GREMLIN Database
KPRS - Ribose-phosphate pyrophosphokinase
UniProt: P0A717 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10774
Length: 315 (307)
Sequences: 4022 (2056)
Seq/√Len: 117.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
18_R273_D4.5471.00
243_R267_D4.3521.00
268_E288_R4.2721.00
259_N263_N3.3691.00
273_D291_T3.3601.00
74_V122_V3.1951.00
67_L113_V3.0251.00
215_D243_R3.0111.00
7_F28_G2.8581.00
256_N260_N2.7191.00
298_E302_R2.6061.00
6_L20_A2.5721.00
22_R297_A2.5591.00
166_V177_A2.5051.00
13_P17_Q2.4871.00
72_V109_T2.4521.00
215_D242_K2.3901.00
251_P271_V2.3401.00
29_D45_N2.3121.00
60_C276_P2.2141.00
234_E238_E2.2071.00
11_A58_S2.1761.00
52_D84_R2.1361.00
128_V296_L2.1201.00
231_K234_E2.1001.00
237_K267_D2.0951.00
229_L246_A2.0881.00
128_V274_T2.0871.00
128_V292_L2.0781.00
126_L303_I2.0731.00
34_R65_D2.0581.00
159_L268_E2.0581.00
19_I56_I2.0201.00
223_I248_A2.0011.00
17_Q21_N1.9971.00
165_I214_R1.9931.00
15_L296_L1.9611.00
117_L122_V1.9591.00
115_D140_D1.9471.00
16_A27_L1.9411.00
234_E265_V1.9061.00
59_T93_G1.9001.00
224_D254_S1.8331.00
167_V216_C1.7901.00
55_I77_L1.7621.00
5_K51_G1.7501.00
168_S173_G1.7411.00
164_P187_T1.7061.00
223_I269_V1.7061.00
112_V120_V1.6801.00
6_L56_I1.6781.00
14_E18_R1.6521.00
31_A45_N1.6501.00
253_F269_V1.6381.00
129_D249_T1.6301.00
246_A266_I1.5891.00
154_E158_Q1.5761.00
226_G230_C1.5641.00
50_G306_E1.5411.00
213_G242_K1.5361.00
284_L287_V1.5361.00
198_R201_V1.5351.00
245_F267_D1.5311.00
10_N32_V1.5291.00
89_I125_V1.5281.00
155_D288_R1.5071.00
30_A73_M1.5031.00
245_F268_E1.4861.00
262_R285_P1.4851.00
161_L164_P1.4591.00
53_I77_L1.4361.00
274_T292_L1.4341.00
223_I229_L1.4261.00
173_G176_R1.4251.00
37_D91_Y1.4151.00
262_R284_L1.3911.00
215_D245_F1.3881.00
156_M270_V1.3661.00
146_V299_A1.3621.00
8_A16_A1.3601.00
279_D283_S1.3551.00
152_L290_L1.3501.00
298_E301_R1.3471.00
86_T124_R1.3451.00
18_R293_S1.3391.00
172_G196_R1.3351.00
20_A27_L1.3351.00
89_I117_L1.3301.00
237_K244_V1.3251.00
155_D270_V1.3191.00
277_L280_E1.3191.00
256_N259_N1.2891.00
202_S231_K1.2811.00
23_L297_A1.2760.99
248_A271_V1.2700.99
31_A43_Q1.2640.99
160_N163_N1.2620.99
48_V77_L1.2610.99
172_G194_K1.2570.99
15_L19_I1.2560.99
167_V190_A1.2390.99
261_L269_V1.2280.99
301_R307_E1.2200.99
14_E17_Q1.2160.99
156_M217_V1.2120.99
301_R305_N1.1980.99
111_K140_D1.1970.99
216_C236_L1.1940.99
233_A266_I1.1880.99
164_P217_V1.1840.99
9_G57_Q1.1770.99
167_V236_L1.1740.99
