GREMLIN Database
KDGT - 2-keto-3-deoxygluconate permease
UniProt: P0A712 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11869
Length: 327 (307)
Sequences: 346 (216)
Seq/√Len: 12.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
261_S302_V4.1321.00
5_R190_E3.9460.99
10_I17_V3.7420.99
124_G206_F3.6630.99
245_D253_G3.5370.99
60_A195_F3.2120.97
89_A115_V3.2020.97
121_T148_E3.1990.97
124_G207_A3.1860.97
300_I304_I3.1420.97
169_H172_V3.0160.96
120_M148_E2.9940.96
262_S266_A2.8430.95
198_A201_T2.5970.91
56_F195_F2.5220.90
80_T244_A2.4710.89
13_G188_D2.4560.89
229_L290_L2.3070.85
85_A119_D2.3000.85
92_A114_L2.2740.84
179_L183_A2.2530.84
4_K8_E2.2280.83
203_I268_A2.2130.83
55_F273_I2.2040.82
12_G124_G2.2000.82
180_V316_R2.1720.82
107_A290_L2.1620.81
76_T175_V2.1560.81
23_A215_D2.1280.80
56_F180_V2.1060.79
233_V294_A2.0480.77
243_I247_L2.0470.77
120_M265_A1.9740.75
121_T149_S1.9670.74
255_A260_S1.9310.73
245_D255_A1.9150.72
41_N45_T1.8400.69
152_L167_E1.8240.68
234_I305_L1.8200.68
52_A275_E1.8190.68
44_I173_G1.8060.68
50_I53_V1.8020.68
56_F175_V1.7750.66
202_L205_F1.7650.66
121_T145_M1.6690.61
12_G207_A1.6680.61
190_E193_E1.5960.58
60_A278_P1.5900.57
155_M273_I1.5870.57
4_K14_M1.5750.57
228_L231_V1.5550.56
56_F227_I1.5410.55
56_F68_G1.5380.55
7_I17_V1.5380.55
24_L91_I1.5350.55
124_G210_L1.5350.55
231_V294_A1.5220.54
12_G125_L1.5000.53
85_A97_P1.4680.51
253_G260_S1.4430.50
215_D227_I1.4250.49
33_G41_N1.4230.49
153_M156_I1.4080.48
219_I296_I1.4060.48
215_D218_V1.3940.48
15_M264_G1.3920.47
53_V205_F1.3900.47
45_T51_L1.3900.47
242_I260_S1.3900.47
150_G162_G1.3890.47
25_C221_Q1.3840.47
16_L89_A1.3790.47
56_F220_A1.3720.46
237_T240_P1.3660.46
44_I296_I1.3430.45
291_V294_A1.3430.45
257_I309_W1.3420.45
43_M116_A1.3350.45
245_D261_S1.3120.43
120_M266_A1.3110.43
72_R260_S1.3040.43
153_M265_A1.3000.43
29_S231_V1.2980.43
15_M204_P1.2910.42
83_A115_V1.2870.42
171_F175_V1.2860.42
34_K41_N1.2820.42
144_L296_I1.2740.42
84_V215_D1.2690.41
171_F237_T1.2690.41
193_E197_K1.2660.41
123_G149_S1.2660.41
116_A207_A1.2630.41
33_G290_L1.2620.41
225_L297_V1.2600.41
230_G234_I1.2560.41
127_A269_T1.2560.41
23_A114_L1.2330.39
180_V197_K1.2290.39
225_L290_L1.2260.39
232_A295_V1.2260.39
36_F172_V1.2180.39
63_K189_P1.2180.39
236_V311_R1.2150.39
116_A269_T1.2110.38
135_T138_E1.1840.37
52_A116_A1.1740.37
4_K7_I1.1730.37
22_G124_G1.1720.37
128_S194_F1.1670.36
242_I255_A1.1630.36
227_I283_M1.1620.36
