KDGT - ECOLI - GREMLIN Contacts

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KDGT - 2-keto-3-deoxygluconate permease

UniProt:	P0A712	Sequences: MQIKRSIEKIPGGMMLVPLFLGALCHTFSPGAGKYFGSFTNGMITGTVPILAVWFFCMGASIKLSATGTVLRKSGTLVVTKIAVAWVVAAIASRIIPEHGVEVGFFAGLSTLALVAAMDMTNGGLYASIMQQYGTKEEAGAFVLMSLESGPLMTMIILGTAGIASFEPHVFVGAVLPFLVGFALGNLDPELREFFSKAVQTLIPFFAFALGNTIDLTVIAQTGLLGILLGVAVIIVTGIPLIIADKLIGGGDGTAGIAASSSAGAAVATPVLIAEMVPAFKPMAPAATSLVATAVIVTSILVPILTSIWSRKVKARAAKIEILGTVK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11869
Length:	327 (307)
Sequences:	346 (216)
Seq/√Len:	12.3

ECOLI - KDGT
BACSU - KDGT

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
261_S	302_V	4.132	1.00
5_R	190_E	3.946	0.99
10_I	17_V	3.742	0.99
124_G	206_F	3.663	0.99
245_D	253_G	3.537	0.99
60_A	195_F	3.212	0.97
89_A	115_V	3.202	0.97
121_T	148_E	3.199	0.97
124_G	207_A	3.186	0.97
300_I	304_I	3.142	0.97
169_H	172_V	3.016	0.96
120_M	148_E	2.994	0.96
262_S	266_A	2.843	0.95
198_A	201_T	2.597	0.91
56_F	195_F	2.522	0.90
80_T	244_A	2.471	0.89
13_G	188_D	2.456	0.89
229_L	290_L	2.307	0.85
85_A	119_D	2.300	0.85
92_A	114_L	2.274	0.84
179_L	183_A	2.253	0.84
4_K	8_E	2.228	0.83
203_I	268_A	2.213	0.83
55_F	273_I	2.204	0.82
12_G	124_G	2.200	0.82
180_V	316_R	2.172	0.82
107_A	290_L	2.162	0.81
76_T	175_V	2.156	0.81
23_A	215_D	2.128	0.80
56_F	180_V	2.106	0.79
233_V	294_A	2.048	0.77
243_I	247_L	2.047	0.77
120_M	265_A	1.974	0.75
121_T	149_S	1.967	0.74
255_A	260_S	1.931	0.73
245_D	255_A	1.915	0.72
41_N	45_T	1.840	0.69
152_L	167_E	1.824	0.68
234_I	305_L	1.820	0.68
52_A	275_E	1.819	0.68
44_I	173_G	1.806	0.68
50_I	53_V	1.802	0.68
56_F	175_V	1.775	0.66
202_L	205_F	1.765	0.66
121_T	145_M	1.669	0.61
12_G	207_A	1.668	0.61
190_E	193_E	1.596	0.58
60_A	278_P	1.590	0.57
155_M	273_I	1.587	0.57
4_K	14_M	1.575	0.57
228_L	231_V	1.555	0.56
56_F	227_I	1.541	0.55
56_F	68_G	1.538	0.55
7_I	17_V	1.538	0.55
24_L	91_I	1.535	0.55
124_G	210_L	1.535	0.55
231_V	294_A	1.522	0.54
12_G	125_L	1.500	0.53
85_A	97_P	1.468	0.51
253_G	260_S	1.443	0.50
215_D	227_I	1.425	0.49
33_G	41_N	1.423	0.49
153_M	156_I	1.408	0.48
219_I	296_I	1.406	0.48
215_D	218_V	1.394	0.48
15_M	264_G	1.392	0.47
53_V	205_F	1.390	0.47
45_T	51_L	1.390	0.47
242_I	260_S	1.390	0.47
150_G	162_G	1.389	0.47
25_C	221_Q	1.384	0.47
16_L	89_A	1.379	0.47
56_F	220_A	1.372	0.46
237_T	240_P	1.366	0.46
44_I	296_I	1.343	0.45
291_V	294_A	1.343	0.45
257_I	309_W	1.342	0.45
43_M	116_A	1.335	0.45
245_D	261_S	1.312	0.43
120_M	266_A	1.311	0.43
72_R	260_S	1.304	0.43
153_M	265_A	1.300	0.43
29_S	231_V	1.298	0.43
15_M	204_P	1.291	0.42
83_A	115_V	1.287	0.42
171_F	175_V	1.286	0.42
34_K	41_N	1.282	0.42
144_L	296_I	1.274	0.42
84_V	215_D	1.269	0.41
171_F	237_T	1.269	0.41
193_E	197_K	1.266	0.41
123_G	149_S	1.266	0.41
116_A	207_A	1.263	0.41
33_G	290_L	1.262	0.41
225_L	297_V	1.260	0.41
230_G	234_I	1.256	0.41
127_A	269_T	1.256	0.41
23_A	114_L	1.233	0.39
180_V	197_K	1.229	0.39
225_L	290_L	1.226	0.39
232_A	295_V	1.226	0.39
36_F	172_V	1.218	0.39
63_K	189_P	1.218	0.39
236_V	311_R	1.215	0.39
116_A	269_T	1.211	0.38
135_T	138_E	1.184	0.37
52_A	116_A	1.174	0.37
4_K	7_I	1.173	0.37
22_G	124_G	1.172	0.37
128_S	194_F	1.167	0.36
242_I	255_A	1.163	0.36
227_I	283_M	1.162	0.36
24_L	32_A	1.160	0.36
120_M	149_S	1.150	0.36
