GREMLIN Database
LPXC - UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
UniProt: P0A725 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10265
Length: 305 (279)
Sequences: 1687 (1018)
Seq/√Len: 60.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
82_A182_F6.0681.00
137_R146_E3.8971.00
33_A123_L3.6741.00
28_L92_I3.6071.00
116_L183_M3.1011.00
66_L77_V3.0721.00
210_G217_V2.9441.00
96_V101_I2.8201.00
29_R95_E2.8181.00
35_T93_V2.7411.00
4_Q91_N2.7331.00
154_S257_A2.6591.00
52_A249_M2.5701.00
40_R93_V2.4681.00
84_L92_I2.4031.00
77_V81_N2.4031.00
25_T97_N2.3351.00
200_Y204_R2.2851.00
274_A277_A2.2291.00
89_I120_I2.2271.00
40_R95_E2.2251.00
188_R231_F2.2181.00
84_L94_I2.1921.00
51_P56_S2.1711.00
148_K259_T2.1661.00
90_D127_K2.1261.00
134_E278_K2.1141.00
138_V267_L2.0821.00
210_G215_A2.0811.00
269_N273_Q2.0381.00
28_L115_L2.0341.00
156_D172_R2.0271.00
157_F263_S2.0241.00
5_R123_L2.0181.00
91_N123_L1.9941.00
131_R283_E1.9441.00
40_R49_D1.9291.00
135_T148_K1.9241.00
158_T261_Y1.9241.00
7_L92_I1.9201.00
132_I256_G1.8751.00
10_I29_R1.8441.00
44_L72_V1.8041.00
156_D257_A1.7750.99
57_V60_T1.7600.99
243_A258_F1.7490.99
11_V28_L1.7410.99
13_A114_L1.7380.99
8_K121_D1.7130.99
14_T25_T1.6970.99
140_D270_K1.6860.99
12_Q27_T1.6810.99
260_A263_S1.6560.99
218_V235_F1.6390.99
86_G112_V1.6200.99
35_T38_I1.6040.99
4_Q34_N1.6010.99
28_L80_L1.5900.99
148_K257_A1.5850.99
103_I216_I1.5780.99
58_R68_N1.5760.99
32_P35_T1.5690.99
87_L112_V1.5630.99
7_L115_L1.5260.98
147_F258_F1.5200.98
9_R118_A1.5050.98
41_R44_L1.4930.98
54_A272_L1.4810.98
196_R220_D1.4610.98
158_T172_R1.4470.98
5_R122_E1.4330.98
34_N125_C1.4190.97
200_Y203_S1.4090.97
274_A278_K1.3960.97
156_D174_A1.3880.97
89_I92_I1.3820.97
113_Y117_D1.3810.97
142_D262_K1.3800.97
37_V94_I1.3790.97
19_H76_T1.3660.97
92_I115_L1.3550.97
186_I240_M1.3490.96
198_I210_G1.3470.96
152_G176_N1.3400.96
173_Y240_M1.3320.96
163_H194_F1.3290.96
248_F262_K1.3250.96
59_D73_R1.3150.96
74_I96_V1.3090.96
216_I229_L1.2560.95
139_E142_D1.2520.95
3_K122_E1.2490.95
131_R255_I1.2450.94
84_L115_L1.2390.94
31_A35_T1.2370.94
80_L101_I1.2340.94
266_A270_K1.2210.94
38_I49_D1.2150.94
146_E259_T1.2100.94
144_W261_Y1.2040.93
134_E280_E1.1990.93
109_A113_Y1.1900.93
27_T95_E1.1880.93
193_G201_L1.1870.93
154_S174_A1.1810.93
34_N128_K1.1730.92
198_I205_G1.1700.92
22_K208_L1.1620.92
189_A231_F1.1570.92
147_F256_G1.1480.92
54_A276_L1.1460.92
139_E146_E1.1340.91
129_F255_I1.1270.91
132_I147_F1.1250.91
145_A271_L1.1200.91
278_K281_A1.1160.90
7_L84_L1.1130.90
272_L276_L1.1120.90
18_L215_A1.1090.90
45_N48_V1.1040.90
68_N71_D1.1030.90
104_M111_F1.0910.89
163_H218_V1.0900.89
150_Y154_S1.0820.89
37_V81_N1.0750.89
137_R144_W1.0590.88
34_N91_N1.0530.88
18_L210_G1.0520.88
155_L240_M1.0500.88
263_S267_L1.0460.87
145_A258_F1.0430.87
252_H284_Y1.0390.87
189_A193_G1.0350.87
250_C253_N1.0320.87
77_V249_M1.0310.87
275_V281_A1.0280.86
26_L80_L1.0220.86
112_V183_M1.0210.86
206_L215_A1.0120.86
81_N248_F1.0060.85
