GREMLIN Database
MURA - UDP-N-acetylglucosamine 1-carboxyvinyltransferase
UniProt: P0A749 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11358
Length: 419 (399)
Sequences: 7935 (4907)
Seq/√Len: 245.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
248_K281_S4.0511.00
15_E252_R3.9631.00
344_H355_H3.7141.00
42_Q225_V3.3871.00
155_H183_E3.1691.00
248_K283_D3.1001.00
179_T216_E3.0951.00
250_I281_S3.0271.00
401_R404_D3.0061.00
42_Q227_R2.8451.00
36_E220_R2.8031.00
204_K216_E2.7821.00
17_T252_R2.7391.00
150_R177_E2.7311.00
366_M390_D2.7121.00
38_P73_D2.6291.00
243_A271_A2.5941.00
399_Y405_K2.5911.00
320_T355_H2.5601.00
40_E225_V2.5561.00
198_L203_A2.5241.00
112_P118_G2.5171.00
244_I378_L2.4021.00
288_R318_E2.3961.00
157_V183_E2.3831.00
155_H181_I2.3831.00
364_Q390_D2.3611.00
46_K51_D2.3601.00
337_E340_R2.3261.00
42_Q69_S2.3121.00
55_K58_S2.2901.00
249_I409_L2.2511.00
240_V313_L2.2481.00
65_E71_H2.1961.00
364_Q388_V2.1681.00
276_G279_W2.1451.00
40_E69_S2.1141.00
40_E71_H2.1091.00
348_E351_T2.0801.00
38_P71_H2.0701.00
162_S165_A2.0631.00
128_G169_I2.0371.00
272_D283_D2.0001.00
316_V382_I1.9871.00
380_G387_T1.9871.00
13_Q248_K1.9681.00
179_T214_V1.9591.00
293_N324_T1.9411.00
359_K384_E1.9391.00
337_E376_L1.9331.00
170_M195_A1.9251.00
135_T148_D1.8991.00
322_F353_I1.8771.00
32_A39_V1.8071.00
63_K73_D1.7991.00
25_A44_V1.7731.00
338_L343_A1.7441.00
250_I276_G1.7291.00
123_D127_S1.7271.00
30_F53_S1.7111.00
153_G176_A1.7061.00
56_L86_L1.6761.00
312_L375_S1.6651.00
99_P168_T1.6451.00
343_A360_L1.6341.00
346_E355_H1.6181.00
290_K318_E1.6131.00
127_S131_Q1.6071.00
181_I214_V1.6051.00
46_K66_R1.6031.00
274_E281_S1.5911.00
341_M387_T1.5901.00
337_E368_T1.5841.00
346_E353_I1.5801.00
54_M70_V1.5761.00
28_I197_F1.5761.00
320_T353_I1.5671.00
183_E212_R1.5531.00
181_I212_R1.5471.00
236_G306_M1.5471.00
137_K146_S1.5171.00
81_C108_Q1.5001.00
54_M64_V1.4931.00
341_M363_A1.4911.00
203_A221_L1.4861.00
106_Q146_S1.4691.00
377_V402_I1.4621.00
15_E250_I1.4611.00
206_S216_E1.4591.00
199_I208_Q1.4461.00
29_L57_L1.4451.00
293_N322_F1.4361.00
239_L263_L1.4351.00
250_I279_W1.4321.00
152_K177_E1.4301.00
335_V345_A1.4291.00
37_E223_G1.4211.00
406_L411_A1.4081.00
365_V376_L1.4051.00
333_M347_I1.4011.00
229_L258_T1.3901.00
335_V347_I1.3751.00
264_A267_R1.3671.00
208_Q213_I1.3551.00
405_K408_A1.3541.00
94_I143_V1.3461.00
315_L343_A1.3411.00
108_Q144_K1.3341.00
58_S64_V1.3321.00
326_T330_N1.3181.00
116_T119_A1.3171.00
333_M336_P1.3051.00
126_I138_L1.3041.00
341_M379_A1.3041.00
