KPRS - ECOLI - GREMLIN Contacts

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KPRS - Ribose-phosphate pyrophosphokinase

UniProt:	P0A717	Sequences: MPDMKLFAGNATPELAQRIANRLYTSLGDAAVGRFSDGEVSVQINENVRGGDIFIIQSTCAPTNDNLMELVVMVDALRRASAGRITAVIPYFGYARQDRRVRSARVPITAKVVADFLSSVGVDRVLTVDLHAEQIQGFFDVPVDNVFGSPILLEDMLQLNLDNPIVVSPDIGGVVRARAIAKLLNDTDMAIIDKRRPRANVSQVMHIIGDVAGRDCVLVDDMIDTGGTLCKAAEALKERGAKRVFAYATHPIFSGNAANNLRNSVIDEVVVCDTIPLSDEIKSLPNVRTLTLSGMLAEAIRRISNEESISAMFEH	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10774
Length:	315 (307)
Sequences:	4022 (2056)
Seq/√Len:	117.3

ECOLI - KPRS
BACSU - KPRS
HALSA - KPRS
SULSO - KPRS

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
18_R	273_D	4.547	1.00
243_R	267_D	4.352	1.00
268_E	288_R	4.272	1.00
259_N	263_N	3.369	1.00
273_D	291_T	3.360	1.00
74_V	122_V	3.195	1.00
67_L	113_V	3.025	1.00
215_D	243_R	3.011	1.00
7_F	28_G	2.858	1.00
256_N	260_N	2.719	1.00
298_E	302_R	2.606	1.00
6_L	20_A	2.572	1.00
22_R	297_A	2.559	1.00
166_V	177_A	2.505	1.00
13_P	17_Q	2.487	1.00
72_V	109_T	2.452	1.00
215_D	242_K	2.390	1.00
251_P	271_V	2.340	1.00
29_D	45_N	2.312	1.00
60_C	276_P	2.214	1.00
234_E	238_E	2.207	1.00
11_A	58_S	2.176	1.00
52_D	84_R	2.136	1.00
128_V	296_L	2.120	1.00
231_K	234_E	2.100	1.00
237_K	267_D	2.095	1.00
229_L	246_A	2.088	1.00
128_V	274_T	2.087	1.00
128_V	292_L	2.078	1.00
126_L	303_I	2.073	1.00
34_R	65_D	2.058	1.00
159_L	268_E	2.058	1.00
19_I	56_I	2.020	1.00
223_I	248_A	2.001	1.00
17_Q	21_N	1.997	1.00
165_I	214_R	1.993	1.00
15_L	296_L	1.961	1.00
117_L	122_V	1.959	1.00
115_D	140_D	1.947	1.00
16_A	27_L	1.941	1.00
234_E	265_V	1.906	1.00
59_T	93_G	1.900	1.00
224_D	254_S	1.833	1.00
167_V	216_C	1.790	1.00
55_I	77_L	1.762	1.00
5_K	51_G	1.750	1.00
168_S	173_G	1.741	1.00
164_P	187_T	1.706	1.00
223_I	269_V	1.706	1.00
112_V	120_V	1.680	1.00
6_L	56_I	1.678	1.00
14_E	18_R	1.652	1.00
31_A	45_N	1.650	1.00
253_F	269_V	1.638	1.00
129_D	249_T	1.630	1.00
246_A	266_I	1.589	1.00
154_E	158_Q	1.576	1.00
226_G	230_C	1.564	1.00
50_G	306_E	1.541	1.00
213_G	242_K	1.536	1.00
284_L	287_V	1.536	1.00
198_R	201_V	1.535	1.00
245_F	267_D	1.531	1.00
10_N	32_V	1.529	1.00
89_I	125_V	1.528	1.00
155_D	288_R	1.507	1.00
30_A	73_M	1.503	1.00
245_F	268_E	1.486	1.00
262_R	285_P	1.485	1.00
161_L	164_P	1.459	1.00
53_I	77_L	1.436	1.00
274_T	292_L	1.434	1.00
