GREMLIN Database
MOAC - Cyclic pyranopterin monophosphate synthase accessory protein
UniProt: P0A738 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11666
Length: 161 (153)
Sequences: 2916 (1710)
Seq/√Len: 138.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
68_R71_D5.2591.00
99_I123_A2.9131.00
101_T118_A2.8601.00
43_M133_V2.5901.00
31_E145_L2.5691.00
32_A142_V2.4181.00
146_A154_D2.3691.00
8_N12_E2.3651.00
31_E98_R2.2741.00
146_A156_K2.1971.00
35_T140_G2.1911.00
32_A119_A2.1481.00
42_A46_D2.1411.00
23_E108_K2.0331.00
62_G122_A1.9101.00
33_F96_R1.8741.00
25_V104_R1.8711.00
148_S154_D1.7851.00
31_E143_R1.6711.00
72_L121_V1.6651.00
29_R102_L1.6581.00
127_Y144_L1.6411.00
33_F98_R1.6361.00
27_E102_L1.6211.00
120_S142_V1.6091.00
34_V123_A1.6081.00
136_D155_F1.6041.00
91_E98_R1.5951.00
37_R40_T1.5551.00
41_L90_A1.5491.00
44_I130_C1.5251.00
23_E106_T1.5231.00
143_R157_V1.5221.00
35_T138_V1.5221.00
66_A118_A1.5071.00
88_L97_V1.4701.00
27_E148_S1.4221.00
130_C137_M1.4201.00
135_K152_S1.4141.00
45_I92_P1.4111.00
36_M40_T1.4101.00
45_I90_A1.4071.00
90_A97_V1.3991.00
33_F141_P1.3801.00
38_S42_A1.3781.00
32_A123_A1.3651.00
27_E104_R1.3421.00
80_M107_G1.3381.00
31_E100_E1.3131.00
53_D56_A1.2841.00
56_A59_R1.2531.00
81_L103_C1.2411.00
60_I75_L1.2401.00
72_L117_T1.2341.00
80_M105_L1.2091.00
62_G86_V1.2041.00
34_V137_M1.1871.00
43_M48_R1.1760.99
101_T119_A1.1750.99
89_Q98_R1.1660.99
17_D104_R1.1640.99
49_H54_V1.1620.99
89_Q100_E1.1600.99
19_S82_S1.1520.99
83_K104_R1.1500.99
7_I57_T1.1400.99
116_L124_L1.1220.99
13_A56_A1.1010.99
29_R100_E1.0940.99
138_V141_P1.0940.99
119_A142_V1.0900.99
82_S108_K1.0890.99
37_R134_Q1.0830.99
123_A139_I1.0810.99
62_G101_T1.0640.99
66_A81_L1.0630.99
43_M49_H1.0560.99
120_S139_I1.0530.99
91_E95_N1.0470.99
97_V126_I1.0410.99
29_R146_A1.0360.99
41_L95_N1.0350.99
49_H130_C1.0010.98
57_T60_I0.9930.98
12_E59_R0.9780.98
81_L111_V0.9690.98
19_S25_V0.9620.98
79_L105_L0.9580.98
87_N100_E0.9540.98
35_T96_R0.9490.98
29_R101_T0.9480.98
54_V126_I0.9460.98
34_V126_I0.9440.98
49_H133_V0.9390.98
66_A84_V0.9350.97
91_E96_R0.9330.97
60_I64_Q0.9250.97
139_I142_V0.9160.97
27_E146_A0.9070.97
59_R87_N0.8980.97
19_S104_R0.8960.97
38_S95_N0.8940.97
145_L157_V0.8920.97
13_A59_R0.8860.96
23_E107_G0.8800.96
36_M41_L0.8780.96
70_W78_P0.8650.96
31_E141_P0.8470.95
103_C111_V0.8370.95
86_V122_A0.8310.95
65_A121_V0.8110.94
120_S123_A0.8110.94
8_N14_H0.8090.94
58_A125_T0.8080.94
100_E145_L0.8050.94
36_M137_M0.8030.94
80_M108_K0.8010.94
39_E42_A0.7980.94
25_V106_T0.7960.94
53_D57_T0.7950.94
55_F97_V0.7930.94
