GREMLIN Database
NADD - Nicotinate-nucleotide adenylyltransferase
UniProt: P0A752 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13241
Length: 213 (190)
Sequences: 4132 (2992)
Seq/√Len: 217.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
74_E78_K4.0401.00
34_R71_T3.4091.00
119_E122_T2.9561.00
27_A69_L2.9001.00
13_D51_A2.8101.00
37_I70_F2.7591.00
6_A32_L2.5791.00
15_V60_L2.4261.00
30_I130_I2.3721.00
90_K122_T2.3541.00
58_H61_E2.3121.00
55_Q209_Q2.3081.00
55_Q205_Y2.1401.00
89_L127_A2.1301.00
55_Q58_H2.0041.00
194_C198_L1.9941.00
57_K74_E1.9891.00
24_E67_K1.9541.00
36_T73_D1.9281.00
59_M205_Y1.9131.00
123_I129_L1.8591.00
23_V37_I1.8551.00
52_N55_Q1.8211.00
53_S77_L1.8151.00
79_R87_Q1.8121.00
93_R126_N1.8101.00
90_K119_E1.8051.00
4_L101_P1.7761.00
186_E190_N1.7731.00
75_R91_E1.7591.00
62_L205_Y1.7571.00
57_K72_L1.7571.00
104_F129_L1.7471.00
64_I72_L1.7461.00
15_V63_A1.7421.00
89_L123_I1.7411.00
183_I187_R1.7391.00
5_Q100_V1.7321.00
86_A90_K1.6351.00
60_L72_L1.6091.00
188_L194_C1.6051.00
86_A119_E1.5961.00
200_E203_L1.5961.00
114_F123_I1.5851.00
37_I64_I1.5201.00
67_K196_D1.5121.00
203_L207_N1.5101.00
26_L105_I1.4951.00
65_A201_P1.3771.00
75_R95_E1.3631.00
60_L64_I1.3461.00
36_T102_L1.3331.00
194_C203_L1.3291.00
45_H116_T1.3281.00
6_A105_I1.3231.00
128_H170_Y1.3031.00
11_T43_P1.2991.00
101_P128_H1.2731.00
79_R91_E1.2681.00
103_A130_I1.2671.00
22_P132_C1.2271.00
57_K61_E1.2211.00
36_T71_T1.2141.00
13_D50_E1.2121.00
17_Y199_P1.1991.00
38_I75_R1.1991.00
58_H62_L1.1961.00
183_I186_E1.1911.00
86_A126_N1.1871.00
114_F124_L1.1851.00
204_T208_Q1.1751.00
111_L131_V1.1631.00
62_L201_P1.1551.00
61_E74_E1.1411.00
8_F22_P1.1381.00
21_K177_F1.1361.00
122_T126_N1.1321.00
187_R192_E1.1251.00
75_R79_R1.1171.00
195_E203_L1.1071.00
135_P176_W1.0981.00
44_P83_S1.0941.00
85_T104_F1.0911.00
113_T116_T1.0901.00
114_F120_Y1.0891.00
91_E95_E1.0771.00
184_I198_L1.0601.00
30_I170_Y1.0601.00
26_L172_A1.0541.00
38_I73_D1.0471.00
91_E94_Q1.0291.00
195_E200_E1.0271.00
36_T97_G1.0271.00
26_L132_C1.0221.00
86_A118_Y1.0151.00
41_N80_N1.0141.00
24_E27_A1.0101.00
87_Q90_K1.0081.00
20_L199_P1.0011.00
15_V59_M1.0011.00
51_A55_Q0.9911.00
27_A35_V0.9901.00
124_L129_L0.9751.00
205_Y209_Q0.9711.00
25_T29_L0.9571.00
179_I197_L0.9471.00
4_L103_A0.9351.00
133_R173_E0.9260.99
110_S113_T0.9230.99
86_A122_T0.9230.99
15_V37_I0.9220.99
20_L196_D0.9200.99
93_R102_L0.9140.99
46_R181_A0.9120.99
122_T125_D0.9040.99
205_Y211_L0.9040.99
133_R176_W0.9000.99
132_C174_T0.8970.99
41_N77_L0.8930.99
7_L38_I0.8890.99
7_L89_L0.8850.99
97_G100_V0.8850.99
51_A211_L0.8850.99
39_P60_L0.8840.99
75_R92_W0.8830.99
5_Q102_L0.8780.99
21_K24_E0.8770.99
29_L173_E0.8670.99
198_L203_L0.8620.99
97_G102_L0.8600.99
55_Q59_M0.8520.99
41_N53_S0.8510.99
57_K77_L0.8400.99
13_D185_R0.8380.99
45_H113_T0.8370.99
90_K126_N0.8360.99
21_K25_T0.8330.99
32_L105_I0.8280.99
20_L63_A0.8230.99
4_L33_T0.8220.99
164_Q168_K0.8220.99
38_I88_T0.8140.99
37_I60_L0.8130.99
13_D48_Q0.8060.99
23_V70_F0.8020.98
59_M202_V0.8000.98
193_S196_D0.7970.98
36_T92_W0.7910.98
85_T89_L0.7850.98
62_L202_V0.7840.98
