GREMLIN Database
KDSA - 2-dehydro-3-deoxyphosphooctonate aldolase
UniProt: P0A715 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10518
Length: 284 (246)
Sequences: 3184 (1524)
Seq/√Len: 97.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
243_D246_H5.3751.00
31_R83_E4.9791.00
114_L128_M3.3801.00
47_K261_E3.2051.00
111_V164_I3.0181.00
197_I235_G2.8031.00
21_L264_L2.7541.00
82_Q86_Q2.6831.00
94_T109_V2.5141.00
137_V155_F2.4601.00
76_E79_K2.4591.00
37_I242_P2.3751.00
215_G224_L2.3221.00
156_K163_V2.2551.00
226_R266_Q2.2161.00
189_K219_A2.1821.00
34_A80_I2.0821.00
100_S127_A2.0711.00
58_F101_Q2.0461.00
218_R245_E2.0291.00
270_I274_V1.9811.00
22_F93_I1.9261.00
35_M88_F1.9251.00
119_A143_V1.9221.00
251_G254_A1.9131.00
30_S33_L1.8851.00
129_A158_G1.8431.00
148_M187_M1.8281.00
218_R259_K1.8131.00
270_I273_L1.8081.00
94_T105_V1.8021.00
105_V109_V1.8011.00
96_V102_A1.8001.00
39_E87_T1.7891.00
82_Q85_K1.7801.00
125_V155_F1.7781.00
271_D275_K1.7661.00
181_M224_L1.7321.00
52_Y111_V1.6901.00
41_Y50_I1.6681.00
40_H258_A1.6421.00
83_E87_T1.6231.00
75_E104_P1.6081.00
35_M87_T1.5811.00
53_V111_V1.5651.00
19_F229_M1.5611.00
96_V112_I1.5581.00
156_K194_S1.5511.00
19_F271_D1.5481.00
222_A266_Q1.5191.00
256_P259_K1.5181.00
48_L261_E1.4971.00
85_K92_I1.4921.00
36_R39_E1.4921.00
41_Y260_L1.4911.00
99_P102_A1.4811.00
39_E88_F1.4681.00
102_A131_T1.4361.00
23_G240_A1.4201.00
155_F160_N1.4141.00
186_I220_Q1.4000.99
163_V194_S1.3980.99
184_F198_F1.3920.99
31_R35_M1.3590.99
132_G162_K1.3510.99
101_Q123_D1.3510.99
41_Y52_Y1.3470.99
85_K88_F1.3380.99
261_E265_K1.3370.99
33_L242_P1.3360.99
35_M84_L1.3330.99
198_F224_L1.3260.99
179_V198_F1.3180.99
152_V165_L1.3130.99
79_K108_V1.3010.99
187_M196_V1.2990.99
13_V20_V1.2980.99
80_I84_L1.2790.99
126_E158_G1.2720.99
104_P108_V1.2580.99
225_A267_M1.2470.99
32_D36_R1.2470.99
130_K158_G1.2460.99
97_H123_D1.2410.99
145_P183_G1.2250.99
269_A273_L1.2190.99
218_R256_P1.2180.99
36_R242_P1.2130.98
146_G175_D1.1990.98
35_M39_E1.1990.98
85_K108_V1.1760.98
34_A84_L1.1700.98
28_L81_F1.1610.98
33_L37_I1.1560.98
203_A215_G1.1540.98
79_K82_Q1.1370.98
82_Q108_V1.1360.98
42_V88_F1.1290.98
98_E123_D1.1200.97
104_P107_D1.1190.97
30_S248_K1.1140.97
188_K234_A1.1080.97
35_M83_E1.1040.97
144_S147_Q1.0940.97
238_I260_L1.0850.97
238_I263_F1.0830.97
240_A260_L1.0740.97
51_P91_K1.0710.97
83_E86_Q1.0670.97
92_I109_V1.0640.97
167_D170_A1.0630.96
52_Y90_V1.0540.96
262_P266_Q1.0530.96
56_A59_D1.0480.96
170_A183_G1.0480.96
72_P77_G1.0400.96
22_F197_I1.0370.96
42_V90_V1.0340.96
128_M135_I1.0310.96
135_I155_F1.0040.95
103_Q107_D1.0020.95
38_C90_V1.0020.95
255_L263_F0.9990.95