138_V143_R0.7930.94
13_A53_D0.7920.94
20_A25_V0.7870.93
61_A125_T0.7870.93
79_L103_C0.7860.93
34_V99_I0.7850.93
24_T149_G0.7800.93
8_N85_E0.7780.93
134_Q137_M0.7770.93
99_I122_A0.7770.93
73_I125_T0.7700.93
33_F140_G0.7630.92
44_I54_V0.7440.91
63_I75_L0.7430.91
88_L126_I0.7420.91
41_L92_P0.7340.91
7_I50_H0.7340.91
96_R140_G0.7250.90
127_Y130_C0.7230.90
87_N102_L0.7220.90
14_H83_K0.7190.90
135_K151_K0.7170.90
84_V103_C0.7140.89
42_A45_I0.7110.89
7_I47_G0.7090.89
40_T134_Q0.7070.89
14_H75_L0.7020.89
82_S106_T0.7000.89
88_L99_I0.6970.88
59_R85_E0.6930.88
17_D83_K0.6750.87
14_H85_E0.6750.87
22_A108_K0.6740.87
41_L45_I0.6720.86
57_T75_L0.6580.85
117_T121_V0.6530.85
85_E102_L0.6530.85
127_Y137_M0.6490.84
99_I119_A0.6490.84
137_M144_L0.6490.84
47_G53_D0.6440.84
127_Y135_K0.6430.84
138_V157_V0.6420.84
70_W80_M0.6360.83
44_I97_V0.6350.83
3_Q9_A0.6330.83
55_F88_L0.6310.83
4_L130_C0.6270.82
73_I132_A0.6240.82
37_R41_L0.6110.81
33_F91_E0.6020.80
44_I49_H0.5970.79
41_L96_R0.5930.79
11_G53_D0.5900.78
13_A88_L0.5890.78
10_A87_N0.5880.78
40_T133_V0.5880.78
50_H133_V0.5860.78
50_H126_I0.5850.78
19_S106_T0.5820.78
70_W79_L0.5810.77
81_L84_V0.5790.77
103_C144_L0.5790.77
42_A92_P0.5770.77
18_V108_K0.5750.77
41_L44_I0.5690.76
37_R136_D0.5670.76
65_A117_T0.5660.76
135_K148_S0.5660.76
136_D144_L0.5660.76
68_R72_L0.5630.75
103_C115_A0.5610.75
64_Q69_T0.5600.75
65_A70_W0.5590.75
30_A119_A0.5580.75
53_D59_R0.5580.75
16_V132_A0.5560.74
7_I56_A0.5560.74
78_P81_L0.5530.74
47_G56_A0.5510.74
40_T130_C0.5500.73
40_T44_I0.5490.73
3_Q156_K0.5470.73
57_T64_Q0.5470.73
92_P95_N0.5470.73
82_S105_L0.5430.73
86_V101_T0.5410.72
20_A23_E0.5360.72
36_M44_I0.5350.71
61_A111_V0.5330.71
117_T124_L0.5330.71
64_Q70_W0.5320.71
54_V107_G0.5310.71
74_P125_T0.5270.70
13_A57_T0.5260.70
40_T43_M0.5250.70
66_A101_T0.5250.70
15_M18_V0.5250.70
3_Q43_M0.5200.69
66_A103_C0.5180.69
135_K153_G0.5170.69
113_M116_L0.5150.69
62_G66_A0.5140.68
22_A153_G0.5120.68
63_I84_V0.5110.68
148_S156_K0.5090.68
50_H59_R0.5030.67
59_R81_L0.5020.67
4_L43_M0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pyaA 3 0.7702 100 0.006 Contact Map
2eeyA 5 0.9814 100 0.009 Contact Map
2iihA 4 0.9068 100 0.038 Contact Map
4fdfA 5 0.8758 100 0.058 Contact Map
2eknA 5 0.8634 100 0.078 Contact Map
2ohdA 5 0.8509 100 0.129 Contact Map
3bkrA 1 0.4161 5.1 0.966 Contact Map
4hatB 1 0.3168 5.1 0.966 Contact Map
1zkiA 2 0.6957 3.4 0.969 Contact Map
3butA 2 0.6832 3.1 0.97 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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