NADD - ECOLI - GREMLIN Contacts

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NADD - Nicotinate-nucleotide adenylyltransferase

UniProt:	P0A752	Sequences: MKSLQALFGGTFDPVHYGHLKPVETLANLIGLTRVTIIPNNVPPHRPQPEANSVQRKHMLELAIADKPLFTLDERELKRNAPSYTAQTLKEWRQEQGPDVPLAFIIGQDSLLTFPTWYEYETILDNAHLIVCRRPGYPLEMAQPQYQQWLEDHLTHNPEDLHLQPAGKIYLAETPWFNISATIIRERLQNGESCEDLLPEPVLTYINQQGLYR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13241
Length:	213 (190)
Sequences:	4132 (2992)
Seq/√Len:	217.0

ECOLI - NADD
BACSU - NADD

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
74_E	78_K	4.040	1.00
34_R	71_T	3.409	1.00
119_E	122_T	2.956	1.00
27_A	69_L	2.900	1.00
13_D	51_A	2.810	1.00
37_I	70_F	2.759	1.00
6_A	32_L	2.579	1.00
15_V	60_L	2.426	1.00
30_I	130_I	2.372	1.00
90_K	122_T	2.354	1.00
58_H	61_E	2.312	1.00
55_Q	209_Q	2.308	1.00
55_Q	205_Y	2.140	1.00
89_L	127_A	2.130	1.00
55_Q	58_H	2.004	1.00
194_C	198_L	1.994	1.00
57_K	74_E	1.989	1.00
24_E	67_K	1.954	1.00
36_T	73_D	1.928	1.00
59_M	205_Y	1.913	1.00
123_I	129_L	1.859	1.00
23_V	37_I	1.855	1.00
52_N	55_Q	1.821	1.00
53_S	77_L	1.815	1.00
79_R	87_Q	1.812	1.00
93_R	126_N	1.810	1.00
90_K	119_E	1.805	1.00
4_L	101_P	1.776	1.00
186_E	190_N	1.773	1.00
75_R	91_E	1.759	1.00
62_L	205_Y	1.757	1.00
57_K	72_L	1.757	1.00
104_F	129_L	1.747	1.00
64_I	72_L	1.746	1.00
15_V	63_A	1.742	1.00
89_L	123_I	1.741	1.00
183_I	187_R	1.739	1.00
5_Q	100_V	1.732	1.00
86_A	90_K	1.635	1.00
60_L	72_L	1.609	1.00
188_L	194_C	1.605	1.00
86_A	119_E	1.596	1.00
200_E	203_L	1.596	1.00
114_F	123_I	1.585	1.00
37_I	64_I	1.520	1.00
67_K	196_D	1.512	1.00
203_L	207_N	1.510	1.00
26_L	105_I	1.495	1.00
65_A	201_P	1.377	1.00
75_R	95_E	1.363	1.00
60_L	64_I	1.346	1.00
36_T	102_L	1.333	1.00
194_C	203_L	1.329	1.00
45_H	116_T	1.328	1.00
6_A	105_I	1.323	1.00
128_H	170_Y	1.303	1.00
11_T	43_P	1.299	1.00
101_P	128_H	1.273	1.00
79_R	91_E	1.268	1.00
103_A	130_I	1.267	1.00
22_P	132_C	1.227	1.00
57_K	61_E	1.221	1.00
36_T	71_T	1.214	1.00
13_D	50_E	1.212	1.00
17_Y	199_P	1.199	1.00
38_I	75_R	1.199	1.00
58_H	62_L	1.196	1.00
183_I	186_E	1.191	1.00
86_A	126_N	1.187	1.00
114_F	124_L	1.185	1.00
204_T	208_Q	1.175	1.00
111_L	131_V	1.163	1.00
62_L	201_P	1.155	1.00
61_E	74_E	1.141	1.00
8_F	22_P	1.138	1.00
21_K	177_F	1.136	1.00
122_T	126_N	1.132	1.00
187_R	192_E	1.125	1.00
75_R	79_R	1.117	1.00
195_E	203_L	1.107	1.00
135_P	176_W	1.098	1.00
44_P	83_S	1.094	1.00
85_T	104_F	1.091	1.00
113_T	116_T	1.090	1.00
114_F	120_Y	1.089	1.00
