GREMLIN Database
KTHY - Thymidylate kinase
UniProt: P0A720 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12302
Length: 213 (199)
Sequences: 4653 (3517)
Seq/√Len: 249.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
191_Q199_A3.5091.00
34_D94_T3.2601.00
26_T201_R3.2491.00
139_L189_A3.0271.00
22_V197_M2.8491.00
111_G173_R2.6671.00
140_D171_R2.5491.00
24_V28_E2.4821.00
191_Q195_A2.3501.00
192_P195_A2.1901.00
145_V148_K2.1651.00
171_R175_L2.1511.00
187_I196_V2.1081.00
80_Q84_T2.0371.00
38_T81_L1.9981.00
36_V94_T1.9871.00
20_R97_I1.9611.00
20_R37_F1.9171.00
140_D175_L1.8951.00
4_K95_W1.8711.00
157_D160_E1.8371.00
24_V37_F1.8131.00
19_A200_I1.7991.00
19_A197_M1.7571.00
175_L186_T1.7531.00
87_K91_A1.7481.00
30_L205_T1.7461.00
185_H203_T1.7161.00
142_T190_T1.6611.00
197_M201_R1.6461.00
26_T30_L1.6451.00
14_A141_V1.6381.00
24_V97_I1.6091.00
103_L183_S1.5831.00
137_L203_T1.5821.00
83_E87_K1.5251.00
138_Y184_I1.5211.00
185_H207_W1.4931.00
19_A22_V1.4841.00
122_T125_D1.4821.00
141_V145_V1.4691.00
113_R162_E1.4631.00
5_Y98_G1.4621.00
138_Y186_T1.3901.00
87_K131_F1.3891.00
48_E77_A1.3731.00
66_T83_E1.3691.00
23_V204_V1.3651.00
172_A176_E1.3511.00
168_N172_A1.3491.00
7_V98_G1.3411.00
46_L65_I1.3361.00
26_T205_T1.3251.00
139_L200_I1.3181.00
49_K52_S1.3141.00
178_A186_T1.3111.00
50_L73_M1.3071.00
26_T197_M1.2971.00
25_E29_Q1.2781.00
176_E180_Q1.2731.00
137_L200_I1.2701.00
12_E146_G1.2691.00
145_V190_T1.2611.00
164_F168_N1.2491.00
11_L167_F1.2441.00
89_A94_T1.2291.00
176_E179_A1.2191.00
201_R205_T1.2181.00
22_V193_L1.2111.00
7_V103_L1.2051.00
8_I23_V1.2041.00
22_V194_E1.2031.00
187_I203_T1.2001.00
107_A111_G1.1991.00
36_V89_A1.1921.00
144_E168_N1.1831.00
103_L136_T1.1811.00
146_G150_A1.1771.00
197_M200_I1.1661.00
143_P164_F1.1601.00
52_S56_D1.1501.00
121_A125_D1.1451.00
71_V75_Y1.1421.00
203_T207_W1.1411.00
21_N25_E1.1291.00
44_T47_A1.1281.00
177_L184_I1.1151.00
82_V131_F1.1141.00
38_T98_G1.1071.00
18_T193_L1.1041.00
165_D168_N1.1011.00
9_E104_S1.0941.00
141_V146_G1.0931.00
203_T206_H1.0801.00
199_A202_T1.0791.00
138_Y178_A1.0701.00
75_Y124_R1.0681.00
138_Y175_L1.0671.00
135_L185_H1.0621.00
142_T145_V1.0581.00
165_D169_R1.0541.00
79_V83_E1.0541.00
30_L201_R1.0531.00
28_E35_M1.0431.00
37_F97_I1.0421.00
188_D191_Q1.0421.00
24_V35_M1.0411.00
150_A153_R1.0341.00
75_Y102_D1.0271.00
193_L197_M1.0251.00
128_L131_F1.0231.00
132_R181_D1.0221.00
25_E28_E1.0211.00
137_L185_H1.0181.00
121_A180_Q1.0161.00
44_T85_V1.0081.00
199_A203_T1.0071.00
57_I161_Q1.0061.00
66_T79_V1.0041.00
195_A199_A1.0021.00
68_K119_M0.9951.00
26_T198_D0.9811.00
118_H122_T0.9761.00
198_D202_T0.9751.00
147_L164_F0.9721.00
138_Y171_R0.9691.00
75_Y105_T0.9661.00
112_G169_R0.9661.00
19_A193_L0.9541.00
135_L207_W0.9521.00
143_P171_R0.9471.00
119_M126_A0.9421.00
68_K126_A0.9341.00
47_A77_A0.9281.00
137_L187_I0.9101.00
74_F159_I0.9091.00
102_D132_R0.9051.00
141_V189_A0.8891.00
77_A81_L0.8861.00
175_L178_A0.8811.00
34_D92_N0.8781.00
135_L203_T0.8751.00
26_T29_Q0.8751.00
147_L150_A0.8741.00
202_T205_T0.8700.99
35_M95_W0.8690.99
124_R127_V0.8660.99
86_I96_V0.8610.99
103_L184_I0.8590.99
17_T21_N0.8580.99
181_D184_I0.8490.99
148_K152_A0.8460.99
7_V183_S0.8330.99
41_P78_R0.8310.99
40_E81_L0.8300.99
