GREMLIN Database
MSRB - Peptide methionine sulfoxide reductase MsrB
UniProt: P0A746 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12394
Length: 137 (124)
Sequences: 4719 (2605)
Seq/√Len: 234.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
15_S18_Q2.9731.00
5_P13_N2.8451.00
20_Y24_N2.8161.00
33_G121_S2.6981.00
81_I94_R2.5971.00
20_Y26_G2.4061.00
84_L89_Q2.3711.00
82_K89_Q2.2021.00
22_T100_A2.1861.00
25_H94_R2.1801.00
48_I100_A2.1671.00
18_Q47_L2.1121.00
93_I119_V2.0181.00
51_A97_N2.0101.00
6_S9_E1.9611.00
45_H127_T1.8971.00
58_T70_Y1.8661.00
38_N126_F1.7251.00
70_Y112_P1.7041.00
49_C98_C1.6791.00
22_T48_I1.6301.00
54_F117_Y1.6171.00
58_T71_E1.6131.00
41_D129_G1.5941.00
51_A96_G1.5811.00
39_K62_S1.5641.00
52_P73_V1.5531.00
22_T47_L1.5221.00
107_P115_E1.4921.00
25_H81_I1.4861.00
21_V122_A1.4771.00
79_R94_R1.4681.00
70_Y113_T1.4591.00
29_P32_T1.4451.00
51_A77_S1.4391.00
80_Y115_E1.4341.00
36_L39_K1.3671.00
85_S88_M1.3481.00
50_D125_R1.3451.00
45_H50_D1.3371.00
95_C98_C1.3221.00
35_L38_N1.3141.00
79_R99_D1.3091.00
17_M20_Y1.2931.00
86_H89_Q1.2631.00
23_Q48_I1.2571.00
79_R96_G1.2541.00
40_R128_D1.2431.00
39_K61_D1.2151.00
56_S59_K1.2001.00
94_R99_D1.1911.00
17_M122_A1.1861.00
108_D114_G1.1791.00
7_A24_N1.1581.00
43_V73_V1.1581.00
34_R121_S1.1391.00
9_E13_N1.0751.00
7_A23_Q1.0721.00
9_E12_K1.0701.00
55_H129_G1.0651.00
34_R125_R1.0431.00
43_V52_P1.0241.00
38_N44_Y1.0121.00
46_C95_C0.9811.00
74_S77_S0.9721.00
10_L23_Q0.9711.00
19_F23_Q0.9691.00
83_D90_R0.9661.00
31_F37_H0.9551.00
8_E12_K0.9511.00
10_L13_N0.9491.00
80_Y91_I0.9421.00
45_H125_R0.9401.00
41_D57_Q0.9171.00
7_A11_K0.9131.00
46_C49_C0.9061.00
46_C98_C0.9051.00
40_R126_F0.8920.99
16_E20_Y0.8870.99
35_L126_F0.8840.99
77_S97_N0.8750.99
22_T123_S0.8730.99
11_K19_F0.8670.99
28_E122_A0.8660.99
39_K64_C0.8530.99
17_M21_V0.8510.99
84_L87_G0.8470.99
19_F24_N0.8450.99
31_F36_L0.8400.99
77_S96_G0.8390.99
10_L48_I0.8270.99
60_Y64_C0.8200.99
49_C95_C0.8150.99
70_Y111_Q0.8120.99
45_H52_P0.8080.99
48_I98_C0.7850.99
36_L61_D0.7740.98
93_I102_L0.7690.98
102_L119_V0.7690.98
17_M29_P0.7660.98
35_L121_S0.7640.98
6_S10_L0.7540.98
33_G36_L0.7460.98
119_V124_L0.7440.98
60_Y70_Y0.7420.98
107_P114_G0.7420.98
55_H73_V0.7350.98
44_Y56_S0.7350.98
59_K62_S0.7250.98
37_H61_D0.7240.98
7_A19_F0.7150.97
5_P9_E0.7140.97
25_H99_D0.7080.97
25_H85_S0.7080.97
47_L100_A0.7050.97
83_D104_H0.7000.97
78_I102_L0.7000.97
72_P76_E0.6930.97
60_Y113_T0.6770.97
17_M26_G0.6720.96
72_P80_Y0.6710.96
76_E96_G0.6660.96
105_V115_E0.6650.96
30_P86_H0.6630.96
41_D56_S0.6520.96
55_H58_T0.6500.96
47_L123_S0.6430.95
38_N59_K0.6410.95
10_L19_F0.6360.95
93_I117_Y0.6360.95
36_L68_S0.6360.95
23_Q100_A0.6320.95
108_D111_Q0.6290.95
72_P117_Y0.6240.95
47_L125_R0.6180.94
64_C68_S0.6150.94
46_C100_A0.6100.94
92_E118_C0.6090.94
8_E11_K0.6090.94
110_P114_G0.6080.94
25_H86_H0.6070.94
50_D127_T0.6020.93
92_E101_H0.6010.93
71_E74_S0.5970.93
38_N121_S0.5910.93
27_T101_H0.5890.93
71_E80_Y0.5860.92
90_R104_H0.5860.92
54_F105_V0.5850.92
18_Q122_A0.5820.92
43_V55_H0.5740.92
5_P10_L0.5740.92
101_H104_H0.5730.92
80_Y107_P0.5710.92
19_F48_I0.5670.91
11_K15_S0.5660.91
56_S126_F0.5620.91
64_C87_G0.5620.91
84_L88_M0.5590.91
7_A10_L0.5560.90
38_N56_S0.5530.90
83_D88_M0.5500.90
72_P78_I0.5490.90
80_Y93_I0.5460.90
38_N69_F0.5450.90
41_D128_D0.5440.89
119_V123_S0.5400.89
13_N19_F0.5400.89
93_I105_V0.5390.89
106_F116_R0.5390.89
54_F80_Y0.5350.89
111_Q114_G0.5290.88
109_G115_E0.5220.87
80_Y117_Y0.5190.87
36_L44_Y0.5170.87
77_S98_C0.5160.87
30_P33_G0.5160.87
83_D91_I0.5140.87
55_H71_E0.5120.86
32_T36_L0.5110.86
32_T121_S0.5110.86
72_P93_I0.5090.86
107_P110_P0.5070.86
53_L102_L0.5070.86
71_E112_P0.5030.85
32_T122_A0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3cxkA 2 0.9489 100 0.032 Contact Map
2k8dA 1 0.9708 100 0.037 Contact Map
3e0oA 3 0.9854 100 0.041 Contact Map
3hcgA 3 0.9927 100 0.044 Contact Map
3e0mA 4 1 100 0.044 Contact Map
2l1uA 1 0.9562 100 0.061 Contact Map
3hcjA 1 0.9927 100 0.063 Contact Map
3maoA 1 0.7591 100 0.279 Contact Map
2kv1A 1 0.8102 100 0.28 Contact Map
5amhA 1 0.6496 63.5 0.934 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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