GREMLIN Database
NANE - Putative N-acetylmannosamine-6-phosphate 2-epimerase
UniProt: P0A761 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12816
Length: 229 (216)
Sequences: 954 (662)
Seq/√Len: 45.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
16_G48_V5.3071.00
139_G174_L3.8201.00
45_A217_C3.6361.00
43_E67_V3.4751.00
134_S138_D2.6991.00
194_A198_R2.5601.00
55_V73_V2.5241.00
193_A204_V2.3721.00
62_R100_D2.3351.00
62_R69_I2.3211.00
36_A60_A2.3101.00
29_L38_M2.2971.00
75_R93_A2.2271.00
134_S160_P2.1391.00
195_D198_R2.1111.00
150_I179_C2.1091.00
208_S215_H2.0470.99
141_A144_K2.0150.99
182_I203_A2.0110.99
168_L195_D2.0040.99
97_A100_D1.9300.99
10_K149_I1.8760.99
119_L147_A1.8320.99
50_I61_T1.8110.99
94_L102_I1.8040.99
43_E66_S1.7990.98
195_D199_H1.7930.98
119_L129_A1.7780.98
197_M224_M1.7750.98
101_I149_I1.7120.98
136_P173_T1.7080.98
188_N192_Q1.7070.98
52_I61_T1.6960.98
188_N219_W1.6850.98
136_P170_L1.6780.98
155_S167_D1.6490.97
19_V217_C1.6350.97
189_T220_Y1.6260.97
165_E186_R1.6180.97
150_I177_A1.6080.97
193_A197_M1.6050.97
81_P159_T1.5970.97
58_L94_L1.5960.97
193_A224_M1.5440.96
140_L144_K1.5170.96
190_P206_V1.5030.95
218_Q222_T1.4990.95
13_A101_I1.4990.95
40_L44_Q1.4690.95
135_T161_E1.4500.94
135_T138_D1.4340.94
138_D160_P1.4310.94
222_T225_K1.4200.94
36_A64_V1.4050.93
34_I37_A1.3970.93
35_V57_N1.3940.93
106_G142_C1.3930.93
215_H219_W1.3610.92
169_A173_T1.3590.92
114_P117_T1.3370.92
168_L199_H1.3290.91
180_R202_W1.3260.91
27_S212_R1.3040.90
129_A147_A1.3030.90
155_S170_L1.2880.90
130_M151_G1.2870.90
95_A99_A1.2830.90
11_I14_N1.2770.90
197_M204_V1.2760.89
18_I203_A1.2750.89
17_L206_V1.2720.89
37_A64_V1.2380.88
155_S166_P1.2380.88
133_C138_D1.2370.88
40_L43_E1.2220.87
89_E93_A1.2170.87
32_P36_A1.2140.87
128_L149_I1.2060.87
149_I182_I1.1920.86
123_H129_A1.1820.86
209_A220_Y1.1790.85
105_D109_R1.1680.85
149_I202_W1.1660.85
115_V145_L1.1620.85
24_V27_S1.1590.84
188_N208_S1.1580.84
130_M149_I1.1550.84
108_D160_P1.1530.84
136_P140_L1.1520.84
17_L224_M1.1510.84
83_R154_L1.1470.84
29_L34_I1.1300.83
35_V61_T1.1270.83
77_L90_D1.1210.82
60_A63_A1.1150.82
88_I121_R1.0930.81
60_A64_V1.0860.80
210_I213_L1.0850.80
182_I205_T1.0810.80
35_V52_I1.0800.80
171_V187_Y1.0780.80
75_R89_E1.0610.79
109_R160_P1.0600.79
80_S112_P1.0450.78
177_A181_V1.0450.78
69_I99_A1.0410.77
187_Y196_A1.0380.77
43_E65_V1.0380.77
143_Q178_G1.0320.77
116_E141_A1.0300.77
30_D57_N1.0290.77
143_Q179_C1.0280.76
81_P109_R1.0170.76
13_A18_I1.0120.75
108_D141_A1.0120.75
155_S163_P1.0070.75
92_D124_H1.0060.75
73_V94_L1.0030.75
24_V212_R0.9870.73
87_Y90_D0.9860.73
82_V112_P0.9800.73
108_D137_E0.9800.73
73_V93_A0.9780.73
55_V93_A0.9720.72
133_C139_G0.9700.72
139_G143_Q0.9600.71
123_H148_E0.9520.71
123_H126_G0.9480.70
171_V201_A0.9410.70
91_V129_A0.9380.70
88_I124_H0.9340.69
193_A206_V0.9320.69
75_R90_D0.9310.69
72_I130_M0.9280.69
37_A60_A0.9270.69
27_S214_E0.9240.68
45_A221_N0.9220.68
88_I92_D0.9050.67
196_A204_V0.9020.67
66_S218_Q0.9020.67
123_H147_A0.8950.66
50_I65_V0.8950.66
82_V109_R0.8950.66
95_A98_G0.8930.66
116_E120_A0.8890.65
100_D128_L0.8860.65
159_T162_T0.8800.65
31_K34_I0.8710.64
88_I118_L0.8700.64
27_S35_V0.8520.62
78_E81_P0.8450.61
158_T161_E0.8320.60
13_A203_A0.8310.60
166_P170_L0.8230.59
115_V147_A0.8200.59
171_V196_A0.8180.59
167_D186_R0.8180.59
134_S161_E0.8170.59
19_V42_A0.8160.59
59_Q97_A0.8160.59
42_A50_I0.8140.59
196_A201_A0.8100.58
141_A145_L0.8100.58
213_L217_C0.8090.58
77_L87_Y0.8040.58
53_E57_N0.8020.57
54_G86_A0.8010.57
193_A223_A0.8010.57