152_V194_S0.9980.95
198_F228_G0.9980.95
217_R220_Q0.9930.95
152_V156_K0.9860.95
26_N249_C0.9850.95
11_I20_V0.9810.95
13_V111_V0.9770.94
75_E79_K0.9740.94
54_F59_D0.9730.94
153_D156_K0.9720.94
184_F233_L0.9670.94
55_K59_D0.9660.94
268_K272_D0.9640.94
184_F231_V0.9590.94
260_L264_L0.9550.94
156_K161_E0.9550.94
143_V151_I0.9480.93
37_I54_F0.9460.93
28_L34_A0.9400.93
153_D157_E0.9350.93
126_E130_K0.9350.93
127_A130_K0.9340.93
148_M151_I0.9320.93
37_I56_A0.9290.93
81_F92_I0.9230.93
59_D70_R0.9210.92
93_I136_N0.9210.92
269_A272_D0.9200.92
22_F52_Y0.9200.92
37_I40_H0.9180.92
262_P265_K0.9160.92
226_R267_M0.9130.92
67_H153_D0.9120.92
129_A155_F0.9100.92
99_P123_D0.9100.92
37_I257_L0.9020.92
182_L203_A0.8960.91
229_M236_L0.8960.91
85_K91_K0.8960.91
77_G81_F0.8950.91
203_A224_L0.8870.91
128_M131_T0.8830.91
31_R80_I0.8700.90
40_H257_L0.8690.90
42_V89_G0.8680.90
229_M267_M0.8660.90
15_N234_A0.8660.90
134_V162_K0.8630.90
224_L231_V0.8630.90
230_A270_I0.8630.90
28_L80_I0.8480.89
16_D234_A0.8440.89
70_R126_E0.8440.89
106_A112_I0.8430.89
97_H101_Q0.8390.88
11_I51_P0.8330.88
111_V134_V0.8300.88
266_Q269_A0.8290.88
174_Y186_I0.8280.88
32_D39_E0.8190.87
221_V255_L0.8100.87
54_F58_F0.8080.87
119_A140_P0.8070.86
84_L88_F0.8040.86
72_P80_I0.7980.86
93_I111_V0.7970.86
38_C88_F0.7970.86
96_V114_L0.7960.86
54_F57_S0.7950.86
13_V52_Y0.7930.85
55_K58_F0.7930.85
38_C81_F0.7820.85
21_L50_I0.7760.84
27_V69_Y0.7750.84
247_A251_G0.7750.84
179_V184_F0.7740.84
98_E101_Q0.7710.84
50_I264_L0.7700.84
102_A128_M0.7670.84
240_A254_A0.7660.83
225_A263_F0.7660.83
234_A275_K0.7630.83
126_E157_E0.7620.83
259_K262_P0.7600.83
248_K254_A0.7590.83
106_A131_T0.7580.83
67_H157_E0.7520.82
142_F177_L0.7430.82
52_Y93_I0.7420.81
52_Y91_K0.7380.81
100_S103_Q0.7350.81
96_V128_M0.7340.81
66_I158_G0.7290.80
20_V51_P0.7290.80
137_V151_I0.7280.80
155_F163_V0.7250.80
129_A157_E0.7230.80
106_A132_G0.7230.80
85_K110_D0.7220.80
20_V235_G0.7180.79
134_V166_C0.7170.79
22_F53_V0.7160.79
242_P257_L0.7160.79
152_V163_V0.7160.79
42_V87_T0.7130.79
13_V53_V0.7090.78
226_R270_I0.7090.78
81_F84_L0.7080.78
225_A236_L0.7050.78
145_P186_I0.7020.78
75_E107_D0.6970.77
96_V105_V0.6960.77
116_A141_Q0.6900.77
200_V225_A0.6890.76
102_A106_A0.6880.76
76_E80_I0.6880.76
13_V22_F0.6830.76
69_Y72_P0.6820.76
103_Q127_A0.6760.75
123_D127_A0.6750.75
226_R231_V0.6730.75
123_D126_E0.6710.75
75_E108_V0.6690.74
9_G91_K0.6690.74
249_C254_A0.6680.74
52_Y56_A0.6650.74
153_D194_S0.6650.74
146_G150_N0.6640.74
110_D133_A0.6640.74
80_I83_E0.6620.74
136_N237_F0.6610.73
36_R40_H0.6590.73
13_V235_G0.6570.73
40_H261_E0.6570.73
28_L56_A0.6560.73
116_A249_C0.6530.73
125_V129_A0.6500.72