24_L32_A1.1600.36
120_M149_S1.1500.36
3_I182_F1.1440.35
3_I13_G1.1430.35
5_R300_I1.1430.35
47_T222_T1.1410.35
78_V86_W1.1340.35
9_K175_V1.1250.34
111_T253_G1.1200.34
31_G215_D1.1200.34
14_M128_S1.1120.34
175_V228_L1.1040.33
44_I175_V1.1040.33
221_Q247_L1.1010.33
118_M237_T1.0950.33
261_S278_P1.0930.33
9_K305_L1.0920.33
63_K231_V1.0920.33
179_L217_T1.0900.33
158_L273_I1.0880.33
95_I308_I1.0830.32
223_G256_G1.0780.32
97_P100_G1.0690.32
154_T273_I1.0660.32
267_V294_A1.0630.32
62_I127_A1.0610.32
19_L208_F1.0590.31
78_V127_A1.0590.31
16_L74_S1.0560.31
114_L126_Y1.0540.31
20_F83_A1.0530.31
220_A307_S1.0420.31
57_C198_A1.0390.31
54_W74_S1.0310.30
121_T259_A1.0290.30
71_L83_A1.0280.30
302_V306_T1.0280.30
160_T215_D1.0260.30
156_I160_T1.0260.30
52_A124_G1.0250.30
184_L191_L1.0230.30
310_S314_K1.0220.30
115_V295_V1.0200.30
3_I187_L1.0190.30
204_P264_G1.0190.30
7_I228_L1.0140.29
90_A171_F1.0050.29
123_G297_V1.0030.29
92_A156_I1.0030.29
82_I157_I1.0020.29
107_A225_L0.9990.29
183_A227_I0.9970.29
9_K193_E0.9780.28
56_F60_A0.9760.28
130_M255_A0.9750.28
84_V235_I0.9740.28
8_E190_E0.9690.28
272_L275_E0.9650.27
117_A229_L0.9630.27
154_T233_V0.9630.27
206_F210_L0.9630.27
55_F257_I0.9580.27
150_G238_G0.9540.27
83_A296_I0.9520.27
97_P265_A0.9520.27
96_I107_A0.9510.27
73_K254_T0.9460.27
245_D260_S0.9440.27
44_I133_Y0.9410.26
130_M260_S0.9410.26
89_A154_T0.9380.26
145_M157_I0.9370.26
41_N277_V0.9340.26
123_G230_G0.9330.26
112_L183_A0.9300.26
227_I235_I0.9280.26
87_V91_I0.9190.26
159_G167_E0.9190.26
16_L174_A0.9130.25
67_T269_T0.9130.25
273_I293_T0.9130.25
26_H212_N0.9130.25
9_K228_L0.9110.25
171_F304_I0.9070.25
15_M123_G0.9020.25
160_T273_I0.8990.25
10_I278_P0.8980.25
153_M215_D0.8940.25
249_G253_G0.8930.25
22_G208_F0.8840.24
180_V301_L0.8830.24
225_L300_I0.8820.24
197_K228_L0.8790.24
156_I170_V0.8750.24
82_I280_F0.8720.24
89_A114_L0.8710.24
130_M159_G0.8690.24
29_S91_I0.8680.24
23_A27_T0.8660.24
172_V179_L0.8590.23
24_L219_I0.8560.23
189_P201_T0.8520.23
232_A235_I0.8500.23
9_K65_S0.8480.23
77_L166_F0.8460.23
29_S179_L0.8410.23
232_A236_V0.8400.23
147_L190_E0.8400.23
117_A190_E0.8330.22
25_C219_I0.8320.22
110_S147_L0.8310.22
61_S133_Y0.8300.22
219_I293_T0.8250.22
115_V233_V0.8240.22
32_A172_V0.8210.22
40_T223_G0.8200.22
91_I228_L0.8200.22
14_M191_L0.8190.22
116_A175_V0.8190.22
96_I231_V0.8180.22
135_T166_F0.8180.22
182_F280_F0.8160.22
138_E290_L0.8090.22
49_P175_V0.8070.22
30_P223_G0.8020.21