91_E	95_E	1.077	1.00
184_I	198_L	1.060	1.00
30_I	170_Y	1.060	1.00
26_L	172_A	1.054	1.00
38_I	73_D	1.047	1.00
91_E	94_Q	1.029	1.00
195_E	200_E	1.027	1.00
36_T	97_G	1.027	1.00
26_L	132_C	1.022	1.00
86_A	118_Y	1.015	1.00
41_N	80_N	1.014	1.00
24_E	27_A	1.010	1.00
87_Q	90_K	1.008	1.00
20_L	199_P	1.001	1.00
15_V	59_M	1.001	1.00
51_A	55_Q	0.991	1.00
27_A	35_V	0.990	1.00
124_L	129_L	0.975	1.00
205_Y	209_Q	0.971	1.00
25_T	29_L	0.957	1.00
179_I	197_L	0.947	1.00
4_L	103_A	0.935	1.00
133_R	173_E	0.926	0.99
110_S	113_T	0.923	0.99
86_A	122_T	0.923	0.99
15_V	37_I	0.922	0.99
20_L	196_D	0.920	0.99
93_R	102_L	0.914	0.99
46_R	181_A	0.912	0.99
122_T	125_D	0.904	0.99
205_Y	211_L	0.904	0.99
133_R	176_W	0.900	0.99
132_C	174_T	0.897	0.99
41_N	77_L	0.893	0.99
7_L	38_I	0.889	0.99
7_L	89_L	0.885	0.99
97_G	100_V	0.885	0.99
51_A	211_L	0.885	0.99
39_P	60_L	0.884	0.99
75_R	92_W	0.883	0.99
5_Q	102_L	0.878	0.99
21_K	24_E	0.877	0.99
29_L	173_E	0.867	0.99
198_L	203_L	0.862	0.99
97_G	102_L	0.860	0.99
55_Q	59_M	0.852	0.99
41_N	53_S	0.851	0.99
57_K	77_L	0.840	0.99
13_D	185_R	0.838	0.99
45_H	113_T	0.837	0.99
90_K	126_N	0.836	0.99
21_K	25_T	0.833	0.99
32_L	105_I	0.828	0.99
20_L	63_A	0.823	0.99
4_L	33_T	0.822	0.99
164_Q	168_K	0.822	0.99
38_I	88_T	0.814	0.99
37_I	60_L	0.813	0.99
13_D	48_Q	0.806	0.99
23_V	70_F	0.802	0.98
59_M	202_V	0.800	0.98
193_S	196_D	0.797	0.98
36_T	92_W	0.791	0.98
85_T	89_L	0.785	0.98
62_L	202_V	0.784	0.98
103_A	128_H	0.776	0.98
130_I	172_A	0.774	0.98
28_N	192_E	0.762	0.98
187_R	193_S	0.762	0.98
41_N	44_P	0.760	0.98
23_V	35_V	0.757	0.98
108_Q	137_Y	0.757	0.98
22_P	174_T	0.757	0.98
74_E	77_L	0.753	0.98
187_R	197_L	0.752	0.98
5_Q	36_T	0.747	0.98
87_Q	118_Y	0.747	0.98
79_R	83_S	0.747	0.98
108_Q	133_R	0.734	0.97
24_E	28_N	0.733	0.97
188_L	198_L	0.733	0.97
58_H	205_Y	0.731	0.97
24_E	193_S	0.731	0.97
64_I	70_F	0.729	0.97
135_P	178_N	0.726	0.97
63_A	202_V	0.723	0.97
7_L	92_W	0.722	0.97
20_L	64_I	0.722	0.97
22_P	26_L	0.721	0.97
76_E	83_S	0.715	0.97
128_H	168_K	0.713	0.97
67_K	70_F	0.713	0.97
130_I	170_Y	0.707	0.97
66_D	201_P	0.705	0.97
28_N	193_S	0.704	0.97
89_L	126_N	0.703	0.96
17_Y	198_L	0.700	0.96
25_T	175_P	0.700	0.96
105_I	130_I	0.700	0.96
81_A	87_Q	0.698	0.96
17_Y	196_D	0.693	0.96
35_V	105_I	0.692	0.96
4_L	31_G	0.691	0.96
18_G	177_F	0.690	0.96
46_R	49_P	0.688	0.96
193_S	203_L	0.685	0.96
26_L	130_I	0.675	0.96
57_K	60_L	0.674	0.96
45_H	110_S	0.668	0.95
54_V	58_H	0.666	0.95
32_L	103_A	0.666	0.95
11_T	40_N	0.665	0.95