314_N321_G1.2911.00
62_A72_I1.2901.00
85_D110_S1.2741.00
241_A381_C1.2691.00
239_L251_C1.2661.00
29_L54_M1.2571.00
319_G356_G1.2561.00
28_I228_V1.2551.00
193_D226_Y1.2521.00
95_W167_V1.2511.00
134_A151_L1.2511.00
55_K59_Q1.2511.00
201_L224_G1.2491.00
291_A321_G1.2491.00
41_I228_V1.2441.00
311_T323_I1.2411.00
65_E73_D1.2401.00
366_M391_R1.2391.00
199_I204_K1.2351.00
18_I251_C1.2331.00
274_E283_D1.2271.00
330_N333_M1.2261.00
108_Q146_S1.2251.00
291_A320_T1.2251.00
276_G281_S1.2241.00
200_T224_G1.2231.00
136_I145_A1.2191.00
269_A292_V1.2171.00
206_S214_V1.2111.00
235_T254_A1.2101.00
137_K148_D1.2081.00
90_M93_S1.2021.00
280_I284_M1.2011.00
296_T325_E1.2001.00
334_H368_T1.1991.00
44_V50_V1.1981.00
170_M215_I1.1971.00
240_V262_V1.1931.00
348_E353_I1.1911.00
266_L271_A1.1871.00
195_A205_I1.1861.00
16_V409_L1.1861.00
239_L266_L1.1821.00
25_A50_V1.1751.00
335_V352_V1.1731.00
182_I185_A1.1721.00
239_L282_L1.1721.00
130_E135_T1.1641.00
35_A39_V1.1571.00
108_Q148_D1.1551.00
177_E219_E1.1401.00
373_S395_I1.1361.00
17_T253_N1.1291.00
238_F399_Y1.1151.00
380_G389_V1.1131.00
56_L87_V1.1051.00
26_L53_S1.1031.00
190_E196_N1.1021.00
312_L379_A1.0971.00
404_D407_R1.0921.00
187_R211_D1.0911.00
373_S394_H1.0881.00
207_G210_T1.0881.00
132_L154_A1.0871.00
58_S63_K1.0871.00
41_I72_I1.0861.00
265_K294_V1.0811.00
241_A378_L1.0781.00
39_V197_F1.0701.00
266_L313_L1.0681.00
401_R405_K1.0671.00
173_A180_T1.0661.00
343_A357_V1.0551.00
243_A287_K1.0511.00
135_T146_S1.0501.00
256_P275_V1.0491.00
244_I382_I1.0491.00
127_S130_E1.0481.00
316_V357_V1.0411.00
345_A352_V1.0411.00
48_K396_D1.0401.00
237_T374_A1.0401.00
281_S284_M1.0351.00
37_E222_G1.0351.00
138_L141_G1.0331.00
178_G217_G1.0291.00
365_V387_T1.0281.00
52_T55_K1.0261.00
126_I130_E1.0261.00
295_R325_E1.0251.00
269_A317_A1.0231.00
265_K310_F1.0211.00
62_A74_A1.0161.00
39_V224_G1.0141.00
236_G309_Q1.0131.00
52_T88_K1.0011.00
332_F352_V1.0011.00
267_R275_V0.9991.00
12_L241_A0.9941.00
361_S384_E0.9861.00
167_V194_T0.9841.00
195_A208_Q0.9761.00
255_Q258_T0.9721.00
32_A72_I0.9721.00
153_G177_E0.9661.00
240_V266_L0.9641.00
265_K268_D0.9591.00
363_A387_T0.9561.00
147_V150_R0.9541.00
106_Q144_K0.9531.00
240_V306_M0.9511.00
151_L176_A0.9501.00
320_T356_G0.9461.00
158_M169_I0.9441.00
339_S344_H0.9411.00
291_A319_G0.9401.00
51_D66_R0.9371.00
85_D112_P0.9361.00
383_A387_T0.9321.00
234_E405_K0.9271.00
306_M309_Q0.9221.00
314_N323_I0.9191.00
14_G409_L0.9191.00
391_R394_H0.9181.00
124_L160_K0.9081.00
110_S146_S0.9031.00
232_R262_V0.9021.00
246_R284_M0.8991.00