223_I	229_L	1.426	1.00
173_G	176_R	1.425	1.00
37_D	91_Y	1.415	1.00
262_R	284_L	1.391	1.00
215_D	245_F	1.388	1.00
156_M	270_V	1.366	1.00
146_V	299_A	1.362	1.00
8_A	16_A	1.360	1.00
279_D	283_S	1.355	1.00
152_L	290_L	1.350	1.00
298_E	301_R	1.347	1.00
86_T	124_R	1.345	1.00
18_R	293_S	1.339	1.00
172_G	196_R	1.335	1.00
20_A	27_L	1.335	1.00
89_I	117_L	1.330	1.00
237_K	244_V	1.325	1.00
155_D	270_V	1.319	1.00
277_L	280_E	1.319	1.00
256_N	259_N	1.289	1.00
202_S	231_K	1.281	1.00
23_L	297_A	1.276	0.99
248_A	271_V	1.270	0.99
31_A	43_Q	1.264	0.99
160_N	163_N	1.262	0.99
48_V	77_L	1.261	0.99
172_G	194_K	1.257	0.99
15_L	19_I	1.256	0.99
167_V	190_A	1.239	0.99
261_L	269_V	1.228	0.99
301_R	307_E	1.220	0.99
14_E	17_Q	1.216	0.99
156_M	217_V	1.212	0.99
301_R	305_N	1.198	0.99
111_K	140_D	1.197	0.99
216_C	236_L	1.194	0.99
233_A	266_I	1.188	0.99
164_P	217_V	1.184	0.99
9_G	57_Q	1.177	0.99
167_V	236_L	1.174	0.99
22_R	294_G	1.173	0.99
33_G	41_S	1.169	0.99
111_K	115_D	1.165	0.99
20_A	26_S	1.163	0.99
44_I	77_L	1.158	0.99
277_L	287_V	1.149	0.99
18_R	291_T	1.142	0.99
75_D	79_R	1.131	0.99
237_K	265_V	1.123	0.99
62_P	65_D	1.118	0.99
10_N	34_R	1.103	0.99
226_G	260_N	1.099	0.98
12_T	58_S	1.096	0.98
218_L	232_A	1.092	0.98
98_D	134_Q	1.090	0.98
23_L	301_R	1.089	0.98
62_P	66_N	1.087	0.98
117_L	125_V	1.082	0.98
223_I	226_G	1.079	0.98
101_V	106_V	1.076	0.98
166_V	184_L	1.068	0.98
204_V	235_A	1.063	0.98
55_I	73_M	1.062	0.98
170_D	196_R	1.044	0.98
84_R	123_D	1.042	0.98
278_S	282_K	1.036	0.98
161_L	215_D	1.035	0.98
4_M	51_G	1.030	0.98
277_L	289_T	1.029	0.98
163_N	214_R	1.028	0.98
192_I	232_A	1.023	0.98
43_Q	106_V	1.023	0.98
212_A	239_R	1.020	0.98
84_R	306_E	1.014	0.97
165_I	216_C	1.008	0.97
170_D	194_K	1.007	0.97
110_A	135_I	1.007	0.97
41_S	106_V	1.006	0.97
251_P	277_L	1.001	0.97
8_A	11_A	1.001	0.97
36_S	224_D	1.000	0.97
153_L	180_I	0.998	0.97
152_L	247_Y	0.995	0.97
19_I	300_I	0.994	0.97
235_A	238_E	0.991	0.97
196_R	227_G	0.988	0.97
246_A	264_S	0.987	0.97
151_I	290_L	0.983	0.97
52_D	86_T	0.981	0.97
253_F	271_V	0.973	0.97
118_S	140_D	0.970	0.97
194_K	227_G	0.969	0.97
155_D	268_E	0.962	0.96
305_N	311_A	0.958	0.96
226_G	256_N	0.958	0.96
10_N	69_E	0.956	0.96
16_A	20_A	0.955	0.96
115_D	118_S	0.953	0.96
71_V	116_F	0.947	0.96
171_I	175_V	0.943	0.96
6_L	25_T	0.943	0.96
55_I	74_V	0.942	0.96
279_D	282_K	0.939	0.96
