GREMLIN Database
NAGB - Glucosamine-6-phosphate deaminase
UniProt: P0A759 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10633
Length: 266 (228)
Sequences: 5181 (3772)
Seq/√Len: 249.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
87_S91_R3.5031.00
210_L246_E2.9071.00
206_S242_P2.7561.00
7_T241_E2.7041.00
198_E234_K2.6601.00
117_E120_Q2.5631.00
140_N207_Q2.5121.00
51_A54_E2.4991.00
8_T11_Q2.4331.00
212_L239_C2.3981.00
90_H95_D2.2441.00
23_R198_E2.2431.00
123_E127_S2.2251.00
107_L186_L2.1671.00
62_S98_D2.1051.00
210_L214_A2.0961.00
6_L15_W2.0891.00
13_G47_T2.0781.00
239_C244_T2.0371.00
23_R35_F2.0041.00
20_I48_T1.9731.00
79_K86_Y1.9661.00
177_D180_Q1.9381.00
91_R95_D1.9121.00
14_K51_A1.9111.00
67_V105_N1.9051.00
12_V204_L1.8941.00
134_F196_A1.8881.00
105_N124_K1.8821.00
132_H197_E1.8421.00
68_T94_F1.8361.00
22_N26_A1.8061.00
86_Y90_H1.7691.00
29_P33_R1.7121.00
46_M92_N1.7091.00
214_A224_W1.7081.00
194_L228_C1.6861.00
34_P67_V1.6661.00
9_A13_G1.6651.00
164_H168_V1.6551.00
113_D116_A1.6271.00
213_Q217_E1.6031.00
53_V96_H1.5921.00
67_V103_N1.5811.00
44_T202_L1.5781.00
119_R123_E1.5711.00
21_V61_V1.5691.00
19_H238_V1.5631.00
86_Y106_L1.5631.00
20_I37_L1.5211.00
90_H101_A1.5201.00
116_A120_Q1.4971.00
138_V203_V1.4951.00
206_S245_M1.4671.00
48_T135_M1.4511.00
50_K92_N1.4471.00
203_V212_L1.4471.00
24_I35_F1.4431.00
64_K98_D1.4221.00
5_P244_T1.4171.00
24_I66_V1.3951.00
140_N169_A1.3851.00
120_Q124_K1.3831.00
32_D197_E1.3491.00
54_E58_A1.3461.00
211_A224_W1.3291.00
20_I133_L1.3291.00
7_T11_Q1.3151.00
111_A117_E1.3011.00
138_V215_A1.3001.00
38_G134_F1.2921.00
6_L238_V1.2921.00
133_L200_M1.2911.00
142_G224_W1.2871.00
40_P71_M1.2861.00
16_A48_T1.2821.00
188_V192_T1.2521.00
16_A200_M1.2371.00
80_E87_S1.2331.00
165_D169_A1.2251.00
215_A226_I1.2231.00
123_E126_R1.2101.00
75_V114_I1.2091.00
82_P87_S1.2091.00
215_A237_M1.2071.00
69_F128_Y1.2041.00
38_G71_M1.2011.00
122_E192_T1.2001.00
120_Q123_E1.1841.00
111_A114_I1.1701.00
19_H200_M1.1591.00
84_S87_S1.1581.00
145_A193_L1.1521.00
48_T202_L1.1501.00
10_E47_T1.1501.00
198_E236_I1.1491.00
36_V67_V1.1441.00
70_N89_M1.1441.00
36_V69_F1.1431.00
47_T50_K1.1401.00
175_D180_Q1.1341.00
126_R195_D1.1331.00
138_V226_I1.1331.00
21_V25_N1.1231.00
6_L12_V1.1201.00
99_I103_N1.1161.00
124_K127_S1.1101.00
100_P103_N1.1041.00
15_W18_R1.0981.00
9_A47_T1.0911.00
6_L11_Q1.0811.00
209_A245_M1.0801.00
175_D178_V1.0631.00
18_R22_N1.0471.00
115_D119_R1.0211.00