44_V70_V0.8931.00
340_R363_A0.8931.00
226_Y229_L0.8921.00
311_T334_H0.8881.00
57_L62_A0.8871.00
291_A317_A0.8871.00
54_M58_S0.8811.00
269_A289_P0.8791.00
28_I41_I0.8781.00
323_I352_V0.8781.00
199_I207_G0.8781.00
27_P30_F0.8750.99
198_L221_L0.8750.99
125_H168_T0.8730.99
59_Q83_P0.8730.99
336_P368_T0.8720.99
381_C411_A0.8680.99
315_L357_V0.8660.99
156_I159_D0.8610.99
35_A223_G0.8480.99
311_T352_V0.8470.99
227_R253_N0.8470.99
267_R272_D0.8460.99
115_C370_L0.8460.99
315_L338_L0.8450.99
190_E232_R0.8440.99
360_L363_A0.8420.99
317_A321_G0.8420.99
37_E74_A0.8390.99
43_N227_R0.8370.99
332_F347_I0.8330.99
241_A411_A0.8330.99
261_A264_A0.8320.99
174_T203_A0.8320.99
289_P317_A0.8320.99
367_A373_S0.8320.99
284_M289_P0.8300.99
245_S284_M0.8280.99
135_T149_G0.8210.99
18_I238_F0.8210.99
284_M287_K0.8200.99
196_N200_T0.8180.99
197_F201_L0.8160.99
30_F100_L0.8150.99
38_P74_A0.8130.99
159_D265_K0.8130.99
99_P171_C0.8130.99
101_V134_A0.8120.99
58_S66_R0.8100.99
18_I235_T0.8100.99
126_I136_I0.8080.99
127_S159_D0.8070.99
208_Q212_R0.8050.99
199_I205_I0.8010.99
316_V358_E0.7980.99
393_Y396_D0.7970.99
244_I316_V0.7960.99
24_A197_F0.7920.99
124_L159_D0.7890.99
153_G180_T0.7890.99
273_I282_L0.7880.99
197_F224_G0.7860.99
34_L100_L0.7850.99
263_L267_R0.7830.99
309_Q378_L0.7810.99
269_A314_N0.7780.99
242_A245_S0.7780.99
12_L247_G0.7760.99
87_V117_I0.7720.99
33_L57_L0.7720.99
256_P280_I0.7720.99
196_N199_I0.7660.99
239_L242_A0.7640.99
275_V280_I0.7640.99
117_I329_E0.7620.99
200_T226_Y0.7620.99
153_G178_G0.7610.99
392_I395_I0.7590.99
174_T221_L0.7580.99
66_R70_V0.7570.99
367_A389_V0.7550.98
269_A313_L0.7550.98
261_A299_H0.7540.98
16_V251_C0.7540.98
94_I122_V0.7530.98
311_T354_C0.7530.98
362_G387_T0.7520.98
235_T251_C0.7490.98
380_G406_L0.7490.98
179_T217_G0.7490.98
28_I226_Y0.7460.98
243_A266_L0.7450.98
244_I312_L0.7420.98
271_A289_P0.7420.98
324_T348_E0.7420.98
238_F405_K0.7410.98
347_I351_T0.7400.98
80_F104_F0.7390.98
24_A193_D0.7380.98
377_V395_I0.7370.98
43_N253_N0.7350.98
29_L72_I0.7330.98
115_C119_A0.7300.98
25_A228_V0.7280.98
29_L70_V0.7270.98
284_M288_R0.7270.98
396_D403_E0.7250.98
98_G147_V0.7240.98
176_A180_T0.7220.98
102_A134_A0.7220.98
242_A249_I0.7210.98
48_K52_T0.7210.98
62_A75_R0.7180.98
173_A182_I0.7180.98
204_K218_V0.7160.98
363_A385_G0.7150.98
19_S234_E0.7120.98
239_L243_A0.7120.98
36_E222_G0.7110.98
17_T43_N0.7110.98
132_L156_I0.7100.98
262_V306_M0.7080.98
19_S405_K0.7060.98
124_L161_V0.7060.98
32_A74_A0.7050.98
54_M72_I0.7050.98
199_I206_S0.7030.98