230_C	260_N	0.937	0.96
234_E	263_N	0.935	0.96
178_R	193_D	0.933	0.96
302_R	307_E	0.930	0.96
4_M	304_S	0.913	0.95
52_D	83_G	0.902	0.95
261_L	264_S	0.897	0.95
12_T	276_P	0.897	0.95
212_A	240_G	0.897	0.95
100_R	108_I	0.893	0.95
164_P	215_D	0.889	0.94
37_D	93_G	0.888	0.94
155_D	247_Y	0.887	0.94
9_G	73_M	0.886	0.94
7_F	73_M	0.885	0.94
155_D	290_L	0.884	0.94
34_R	40_V	0.883	0.94
233_A	265_V	0.883	0.94
156_M	245_F	0.880	0.94
269_V	287_V	0.877	0.94
184_L	187_T	0.874	0.94
130_L	145_N	0.872	0.94
248_A	251_P	0.868	0.94
199_A	202_S	0.867	0.94
44_I	73_M	0.863	0.94
10_N	13_P	0.860	0.93
307_E	311_A	0.860	0.93
166_V	180_I	0.858	0.93
172_G	227_G	0.857	0.93
128_V	295_M	0.856	0.93
200_N	224_D	0.853	0.93
71_V	120_V	0.853	0.93
179_A	182_K	0.852	0.93
280_E	283_S	0.848	0.93
39_E	97_Q	0.846	0.93
264_S	286_N	0.842	0.93
229_L	248_A	0.842	0.93
14_E	276_P	0.838	0.93
197_P	202_S	0.838	0.93
196_R	228_T	0.836	0.92
259_N	262_R	0.836	0.92
17_Q	27_L	0.835	0.92
60_C	275_I	0.834	0.92
39_E	222_M	0.834	0.92
36_S	255_G	0.829	0.92
163_N	242_K	0.828	0.92
261_L	284_L	0.824	0.92
234_E	237_K	0.823	0.92
230_C	234_E	0.817	0.92
85_I	123_D	0.815	0.91
102_R	106_V	0.813	0.91
294_G	297_A	0.813	0.91
235_A	239_R	0.807	0.91
241_A	244_V	0.805	0.91
129_D	176_R	0.800	0.91
194_K	202_S	0.797	0.91
155_D	159_L	0.796	0.91
152_L	272_C	0.794	0.90
169_P	228_T	0.794	0.90
70_L	117_L	0.794	0.90
252_I	275_I	0.791	0.90
8_A	12_T	0.789	0.90
180_I	219_V	0.789	0.90
59_T	62_P	0.787	0.90
87_A	122_V	0.786	0.90
197_P	201_V	0.786	0.90
216_C	244_V	0.784	0.90
37_D	99_R	0.784	0.90
148_G	152_L	0.782	0.90
22_R	298_E	0.781	0.90
112_V	116_F	0.781	0.90
29_D	46_E	0.768	0.89
43_Q	102_R	0.766	0.89
148_G	249_T	0.766	0.89
13_P	29_D	0.765	0.89
271_V	287_V	0.764	0.89
77_L	82_A	0.762	0.89
211_V	236_L	0.759	0.88
130_L	135_I	0.759	0.88
180_I	290_L	0.758	0.88
74_V	87_A	0.758	0.88
114_A	139_F	0.756	0.88
20_A	25_T	0.753	0.88
40_V	64_N	0.752	0.88
15_L	56_I	0.748	0.88
54_F	304_S	0.747	0.88
8_A	27_L	0.747	0.88
60_C	66_N	0.744	0.87
124_R	144_D	0.738	0.87
258_A	262_R	0.736	0.87
200_N	225_T	0.732	0.86
156_M	247_Y	0.727	0.86
8_A	13_P	0.726	0.86
164_P	214_R	0.725	0.86
118_S	141_V	0.724	0.86
223_I	271_V	0.723	0.86
154_E	157_L	0.721	0.86
170_D	221_D	0.717	0.85
67_L	71_V	0.717	0.85
174_V	191_I	0.717	0.85
197_P	203_Q	0.711	0.85
75_D	112_V	0.709	0.85
