GREMLIN Database
MSRA - Peptide methionine sulfoxide reductase MsrA
UniProt: P0A744 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11433
Length: 212 (165)
Sequences: 3356 (2212)
Seq/√Len: 172.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
147_D151_R3.6421.00
46_A108_Y3.5101.00
47_I142_L3.4071.00
116_W153_S3.0541.00
45_I98_R3.0041.00
141_P147_D2.7301.00
70_A180_F2.4361.00
48_F111_L2.3541.00
74_T96_A2.3231.00
49_A96_A2.2111.00
154_L174_I2.1701.00
78_T85_E2.1611.00
44_E143_T2.1531.00
89_G134_Q2.1251.00
124_G171_T2.1081.00
50_M56_V2.0551.00
141_P176_N2.0171.00
63_L114_V2.0071.00
43_M67_Y1.9971.00
75_G138_A1.9331.00
56_V118_N1.8931.00
116_W154_L1.8651.00
109_E149_A1.8561.00
63_L106_I1.8351.00
47_I98_R1.7851.00
53_F73_Y1.7781.00
74_T177_A1.7761.00
64_P105_V1.7411.00
94_A138_A1.6971.00
44_E146_Q1.6901.00
126_R131_H1.6511.00
94_A136_R1.6491.00
139_I150_A1.5871.00
47_I96_A1.5711.00
109_E152_A1.5711.00
44_E101_Y1.5671.00
70_A98_R1.5541.00
47_I74_T1.5211.00
82_T85_E1.5031.00
94_A175_A1.4891.00
119_H137_S1.4651.00
107_S110_Q1.4651.00
70_A182_Y1.4531.00
144_P147_D1.4461.00
155_E159_A1.4441.00
112_L149_A1.4401.00
123_Q126_R1.4241.00
50_M118_N1.4061.00
48_F60_F1.3941.00
84_R186_D1.3811.00
70_A100_V1.3681.00
61_W69_T1.3451.00
148_A152_A1.3081.00
152_A156_R1.2781.00
76_G93_H1.2421.00
138_A173_E1.2321.00
87_C134_Q1.2301.00
48_F112_L1.2271.00
185_D193_K1.2261.00
140_Y173_E1.2251.00
92_G133_T1.2141.00
102_D105_V1.2001.00
71_A188_Q1.1831.00
151_R154_L1.1561.00
48_F108_Y1.1461.00
45_I100_V1.1131.00
55_G191_L1.1111.00
145_E148_A1.1081.00
101_Y146_Q1.1051.00
49_A138_A1.0941.00
43_M100_V1.0821.00
42_G104_S1.0801.00
58_R202_G1.0571.00
136_R173_E1.0480.99
86_V91_T1.0390.99
61_W192_H1.0350.99
137_S172_T1.0340.99
47_I177_A1.0270.99
138_A175_A1.0190.99
142_L146_Q1.0130.99
119_H172_T1.0110.99
151_R155_E1.0030.99
158_Q170_I1.0030.99
110_Q113_Q1.0020.99
59_L118_N0.9890.99
81_P181_Y0.9860.99
61_W189_Q0.9820.99
144_P148_A0.9820.99
74_T178_T0.9650.99
43_M103_P0.9580.99
200_G203_G0.9420.99
66_V106_I0.9400.99
150_A174_I0.9360.99
197_G200_G0.9340.99
73_Y184_E0.9090.99
79_P179_P0.9020.98
133_T136_R0.8970.98
48_F99_I0.8940.98
166_D169_H0.8940.98
123_Q131_H0.8870.98
79_P181_Y0.8790.98
39_V182_Y0.8720.98
123_Q171_T0.8710.98
141_P174_I0.8660.98
148_A151_R0.8630.98
154_L170_I0.8490.98
45_I142_L0.8440.98
74_T179_P0.8430.98
68_S100_V0.8370.97
78_T81_P0.8340.97
40_P67_Y0.8300.97
124_G133_T0.8280.97
77_Y92_G0.8270.97
157_F170_I0.8260.97
175_A178_T0.8240.97
147_D176_N0.8220.97
58_R191_L0.8220.97
112_L139_I0.8210.97
78_T91_T0.8160.97
142_L177_A0.8140.97
49_A94_A0.8130.97
108_Y150_A0.8060.97
125_M133_T0.8020.97
106_I110_Q0.7960.97
58_R203_G0.7960.97
113_Q117_E0.7910.96
114_V117_E0.7870.96
35_S38_N0.7870.96
156_R159_A0.7840.96
195_P198_Y0.7790.96
