GREMLIN Database
LPXA - Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase
UniProt: P0A722 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10545
Length: 262 (214)
Sequences: 3965 (2491)
Seq/√Len: 170.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
59_D89_R4.5021.00
19_S37_E3.4681.00
89_R114_D3.3221.00
41_G59_D2.9441.00
15_E34_P2.9061.00
21_G40_E2.6941.00
40_E58_R2.5471.00
30_C44_L2.5351.00
37_E55_K2.5131.00
131_N149_D2.4131.00
150_F168_H2.3891.00
58_R88_D2.3261.00
117_L121_A2.3171.00
23_N41_G2.3171.00
113_S131_N2.2511.00
132_R150_F2.2121.00
148_D167_A2.1251.00
114_D132_R2.0401.00
29_F47_H2.0341.00
88_D113_S2.0311.00
62_I66_A2.0011.00
87_G113_S1.9901.00
11_T29_F1.9671.00
24_A42_T1.9411.00
30_C48_V1.9301.00
25_H43_V1.9301.00
129_V133_C1.8811.00
149_D167_A1.8671.00
20_I24_A1.8611.00
45_K61_E1.8601.00
211_A216_R1.8361.00
35_H53_H1.8241.00
22_A40_E1.8101.00
85_E110_K1.7571.00
146_S164_I1.7241.00
20_I26_I1.7241.00
60_N90_N1.6591.00
112_G131_N1.6441.00
95_S120_N1.6301.00
56_I62_I1.6241.00
85_E108_L1.6111.00
128_T146_S1.5451.00
153_I159_V1.5431.00
42_T60_N1.5351.00
38_I42_T1.5251.00
92_I98_I1.5231.00
110_K128_T1.4781.00
24_A58_R1.4511.00
23_N40_E1.4391.00
65_F95_S1.4381.00
174_C190_N1.4171.00
160_H163_C1.4101.00
172_G188_Q1.3991.00
55_K85_E1.3911.00
171_V177_V1.3521.00
140_T156_M1.3411.00
140_T158_A1.3361.00
115_N133_C1.3231.00
152_I170_M1.3151.00
43_V61_E1.3131.00
62_I92_I1.3041.00
42_T58_R1.2981.00
68_I84_V1.2961.00
101_G108_L1.2711.00
90_N115_N1.2671.00
158_A173_G1.2531.00
21_G24_A1.2351.00
175_S192_A1.2081.00
62_I68_I1.2051.00
218_A223_Y1.1991.00
130_G149_D1.1961.00
61_E71_V1.1951.00
28_P46_S1.1841.00
38_I50_V1.1581.00
42_T56_I1.1461.00
39_G58_R1.1451.00
133_C151_A1.1361.00
61_E91_R1.1271.00
181_V187_A1.1221.00
115_N149_D1.1221.00
138_N156_M1.1191.00
17_G35_H1.1131.00
84_V98_I1.1071.00
112_G128_T1.1071.00
166_G169_V1.1061.00
204_R209_R1.1021.00
194_P197_V1.0981.00
35_H81_P1.0961.00
66_A96_V1.0921.00
63_Y70_E1.0911.00
166_G182_P1.0861.00
127_C141_L1.0831.00
87_G112_G1.0761.00
86_I92_I1.0761.00
168_H205_R1.0681.00
167_A183_P1.0631.00
165_I169_V1.0560.99
156_M174_C1.0490.99
182_P185_V1.0450.99
164_I180_D1.0440.99
158_A174_C1.0400.99
51_N70_E1.0310.99
51_N64_Q1.0310.99
24_A40_E1.0270.99
32_V44_L1.0260.99
166_G183_P1.0260.99
204_R207_F1.0250.99
41_G58_R1.0230.99
147_V151_A1.0230.99
118_M136_A1.0090.99
12_A30_C1.0080.99
188_Q195_F1.0050.99
136_A154_G1.0030.99
17_G34_P1.0000.99
133_C147_V0.9990.99
157_T171_V0.9980.99
208_S212_I0.9950.99
75_L116_L0.9880.99
183_P187_A0.9870.99
83_R108_L0.9770.99
184_Y187_A0.9740.99
12_A26_I0.9730.99
15_E18_A0.9720.99
213_T217_N0.9600.99
151_A167_A0.9580.99
141_L147_V0.9550.99
68_I98_I0.9520.99
42_T88_D0.9480.99
211_A215_I0.9410.99
209_R212_I0.9410.99
97_T120_N0.9340.99
13_I31_I0.9310.99
67_S70_E0.9220.99
37_E40_E0.9200.99
18_A32_V0.9170.99
203_K206_G0.9160.99
98_I117_L0.9150.99
56_I60_N0.9110.98
26_I30_C0.9000.98
203_K207_F0.8990.98
214_A219_Y0.8950.98
44_L48_V0.8930.98
70_E94_E0.8880.98
26_I32_V0.8840.98
18_A36_V0.8830.98
145_V159_V0.8650.98
172_G195_F0.8640.98
208_S211_A0.8640.98
47_H65_F0.8600.98
63_Y71_V0.8510.98
46_S64_Q0.8490.98
142_A160_H0.8460.98
153_I157_T0.8450.98
59_D114_D0.8370.97
207_F210_E0.8350.97
134_I152_I0.8240.97
129_V135_L0.8230.97
135_L141_L0.8180.97
76_K161_Q0.8130.97
133_C167_A0.8050.97
170_M186_I0.8050.97
135_L153_I0.8030.97
154_G170_M0.8010.97
60_N113_S0.8000.97
124_A127_C0.7990.97
157_T175_S0.7980.97
15_E31_I0.7940.96
33_G51_N0.7890.96