76_A	80_A	0.707	0.85
188_D	214_R	0.705	0.84
18_R	21_N	0.704	0.84
75_D	111_K	0.703	0.84
49_R	81_S	0.701	0.84
200_N	254_S	0.700	0.84
233_A	246_A	0.698	0.84
18_R	22_R	0.698	0.84
97_Q	222_M	0.697	0.84
32_V	42_V	0.695	0.84
191_I	208_I	0.694	0.83
197_P	204_V	0.693	0.83
72_V	112_V	0.693	0.83
98_D	196_R	0.690	0.83
233_A	264_S	0.690	0.83
216_C	241_A	0.690	0.83
211_V	241_A	0.689	0.83
269_V	284_L	0.688	0.83
258_A	284_L	0.686	0.83
230_C	233_A	0.684	0.83
162_D	215_D	0.684	0.83
10_N	30_A	0.684	0.83
71_V	112_V	0.683	0.82
149_S	180_I	0.683	0.82
59_T	70_L	0.681	0.82
160_N	215_D	0.680	0.82
262_R	286_N	0.678	0.82
122_V	141_V	0.676	0.82
163_N	215_D	0.670	0.81
273_D	292_L	0.670	0.81
223_I	253_F	0.670	0.81
199_A	227_G	0.667	0.81
84_R	304_S	0.666	0.81
4_M	25_T	0.666	0.81
156_M	180_I	0.665	0.81
147_F	179_A	0.663	0.81
74_V	120_V	0.663	0.81
292_L	296_L	0.661	0.80
6_L	23_L	0.659	0.80
41_S	102_R	0.659	0.80
193_D	206_H	0.651	0.79
148_G	272_C	0.649	0.79
22_R	293_S	0.647	0.79
75_D	115_D	0.645	0.79
7_F	30_A	0.644	0.79
89_I	93_G	0.643	0.78
218_L	266_I	0.642	0.78
9_G	171_I	0.642	0.78
265_V	286_N	0.642	0.78
24_Y	157_L	0.641	0.78
38_G	225_T	0.641	0.78
43_Q	223_I	0.640	0.78
131_H	221_D	0.639	0.78
299_A	309_I	0.637	0.78
178_R	195_R	0.637	0.78
49_R	54_F	0.636	0.78
5_K	28_G	0.635	0.78
130_L	143_V	0.631	0.77
271_V	289_T	0.629	0.77
258_A	287_V	0.629	0.77
168_S	172_G	0.628	0.77
107_P	112_V	0.623	0.76
7_F	48_V	0.623	0.76
197_P	200_N	0.623	0.76
92_F	95_A	0.622	0.76
74_V	82_A	0.617	0.76
28_G	46_E	0.616	0.75
172_G	228_T	0.616	0.75
237_K	243_R	0.610	0.75
20_A	23_L	0.610	0.75
36_S	200_N	0.610	0.75
147_F	153_L	0.609	0.75
193_D	208_I	0.606	0.74
100_R	105_R	0.601	0.74
309_I	312_M	0.600	0.74
11_A	57_Q	0.599	0.73
299_A	312_M	0.598	0.73
134_Q	137_G	0.597	0.73
270_V	290_L	0.596	0.73
233_A	237_K	0.596	0.73
44_I	48_V	0.594	0.73
47_N	51_G	0.592	0.73
196_R	202_S	0.592	0.73
96_R	224_D	0.592	0.73
237_K	241_A	0.590	0.72
285_P	288_R	0.587	0.72
40_V	69_E	0.586	0.72
102_R	198_R	0.585	0.72
165_I	211_V	0.585	0.72
262_R	265_V	0.582	0.71
269_V	286_N	0.581	0.71
170_D	227_G	0.580	0.71
302_R	311_A	0.579	0.71
203_Q	206_H	0.578	0.71
70_L	89_I	0.575	0.70
226_G	258_A	0.574	0.70
92_F	139_F	0.573	0.70
127_T	130_L	0.572	0.70
131_H	170_D	0.571	0.70
88_V	300_I	0.571	0.70
277_L	283_S	0.570	0.70
133_E	175_V	0.569	0.70
227_G	256_N	0.568	0.70