140_D143_K0.9940.85
83_A108_A0.9940.85
197_D200_Y0.9900.84
7_L28_L0.9890.84
145_A243_A0.9850.84
49_D93_V0.9850.84
12_Q25_T0.9720.83
263_S268_N0.9580.82
147_F243_A0.9520.82
155_L177_F0.9510.82
132_I275_V0.9430.81
33_A125_C0.9420.81
114_L117_D0.9310.80
53_D56_S0.9290.80
207_C215_A0.9280.80
24_V98_A0.9280.80
178_S181_A0.9250.80
42_T95_E0.9240.80
271_L275_V0.9240.80
233_D237_R0.9230.80
43_D48_V0.9180.80
55_K276_L0.9100.79
138_V271_L0.9090.79
128_K284_Y0.9060.79
63_C198_I0.9030.78
4_Q123_L0.9010.78
57_V64_T0.9000.78
84_L89_I0.8920.78
137_R148_K0.8900.77
39_Y81_N0.8850.77
63_C250_C0.8800.77
13_A104_M0.8730.76
26_L96_V0.8650.75
161_F192_F0.8550.74
92_I112_V0.8520.74
107_S230_R0.8520.74
134_E281_A0.8510.74
216_I223_V0.8500.74
29_R93_V0.8430.73
159_I166_I0.8410.73
204_R208_L0.8310.72
26_L111_F0.8230.72
31_A91_N0.8220.72
39_Y101_I0.8130.71
109_A188_R0.8120.71
175_M186_I0.8120.71
147_F271_L0.8110.71
250_C272_L0.8100.70
135_T146_E0.8090.70
175_M240_M0.8060.70
147_F275_V0.8050.70
51_P69_E0.8050.70
38_I93_V0.8050.70
143_K267_L0.7980.69
58_R73_R0.7950.69
62_L197_D0.7940.69
279_Q282_W0.7920.69
90_D268_N0.7790.67
236_V240_M0.7760.67
143_K194_F0.7730.67
212_F225_N0.7730.67
37_V92_I0.7640.66
44_L108_A0.7610.66
159_I235_F0.7560.65
128_K252_H0.7540.65
19_H209_G0.7510.65
219_D222_R0.7460.64
57_V269_N0.7410.64
157_F240_M0.7380.63
4_Q90_D0.7350.63
32_P123_L0.7310.62
3_K126_A0.7270.62
166_I171_Q0.7270.62
62_L201_L0.7260.62
19_H206_L0.7250.62
44_L48_V0.7240.62
159_I192_F0.7240.62
205_G208_L0.7230.62
195_M219_D0.7170.61
158_T170_N0.7160.61
157_F268_N0.7160.61
193_G264_G0.7150.61
193_G210_G0.7130.61
194_F218_V0.7120.60
85_A248_F0.7090.60
43_D97_N0.7040.60
207_C214_C0.7040.60
56_S69_E0.7030.59
56_S66_L0.7030.59
173_Y233_D0.6990.59
74_I203_S0.6990.59
39_Y52_A0.6980.59
130_V284_Y0.6980.59
86_G179_A0.6980.59
58_R66_L0.6970.59
199_E203_S0.6970.59
223_V235_F0.6950.59
114_L118_A0.6940.58
278_K282_W0.6930.58
199_E264_G0.6920.58
76_T206_L0.6900.58
175_M181_A0.6880.58
66_L81_N0.6880.58
89_I115_L0.6870.58
150_Y176_N0.6860.58
247_L272_L0.6860.58
97_N141_G0.6810.57
136_V278_K0.6790.57
223_V272_L0.6780.57
87_L115_L0.6780.57
61_M204_R0.6760.56
269_N272_L0.6740.56
161_F262_K0.6740.56
13_A117_D0.6690.56
144_W267_L0.6670.55
65_C73_R0.6660.55
80_L94_I0.6650.55
223_V228_G0.6650.55
87_L116_L0.6640.55
127_K183_M0.6640.55
175_M244_I0.6610.55
260_A271_L0.6580.54
16_V22_K0.6570.54
33_A124_N0.6540.54
42_T97_N0.6530.54
250_C254_I0.6520.54
113_Y188_R0.6520.54
139_E144_W0.6510.54
41_R90_D0.6510.54
81_N207_C0.6500.54
231_F237_R0.6490.53
39_Y50_F0.6490.53
218_V223_V0.6490.53
133_K283_E0.6490.53
162_N205_G0.6490.53
127_K268_N0.6480.53
63_C249_M0.6480.53
98_A160_D0.6480.53
63_C75_S0.6470.53
13_A26_L0.6460.53
41_R97_N0.6450.53
173_Y236_V0.6440.53
193_G235_F0.6430.53
4_Q31_A0.6370.52
4_Q125_C0.6300.51
186_I244_I0.6280.51
173_Y186_I0.6280.51
132_I278_K0.6260.51
130_V282_W0.6250.51
237_R248_F0.6240.51
16_V211_S0.6230.51
189_A194_F0.6200.50
109_A187_S0.6190.50