231_L235_A1.0211.00
19_H198_E1.0171.00
16_A202_L1.0171.00
78_P110_N1.0131.00
4_I236_I1.0091.00
46_M50_K1.0061.00
63_F66_V1.0051.00
9_A204_L0.9971.00
209_A213_Q0.9931.00
38_G131_I0.9931.00
88_F92_N0.9911.00
118_C122_E0.9871.00
211_A214_A0.9871.00
12_V238_V0.9801.00
62_S65_H0.9791.00
50_K96_H0.9781.00
178_V181_V0.9761.00
11_Q14_K0.9751.00
90_H104_I0.9741.00
25_N60_Q0.9701.00
191_G195_D0.9681.00
35_F66_V0.9601.00
46_M88_F0.9571.00
94_F104_I0.9511.00
16_A238_V0.9401.00
153_L228_C0.9391.00
108_N117_E0.9321.00
5_P241_E0.9301.00
116_A119_R0.9301.00
35_F133_L0.9241.00
10_E51_A0.9171.00
4_I15_W0.9131.00
178_V183_K0.9011.00
26_A31_A0.8961.00
4_I238_V0.8961.00
63_F97_V0.8941.00
23_R26_A0.8881.00
125_I131_I0.8851.00
190_V228_C0.8771.00
209_A246_E0.8761.00
40_P134_F0.8751.00
19_H23_R0.8721.00
90_H106_L0.8711.00
213_Q246_E0.8690.99
39_L68_T0.8680.99
20_I135_M0.8650.99
29_P32_D0.8600.99
114_I186_L0.8580.99
212_L215_A0.8570.99
138_V212_L0.8570.99
13_G48_T0.8540.99
100_P104_I0.8470.99
206_S246_E0.8440.99
194_L232_H0.8430.99
9_A12_V0.8400.99
215_A224_W0.8380.99
61_V66_V0.8370.99
214_A223_M0.8280.99
78_P81_H0.8260.99
224_W227_S0.8250.99
32_D132_H0.8210.99
196_A199_V0.8190.99
199_V235_A0.8170.99
72_D143_H0.8170.99
39_L49_Y0.8160.99
131_I134_F0.8150.99
43_G88_F0.8090.99
69_F124_K0.8080.99
201_I226_I0.7970.99
67_V100_P0.7940.99
64_K100_P0.7840.99
29_P65_H0.7820.99
212_L237_M0.7790.99
89_M94_F0.7780.99
130_K197_E0.7770.99
179_N183_K0.7750.99
45_P49_Y0.7710.99
220_V231_L0.7610.99
47_T51_A0.7600.99
44_T204_L0.7600.99
67_V128_Y0.7530.99
153_L222_H0.7480.98
101_A104_I0.7450.98
79_K106_L0.7430.98
18_R60_Q0.7430.98
79_K90_H0.7420.98
50_K54_E0.7410.98
69_F105_N0.7400.98
10_E50_K0.7380.98
33_R65_H0.7380.98
122_E126_R0.7360.98
85_Y185_A0.7350.98
219_C227_S0.7340.98
71_M193_L0.7330.98
71_M188_V0.7320.98
125_I130_K0.7300.98
164_H167_R0.7290.98
194_L231_L0.7260.98
10_E14_K0.7250.98
214_A218_G0.7190.98
239_C243_S0.7180.98
114_I184_Y0.7170.98
142_G211_A0.7170.98
14_K18_R0.7150.98
193_L199_V0.7130.98
17_A52_L0.7080.98
86_Y104_I0.7070.98
140_N211_A0.7070.98
117_E186_L0.7050.98
43_G46_M0.7010.98
240_D243_S0.6880.97
144_I201_I0.6870.97
40_P144_I0.6870.97
41_T85_Y0.6830.97
122_E167_R0.6820.97
136_G193_L0.6780.97
135_M202_L0.6750.97
194_L229_L0.6740.97
83_E183_K0.6720.97
99_I104_I0.6720.97
24_I37_L0.6680.97
70_N106_L0.6600.97
209_A244_T0.6560.97
37_L68_T0.6560.97
25_N61_V0.6500.96
5_P239_C0.6480.96
216_V237_M0.6460.96
