99
112_E115_G1.1650.99
394_V398_V1.1630.99
269_V274_E1.1600.99
277_L281_P1.1490.99
172_L252_A1.1430.99
374_S379_D1.1390.99
336_F339_I1.1360.99
75_I235_T1.1350.99
48_F193_T1.1310.99
172_L255_A1.1300.99
155_K158_G1.1280.99
368_L391_W1.1270.99
62_M204_L1.1250.99
137_I141_L1.1140.99
364_L393_I1.1140.99
321_H325_W1.1060.99
35_P299_G1.1040.99
160_L297_A1.1040.99
368_L387_K1.1010.99
175_S259_A1.1010.99
181_Q184_K1.0990.99
168_Y249_V1.0970.99
61_L65_L1.0900.99
192_P195_E1.0800.99
190_S193_T1.0730.99
382_N385_R1.0710.99
206_A209_M1.0680.99
65_L389_T1.0660.99
358_F401_N1.0650.99
161_L301_S1.0620.99
398_V402_I1.0610.99
51_Q190_S1.0610.99
17_M20_A1.0600.99
332_M336_F1.0560.99
210_P356_L1.0560.99
392_V395_V1.0540.99
67_Q82_A1.0460.99
100_Q105_A1.0440.99
136_G336_F1.0370.98
276_Y288_A1.0280.98
220_T223_L1.0240.98
44_A199_L1.0240.98
173_I176_Q1.0220.98
27_I305_V1.0210.98
60_N247_G1.0170.98
25_A29_A1.0150.98
348_I352_S1.0140.98
361_A398_V1.0110.98
49_G262_H1.0110.98
108_T112_E1.0090.98
69_L371_T1.0070.98
399_A403_W1.0060.98
351_M355_L1.0060.98
285_H288_A1.0040.98
67_Q208_I1.0040.98
321_H324_L1.0030.98
191_L200_A1.0030.98
132_A135_T0.9980.98
133_V137_I0.9950.98
89_Y370_F0.9880.98
324_L327_R0.9790.98
167_A290_V0.9790.98
80_N221_Q0.9760.98
42_I275_A0.9740.98
378_G381_V0.9730.98
212_V305_V0.9720.98
65_L390_G0.9690.98
379_D383_S0.9660.98
37_N41_N0.9520.97
101_A105_A0.9520.97
240_A244_T0.9510.97
126_V134_L0.9510.97
170_V174_F0.9450.97
184_K187_V0.9400.97
171_E174_F0.9370.97
334_P337_I0.9350.97
388_Q395_V0.9340.97
70_S74_G0.9280.97
323_P327_R0.9260.97
15_R19_L0.9220.97
381_V387_K0.9210.97
77_T376_L0.9180.97
77_T84_Q0.9170.97
396_L399_A0.9150.97
335_S338_V0.9080.96
111_A352_S0.9030.96
388_Q392_V0.8990.96
79_K83_E0.8970.96
121_K273_D0.8970.96
337_I340_L0.8960.96
54_W192_P0.8940.96
130_Q183_G0.8910.96
38_F294_S0.8900.96
232_Y236_K0.8870.96
112_E206_A0.8860.96
100_Q104_I0.8860.96
152_P155_K0.8860.96
47_S195_E0.8850.96
47_S191_L0.8840.96
257_A260_A0.8840.96
180_A184_K0.8810.96
321_H326_V0.8800.96
34_D37_N0.8780.96
69_L73_L0.8770.96
133_V336_F0.8740.96
41_N253_M0.8720.96
212_V216_H0.8710.96
73_L370_F0.8690.96
111_A349_L0.8640.95
229_Q379_D0.8590.95
141_L145_L0.8560.95
124_L289_T0.8560.95
339_I345_P0.8550.95
216_H220_T0.8540.95
120_F131_G0.8520.95
84_Q370_F0.8500.95
130_Q133_V0.8470.95
169_I173_I0.8470.95