196_D	200_E	0.661	0.95
21_K	197_L	0.659	0.95
8_F	104_F	0.656	0.95
42_V	82_P	0.653	0.95
38_I	92_W	0.651	0.95
188_L	203_L	0.650	0.95
201_P	204_T	0.649	0.95
10_G	16_H	0.645	0.94
40_N	44_P	0.643	0.94
25_T	174_T	0.638	0.94
114_F	129_L	0.638	0.94
161_L	164_Q	0.634	0.94
179_I	184_I	0.634	0.94
44_P	82_P	0.634	0.94
54_V	74_E	0.632	0.94
16_H	84_Y	0.630	0.94
85_T	123_I	0.629	0.94
108_Q	136_G	0.626	0.93
17_Y	21_K	0.622	0.93
90_K	94_Q	0.621	0.93
124_L	169_I	0.621	0.93
17_Y	179_I	0.620	0.93
93_R	127_A	0.615	0.93
89_L	93_R	0.611	0.93
62_L	65_A	0.608	0.92
51_A	59_M	0.607	0.92
133_R	174_T	0.606	0.92
39_P	72_L	0.603	0.92
187_R	194_C	0.601	0.92
183_I	197_L	0.601	0.92
33_T	100_V	0.600	0.92
106_I	110_S	0.600	0.92
76_E	88_T	0.598	0.92
77_L	80_N	0.594	0.92
106_I	111_L	0.594	0.92
11_T	45_H	0.592	0.91
204_T	207_N	0.590	0.91
168_K	172_A	0.589	0.91
18_G	179_I	0.589	0.91
184_I	197_L	0.584	0.91
63_A	66_D	0.584	0.91
108_Q	139_L	0.582	0.91
78_K	95_E	0.582	0.91
21_K	196_D	0.579	0.90
53_S	57_K	0.578	0.90
8_F	23_V	0.574	0.90
23_V	60_L	0.565	0.89
108_Q	112_L	0.563	0.89
86_A	120_Y	0.557	0.89
92_W	102_L	0.554	0.88
24_E	70_F	0.550	0.88
35_V	70_F	0.550	0.88
21_K	175_P	0.550	0.88
41_N	82_P	0.546	0.88
84_Y	118_Y	0.545	0.88
45_H	120_Y	0.544	0.88
43_P	110_S	0.541	0.87
120_Y	129_L	0.536	0.87
138_P	142_A	0.535	0.87
45_H	83_S	0.535	0.87
177_F	183_I	0.534	0.87
8_F	21_K	0.530	0.86
110_S	120_Y	0.530	0.86
131_V	171_L	0.527	0.86
37_I	72_L	0.527	0.86
93_R	99_D	0.524	0.86
63_A	199_P	0.522	0.85
124_L	167_G	0.519	0.85
112_L	137_Y	0.516	0.85
93_R	101_P	0.516	0.85
101_P	168_K	0.515	0.85
188_L	206_I	0.515	0.85
25_T	132_C	0.515	0.85
60_L	70_F	0.514	0.85
6_A	102_L	0.513	0.84
5_Q	34_R	0.512	0.84
30_I	172_A	0.512	0.84
4_L	35_V	0.511	0.84
108_Q	138_P	0.510	0.84
111_L	169_I	0.508	0.84
84_Y	88_T	0.507	0.84
40_N	83_S	0.506	0.84
112_L	115_P	0.505	0.83
195_E	207_N	0.504	0.83
135_P	179_I	0.502	0.83
9_G	13_D	0.502	0.83
186_E	189_Q	0.501	0.83
17_Y	177_F	0.500	0.83

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1k4mA	3	1	100	0.212	Contact Map
1yumA	4	0.9859	100	0.246	Contact Map
4x0eA	1	0.9108	100	0.256	Contact Map
1kqnA	3	0.9249	100	0.264	Contact Map
4wsoA	1	0.9859	100	0.287	Contact Map
1nupA	4	0.9296	100	0.292	Contact Map
1kamA	3	0.8545	100	0.307	Contact Map
2qtrA	2	0.8779	100	0.315	Contact Map
2h29A	2	0.8779	100	0.327	Contact Map
3h05A	2	0.7371	100	0.405	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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