22_R294_G1.1730.99
33_G41_S1.1690.99
111_K115_D1.1650.99
20_A26_S1.1630.99
44_I77_L1.1580.99
277_L287_V1.1490.99
18_R291_T1.1420.99
75_D79_R1.1310.99
237_K265_V1.1230.99
62_P65_D1.1180.99
10_N34_R1.1030.99
226_G260_N1.0990.98
12_T58_S1.0960.98
218_L232_A1.0920.98
98_D134_Q1.0900.98
23_L301_R1.0890.98
62_P66_N1.0870.98
117_L125_V1.0820.98
223_I226_G1.0790.98
101_V106_V1.0760.98
166_V184_L1.0680.98
204_V235_A1.0630.98
55_I73_M1.0620.98
170_D196_R1.0440.98
84_R123_D1.0420.98
278_S282_K1.0360.98
161_L215_D1.0350.98
4_M51_G1.0300.98
277_L289_T1.0290.98
163_N214_R1.0280.98
192_I232_A1.0230.98
43_Q106_V1.0230.98
212_A239_R1.0200.98
84_R306_E1.0140.97
165_I216_C1.0080.97
170_D194_K1.0070.97
110_A135_I1.0070.97
41_S106_V1.0060.97
251_P277_L1.0010.97
8_A11_A1.0010.97
36_S224_D1.0000.97
153_L180_I0.9980.97
152_L247_Y0.9950.97
19_I300_I0.9940.97
235_A238_E0.9910.97
196_R227_G0.9880.97
246_A264_S0.9870.97
151_I290_L0.9830.97
52_D86_T0.9810.97
253_F271_V0.9730.97
118_S140_D0.9700.97
194_K227_G0.9690.97
155_D268_E0.9620.96
305_N311_A0.9580.96
226_G256_N0.9580.96
10_N69_E0.9560.96
16_A20_A0.9550.96
115_D118_S0.9530.96
71_V116_F0.9470.96
171_I175_V0.9430.96
6_L25_T0.9430.96
55_I74_V0.9420.96
279_D282_K0.9390.96
230_C260_N0.9370.96
234_E263_N0.9350.96
178_R193_D0.9330.96
302_R307_E0.9300.96
4_M304_S0.9130.95
52_D83_G0.9020.95
261_L264_S0.8970.95
12_T276_P0.8970.95
212_A240_G0.8970.95
100_R108_I0.8930.95
164_P215_D0.8890.94
37_D93_G0.8880.94
155_D247_Y0.8870.94
9_G73_M0.8860.94
7_F73_M0.8850.94
155_D290_L0.8840.94
34_R40_V0.8830.94
233_A265_V0.8830.94
156_M245_F0.8800.94
269_V287_V0.8770.94
184_L187_T0.8740.94
130_L145_N0.8720.94
248_A251_P0.8680.94
199_A202_S0.8670.94
44_I73_M0.8630.94
10_N13_P0.8600.93
307_E311_A0.8600.93
166_V180_I0.8580.93
172_G227_G0.8570.93
128_V295_M0.8560.93
200_N224_D0.8530.93
71_V120_V0.8530.93
179_A182_K0.8520.93
280_E283_S0.8480.93
39_E97_Q0.8460.93
264_S286_N0.8420.93
229_L248_A0.8420.93
14_E276_P0.8380.93
197_P202_S0.8380.93
196_R228_T0.8360.92
259_N262_R0.8360.92
17_Q27_L0.8350.92
60_C275_I0.8340.92
39_E222_M0.8340.92
36_S255_G0.8290.92
163_N242_K0.8280.92
261_L284_L0.8240.92
234_E237_K0.8230.92
230_C234_E0.8170.92
85_I123_D0.8150.91
102_R106_V0.8130.91
294_G297_A0.8130.91
235_A239_R0.8070.91
241_A244_V0.8050.91
129_D176_R0.8000.91
194_K202_S0.7970.91
155_D159_L0.7960.91
152_L272_C0.7940.90
169_P228_T0.7940.90
70_L117_L0.7940.90
252_I275_I0.7910.90
8_A12_T0.7890.90