386_V390_G0.8470.95
178_N395_V0.8410.95
271_D346_T0.8400.95
260_A263_F0.8400.95
81_L214_Y0.8390.95
51_Q192_P0.8380.95
199_L350_V0.8350.94
32_Y211_H0.8330.94
185_G193_T0.8310.94
98_W105_A0.8310.94
135_T143_L0.8290.94
334_P338_V0.8290.94
68_I232_Y0.8260.94
41_N108_T0.8240.94
36_G353_Q0.8240.94
23_G238_D0.8230.94
183_G186_M0.8170.94
171_E175_S0.8140.94
129_L133_V0.8130.94
105_A310_G0.8130.94
169_I248_F0.8100.93
71_A216_H0.8060.93
150_Q222_H0.8040.93
371_T377_M0.7960.93
149_G152_P0.7940.93
379_D384_K0.7920.93
170_V290_V0.7920.93
207_T353_Q0.7920.93
204_L361_A0.7910.93
44_A56_V0.7910.93
82_A214_Y0.7890.93
132_A139_T0.7830.92
33_I249_V0.7820.92
99_V333_L0.7810.92
56_V203_V0.7800.92
137_I180_A0.7800.92
30_I34_D0.7740.92
356_L360_I0.7700.92
33_I301_S0.7680.92
283_L290_V0.7650.91
388_Q399_A0.7650.91
108_T111_A0.7650.91
383_S387_K0.7640.91
289_T292_G0.7640.91
211_H217_S0.7620.91
229_Q380_L0.7620.91
27_I30_I0.7610.91
285_H379_D0.7610.91
51_Q194_S0.7610.91
113_F136_G0.7580.91
291_F350_V0.7580.91
35_P349_L0.7580.91
134_L138_A0.7560.91
39_A349_L0.7520.91
167_A283_L0.7520.91
284_S287_A0.7500.91
347_R351_M0.7480.90
209_M213_I0.7470.90
66_I393_I0.7450.90
27_I31_G0.7450.90
168_Y279_L0.7440.90
50_Y185_G0.7420.90
28_A239_V0.7400.90
56_V256_T0.7390.90
133_V136_G0.7380.90
329_T333_L0.7380.90
123_I289_T0.7370.90
253_M294_S0.7350.90
168_Y253_M0.7350.90
67_Q210_P0.7350.90
135_T139_T0.7350.90
131_G134_L0.7330.90
113_F131_G0.7320.90
281_P287_A0.7310.89
357_S401_N0.7290.89
170_V173_I0.7290.89
90_P373_D0.7270.89
42_I272_L0.7260.89
47_S166_A0.7220.89
24_P238_D0.7210.89
30_I161_L0.7210.89
197_V403_W0.7210.89
31_G38_F0.7130.88
231_R234_A0.7110.88
134_L137_I0.7100.88
209_M356_L0.7100.88
130_Q137_I0.7090.88
137_I140_F0.7090.88
278_T294_S0.7080.88
166_A170_V0.7080.88
29_A75_I0.7080.88
40_T353_Q0.7060.88
209_M216_H0.7050.88
32_Y63_A0.7050.88
108_T356_L0.7050.88
402_I405_L0.6990.87
32_Y37_N0.6990.87
109_D112_E0.6980.87
121_K128_L0.6960.87
96_F100_Q0.6940.87
140_F144_M0.6940.87
285_H289_T0.6930.87
337_I341_M0.6930.87
183_G355_L0.6910.87
166_A277_L0.6900.87
212_V215_L0.6890.86
334_P339_I0.6880.86
112_E302_S0.6880.86
159_G170_V0.6860.86
37_N206_A0.6840.86
247_G251_L0.6840.86
359_G363_A0.6810.86
213_I364_L0.6800.86
120_F126_V0.6800.86
67_Q207_T0.6790.86
396_L400_L0.6780.86
28_A213_I0.6770.86
50_Y178_N0.6770.86
84_Q376_L0.6760.85