9_H13_I0.7860.96
169_V183_P0.7840.96
24_A38_I0.7810.96
50_V54_T0.7760.96
27_G30_C0.7710.96
153_I171_V0.7680.96
60_N88_D0.7630.96
126_D144_H0.7630.96
14_V18_A0.7630.96
169_V181_V0.7570.95
57_G88_D0.7540.95
211_A219_Y0.7540.95
77_Y81_P0.7510.95
147_V153_I0.7490.95
203_K211_A0.7460.95
30_C45_K0.7450.95
141_L145_V0.7440.95
215_I218_A0.7430.95
176_G188_Q0.7430.95
49_V65_F0.7430.95
44_L50_V0.7420.95
34_P52_G0.7390.95
38_I44_L0.7380.95
112_G149_D0.7340.94
158_A176_G0.7300.94
54_T69_G0.7270.94
120_N140_T0.7270.94
62_I98_I0.7230.94
217_N221_L0.7220.94
159_V165_I0.7160.94
76_K104_Q0.7150.94
90_N113_S0.7130.94
136_A155_G0.7110.94
151_A169_V0.7090.93
36_V50_V0.7030.93
215_I219_Y0.7010.93
64_Q70_E0.7000.93
135_L147_V0.6930.93
203_K209_R0.6930.93
18_A33_G0.6910.93
213_T216_R0.6910.93
78_A81_P0.6890.92
211_A218_A0.6790.92
189_G192_A0.6780.92
141_L159_V0.6780.92
32_V38_I0.6760.92
185_V194_P0.6760.92
200_E203_K0.6750.92
204_R212_I0.6710.91
211_A214_A0.6640.91
209_R213_T0.6630.91
13_I29_F0.6630.91
39_G42_T0.6630.91
139_A153_I0.6620.91
199_I203_K0.6610.91
160_H173_G0.6600.91
99_H119_I0.6580.91
133_C149_D0.6570.91
139_A157_T0.6570.91
194_P223_Y0.6540.90
96_V121_A0.6500.90
178_A190_N0.6490.90
166_G181_V0.6490.90
27_G43_V0.6480.90
75_L134_I0.6480.90
21_G39_G0.6480.90
216_R219_Y0.6480.90
172_G187_A0.6480.90
188_Q198_N0.6450.90
89_R113_S0.6350.89
177_V192_A0.6350.89
206_G209_R0.6330.89
45_K51_N0.6320.89
32_V36_V0.6310.89
54_T84_V0.6270.88
70_E99_H0.6220.88
151_A183_P0.6160.88
205_R209_R0.6150.87
160_H176_G0.6150.87
135_L139_A0.6140.87
19_S22_A0.6130.87
45_K64_Q0.6090.87
144_H162_F0.6090.87
145_V165_I0.6090.87
11_T14_V0.6070.87
77_Y82_T0.6060.87
178_A191_H0.6010.86
176_G191_H0.5990.86
156_M173_G0.5980.86
197_V215_I0.5950.86
11_T47_H0.5940.86
202_L215_I0.5930.85
33_G52_G0.5920.85
36_V54_T0.5910.85
87_G110_K0.5870.85
182_P223_Y0.5860.85
41_G89_R0.5850.85
154_G157_T0.5840.85
220_K224_R0.5840.85
145_V161_Q0.5800.84
94_E97_T0.5780.84
173_G176_G0.5760.84
150_F205_R0.5750.84
177_V181_V0.5680.83
46_S49_V0.5680.83
202_L205_R0.5670.83
39_G88_D0.5630.82
140_T173_G0.5620.82
202_L212_I0.5620.82
92_I117_L0.5610.82
202_L206_G0.5580.82
62_I86_I0.5570.82
113_S132_R0.5550.82
123_I129_V0.5550.82
214_A218_A0.5550.82
9_H12_A0.5520.81
36_V51_N0.5500.81
119_I137_N0.5470.81
14_V26_I0.5460.81
119_I122_H0.5460.81
39_G55_K0.5430.80
24_A41_G0.5410.80
9_H27_G0.5390.80
115_N131_N0.5370.79
168_H184_Y0.5350.79
111_V123_I0.5350.79
147_V165_I0.5310.79
112_G115_N0.5270.78
77_Y80_E0.5260.78
203_K216_R0.5250.78
120_N138_N0.5250.78
96_V117_L0.5240.78
127_C145_V0.5230.78
203_K212_I0.5210.77
117_L123_I0.5210.77
123_I127_C0.5160.77
219_Y223_Y0.5160.77
53_H81_P0.5150.77
165_I177_V0.5140.76
78_A82_T0.5120.76
71_V91_R0.5120.76
68_I86_I0.5120.76
13_I27_G0.5110.76
148_D164_I0.5110.76
210_E214_A0.5090.76
187_A192_A0.5080.76
19_S35_H0.5070.75
71_V75_L0.5040.75
9_H28_P0.5040.75
168_H207_F0.5040.75
183_P186_I0.5030.75
112_G133_C0.5020.75
132_R168_H0.5000.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1j2zA 3 0.9771 100 0.283 Contact Map
3t57A 3 0.9733 100 0.312 Contact Map
2qiaA 3 1 100 0.319 Contact Map
4eqyA 3 0.9733 100 0.322 Contact Map
3r0sA 3 0.9542 100 0.323 Contact Map
3hsqA 3 0.9771 100 0.328 Contact Map
4r36A 3 0.9695 100 0.332 Contact Map
4e6uA 2 0.9809 100 0.345 Contact Map
3pmoA 3 0.8244 100 0.481 Contact Map
2iu8A 3 0.8511 100 0.487 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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