103_A128_H0.7760.98
130_I172_A0.7740.98
28_N192_E0.7620.98
187_R193_S0.7620.98
41_N44_P0.7600.98
23_V35_V0.7570.98
108_Q137_Y0.7570.98
22_P174_T0.7570.98
74_E77_L0.7530.98
187_R197_L0.7520.98
5_Q36_T0.7470.98
87_Q118_Y0.7470.98
79_R83_S0.7470.98
108_Q133_R0.7340.97
24_E28_N0.7330.97
188_L198_L0.7330.97
58_H205_Y0.7310.97
24_E193_S0.7310.97
64_I70_F0.7290.97
135_P178_N0.7260.97
63_A202_V0.7230.97
7_L92_W0.7220.97
20_L64_I0.7220.97
22_P26_L0.7210.97
76_E83_S0.7150.97
128_H168_K0.7130.97
67_K70_F0.7130.97
130_I170_Y0.7070.97
66_D201_P0.7050.97
28_N193_S0.7040.97
89_L126_N0.7030.96
17_Y198_L0.7000.96
25_T175_P0.7000.96
105_I130_I0.7000.96
81_A87_Q0.6980.96
17_Y196_D0.6930.96
35_V105_I0.6920.96
4_L31_G0.6910.96
18_G177_F0.6900.96
46_R49_P0.6880.96
193_S203_L0.6850.96
26_L130_I0.6750.96
57_K60_L0.6740.96
45_H110_S0.6680.95
54_V58_H0.6660.95
32_L103_A0.6660.95
11_T40_N0.6650.95
196_D200_E0.6610.95
21_K197_L0.6590.95
8_F104_F0.6560.95
42_V82_P0.6530.95
38_I92_W0.6510.95
188_L203_L0.6500.95
201_P204_T0.6490.95
10_G16_H0.6450.94
40_N44_P0.6430.94
25_T174_T0.6380.94
114_F129_L0.6380.94
161_L164_Q0.6340.94
179_I184_I0.6340.94
44_P82_P0.6340.94
54_V74_E0.6320.94
16_H84_Y0.6300.94
85_T123_I0.6290.94
108_Q136_G0.6260.93
17_Y21_K0.6220.93
90_K94_Q0.6210.93
124_L169_I0.6210.93
17_Y179_I0.6200.93
93_R127_A0.6150.93
89_L93_R0.6110.93
62_L65_A0.6080.92
51_A59_M0.6070.92
133_R174_T0.6060.92
39_P72_L0.6030.92
187_R194_C0.6010.92
183_I197_L0.6010.92
33_T100_V0.6000.92
106_I110_S0.6000.92
76_E88_T0.5980.92
77_L80_N0.5940.92
106_I111_L0.5940.92
11_T45_H0.5920.91
204_T207_N0.5900.91
168_K172_A0.5890.91
18_G179_I0.5890.91
184_I197_L0.5840.91
63_A66_D0.5840.91
108_Q139_L0.5820.91
78_K95_E0.5820.91
21_K196_D0.5790.90
53_S57_K0.5780.90
8_F23_V0.5740.90
23_V60_L0.5650.89
108_Q112_L0.5630.89
86_A120_Y0.5570.89
92_W102_L0.5540.88
24_E70_F0.5500.88
35_V70_F0.5500.88
21_K175_P0.5500.88
41_N82_P0.5460.88
84_Y118_Y0.5450.88
45_H120_Y0.5440.88
43_P110_S0.5410.87
120_Y129_L0.5360.87
138_P142_A0.5350.87
45_H83_S0.5350.87
177_F183_I0.5340.87
8_F21_K0.5300.86
110_S120_Y0.5300.86
131_V171_L0.5270.86
37_I72_L0.5270.86
93_R99_D0.5240.86
63_A199_P0.5220.85
124_L167_G0.5190.85
112_L137_Y0.5160.85
93_R101_P0.5160.85
101_P168_K0.5150.85
188_L206_I0.5150.85
25_T132_C0.5150.85
60_L70_F0.5140.85
6_A102_L0.5130.84
5_Q34_R0.5120.84
30_I172_A0.5120.84
4_L35_V0.5110.84
108_Q138_P0.5100.84
111_L169_I0.5080.84
84_Y88_T0.5070.84
40_N83_S0.5060.84
112_L115_P0.5050.83
195_E207_N0.5040.83
135_P179_I0.5020.83
9_G13_D0.5020.83
186_E189_Q0.5010.83
17_Y177_F0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1k4mA 3 1 100 0.212 Contact Map
1yumA 4 0.9859 100 0.246 Contact Map
4x0eA 1 0.9108 100 0.256 Contact Map
1kqnA 3 0.9249 100 0.264 Contact Map
4wsoA 1 0.9859 100 0.287 Contact Map
1nupA 4 0.9296 100 0.292 Contact Map
1kamA 3 0.8545 100 0.307 Contact Map
2qtrA 2 0.8779 100 0.315 Contact Map
2h29A 2 0.8779 100 0.327 Contact Map
3h05A 2 0.7371 100 0.405 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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