308_L312_V0.6750.85
185_G188_I0.6740.85
333_L337_I0.6740.85
328_R334_P0.6740.85
35_P216_H0.6730.85
263_F266_H0.6720.85
159_G289_T0.6690.85
37_N209_M0.6690.85
43_Q346_T0.6660.85
31_G363_A0.6640.84
265_G268_G0.6570.84
31_G210_P0.6550.84
76_A221_Q0.6550.84
115_G177_P0.6540.84
252_A283_L0.6540.84
73_L367_L0.6530.83
57_V186_M0.6530.83
25_A119_G0.6520.83
63_A207_T0.6510.83
159_G395_V0.6510.83
196_A200_A0.6470.83
27_I212_V0.6460.83
18_R22_M0.6460.83
399_A402_I0.6450.83
22_M26_F0.6450.83
311_Q315_Q0.6440.83
203_V254_M0.6420.82
63_A246_A0.6420.82
71_A75_I0.6410.82
332_M338_V0.6410.82
74_G217_S0.6410.82
208_I295_L0.6400.82
84_Q87_D0.6380.82
33_I164_V0.6370.82
209_M353_Q0.6370.82
238_D242_A0.6370.82
137_I325_W0.6350.82
161_L165_A0.6340.82
122_L292_G0.6330.82
205_G309_A0.6330.82
159_G337_I0.6320.81
34_D112_E0.6300.81
177_P255_A0.6300.81
162_L251_L0.6260.81
211_H357_S0.6260.81
178_N183_G0.6250.81
245_I249_V0.6250.81
373_D387_K0.6250.81
67_Q214_Y0.6240.81
33_I41_N0.6210.80
120_F135_T0.6200.80
126_V131_G0.6200.80
60_N64_M0.6200.80
82_A316_G0.6190.80
97_Y366_P0.6190.80
342_G345_P0.6180.80
34_D41_N0.6160.80
58_W396_L0.6140.80
33_I168_Y0.6130.79
69_L72_K0.6130.79
74_G81_L0.6100.79
80_N316_G0.6100.79
275_A291_F0.6090.79
131_G135_T0.6080.79
206_A353_Q0.6070.79
294_S298_A0.6050.79
89_Y93_V0.6050.79
86_R319_R0.6050.79
83_E221_Q0.6010.78
387_K391_W0.6000.78
385_R389_T0.5980.78
87_D319_R0.5980.78
132_A339_I0.5980.78
384_K406_V0.5970.78
124_L134_L0.5960.78
217_S220_T0.5960.78
50_Y258_A0.5940.77
127_S328_R0.5930.77
37_N250_N0.5930.77
34_D108_T0.5920.77
175_S398_V0.5900.77
116_A119_G0.5880.77
210_P218_S0.5880.77
299_G302_S0.5870.76
139_T303_T0.5860.76
263_F358_F0.5850.76
70_S81_L0.5840.76
172_L179_L0.5840.76
101_A104_I0.5840.76
227_S231_R0.5820.76
83_E316_G0.5800.76
241_I337_I0.5790.75
201_A398_V0.5790.75
71_A78_G0.5780.75
164_V249_V0.5780.75
156_V162_L0.5770.75
63_A243_M0.5760.75
126_V317_F0.5760.75
103_I151_K0.5760.75
159_G163_F0.5750.75
256_T278_T0.5750.75
70_S217_S0.5740.75
363_A366_P0.5740.75
87_D374_S0.5730.75
183_G229_Q0.5730.75
265_G269_V0.5720.75
250_N401_N0.5700.74
93_V366_P0.5700.74
172_L256_T0.5700.74
266_H274_E0.5670.74
260_A281_P0.5660.74
391_W394_V0.5660.74
17_M230_Q0.5660.74
27_I231_R0.5650.74
74_G80_N0.5630.73
249_V253_M0.5630.73
206_A210_P0.5630.73
260_A287_A0.5610.73
47_S51_Q0.5610.73
