MOAC - ECOLI - GREMLIN Contacts

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MOAC - Cyclic pyranopterin monophosphate synthase accessory protein

UniProt:	P0A738	Sequences: MSQLTHINAAGEAHMVDVSAKAETVREARAEAFVTMRSETLAMIIDGRHHKGDVFATARIAGIQAAKRTWDLIPLCHPLMLSKVEVNLQAEPEHNRVRIETLCRLTGKTGVEMEALTAASVAALTIYDMCKAVQKDMVIGPVRLLAKSGGKSGDFKVEADD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11666
Length:	161 (153)
Sequences:	2916 (1710)
Seq/√Len:	138.2

ECOLI - MOAC
BACSU - MOAC
HALSA - MOAC
SULSO - MOAC

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
68_R	71_D	5.259	1.00
99_I	123_A	2.913	1.00
101_T	118_A	2.860	1.00
43_M	133_V	2.590	1.00
31_E	145_L	2.569	1.00
32_A	142_V	2.418	1.00
146_A	154_D	2.369	1.00
8_N	12_E	2.365	1.00
31_E	98_R	2.274	1.00
146_A	156_K	2.197	1.00
35_T	140_G	2.191	1.00
32_A	119_A	2.148	1.00
42_A	46_D	2.141	1.00
23_E	108_K	2.033	1.00
62_G	122_A	1.910	1.00
33_F	96_R	1.874	1.00
25_V	104_R	1.871	1.00
148_S	154_D	1.785	1.00
31_E	143_R	1.671	1.00
72_L	121_V	1.665	1.00
29_R	102_L	1.658	1.00
127_Y	144_L	1.641	1.00
33_F	98_R	1.636	1.00
27_E	102_L	1.621	1.00
120_S	142_V	1.609	1.00
34_V	123_A	1.608	1.00
136_D	155_F	1.604	1.00
91_E	98_R	1.595	1.00
37_R	40_T	1.555	1.00
41_L	90_A	1.549	1.00
44_I	130_C	1.525	1.00
23_E	106_T	1.523	1.00
143_R	157_V	1.522	1.00
35_T	138_V	1.522	1.00
66_A	118_A	1.507	1.00
88_L	97_V	1.470	1.00
27_E	148_S	1.422	1.00
130_C	137_M	1.420	1.00
135_K	152_S	1.414	1.00
45_I	92_P	1.411	1.00
36_M	40_T	1.410	1.00
45_I	90_A	1.407	1.00
90_A	97_V	1.399	1.00
33_F	141_P	1.380	1.00
38_S	42_A	1.378	1.00
32_A	123_A	1.365	1.00
27_E	104_R	1.342	1.00
80_M	107_G	1.338	1.00
31_E	100_E	1.313	1.00
53_D	56_A	1.284	1.00
56_A	59_R	1.253	1.00
81_L	103_C	1.241	1.00
60_I	75_L	1.240	1.00
72_L	117_T	1.234	1.00
80_M	105_L	1.209	1.00
62_G	86_V	1.204	1.00
34_V	137_M	1.187	1.00
43_M	48_R	1.176	0.99
101_T	119_A	1.175	0.99
89_Q	98_R	1.166	0.99
17_D	104_R	1.164	0.99
49_H	54_V	1.162	0.99
89_Q	100_E	1.160	0.99
19_S	82_S	1.152	0.99
83_K	104_R	1.150	0.99
7_I	57_T	1.140	0.99
116_L	124_L	1.122	0.99
13_A	56_A	1.101	0.99
29_R	100_E	1.094	0.99
138_V	141_P	1.094	0.99
119_A	142_V	1.090	0.99
82_S	108_K	1.089	0.99
37_R	134_Q	1.083	0.99
123_A	139_I	1.081	0.99
62_G	101_T	1.064	0.99
66_A	81_L	1.063	0.99
43_M	49_H	1.056	0.99
120_S	139_I	1.053	0.99
91_E	95_N	1.047	0.99
97_V	126_I	1.041	0.99
29_R	146_A	1.036	0.99
41_L	95_N	1.035	0.99
49_H	130_C	1.001	0.98
57_T	60_I	0.993	0.98
12_E	59_R	0.978	0.98
81_L	111_V	0.969	0.98
19_S	25_V	0.962	0.98
79_L	105_L	0.958	0.98
87_N	100_E	0.954	0.98
35_T	96_R	0.949	0.98
29_R	101_T	0.948	0.98
54_V	126_I	0.946	0.98
34_V	126_I	0.944	0.98
49_H	133_V	0.939	0.98
66_A	84_V	0.935	0.97
91_E	96_R	0.933	0.97
60_I	64_Q	0.925	0.97
139_I	142_V	0.916	0.97
27_E	146_A	0.907	0.97
59_R	87_N	0.898	0.97
19_S	104_R	0.896	0.97
38_S	95_N	0.894	0.97
145_L	157_V	0.892	0.97
13_A	59_R	0.886	0.96
23_E	107_G	0.880	0.96
36_M	41_L	0.878	0.96
70_W	78_P	0.865	0.96
31_E	141_P	0.847	0.95
103_C	111_V	0.837	0.95
86_V	122_A	0.831	0.95
65_A	121_V	0.811	0.94
120_S	123_A	0.811	0.94
8_N	14_H	0.809	0.94
