GREMLIN Database
KEFG - Glutathione-regulated potassium-efflux system ancillary protein KefG
UniProt: P0A756 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12902
Length: 184 (167)
Sequences: 3750 (2695)
Seq/√Len: 208.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
37_T61_E3.7191.00
82_E86_R2.5021.00
13_A79_L2.3951.00
39_H58_L2.3731.00
40_D43_A2.3731.00
7_K35_N2.3581.00
56_Q92_F2.1521.00
37_T58_L2.1041.00
106_W140_A2.0441.00
71_L110_I2.0031.00
12_Y23_N1.9891.00
39_H44_H1.9731.00
57_A61_E1.9681.00
64_V105_Y1.9031.00
65_I145_M1.9021.00
8_V64_V1.9001.00
105_Y146_H1.8961.00
53_P57_A1.8671.00
24_R28_K1.8601.00
7_K61_E1.8341.00
60_R92_F1.8081.00
128_P131_D1.7891.00
57_A60_R1.7741.00
27_L31_T1.7721.00
9_L58_L1.7401.00
54_R58_L1.7311.00
81_K85_D1.7081.00
161_A165_A1.6841.00
169_R172_G1.6621.00
160_S163_E1.6551.00
37_T62_H1.6481.00
44_H58_L1.6431.00
13_A42_Y1.5961.00
78_A82_E1.5941.00
28_K31_T1.5701.00
10_L27_L1.5581.00
22_A111_T1.5541.00
68_Q171_Y1.5441.00
55_E83_W1.4751.00
84_L88_L1.4701.00
163_E166_S1.4431.00
109_V171_Y1.4371.00
29_P172_G1.4251.00
28_K32_Q1.3961.00
167_H170_A1.3801.00
102_A144_R1.3641.00
56_Q93_A1.3531.00
25_V29_P1.3521.00
9_L62_H1.3421.00
39_H55_E1.3351.00
159_Q164_L1.3201.00
44_H54_R1.3101.00
166_S170_A1.3071.00
8_V34_S1.3051.00
99_N102_A1.3021.00
23_N38_V1.2941.00
68_Q109_V1.2811.00
52_I56_Q1.2781.00
95_G98_G1.2771.00
165_A169_R1.2761.00
54_R57_A1.2681.00
29_P32_Q1.2631.00
106_W145_M1.2571.00
151_I170_A1.2431.00
129_M152_I1.2371.00
71_L129_M1.2341.00
42_Y79_L1.1991.00
51_D54_R1.1921.00
153_I159_Q1.1821.00
140_A145_M1.1801.00
131_D134_R1.1601.00
13_A80_L1.1521.00
116_E154_Y1.1411.00
109_V151_I1.1161.00
171_Y175_L1.0981.00
44_H55_E1.0971.00
164_L168_A1.0951.00
29_P33_L1.0941.00
29_P176_A1.0911.00
66_V107_R1.0871.00
27_L38_V1.0841.00
76_C80_L1.0811.00
103_G146_H1.0811.00
26_L30_A1.0791.00
48_F82_E1.0771.00
25_V28_K1.0751.00
25_V172_G1.0731.00
112_T154_Y1.0721.00
62_H65_I1.0631.00
138_L141_G1.0621.00
101_L145_M1.0511.00
116_E120_R1.0491.00
169_R173_D1.0451.00
171_Y174_W1.0331.00
88_L143_C1.0301.00
69_H108_S1.0291.00
95_G100_Q1.0081.00
63_E104_K1.0061.00
11_L39_H1.0051.00
58_L61_E0.9991.00
21_V161_A0.9981.00
32_Q172_G0.9861.00
53_P56_Q0.9841.00
73_T85_D0.9540.99
12_Y20_S0.9510.99
13_A41_L0.9450.99
153_I167_H0.9420.99
134_R137_E0.9320.99
46_P49_F0.9310.99
46_P82_E0.9290.99
60_R100_Q0.9040.99
56_Q89_S0.9020.99
35_N61_E0.8970.99
31_T35_N0.8810.99
74_Y142_M0.8730.99
115_P118_A0.8670.99
149_S174_W0.8620.99
59_L65_I0.8610.99
7_K63_E0.8470.99
20_S23_N0.8430.99
21_V168_A0.8410.99
114_E125_N0.8410.99
140_A147_W0.8310.99
172_G176_A0.8260.99
109_V153_I0.8240.99
15_P72_Y0.8240.99
105_Y148_L0.8210.98
139_A143_C0.8210.98
110_I133_L0.8200.98
132_V138_L0.8150.98
173_D176_A0.8120.98