85_D118_G0.7030.98
242_A284_M0.7030.98
169_I182_I0.7030.98
324_T351_T0.7010.98
87_V111_L0.7000.98
31_A197_F0.6980.97
58_S65_E0.6960.97
111_L143_V0.6920.97
21_A25_A0.6920.97
296_T307_Q0.6920.97
160_K327_V0.6910.97
98_G125_H0.6900.97
308_A372_A0.6890.97
341_M365_V0.6870.97
193_D196_N0.6860.97
93_S397_R0.6850.97
12_L411_A0.6850.97
292_V321_G0.6840.97
243_A289_P0.6820.97
80_F106_Q0.6800.97
158_M161_V0.6800.97
158_M182_I0.6790.97
241_A406_L0.6750.97
151_L178_G0.6690.97
321_G354_C0.6670.97
20_G228_V0.6660.97
164_G191_I0.6650.97
263_L275_V0.6640.97
57_L97_L0.6630.97
295_R324_T0.6620.97
341_M360_L0.6610.97
117_I143_V0.6600.96
82_A87_V0.6600.96
275_V279_W0.6580.96
237_T309_Q0.6560.96
265_K292_V0.6560.96
39_V223_G0.6560.96
57_L64_V0.6560.96
98_G111_L0.6510.96
172_A176_A0.6510.96
188_E192_V0.6500.96
95_W164_G0.6500.96
315_L358_E0.6490.96
331_R369_D0.6460.96
156_I182_I0.6460.96
236_G262_V0.6460.96
101_V109_V0.6450.96
11_K247_G0.6450.96
24_A27_P0.6440.96
129_L134_A0.6430.96
344_H357_V0.6420.96
196_N226_Y0.6410.96
84_Y118_G0.6410.96
97_L129_L0.6390.96
403_E407_R0.6360.96
94_I111_L0.6350.96
341_M383_A0.6350.96
246_R287_K0.6340.96
152_K178_G0.6320.96
238_F402_I0.6310.95
16_V405_K0.6310.95
308_A334_H0.6300.95
25_A45_P0.6290.95
381_C406_L0.6290.95
312_L376_L0.6280.95
283_D286_G0.6260.95
170_M213_I0.6250.95
201_L221_L0.6240.95
242_A251_C0.6230.95
74_A103_R0.6230.95
199_I203_A0.6210.95
122_V126_I0.6180.95
122_V143_V0.6180.95
242_A247_G0.6160.95
87_V93_S0.6160.95
362_G383_A0.6150.95
38_P223_G0.6150.95
230_P251_C0.6140.95
33_L62_A0.6130.95
368_T372_A0.6110.95
263_L273_I0.6090.95
395_I403_E0.6080.94
48_K51_D0.6060.94
240_V309_Q0.6050.94
120_R331_R0.6050.94
87_V94_I0.6030.94
27_P95_W0.6020.94
311_T335_V0.6020.94
139_E144_K0.6020.94
138_L145_A0.5990.94
120_R371_R0.5980.94
36_E74_A0.5970.94
124_L127_S0.5970.94
158_M188_E0.5960.94
332_F351_T0.5960.94
340_R366_M0.5950.94
291_A318_E0.5950.94
170_M182_I0.5910.94
150_R176_A0.5900.94
268_D298_P0.5880.93
101_V129_L0.5880.93
339_S345_A0.5870.93
130_E136_I0.5870.93
101_V111_L0.5870.93
35_A74_A0.5860.93
318_E358_E0.5860.93
322_F348_E0.5860.93
66_R69_S0.5850.93
267_R273_I0.5850.93
377_V403_E0.5830.93
197_F226_Y0.5810.93
312_L315_L0.5800.93
46_K70_V0.5790.93
367_A394_H0.5790.93
296_T310_F0.5790.93
51_D55_K0.5770.93
336_P339_S0.5750.93
26_L30_F0.5750.93
16_V238_F0.5750.93
325_E329_E0.5750.93
123_D141_G0.5720.93
336_P366_M0.5710.92
8_G11_K0.5710.92
139_E142_Y0.5700.92
334_H372_A0.5680.92
238_F406_L0.5680.92
35_A201_L0.5670.92
244_I313_L0.5660.92
