GREMLIN Database
MINE - Cell division topological specificity factor
UniProt: P0A734 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10598
Length: 88 (83)
Sequences: 502 (281)
Seq/√Len: 30.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
44_K48_E3.2561.00
51_C58_P2.8331.00
29_R37_H2.5511.00
57_D60_M2.3700.99
5_D77_L2.2440.99
26_V67_Q2.0680.98
48_E52_K2.0350.98
26_V80_T1.9870.97
77_L80_T1.9480.97
25_I65_L1.8940.96
3_L25_I1.8870.96
19_K45_D1.8260.95
58_P65_L1.6940.93
56_I60_M1.6190.91
41_Q45_D1.5880.91
61_V73_S1.5240.89
51_C60_M1.5140.88
3_L72_I1.4890.87
4_L37_H1.3880.83
67_Q73_S1.3490.82
57_D66_E1.3440.81
46_I73_S1.3350.81
73_S79_V1.3270.81
51_C61_V1.2960.79
37_H40_P1.2840.78
25_I74_I1.2500.76
42_L46_I1.2390.76
29_R67_Q1.2280.75
37_H65_L1.2220.75
44_K61_V1.2190.74
8_L61_V1.1740.72
51_C74_I1.1630.71
57_D69_D1.1480.70
39_L81_L1.1420.69
34_A79_V1.0920.66
19_K26_V1.0880.66
41_Q50_I1.0860.66
54_V63_V1.0820.65
38_Y53_Y1.0800.65
24_I50_I1.0770.65
26_V51_C1.0770.65
47_L60_M1.0580.63
20_E70_G1.0520.63
36_P40_P1.0170.60
67_Q84_A1.0140.60
4_L9_S1.0100.60
43_R60_M1.0090.60
52_K83_E1.0040.59
33_D36_P0.9960.59
35_E55_Q0.9710.57
4_L64_Q0.9580.56
23_Q29_R0.9410.54
61_V67_Q0.9410.54
35_E61_V0.9340.54
60_M69_D0.9320.54
54_V70_G0.9120.52
29_R45_D0.8960.51
31_R35_E0.8960.51
38_Y78_N0.8920.50
48_E66_E0.8890.50
47_L50_I0.8880.50
13_N41_Q0.8870.50
24_I38_Y0.8590.48
19_K42_L0.8300.45
11_K71_D0.8120.44
24_I81_L0.8110.44
24_I79_V0.8100.44
15_A18_A0.8040.43
32_S36_P0.8030.43
24_I39_L0.7780.41
16_N20_E0.7630.40
48_E51_C0.7600.40
41_Q44_K0.7550.40
20_E27_A0.7550.40
50_I73_S0.7510.39
19_K38_Y0.7280.37
10_R34_A0.7200.37
47_L59_E0.7150.37
45_D49_V0.7120.36
59_E69_D0.7050.36
28_E43_R0.7020.36
5_D10_R0.7010.35
2_A73_S0.6930.35
55_Q61_V0.6920.35
14_T47_L0.6890.35
55_Q84_A0.6880.35
25_I28_E0.6760.34
23_Q66_E0.6740.33
15_A81_L0.6690.33
53_Y83_E0.6620.33
47_L57_D0.6450.31
8_L12_K0.6450.31
20_E26_V0.6440.31
19_K41_Q0.6280.30
29_R43_R0.6120.29
40_P53_Y0.6070.29
74_I77_L0.6060.29
9_S47_L0.6030.29
9_S26_V0.6000.28
7_F26_V0.5960.28
77_L83_E0.5810.27
54_V66_E0.5770.27
20_E77_L0.5760.27
30_R54_V0.5740.27
71_D81_L0.5730.27
40_P81_L0.5670.26
26_V70_G0.5660.26
28_E60_M0.5640.26
18_A21_R0.5630.26
13_N31_R0.5580.26
35_E40_P0.5510.25
2_A79_V0.5430.25
4_L27_A0.5330.24
44_K55_Q0.5310.24
38_Y47_L0.5280.24
43_R46_I0.5270.24
8_L19_K0.5180.23
11_K65_L0.5160.23
8_L55_Q0.5090.23
34_A44_K0.5080.23
64_Q73_S0.5060.23
75_L82_P0.5060.23
25_I46_I0.5050.23
28_E45_D0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2kxoA 2 0.9886 100 0.246 Contact Map
3ku7A 2 0.6932 99.9 0.333 Contact Map
3r9jC 2 0.7955 99.9 0.351 Contact Map
4rgwA 1 0.9432 13.9 0.928 Contact Map
2r44A 1 0.6591 9.7 0.932 Contact Map
4mtnA 1 0.7727 9.1 0.933 Contact Map
2mt4A 1 0.7955 9 0.933 Contact Map
2kwpA 1 0.7955 8.4 0.934 Contact Map
1r2dA 1 0.0909 6.9 0.937 Contact Map
4rr2B 1 0.875 6.4 0.938 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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