112_T152_I0.8000.98
69_H129_M0.8000.98
90_R96_P0.7990.98
112_T129_M0.7970.98
110_I152_I0.7920.98
159_Q163_E0.7910.98
45_Y50_I0.7810.98
39_H83_W0.7800.98
26_L171_Y0.7790.98
107_R174_W0.7770.98
84_L139_A0.7680.98
71_L132_V0.7670.98
78_A86_R0.7650.98
16_E19_D0.7640.98
73_T94_S0.7610.98
98_G102_A0.7560.97
33_L176_A0.7380.97
23_N68_Q0.7360.97
107_R151_I0.7320.97
19_D82_E0.7320.97
59_L83_W0.7300.97
71_L119_Y0.7250.97
166_S169_R0.7250.97
90_R94_S0.7200.97
10_L66_V0.7190.97
64_V107_R0.7190.97
28_K172_G0.7190.97
67_F140_A0.7170.96
118_A124_L0.7170.96
21_V164_L0.7120.96
17_S43_A0.7070.96
51_D55_E0.7030.96
170_A173_D0.7010.96
59_L67_F0.6990.96
69_H110_I0.6990.96
9_L39_H0.6910.96
26_L109_V0.6900.96
53_P166_S0.6860.95
25_V165_A0.6840.95
11_L67_F0.6820.95
55_E58_L0.6790.95
46_P50_I0.6710.95
10_L26_L0.6710.95
112_T119_Y0.6690.95
99_N144_R0.6690.95
15_P19_D0.6680.95
168_A172_G0.6620.95
11_L83_W0.6550.94
93_A101_L0.6510.94
7_K40_D0.6500.94
151_I171_Y0.6490.94
13_A40_D0.6420.94
164_L167_H0.6420.94
21_V25_V0.6380.93
46_P86_R0.6370.93
69_H133_L0.6250.93
22_A109_V0.6230.93
48_F89_S0.6220.92
69_H80_L0.6220.92
151_I174_W0.6170.92
25_V168_A0.6160.92
114_E155_W0.6160.92
131_D137_E0.6150.92
124_L142_M0.6150.92
59_L88_L0.6130.92
125_N138_L0.6110.92
162_Q166_S0.6060.92
106_W147_W0.6050.91
49_F82_E0.6040.91
56_Q87_V0.6030.91
26_L167_H0.5990.91
26_L153_I0.5970.91
20_S24_R0.5960.91
105_Y144_R0.5960.91
69_H76_C0.5930.91
79_L83_W0.5930.91
56_Q90_R0.5880.90
77_P85_D0.5860.90
69_H77_P0.5850.90
50_I54_R0.5830.90
30_A171_Y0.5750.89
76_C84_L0.5720.89
110_I129_M0.5710.89
156_A164_L0.5700.89
12_Y17_S0.5690.89
119_Y123_A0.5640.88
74_Y138_L0.5630.88
91_G95_G0.5630.88
126_R138_L0.5600.88
10_L36_V0.5550.88
80_L84_L0.5480.87
98_G101_L0.5430.86
66_V171_Y0.5410.86
137_E150_P0.5390.86
7_K37_T0.5370.86
67_F80_L0.5350.86
49_F86_R0.5350.86
134_R138_L0.5340.85
160_S164_L0.5340.85
34_S64_V0.5330.85
86_R89_S0.5320.85
74_Y114_E0.5310.85
12_Y27_L0.5310.85
168_A171_Y0.5280.85
130_S137_E0.5280.85
96_P143_C0.5260.85
108_S133_L0.5250.85
18_Q24_R0.5200.84
31_T36_V0.5140.83
105_Y147_W0.5100.83
29_P175_L0.5080.83
74_Y125_N0.5080.83
169_R176_A0.5070.82
121_Y131_D0.5060.82
12_Y42_Y0.5050.82
44_H49_F0.5040.82
36_V41_L0.5030.82
107_R149_S0.5020.82
130_S150_P0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1d4aA 2 0.9783 100 0.378 Contact Map
4gi5A 2 0.9837 100 0.394 Contact Map
3l9wA 2 0.9511 100 0.406 Contact Map
4fglA 2 0.9837 100 0.436 Contact Map
3f2vA 2 0.9239 100 0.442 Contact Map
2amjA 2 0.9022 100 0.447 Contact Map
3rpeA 2 0.9293 100 0.449 Contact Map
3ha2A 2 0.8967 100 0.463 Contact Map
3lcmA 2 0.9402 100 0.481 Contact Map
4r81A 4 0.962 100 0.485 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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