58_R199_C0.7760.96
115_F137_S0.7760.96
98_R142_L0.7730.96
71_A189_Q0.7680.96
48_F139_I0.7620.96
156_R160_A0.7560.95
161_M166_D0.7550.95
157_F161_M0.7500.95
94_A140_Y0.7500.95
56_V59_L0.7440.95
57_E69_T0.7380.95
113_Q153_S0.7370.95
149_A152_A0.7350.95
116_W174_I0.7340.95
108_Y146_Q0.7290.94
196_Y200_G0.7210.94
154_L158_Q0.7170.94
109_E156_R0.7160.94
80_N85_E0.7150.94
44_E103_P0.7070.94
63_L66_V0.7040.93
189_Q192_H0.7030.93
158_Q169_H0.7020.93
55_G71_A0.6960.93
53_F184_E0.6940.93
67_Y70_A0.6910.93
75_G140_Y0.6900.93
56_V71_A0.6900.93
186_D194_N0.6890.93
145_E149_A0.6880.93
86_V134_Q0.6800.92
60_F99_I0.6730.92
78_T93_H0.6690.92
85_E91_T0.6660.91
96_A140_Y0.6600.91
153_S157_F0.6570.91
85_E90_D0.6480.90
197_G201_I0.6460.90
59_L62_Q0.6460.90
40_P43_M0.6370.89
59_L202_G0.6370.89
109_E153_S0.6340.89
129_N201_I0.6340.89
88_S91_T0.6330.89
58_R61_W0.6320.89
91_T133_T0.6320.89
194_N198_Y0.6290.89
39_V43_M0.6280.89
55_G200_G0.6250.89
59_L114_V0.6240.88
89_G133_T0.6230.88
112_L153_S0.6140.88
75_G175_A0.6110.87
151_R174_I0.6110.87
189_Q193_K0.6100.87
75_G93_H0.6060.87
109_E113_Q0.5980.86
94_A137_S0.5960.86
58_R62_Q0.5960.86
149_A153_S0.5950.86
78_T82_T0.5940.86
129_N196_Y0.5930.86
125_M131_H0.5920.86
44_E145_E0.5920.86
115_F119_H0.5890.85
56_V115_F0.5890.85
157_F160_A0.5890.85
144_P176_N0.5870.85
74_T138_A0.5860.85
118_N201_I0.5840.85
119_H123_Q0.5800.85
69_T97_V0.5800.85
152_A155_E0.5790.84
62_Q192_H0.5730.84
86_V89_G0.5700.84
129_N200_G0.5680.83
66_V99_I0.5670.83
114_V118_N0.5640.83
122_A171_T0.5600.82
118_N202_G0.5590.82
80_N181_Y0.5550.82
112_L116_W0.5550.82
140_Y175_A0.5530.82
44_E142_L0.5520.82
122_A168_R0.5500.81
81_P85_E0.5500.81
141_P150_A0.5450.81
68_S182_Y0.5450.81
190_Y197_G0.5440.81
87_C129_N0.5420.80
141_P177_A0.5410.80
120_D126_R0.5380.80
58_R200_G0.5380.80
94_A125_M0.5380.80
128_G197_G0.5370.80
43_M102_D0.5360.80
127_Q136_R0.5340.79
190_Y194_N0.5330.79
196_Y201_I0.5320.79
123_Q128_G0.5260.78
61_W191_L0.5260.78
49_A74_T0.5240.78
128_G199_C0.5240.78
49_A140_Y0.5200.78
194_N197_G0.5200.78
39_V68_S0.5200.78
153_S156_R0.5190.77
63_L110_Q0.5140.77
55_G58_R0.5140.77
42_G103_P0.5100.76
41_D104_S0.5080.76
94_A126_R0.5080.76
122_A170_I0.5080.76
120_D168_R0.5060.76
46_A111_L0.5020.75
64_P106_I0.5010.75
125_M137_S0.5010.75
69_T99_I0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ff3A 5 0.9906 100 0.051 Contact Map
4d7lA 3 0.9623 100 0.054 Contact Map
1fvgA 1 0.9009 100 0.105 Contact Map
3bqhA 1 0.7642 100 0.155 Contact Map
2j89A 1 0.8443 100 0.159 Contact Map
3e0mA 4 0.7736 100 0.17 Contact Map
3pimA 2 0.8066 100 0.177 Contact Map
1nwaA 1 0.7877 100 0.208 Contact Map
4gwbA 2 0.7689 100 0.221 Contact Map
4lwlA 1 0.7406 100 0.273 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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