180_I219_V0.7890.90
59_T62_P0.7870.90
87_A122_V0.7860.90
197_P201_V0.7860.90
216_C244_V0.7840.90
37_D99_R0.7840.90
148_G152_L0.7820.90
22_R298_E0.7810.90
112_V116_F0.7810.90
29_D46_E0.7680.89
43_Q102_R0.7660.89
148_G249_T0.7660.89
13_P29_D0.7650.89
271_V287_V0.7640.89
77_L82_A0.7620.89
211_V236_L0.7590.88
130_L135_I0.7590.88
180_I290_L0.7580.88
74_V87_A0.7580.88
114_A139_F0.7560.88
20_A25_T0.7530.88
40_V64_N0.7520.88
15_L56_I0.7480.88
54_F304_S0.7470.88
8_A27_L0.7470.88
60_C66_N0.7440.87
124_R144_D0.7380.87
258_A262_R0.7360.87
200_N225_T0.7320.86
156_M247_Y0.7270.86
8_A13_P0.7260.86
164_P214_R0.7250.86
118_S141_V0.7240.86
223_I271_V0.7230.86
154_E157_L0.7210.86
170_D221_D0.7170.85
67_L71_V0.7170.85
174_V191_I0.7170.85
197_P203_Q0.7110.85
75_D112_V0.7090.85
76_A80_A0.7070.85
188_D214_R0.7050.84
18_R21_N0.7040.84
75_D111_K0.7030.84
49_R81_S0.7010.84
200_N254_S0.7000.84
233_A246_A0.6980.84
18_R22_R0.6980.84
97_Q222_M0.6970.84
32_V42_V0.6950.84
191_I208_I0.6940.83
197_P204_V0.6930.83
72_V112_V0.6930.83
98_D196_R0.6900.83
233_A264_S0.6900.83
216_C241_A0.6900.83
211_V241_A0.6890.83
269_V284_L0.6880.83
258_A284_L0.6860.83
230_C233_A0.6840.83
162_D215_D0.6840.83
10_N30_A0.6840.83
71_V112_V0.6830.82
149_S180_I0.6830.82
59_T70_L0.6810.82
160_N215_D0.6800.82
262_R286_N0.6780.82
122_V141_V0.6760.82
163_N215_D0.6700.81
273_D292_L0.6700.81
223_I253_F0.6700.81
199_A227_G0.6670.81
84_R304_S0.6660.81
4_M25_T0.6660.81
156_M180_I0.6650.81
147_F179_A0.6630.81
74_V120_V0.6630.81
292_L296_L0.6610.80
6_L23_L0.6590.80
41_S102_R0.6590.80
193_D206_H0.6510.79
148_G272_C0.6490.79
22_R293_S0.6470.79
75_D115_D0.6450.79
7_F30_A0.6440.79
89_I93_G0.6430.78
218_L266_I0.6420.78
9_G171_I0.6420.78
265_V286_N0.6420.78
24_Y157_L0.6410.78
38_G225_T0.6410.78
43_Q223_I0.6400.78
131_H221_D0.6390.78
299_A309_I0.6370.78
178_R195_R0.6370.78
49_R54_F0.6360.78
5_K28_G0.6350.78
130_L143_V0.6310.77
271_V289_T0.6290.77
258_A287_V0.6290.77
168_S172_G0.6280.77
107_P112_V0.6230.76
7_F48_V0.6230.76
197_P200_N0.6230.76
92_F95_A0.6220.76
74_V82_A0.6170.76
28_G46_E0.6160.75
172_G228_T0.6160.75
237_K243_R0.6100.75
20_A23_L0.6100.75
36_S200_N0.6100.75
147_F153_L0.6090.75
193_D208_I0.6060.74
100_R105_R0.6010.74
309_I312_M0.6000.74
11_A57_Q0.5990.73
299_A312_M0.5980.73
134_Q137_G0.5970.73
270_V290_L0.5960.73
233_A237_K0.5960.73
44_I48_V0.5940.73
47_N51_G0.5920.73
196_R202_S0.5920.73
96_R224_D0.5920.73
237_K241_A0.5900.72