373_S403_E0.5660.92
192_V195_A0.5650.92
130_E137_K0.5650.92
56_L97_L0.5650.92
26_L93_S0.5650.92
207_G211_D0.5640.92
362_G380_G0.5640.92
315_L360_L0.5630.92
132_L180_T0.5630.92
271_A282_L0.5630.92
245_S381_C0.5630.92
37_E73_D0.5620.92
60_L101_V0.5610.92
105_G150_R0.5580.92
340_R376_L0.5580.92
404_D408_A0.5560.91
130_E140_E0.5550.91
265_K299_H0.5540.91
193_D229_L0.5540.91
315_L382_I0.5520.91
59_Q84_Y0.5510.91
254_A258_T0.5510.91
312_L338_L0.5500.91
339_S346_E0.5490.91
130_E138_L0.5490.91
168_T172_A0.5480.91
392_I403_E0.5460.91
92_A96_A0.5460.91
89_T114_G0.5450.91
45_P234_E0.5450.91
307_Q323_I0.5450.91
174_T218_V0.5450.91
294_V310_F0.5440.91
180_T217_G0.5430.90
334_H394_H0.5420.90
272_D287_K0.5420.90
128_G132_L0.5410.90
67_N71_H0.5410.90
292_V317_A0.5380.90
18_I230_P0.5380.90
173_A198_L0.5380.90
252_R279_W0.5380.90
203_A218_V0.5380.90
233_I370_L0.5370.90
295_R326_T0.5360.90
19_S400_E0.5340.90
323_I354_C0.5340.90
62_A77_V0.5340.90
254_A280_I0.5330.90
311_T345_A0.5330.90
239_L273_I0.5330.90
151_L172_A0.5320.90
125_H128_G0.5320.90
343_A379_A0.5290.89
242_A271_A0.5280.89
204_K219_E0.5270.89
307_Q332_F0.5270.89
21_A229_L0.5260.89
56_L96_A0.5250.89
374_A402_I0.5250.89
12_L249_I0.5250.89
272_D275_V0.5240.89
124_L162_S0.5240.89
64_V70_V0.5240.89
95_W328_F0.5220.89
269_A321_G0.5220.89
98_G168_T0.5210.89
247_G284_M0.5210.89
22_K120_R0.5200.89
126_I145_A0.5190.88
216_E219_E0.5190.88
242_A246_R0.5190.88
192_V213_I0.5180.88
131_Q156_I0.5180.88
291_A356_G0.5180.88
246_R283_D0.5180.88
334_H397_R0.5170.88
192_V207_G0.5170.88
360_L383_A0.5160.88
312_L316_V0.5150.88
195_A213_I0.5150.88
297_A325_E0.5150.88
164_G167_V0.5140.88
26_L398_G0.5140.88
264_A268_D0.5140.88
131_Q157_V0.5120.88
198_L201_L0.5100.88
39_V201_L0.5100.88
37_E224_G0.5090.87
332_F335_V0.5080.87
263_L280_I0.5080.87
75_R79_V0.5080.87
314_N354_C0.5050.87
207_G213_I0.5040.87
30_F57_L0.5040.87
203_A219_E0.5030.87
138_L142_Y0.5030.87
196_N208_Q0.5030.87
117_I328_F0.5010.87
18_I254_A0.5000.87
322_F351_T0.5000.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rmtA 4 0.9809 100 0.129 Contact Map
2pqcA 1 0.9785 100 0.166 Contact Map
3slhA 4 0.9785 100 0.177 Contact Map
3zh4A 1 0.9761 100 0.184 Contact Map
3r38A 2 0.9905 100 0.185 Contact Map
1ejdA 4 0.9976 100 0.189 Contact Map
1rf6A 1 0.9618 100 0.201 Contact Map
5bq2A 4 0.9952 100 0.203 Contact Map
4fqdA 2 0.9761 100 0.204 Contact Map
2yvwA 1 0.9881 100 0.208 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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