58_A	125_T	0.808	0.94
100_E	145_L	0.805	0.94
36_M	137_M	0.803	0.94
80_M	108_K	0.801	0.94
39_E	42_A	0.798	0.94
25_V	106_T	0.796	0.94
53_D	57_T	0.795	0.94
55_F	97_V	0.793	0.94
138_V	143_R	0.793	0.94
13_A	53_D	0.792	0.94
20_A	25_V	0.787	0.93
61_A	125_T	0.787	0.93
79_L	103_C	0.786	0.93
34_V	99_I	0.785	0.93
24_T	149_G	0.780	0.93
8_N	85_E	0.778	0.93
134_Q	137_M	0.777	0.93
99_I	122_A	0.777	0.93
73_I	125_T	0.770	0.93
33_F	140_G	0.763	0.92
44_I	54_V	0.744	0.91
63_I	75_L	0.743	0.91
88_L	126_I	0.742	0.91
41_L	92_P	0.734	0.91
7_I	50_H	0.734	0.91
96_R	140_G	0.725	0.90
127_Y	130_C	0.723	0.90
87_N	102_L	0.722	0.90
14_H	83_K	0.719	0.90
135_K	151_K	0.717	0.90
84_V	103_C	0.714	0.89
42_A	45_I	0.711	0.89
7_I	47_G	0.709	0.89
40_T	134_Q	0.707	0.89
14_H	75_L	0.702	0.89
82_S	106_T	0.700	0.89
88_L	99_I	0.697	0.88
59_R	85_E	0.693	0.88
17_D	83_K	0.675	0.87
14_H	85_E	0.675	0.87
22_A	108_K	0.674	0.87
41_L	45_I	0.672	0.86
57_T	75_L	0.658	0.85
117_T	121_V	0.653	0.85
85_E	102_L	0.653	0.85
127_Y	137_M	0.649	0.84
99_I	119_A	0.649	0.84
137_M	144_L	0.649	0.84
47_G	53_D	0.644	0.84
127_Y	135_K	0.643	0.84
138_V	157_V	0.642	0.84
70_W	80_M	0.636	0.83
44_I	97_V	0.635	0.83
3_Q	9_A	0.633	0.83
55_F	88_L	0.631	0.83
4_L	130_C	0.627	0.82
73_I	132_A	0.624	0.82
37_R	41_L	0.611	0.81
33_F	91_E	0.602	0.80
44_I	49_H	0.597	0.79
41_L	96_R	0.593	0.79
11_G	53_D	0.590	0.78
13_A	88_L	0.589	0.78
10_A	87_N	0.588	0.78
40_T	133_V	0.588	0.78
50_H	133_V	0.586	0.78
50_H	126_I	0.585	0.78
19_S	106_T	0.582	0.78
70_W	79_L	0.581	0.77
81_L	84_V	0.579	0.77
103_C	144_L	0.579	0.77
42_A	92_P	0.577	0.77
18_V	108_K	0.575	0.77
41_L	44_I	0.569	0.76
37_R	136_D	0.567	0.76
65_A	117_T	0.566	0.76
135_K	148_S	0.566	0.76
136_D	144_L	0.566	0.76
68_R	72_L	0.563	0.75
103_C	115_A	0.561	0.75
64_Q	69_T	0.560	0.75
65_A	70_W	0.559	0.75
30_A	119_A	0.558	0.75
53_D	59_R	0.558	0.75
16_V	132_A	0.556	0.74
7_I	56_A	0.556	0.74
78_P	81_L	0.553	0.74
47_G	56_A	0.551	0.74
40_T	130_C	0.550	0.73
40_T	44_I	0.549	0.73
3_Q	156_K	0.547	0.73
57_T	64_Q	0.547	0.73
92_P	95_N	0.547	0.73
82_S	105_L	0.543	0.73
86_V	101_T	0.541	0.72
20_A	23_E	0.536	0.72
36_M	44_I	0.535	0.71
61_A	111_V	0.533	0.71
117_T	124_L	0.533	0.71
64_Q	70_W	0.532	0.71
54_V	107_G	0.531	0.71
74_P	125_T	0.527	0.70
13_A	57_T	0.526	0.70
40_T	43_M	0.525	0.70
66_A	101_T	0.525	0.70
15_M	18_V	0.525	0.70
3_Q	43_M	0.520	0.69
66_A	103_C	0.518	0.69
135_K	153_G	0.517	0.69
113_M	116_L	0.515	0.69
62_G	66_A	0.514	0.68
22_A	153_G	0.512	0.68
63_I	84_V	0.511	0.68
148_S	156_K	0.509	0.68
50_H	59_R	0.503	0.67
59_R	81_L	0.502	0.67
4_L	43_M	0.500	0.66

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4pyaA	3	0.7702	100	0.006	Contact Map
2eeyA	5	0.9814	100	0.009	Contact Map
2iihA	4	0.9068	100	0.038	Contact Map
4fdfA	5	0.8758	100	0.058	Contact Map
2eknA	5	0.8634	100	0.078	Contact Map
2ohdA	5	0.8509	100	0.129	Contact Map
3bkrA	1	0.4161	5.1	0.966	Contact Map
4hatB	1	0.3168	5.1	0.966	Contact Map
1zkiA	2	0.6957	3.4	0.969	Contact Map
3butA	2	0.6832	3.1	0.97	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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