23_P27_S0.8000.57
95_A127_L0.8000.57
168_L171_V0.7990.57
155_S161_E0.7940.57
118_L121_R0.7850.56
143_Q177_A0.7760.55
139_G155_S0.7740.55
42_A139_G0.7690.54
104_I129_A0.7670.54
116_E119_L0.7600.53
190_P220_Y0.7590.53
59_Q96_Q0.7590.53
165_E192_Q0.7550.53
91_V122_I0.7470.52
104_I122_I0.7460.52
88_I91_V0.7420.52
102_I127_L0.7390.51
73_V90_D0.7390.51
172_K199_H0.7370.51
170_L174_L0.7360.51
58_L71_G0.7340.51
24_V35_V0.7310.51
83_R86_A0.7300.50
24_V53_E0.7280.50
186_R208_S0.7280.50
52_I69_I0.7260.50
59_Q63_A0.7260.50
40_L64_V0.7250.50
192_Q219_W0.7220.50
155_S186_R0.7220.50
106_G147_A0.7130.49
151_G182_I0.7090.48
118_L122_I0.7020.48
201_A204_V0.7010.48
133_C174_L0.7010.48
121_R125_H0.7010.48
214_E218_Q0.6990.47
33_E36_A0.6970.47
196_A200_G0.6910.47
166_P169_A0.6880.46
149_I180_R0.6880.46
38_M41_A0.6870.46
104_I118_L0.6810.46
175_S181_V0.6800.46
117_T120_A0.6800.46
106_G115_V0.6770.45
115_V119_L0.6670.44
44_Q214_E0.6660.44
45_A216_I0.6640.44
55_V59_Q0.6600.44
183_A187_Y0.6590.44
50_I62_R0.6590.44
208_S212_R0.6520.43
104_I147_A0.6520.43
96_Q203_A0.6510.43
52_I72_I0.6490.43
70_I205_T0.6460.42
96_Q176_D0.6440.42
119_L123_H0.6430.42
27_S53_E0.6410.42
27_S57_N0.6410.42
165_E169_A0.6400.42
115_V120_A0.6390.42
110_P126_G0.6350.41
35_V38_M0.6330.41
190_P200_G0.6320.41
125_H129_A0.6310.41
10_K13_A0.6280.41
79_D82_V0.6280.41
49_A67_V0.6280.41
35_V212_R0.6270.41
25_P45_A0.6250.40
33_E60_A0.6240.40
162_T171_V0.6230.40
188_N206_V0.6200.40
133_C150_I0.6190.40
54_G57_N0.6120.39
213_L216_I0.6110.39
52_I67_V0.6060.39
18_I101_I0.6060.39
210_I216_I0.6060.39
101_I151_G0.6040.38
43_E64_V0.6020.38
160_P163_P0.6020.38
155_S174_L0.6010.38
52_I58_L0.6000.38
82_V111_R0.5990.38
166_P192_Q0.5960.38
168_L187_Y0.5920.37
53_E90_D0.5900.37
181_V202_W0.5890.37
208_S214_E0.5890.37
58_L62_R0.5870.37
164_E186_R0.5870.37
140_L176_D0.5850.37
113_V118_L0.5830.36
49_A126_G0.5820.36
105_D154_L0.5790.36
17_L21_C0.5780.36
155_S192_Q0.5780.36
165_E170_L0.5720.35
24_V208_S0.5700.35
92_D96_Q0.5700.35
16_G225_K0.5690.35
53_E183_A0.5690.35
200_G204_V0.5680.35
190_P193_A0.5680.35
176_D195_D0.5670.35
29_L57_N0.5620.35
24_V214_E0.5620.35
121_R124_H0.5560.34
34_I38_M0.5560.34
172_K176_D0.5530.34
92_D125_H0.5510.34
26_D30_D0.5500.34
36_A40_L0.5490.33
95_A102_I0.5480.33
19_V45_A0.5470.33
137_E140_L0.5460.33
89_E95_A0.5440.33
69_I100_D0.5430.33
92_D102_I0.5430.33
39_A42_A0.5410.33
49_A72_I0.5380.33
187_Y192_Q0.5370.32
24_V57_N0.5350.32
74_K153_T0.5340.32
171_V174_L0.5340.32
30_D35_V0.5310.32
23_P35_V0.5310.32
126_G129_A0.5290.32
59_Q222_T0.5260.31
139_G196_A0.5260.31
140_L177_A0.5230.31
54_G76_D0.5200.31
113_V154_L0.5190.31
175_S202_W0.5180.31
93_A176_D0.5160.31
49_A127_L0.5160.31
35_V214_E0.5150.31
45_A223_A0.5150.31
84_I132_D0.5140.30
31_K36_A0.5140.30
187_Y193_A0.5140.30
122_I127_L0.5130.30
133_C179_C0.5110.30
137_E171_V0.5100.30
89_E218_Q0.5090.30
164_E192_Q0.5090.30
73_V91_V0.5080.30
51_R74_K0.5070.30
51_R153_T0.5070.30
35_V216_I0.5030.30
114_P145_L0.5010.29
94_L99_A0.5000.29
120_A126_G0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3q58A 2 0.9869 100 0.637 Contact Map
3igsA 1 1 100 0.64 Contact Map
1yxyA 2 0.9738 100 0.647 Contact Map
1y0eA 2 0.9389 100 0.657 Contact Map
2p10A 5 0.9214 100 0.673 Contact Map
4utuA 2 0.9782 100 0.675 Contact Map
4mozA 5 0.9563 100 0.688 Contact Map
2yzrA 5 0.8865 99.9 0.737 Contact Map
1n7kA 3 0.9039 99.9 0.739 Contact Map
3ndoA 2 0.8952 99.9 0.739 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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