23_A125_L0.7990.21
76_T91_I0.7970.21
39_F150_G0.7930.21
210_L293_T0.7920.21
89_A157_I0.7870.21
112_L288_T0.7870.21
223_G293_T0.7850.21
47_T210_L0.7840.21
91_I96_I0.7750.20
123_G152_L0.7730.20
12_G269_T0.7720.20
15_M210_L0.7700.20
19_L206_F0.7700.20
27_T129_I0.7700.20
15_M159_G0.7640.20
97_P135_T0.7560.20
95_I227_I0.7550.20
278_P300_I0.7520.20
25_C32_A0.7520.20
138_E265_A0.7510.20
70_V110_S0.7490.20
16_L233_V0.7470.20
110_S280_F0.7460.19
118_M252_D0.7450.19
85_A259_A0.7430.19
83_A87_V0.7340.19
148_E233_V0.7300.19
166_F277_V0.7270.19
157_I178_F0.7260.19
76_T80_T0.7260.19
150_G288_T0.7240.19
15_M19_L0.7230.19
76_T248_I0.7220.19
47_T203_I0.7210.19
77_L145_M0.7150.19
12_G206_F0.7120.18
184_L189_P0.7120.18
195_F198_A0.7100.18
158_L209_A0.7050.18
64_L182_F0.7030.18
44_I212_N0.7030.18
13_G190_E0.6990.18
54_W144_L0.6980.18
19_L207_A0.6970.18
31_G34_K0.6940.18
306_T313_V0.6930.18
16_L138_E0.6890.18
72_R253_G0.6890.18
136_K236_V0.6880.18
191_L195_F0.6870.18
51_L276_M0.6870.18
36_F173_G0.6840.18
143_V178_F0.6820.18
51_L124_G0.6800.17
162_G238_G0.6790.17
114_L213_T0.6740.17
113_A204_P0.6730.17
162_G256_G0.6730.17
20_F64_L0.6720.17
31_G171_F0.6710.17
47_T128_S0.6710.17
74_S126_Y0.6710.17
21_L208_F0.6700.17
79_V246_K0.6690.17
29_S281_K0.6680.17
237_T241_L0.6660.17
106_F180_V0.6660.17
87_V304_I0.6650.17
145_M149_S0.6620.17
36_F40_T0.6610.17
7_I191_L0.6610.17
172_V175_V0.6580.17
17_V180_V0.6570.17
214_I295_V0.6570.17
73_K252_D0.6560.17
14_M116_A0.6540.17
228_L243_I0.6510.17
93_S167_E0.6500.17
73_K146_S0.6490.17
9_K28_F0.6490.17
68_G237_T0.6470.17
207_A210_L0.6450.16
22_G203_I0.6450.16
57_C60_A0.6430.16
38_S293_T0.6430.16
73_K245_D0.6420.16
43_M128_S0.6410.16
19_L67_T0.6410.16
224_L228_L0.6380.16
21_L111_T0.6370.16
33_G36_F0.6350.16
304_I311_R0.6350.16
49_P141_A0.6340.16
267_V289_S0.6340.16
73_K137_E0.6340.16
9_K217_T0.6330.16
199_V210_L0.6280.16
150_G154_T0.6270.16
24_L183_A0.6270.16
5_R147_L0.6250.16
41_N269_T0.6220.16
22_G150_G0.6210.16
7_I252_D0.6200.16
32_A36_F0.6200.16
65_S156_I0.6180.16
224_L235_I0.6180.16
150_G230_G0.6160.16
242_I309_W0.6160.16
126_Y141_A0.6150.16
67_T222_T0.6140.16
47_T207_A0.6140.16
22_G140_G0.6140.16
93_S111_T0.6080.15
146_S192_R0.6060.15
69_T178_F0.6060.15
95_I244_A0.6060.15
109_L114_L0.6050.15
298_T306_T0.6050.15
138_E173_G0.6040.15
260_S306_T0.6030.15
161_A248_I0.6030.15
216_L234_I0.5990.15
254_T261_S0.5990.15
203_I206_F0.5990.15
32_A307_S0.5960.15