103_Q130_K0.6500.72
118_L124_L0.6480.72
263_F267_M0.6480.72
99_P127_A0.6450.72
66_I157_E0.6450.72
27_V56_A0.6400.71
236_L267_M0.6390.71
19_F275_K0.6370.71
141_Q177_L0.6350.70
18_P51_P0.6340.70
34_A54_F0.6330.70
227_A231_V0.6300.70
72_P76_E0.6260.69
106_A109_V0.6250.69
78_M105_V0.6230.69
101_Q104_P0.6210.69
66_I126_E0.6180.68
12_N18_P0.6180.68
22_F235_G0.6140.68
70_R123_D0.6130.68
182_L185_S0.6130.68
31_R84_L0.6110.68
136_N164_I0.6100.67
147_Q176_N0.6060.67
174_Y190_V0.6060.67
112_I128_M0.6050.67
48_L257_L0.6050.67
218_R221_V0.6050.67
40_H48_L0.6030.67
174_Y177_L0.6010.66
69_Y248_K0.5950.65
53_V84_L0.5940.65
147_Q175_D0.5940.65
128_M158_G0.5920.65
102_A127_A0.5900.65
112_I131_T0.5900.65
27_V249_C0.5890.65
73_G123_D0.5890.65
135_I166_C0.5870.64
215_G220_Q0.5870.64
36_R243_D0.5870.64
221_V263_F0.5860.64
148_M165_L0.5850.64
35_M85_K0.5770.63
9_G85_K0.5740.63
85_K89_G0.5720.62
56_A77_G0.5710.62
116_A237_F0.5690.62
109_V112_I0.5690.62
19_F51_P0.5660.62
125_V128_M0.5660.62
170_A178_V0.5630.61
234_A271_D0.5630.61
179_V224_L0.5610.61
34_A53_V0.5610.61
59_D77_G0.5610.61
200_V228_G0.5610.61
86_Q108_V0.5600.61
15_N18_P0.5600.61
22_F136_N0.5580.61
255_L259_K0.5570.60
30_S34_A0.5540.60
66_I153_D0.5530.60
133_A162_K0.5530.60
186_I217_R0.5510.60
141_Q172_F0.5510.60
107_D133_A0.5510.60
164_I197_I0.5500.59
149_G153_D0.5490.59
167_D183_G0.5490.59
27_V68_S0.5470.59
31_R79_K0.5460.59
136_N166_C0.5370.58
185_S223_E0.5370.58
22_F111_V0.5360.58
221_V238_I0.5350.57
33_L36_R0.5350.57
149_G189_K0.5320.57
268_K271_D0.5320.57
27_V72_P0.5310.57
15_N20_V0.5290.57
28_L77_G0.5290.57
28_L249_C0.5260.56
33_L248_K0.5250.56
51_P260_L0.5240.56
41_Y90_V0.5220.56
159_G163_V0.5220.56
185_S188_K0.5200.55
63_R202_H0.5200.55
181_M198_F0.5190.55
19_F50_I0.5190.55
20_V197_I0.5150.55
131_T158_G0.5130.54
58_F105_V0.5120.54
67_H193_N0.5120.54
28_L84_L0.5110.54
10_D13_V0.5110.54
145_P174_Y0.5110.54
229_M270_I0.5100.54
176_N179_V0.5090.54
114_L124_L0.5090.54
222_A238_I0.5040.53
84_L90_V0.5020.53
186_I190_V0.5020.53
220_Q223_E0.5010.53
229_M233_L0.5010.53
92_I134_V0.5010.53
21_L260_L0.5000.52
53_V134_V0.5000.52
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4lu0A 4 0.9049 100 0.319 Contact Map
3tmlA 4 0.912 100 0.323 Contact Map
2qkfA 4 0.9155 100 0.325 Contact Map
3sz8A 4 0.9331 100 0.328 Contact Map
1o60A 4 0.9437 100 0.33 Contact Map
3fs2A 4 0.9085 100 0.332 Contact Map
1vr6A 4 0.912 100 0.357 Contact Map
2nwrA 4 0.8979 100 0.36 Contact Map
3nvtA 4 0.8944 100 0.384 Contact Map
4c1lA 4 0.8908 100 0.405 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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