285_P288_R0.5870.72
40_V69_E0.5860.72
102_R198_R0.5850.72
165_I211_V0.5850.72
262_R265_V0.5820.71
269_V286_N0.5810.71
170_D227_G0.5800.71
302_R311_A0.5790.71
203_Q206_H0.5780.71
70_L89_I0.5750.70
226_G258_A0.5740.70
92_F139_F0.5730.70
127_T130_L0.5720.70
131_H170_D0.5710.70
88_V300_I0.5710.70
277_L283_S0.5700.70
133_E175_V0.5690.70
227_G256_N0.5680.70
168_S176_R0.5660.69
82_A85_I0.5660.69
125_V139_F0.5660.69
132_A135_I0.5650.69
126_L299_A0.5650.69
80_A100_R0.5630.69
277_L282_K0.5620.69
61_A66_N0.5610.69
96_R170_D0.5590.68
98_D132_A0.5570.68
180_I247_Y0.5560.68
78_R85_I0.5540.68
9_G12_T0.5530.67
97_Q109_T0.5520.67
127_T145_N0.5520.67
42_V73_M0.5520.67
171_I189_M0.5510.67
293_S297_A0.5510.67
303_I309_I0.5480.67
173_G177_A0.5480.67
308_S311_A0.5470.67
247_Y270_V0.5470.67
248_A269_V0.5460.66
122_V125_V0.5420.66
151_I273_D0.5420.66
5_K46_E0.5410.66
178_R182_K0.5390.66
112_V115_D0.5380.65
49_R209_G0.5370.65
194_K228_T0.5360.65
169_P194_K0.5350.65
128_V146_V0.5350.65
98_D131_H0.5340.65
8_A30_A0.5340.65
179_A183_L0.5330.65
282_K287_V0.5330.65
38_G222_M0.5330.65
226_G246_A0.5330.65
294_G298_E0.5310.64
177_A189_M0.5290.64
84_R126_L0.5280.64
98_D170_D0.5270.64
53_I82_A0.5270.64
151_I295_M0.5260.64
92_F110_A0.5260.64
216_C247_Y0.5250.63
295_M312_M0.5240.63
31_A41_S0.5220.63
64_N68_M0.5210.63
49_R144_D0.5210.63
165_I190_A0.5200.63
86_T126_L0.5200.63
174_V178_R0.5200.63
6_L28_G0.5190.63
134_Q138_F0.5170.62
59_T67_L0.5160.62
233_A244_V0.5140.62
22_R301_R0.5140.62
49_R105_R0.5140.62
56_I88_V0.5130.62
64_N72_V0.5130.62
19_I296_L0.5110.61
98_D194_K0.5090.61
243_R285_P0.5080.61
39_E94_Y0.5080.61
78_R123_D0.5060.61
247_Y290_L0.5060.61
190_A216_C0.5060.61
87_A125_V0.5060.61
226_G284_L0.5060.61
302_R312_M0.5050.61
154_E294_G0.5040.60
70_L88_V0.5040.60
145_N175_V0.5020.60
192_I235_A0.5010.60
190_A207_I0.5010.60
58_S93_G0.5010.60
101_V109_T0.5000.60
63_T66_N0.5000.60
230_C264_S0.5000.60
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ji4A 5 0.9302 100 0.139 Contact Map
3s5jB 2 0.9651 100 0.142 Contact Map
1dkuA 5 0.9365 100 0.148 Contact Map
3dahA 5 0.9619 100 0.163 Contact Map
4twbA 2 0.8825 100 0.203 Contact Map
1u9yA 3 0.8698 100 0.234 Contact Map
3lrtA 2 0.9079 100 0.237 Contact Map
3dezA 2 0.6095 100 0.705 Contact Map
1o57A 2 0.7841 99.9 0.731 Contact Map
3m3hA 2 0.5556 99.9 0.754 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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