175_V217_T0.5960.15
74_S154_T0.5950.15
125_L141_A0.5910.15
28_F220_A0.5910.15
282_P285_P0.5900.15
193_E300_I0.5880.15
57_C178_F0.5880.15
60_A182_F0.5870.15
219_I289_S0.5870.15
149_S265_A0.5860.15
149_S157_I0.5850.15
245_D256_G0.5840.15
179_L224_L0.5830.15
225_L307_S0.5810.15
71_L284_A0.5800.15
10_I129_I0.5800.15
56_F184_L0.5790.15
16_L85_A0.5740.15
80_T240_P0.5720.15
64_L183_A0.5710.14
114_L229_L0.5700.14
95_I99_H0.5690.14
219_I307_S0.5670.14
274_A284_A0.5670.14
296_I301_L0.5660.14
7_I115_V0.5660.14
37_G134_G0.5650.14
144_L192_R0.5640.14
10_I304_I0.5640.14
65_S94_R0.5630.14
142_F269_T0.5620.14
221_Q231_V0.5620.14
163_I167_E0.5620.14
64_L91_I0.5620.14
63_K234_I0.5620.14
17_V291_V0.5600.14
172_V183_A0.5590.14
162_G230_G0.5580.14
17_V25_C0.5580.14
275_E298_T0.5580.14
65_S190_E0.5570.14
8_E14_M0.5570.14
17_V77_L0.5560.14
123_G167_E0.5540.14
74_S119_D0.5530.14
214_I218_V0.5520.14
124_G241_L0.5520.14
14_M310_S0.5520.14
20_F201_T0.5520.14
106_F190_E0.5510.14
246_K312_K0.5510.14
67_T207_A0.5490.14
166_F296_I0.5480.14
237_T260_S0.5440.14
257_I269_T0.5440.14
227_I308_I0.5430.14
200_Q222_T0.5420.14
236_V316_R0.5420.14
112_L276_M0.5410.14
176_L224_L0.5410.14
49_P53_V0.5400.14
34_K87_V0.5390.14
173_G252_D0.5370.14
72_R245_D0.5350.14
19_L162_G0.5350.14
23_A314_K0.5350.14
28_F277_V0.5330.14
68_G170_V0.5310.14
191_L249_G0.5300.13
51_L195_F0.5290.13
109_L154_T0.5290.13
67_T147_L0.5290.13
150_G256_G0.5290.13
41_N279_A0.5280.13
128_S299_S0.5270.13
41_N290_L0.5270.13
129_I306_T0.5250.13
41_N225_L0.5250.13
90_A279_A0.5240.13
40_T299_S0.5240.13
162_G167_E0.5220.13
38_S173_G0.5200.13
79_V315_A0.5180.13
224_L299_S0.5170.13
20_F61_S0.5170.13
86_W282_P0.5150.13
119_D168_P0.5120.13
120_M267_V0.5120.13
245_D249_G0.5110.13
46_G55_F0.5100.13
163_I305_L0.5100.13
58_M131_Q0.5090.13
79_V193_E0.5070.13
112_L268_A0.5070.13
172_V316_R0.5070.13
230_G293_T0.5050.13
174_A291_V0.5030.13
133_Y156_I0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zuxA 1 0.8746 99.9 0.797 Contact Map
4n7wA 2 0.8807 99.6 0.868 Contact Map
4bwzA 2 0.9235 98.4 0.919 Contact Map
4czbA 2 0.9235 97.9 0.93 Contact Map
4cz8A 2 0.8991 97.3 0.938 Contact Map
1zcdA 1 0.9021 89.4 0.958 Contact Map
4huqS 1 0.4618 45.1 0.971 Contact Map
4rfsS 1 0.4832 35.5 0.972 Contact Map
3qnqA 2 0.4587 31.2 0.973 Contact Map
2kv5A 1 0.0887 27.2 0.974 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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