106_Q177_L0.8240.99
119_M122_T0.8140.99
140_D186_T0.8130.99
22_V25_E0.8130.99
49_K56_D0.8110.99
202_T206_H0.8080.99
82_V87_K0.8050.99
11_L146_G0.8020.99
5_Y101_H0.7970.99
36_V85_V0.7950.99
82_V86_I0.7920.99
54_V74_F0.7900.99
187_I200_I0.7880.99
51_R55_L0.7860.99
137_L204_V0.7760.99
12_E167_F0.7750.99
144_E164_F0.7720.99
8_I200_I0.7710.99
102_D124_R0.7670.99
113_R166_F0.7650.99
107_A173_R0.7550.99
116_D119_M0.7490.98
21_N24_V0.7460.98
31_G34_D0.7440.98
81_L98_G0.7430.98
136_T183_S0.7430.98
68_K83_E0.7430.98
75_Y120_L0.7410.98
35_M94_T0.7400.98
21_N37_F0.7400.98
116_D120_L0.7340.98
8_I20_R0.7300.98
169_R172_A0.7260.98
66_T69_A0.7230.98
147_L151_R0.7220.98
121_A181_D0.7170.98
195_A198_D0.7140.98
56_D62_D0.7060.98
19_A23_V0.7050.98
107_A112_G0.7040.98
78_R105_T0.7030.98
173_R176_E0.7030.98
28_E34_D0.7020.98
106_Q117_Q0.7000.98
121_A132_R0.6960.98
71_V123_L0.6960.98
117_Q176_E0.6950.98
35_M97_I0.6900.97
47_A80_Q0.6880.97
31_G35_M0.6860.97
108_Y166_F0.6860.97
156_L161_Q0.6770.97
8_I139_L0.6720.97
118_H121_A0.6700.97
11_L138_Y0.6670.97
89_A92_N0.6670.97
196_V199_A0.6630.97
178_A184_I0.6620.97
7_V184_I0.6600.97
88_P92_N0.6560.97
4_K134_D0.6510.96
68_K129_G0.6480.96
49_K62_D0.6450.96
69_A79_V0.6440.96
19_A196_V0.6380.96
114_G169_R0.6350.96
72_L123_L0.6290.96
143_P168_N0.6290.96
74_F77_A0.6280.96
17_T39_R0.6280.96
5_Y90_L0.6150.95
71_V120_L0.6110.95
28_E37_F0.6090.95
13_G150_A0.6070.95
151_R156_L0.6070.95
102_D128_L0.6070.95
122_T126_A0.6060.95
150_A154_G0.6030.94
75_Y127_V0.5990.94
112_G116_D0.5980.94
19_A189_A0.5980.94
8_I137_L0.5960.94
7_V136_T0.5960.94
69_A76_A0.5950.94
62_D65_I0.5950.94
125_D132_R0.5920.94
4_K207_W0.5920.94
107_A170_T0.5900.94
9_E108_Y0.5850.94
8_I19_A0.5830.93
191_Q196_V0.5820.93
101_H131_F0.5810.93
143_P146_G0.5810.93
102_D127_V0.5810.93
144_E148_K0.5810.93
112_G170_T0.5790.93
166_F170_T0.5770.93
6_I134_D0.5760.93
39_R48_E0.5710.93
105_T109_Q0.5710.93
71_V105_T0.5670.92
157_D161_Q0.5620.92
56_D63_E0.5600.92
14_A146_G0.5600.92
117_Q121_A0.5570.92
193_L196_V0.5560.92
162_E166_F0.5550.92
106_Q121_A0.5550.92
42_G55_L0.5540.92
40_E78_R0.5540.92
136_T184_I0.5530.92
19_A139_L0.5470.91
104_S174_Y0.5420.91
3_S93_G0.5420.91
41_P74_F0.5420.91
89_A96_V0.5400.91
57_I74_F0.5390.90
39_R43_G0.5370.90
105_T120_L0.5350.90
102_D105_T0.5340.90
47_A50_L0.5320.90
27_L97_I0.5310.90
23_V197_M0.5300.90
9_E138_Y0.5280.90
46_L49_K0.5240.89
46_L62_D0.5230.89
66_T80_Q0.5220.89
71_V102_D0.5210.89
22_V200_I0.5200.89
57_I63_E0.5190.89
6_I204_V0.5180.89
127_V130_D0.5160.89
112_G166_F0.5130.88
38_T96_V0.5120.88
12_E150_A0.5120.88
103_L177_L0.5110.88
172_A175_L0.5100.88
74_F167_F0.5100.88
77_A101_H0.5080.88
159_I162_E0.5040.87
42_G51_R0.5010.87
198_D201_R0.5010.87
200_I204_V0.5000.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3czpA 2 0.8075 100 0.366 Contact Map
4edhA 2 0.9812 100 0.407 Contact Map
2plrA 2 0.9296 100 0.411 Contact Map
4tmkA 3 0.9812 100 0.414 Contact Map
2yogA 1 0.8779 100 0.42 Contact Map
1nn5A 2 0.9108 100 0.431 Contact Map
1p6xA 3 0.9624 100 0.434 Contact Map
1gtvA 2 0.9061 100 0.435 Contact Map
4eaqA 2 0.9343 100 0.438 Contact Map
4hlcA 2 0.9249 100 0.445 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0084 seconds.