109_G117_E0.6440.96
162_L170_N0.6430.96
76_G114_I0.6430.96
17_A51_A0.6380.96
79_K110_N0.6360.96
21_V52_L0.6360.96
19_H236_I0.6350.96
215_A230_Q0.6350.96
166_T169_A0.6340.96
108_N120_Q0.6280.96
69_F125_I0.6250.95
29_P35_F0.6230.95
11_Q15_W0.6230.95
163_T167_R0.6210.95
29_P62_S0.6190.95
19_H22_N0.6170.95
76_G109_G0.6150.95
107_L121_Y0.6140.95
77_L87_S0.6140.95
68_T89_M0.6110.95
210_L213_Q0.6110.95
53_V92_N0.6080.95
77_L81_H0.6070.95
99_I102_E0.6030.95
77_L84_S0.6020.94
15_W238_V0.6020.94
3_L216_V0.6020.94
146_F185_A0.6000.94
39_L89_M0.5990.94
21_V59_G0.5970.94
108_N111_A0.5960.94
83_E180_Q0.5940.94
134_F193_L0.5930.94
190_V225_T0.5920.94
150_A222_H0.5920.94
199_V231_L0.5910.94
138_V211_A0.5910.94
70_N86_Y0.5890.94
15_W19_H0.5880.94
137_G208_K0.5870.94
201_I237_M0.5860.94
148_E185_A0.5850.94
52_L63_F0.5830.93
145_A187_T0.5780.93
93_F97_V0.5760.93
43_G140_N0.5680.93
151_S223_M0.5680.93
69_F131_I0.5650.92
85_Y148_E0.5620.92
228_C231_L0.5580.92
168_V178_V0.5560.92
107_L117_E0.5550.92
20_I52_L0.5550.92
113_D184_Y0.5540.92
212_L216_V0.5530.92
72_D208_K0.5520.92
118_C186_L0.5500.91
25_N59_G0.5500.91
192_T195_D0.5500.91
199_V229_L0.5480.91
187_T191_G0.5480.91
59_G63_F0.5470.91
200_M238_V0.5450.91
40_P49_Y0.5430.91
25_N30_T0.5430.91
71_M145_A0.5420.91
23_R133_L0.5410.91
211_A215_A0.5390.91
17_A21_V0.5390.91
85_Y146_F0.5380.90
118_C187_T0.5380.90
41_T148_E0.5360.90
153_L170_N0.5310.90
125_I129_G0.5310.90
89_M104_I0.5300.90
190_V229_L0.5290.90
20_I200_M0.5290.90
21_V60_Q0.5290.90
111_A116_A0.5280.90
177_D183_K0.5280.90
18_R59_G0.5230.89
13_G17_A0.5200.89
16_A135_M0.5190.89
72_D137_G0.5180.89
125_I192_T0.5150.88
167_R187_T0.5150.88
170_N174_F0.5130.88
13_G51_A0.5110.88
84_S109_G0.5090.88
3_L239_C0.5090.88
242_P245_M0.5090.88
221_N227_S0.5070.88
77_L80_E0.5060.88
180_Q183_K0.5030.87
130_K192_T0.5030.87
124_K128_Y0.5030.87
71_M134_F0.5020.87
167_R183_K0.5020.87
106_L110_N0.5000.87
166_T170_N0.5000.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3icoA 1 0.8797 100 0.138 Contact Map
3tx2A 1 0.8759 100 0.142 Contact Map
4tm7A 1 0.8722 100 0.145 Contact Map
3eb9A 1 0.8722 100 0.165 Contact Map
3e15A 2 0.9248 100 0.202 Contact Map
3cssA 1 0.8759 100 0.213 Contact Map
1ne7A 4 0.9962 100 0.214 Contact Map
3lwdA 2 0.8346 100 0.215 Contact Map
1fs5A 4 0.9925 100 0.216 Contact Map
1vl1A 1 0.812 100 0.219 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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