168_S	176_R	0.566	0.69
82_A	85_I	0.566	0.69
125_V	139_F	0.566	0.69
132_A	135_I	0.565	0.69
126_L	299_A	0.565	0.69
80_A	100_R	0.563	0.69
277_L	282_K	0.562	0.69
61_A	66_N	0.561	0.69
96_R	170_D	0.559	0.68
98_D	132_A	0.557	0.68
180_I	247_Y	0.556	0.68
78_R	85_I	0.554	0.68
9_G	12_T	0.553	0.67
97_Q	109_T	0.552	0.67
127_T	145_N	0.552	0.67
42_V	73_M	0.552	0.67
171_I	189_M	0.551	0.67
293_S	297_A	0.551	0.67
303_I	309_I	0.548	0.67
173_G	177_A	0.548	0.67
308_S	311_A	0.547	0.67
247_Y	270_V	0.547	0.67
248_A	269_V	0.546	0.66
122_V	125_V	0.542	0.66
151_I	273_D	0.542	0.66
5_K	46_E	0.541	0.66
178_R	182_K	0.539	0.66
112_V	115_D	0.538	0.65
49_R	209_G	0.537	0.65
194_K	228_T	0.536	0.65
169_P	194_K	0.535	0.65
128_V	146_V	0.535	0.65
98_D	131_H	0.534	0.65
8_A	30_A	0.534	0.65
179_A	183_L	0.533	0.65
282_K	287_V	0.533	0.65
38_G	222_M	0.533	0.65
226_G	246_A	0.533	0.65
294_G	298_E	0.531	0.64
177_A	189_M	0.529	0.64
84_R	126_L	0.528	0.64
98_D	170_D	0.527	0.64
53_I	82_A	0.527	0.64
151_I	295_M	0.526	0.64
92_F	110_A	0.526	0.64
216_C	247_Y	0.525	0.63
295_M	312_M	0.524	0.63
31_A	41_S	0.522	0.63
64_N	68_M	0.521	0.63
49_R	144_D	0.521	0.63
165_I	190_A	0.520	0.63
86_T	126_L	0.520	0.63
174_V	178_R	0.520	0.63
6_L	28_G	0.519	0.63
134_Q	138_F	0.517	0.62
59_T	67_L	0.516	0.62
233_A	244_V	0.514	0.62
22_R	301_R	0.514	0.62
49_R	105_R	0.514	0.62
56_I	88_V	0.513	0.62
64_N	72_V	0.513	0.62
19_I	296_L	0.511	0.61
98_D	194_K	0.509	0.61
243_R	285_P	0.508	0.61
39_E	94_Y	0.508	0.61
78_R	123_D	0.506	0.61
247_Y	290_L	0.506	0.61
190_A	216_C	0.506	0.61
87_A	125_V	0.506	0.61
226_G	284_L	0.506	0.61
302_R	312_M	0.505	0.61
154_E	294_G	0.504	0.60
70_L	88_V	0.504	0.60
145_N	175_V	0.502	0.60
192_I	235_A	0.501	0.60
190_A	207_I	0.501	0.60
58_S	93_G	0.501	0.60
101_V	109_T	0.500	0.60
63_T	66_N	0.500	0.60
230_C	264_S	0.500	0.60

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2ji4A	5	0.9302	100	0.139	Contact Map
3s5jB	2	0.9651	100	0.142	Contact Map
1dkuA	5	0.9365	100	0.148	Contact Map
3dahA	5	0.9619	100	0.163	Contact Map
4twbA	2	0.8825	100	0.203	Contact Map
1u9yA	3	0.8698	100	0.234	Contact Map
3lrtA	2	0.9079	100	0.237	Contact Map
3dezA	2	0.6095	100	0.705	Contact Map
1o57A	2	0.7841	99.9	0.731	Contact Map
3m3hA	2	0.5556	99.9	0.754	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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