253_M279_L0.5600.73
25_A53_L0.5590.73
88_H375_K0.5590.73
28_A212_V0.5570.73
112_E211_H0.5560.73
343_L374_S0.5540.72
61_L64_M0.5520.72
157_I304_V0.5520.72
16_K103_I0.5520.72
182_L258_A0.5510.72
223_L238_D0.5510.72
295_L299_G0.5510.72
132_A136_G0.5500.72
209_M217_S0.5490.72
92_P95_W0.5450.71
203_V207_T0.5440.71
340_L345_P0.5430.71
157_I301_S0.5430.71
293_L399_A0.5430.71
108_T352_S0.5400.70
85_I317_F0.5400.70
197_V201_A0.5400.70
184_K374_S0.5340.70
209_M246_A0.5330.69
59_A360_I0.5320.69
260_A264_S0.5320.69
67_Q74_G0.5320.69
322_I325_W0.5310.69
156_V304_V0.5310.69
60_N244_T0.5310.69
119_G292_G0.5310.69
64_M244_T0.5300.69
35_P115_G0.5300.69
224_H228_R0.5280.69
28_A31_G0.5280.69
403_W406_V0.5270.69
90_P369_I0.5270.69
108_T353_Q0.5270.69
232_Y380_L0.5260.68
101_A359_G0.5250.68
273_D277_L0.5250.68
269_V281_P0.5250.68
38_F305_V0.5240.68
304_V308_L0.5230.68
112_E210_P0.5220.68
106_M220_T0.5220.68
266_H269_V0.5210.68
97_Y363_A0.5210.68
122_L288_A0.5200.67
209_M250_N0.5200.67
352_S356_L0.5190.67
168_Y275_A0.5190.67
324_L329_T0.5180.67
31_G211_H0.5180.67
55_V200_A0.5170.67
103_I355_L0.5170.67
134_L145_L0.5170.67
313_V316_G0.5170.67
166_A241_I0.5150.67
238_D363_A0.5150.67
50_Y154_E0.5150.67
98_W327_R0.5150.67
123_I296_V0.5140.67
102_E334_P0.5140.67
121_K369_I0.5140.67
62_M261_F0.5140.67
31_G212_V0.5140.67
236_K399_A0.5130.66
44_A294_S0.5130.66
34_D301_S0.5130.66
368_L382_N0.5120.66
171_E279_L0.5120.66
34_D302_S0.5110.66
104_I349_L0.5110.66
39_A43_Q0.5100.66
43_Q275_A0.5080.66
32_Y216_H0.5080.66
72_K298_A0.5080.66
322_I327_R0.5070.66
148_R152_P0.5060.65
372_S375_K0.5050.65
115_G299_G0.5040.65
191_L329_T0.5040.65
129_L340_L0.5040.65
152_P194_S0.5030.65
297_A301_S0.5030.65
153_L304_V0.5030.65
326_V330_V0.5020.65
95_W137_I0.5020.65
98_W306_G0.5010.65
214_Y219_L0.5000.64
191_L289_T0.5000.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4wgvA 2 0.9053 100 0.193 Contact Map
3dh4A 3 0.9053 99.3 0.845 Contact Map
3l1lA 2 0.8956 99 0.867 Contact Map
2xq2A 2 0.915 98.9 0.87 Contact Map
2jlnA 1 0.9417 98.8 0.875 Contact Map
3giaA 1 0.9102 98.7 0.878 Contact Map
4djkA 2 0.8859 98.4 0.89 Contact Map
4us3A 1 0.9053 98.1 0.898 Contact Map
2a65A 2 0.9296 97.7 0.908 Contact Map
4xp4A 1 0.9296 96.8 0.92 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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