246_D265_H0.6160.50
50_F58_R0.6160.50
89_I121_D0.6130.49
163_H220_D0.6130.49
68_N108_A0.6110.49
157_F243_A0.6050.48
144_W259_T0.6050.48
207_C235_F0.6040.48
9_R117_D0.6030.48
35_T123_L0.6020.48
204_R207_C0.5990.48
69_E94_I0.5990.48
8_K113_Y0.5980.48
104_M225_N0.5980.48
115_L119_G0.5970.48
209_G214_C0.5960.47
155_L243_A0.5940.47
11_V118_A0.5930.47
145_A155_L0.5920.47
68_N73_R0.5920.47
32_P93_V0.5910.47
105_D230_R0.5900.47
85_A135_T0.5890.47
64_T75_S0.5890.47
5_R120_I0.5890.47
211_S225_N0.5880.47
110_P113_Y0.5870.46
96_V104_M0.5850.46
156_D259_T0.5840.46
163_H193_G0.5830.46
154_S176_N0.5800.46
271_L274_A0.5790.46
40_R48_V0.5780.45
46_P101_I0.5770.45
161_F171_Q0.5760.45
155_L258_F0.5750.45
239_K246_D0.5730.45
127_K253_N0.5720.45
260_A268_N0.5720.45
44_L68_N0.5710.45
243_A260_A0.5710.45
198_I203_S0.5700.45
194_F201_L0.5690.44
86_G178_S0.5680.44
81_N264_G0.5680.44
229_L235_F0.5680.44
56_S64_T0.5670.44
111_F228_G0.5670.44
159_I225_N0.5670.44
143_K266_A0.5660.44
100_E106_G0.5650.44
177_F244_I0.5640.44
80_L211_S0.5630.44
197_D205_G0.5620.44
53_D276_L0.5600.43
158_T259_T0.5600.43
16_V208_L0.5540.43
250_C276_L0.5540.43
52_A66_L0.5520.43
98_A226_E0.5520.43
24_V103_I0.5520.43
50_F92_I0.5510.42
75_S101_I0.5500.42
11_V104_M0.5480.42
85_A251_G0.5480.42
38_I80_L0.5450.42
247_L271_L0.5450.42
145_A260_A0.5450.42
104_M193_G0.5440.42
151_N176_N0.5440.42
40_R47_P0.5430.42
20_T259_T0.5420.41
141_G262_K0.5390.41
80_L256_G0.5390.41
5_R127_K0.5390.41
254_I275_V0.5390.41
180_D184_R0.5380.41
61_M198_I0.5350.41
66_L218_V0.5350.41
13_A111_F0.5340.41
10_I27_T0.5340.41
22_K99_P0.5330.40
193_G217_V0.5320.40
42_T99_P0.5310.40
189_A205_G0.5310.40
91_N127_K0.5290.40
54_A219_D0.5280.40
206_L210_G0.5260.40
154_S184_R0.5250.40
128_K131_R0.5250.40
30_P36_G0.5230.39
19_H103_I0.5230.39
198_I215_A0.5230.39
11_V180_D0.5220.39
167_D226_E0.5210.39
20_T99_P0.5210.39
18_L76_T0.5200.39
131_R254_I0.5190.39
65_C75_S0.5190.39
86_G244_I0.5190.39
43_D99_P0.5190.39
209_G215_A0.5180.39
35_T49_D0.5160.39
72_V95_E0.5160.39
207_C211_S0.5160.39
54_A249_M0.5150.39
205_G239_K0.5150.39
23_K113_Y0.5150.39
64_T81_N0.5140.38
86_G108_A0.5120.38
184_R205_G0.5110.38
219_D224_L0.5110.38
167_D170_N0.5110.38
198_I217_V0.5100.38
160_D170_N0.5100.38
225_N228_G0.5080.38
24_V269_N0.5070.38
80_L111_F0.5060.38
66_L101_I0.5030.37
147_F199_E0.5020.37
186_I273_Q0.5020.37
194_F199_E0.5010.37
182_F187_S0.5010.37
89_I254_I0.5010.37
9_R115_L0.5000.37
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3uhmA 1 0.9738 100 0.023 Contact Map
3p3gA 1 0.9738 100 0.023 Contact Map
4u3dA 1 0.8754 100 0.082 Contact Map
3bpuA 1 0.282 30.5 0.971 Contact Map
4kiyE 1 0.2525 14.6 0.975 Contact Map
3soeA 1 0.3311 13.1 0.976 Contact Map
1pkpA 2 0.2426 13.1 0.976 Contact Map
1q7xA 1 0.3475 10.8 0.977 Contact Map
3bbnE 1 0.4098 10.8 0.977 Contact Map
1um1A 1 0.3475 10.3 0.977 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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