3_I	182_F	1.144	0.35
3_I	13_G	1.143	0.35
5_R	300_I	1.143	0.35
47_T	222_T	1.141	0.35
78_V	86_W	1.134	0.35
9_K	175_V	1.125	0.34
111_T	253_G	1.120	0.34
31_G	215_D	1.120	0.34
14_M	128_S	1.112	0.34
175_V	228_L	1.104	0.33
44_I	175_V	1.104	0.33
221_Q	247_L	1.101	0.33
118_M	237_T	1.095	0.33
261_S	278_P	1.093	0.33
9_K	305_L	1.092	0.33
63_K	231_V	1.092	0.33
179_L	217_T	1.090	0.33
158_L	273_I	1.088	0.33
95_I	308_I	1.083	0.32
223_G	256_G	1.078	0.32
97_P	100_G	1.069	0.32
154_T	273_I	1.066	0.32
267_V	294_A	1.063	0.32
62_I	127_A	1.061	0.32
19_L	208_F	1.059	0.31
78_V	127_A	1.059	0.31
16_L	74_S	1.056	0.31
114_L	126_Y	1.054	0.31
20_F	83_A	1.053	0.31
220_A	307_S	1.042	0.31
57_C	198_A	1.039	0.31
54_W	74_S	1.031	0.30
121_T	259_A	1.029	0.30
71_L	83_A	1.028	0.30
302_V	306_T	1.028	0.30
160_T	215_D	1.026	0.30
156_I	160_T	1.026	0.30
52_A	124_G	1.025	0.30
184_L	191_L	1.023	0.30
310_S	314_K	1.022	0.30
115_V	295_V	1.020	0.30
3_I	187_L	1.019	0.30
204_P	264_G	1.019	0.30
7_I	228_L	1.014	0.29
90_A	171_F	1.005	0.29
123_G	297_V	1.003	0.29
92_A	156_I	1.003	0.29
82_I	157_I	1.002	0.29
107_A	225_L	0.999	0.29
183_A	227_I	0.997	0.29
9_K	193_E	0.978	0.28
56_F	60_A	0.976	0.28
130_M	255_A	0.975	0.28
84_V	235_I	0.974	0.28
8_E	190_E	0.969	0.28
272_L	275_E	0.965	0.27
117_A	229_L	0.963	0.27
154_T	233_V	0.963	0.27
206_F	210_L	0.963	0.27
55_F	257_I	0.958	0.27
150_G	238_G	0.954	0.27
83_A	296_I	0.952	0.27
97_P	265_A	0.952	0.27
96_I	107_A	0.951	0.27
73_K	254_T	0.946	0.27
245_D	260_S	0.944	0.27
44_I	133_Y	0.941	0.26
130_M	260_S	0.941	0.26
89_A	154_T	0.938	0.26
145_M	157_I	0.937	0.26
41_N	277_V	0.934	0.26
123_G	230_G	0.933	0.26
112_L	183_A	0.930	0.26
227_I	235_I	0.928	0.26
87_V	91_I	0.919	0.26
159_G	167_E	0.919	0.26
16_L	174_A	0.913	0.25
67_T	269_T	0.913	0.25
273_I	293_T	0.913	0.25
26_H	212_N	0.913	0.25
9_K	228_L	0.911	0.25
171_F	304_I	0.907	0.25
15_M	123_G	0.902	0.25
160_T	273_I	0.899	0.25
10_I	278_P	0.898	0.25
153_M	215_D	0.894	0.25
249_G	253_G	0.893	0.25
22_G	208_F	0.884	0.24
180_V	301_L	0.883	0.24
225_L	300_I	0.882	0.24
197_K	228_L	0.879	0.24
156_I	170_V	0.875	0.24
82_I	280_F	0.872	0.24
89_A	114_L	0.871	0.24
130_M	159_G	0.869	0.24
29_S	91_I	0.868	0.24
23_A	27_T	0.866	0.24
172_V	179_L	0.859	0.23
24_L	219_I	0.856	0.23
189_P	201_T	0.852	0.23
232_A	235_I	0.850	0.23
9_K	65_S	0.848	0.23
77_L	166_F	0.846	0.23
29_S	179_L	0.841	0.23
232_A	236_V	0.840	0.23
147_L	190_E	0.840	0.23
117_A	190_E	0.833	0.22
25_C	219_I	0.832	0.22
110_S	147_L	0.831	0.22
61_S	133_Y	0.830	0.22
219_I	293_T	0.825	0.22
115_V	233_V	0.824	0.22
32_A	172_V	0.821	0.22
40_T	223_G	0.820	0.22
91_I	228_L	0.820	0.22
14_M	191_L	0.819	0.22
116_A	175_V	0.819	0.22
96_I	231_V	0.818	0.22
135_T	166_F	0.818	0.22
182_F	280_F	0.816	0.22
138_E	290_L	0.809	0.22
49_P	175_V	0.807	0.22
30_P	223_G	0.802	0.21
23_A	125_L	0.799	0.21
76_T	91_I	0.797	0.21
39_F	150_G	0.793	0.21
210_L	293_T	0.792	0.21
89_A	157_I	0.787	0.21
112_L	288_T	0.787	0.21
223_G	293_T	0.785	0.21
47_T	210_L	0.784	0.21
91_I	96_I	0.775	0.20
123_G	152_L	0.773	0.20
12_G	269_T	0.772	0.20
15_M	210_L	0.770	0.20
19_L	206_F	0.770	0.20
27_T	129_I	0.770	0.20
15_M	159_G	0.764	0.20
97_P	135_T	0.756	0.20
95_I	227_I	0.755	0.20
278_P	300_I	0.752	0.20
25_C	32_A	0.752	0.20
138_E	265_A	0.751	0.20
70_V	110_S	0.749	0.20
16_L	233_V	0.747	0.20
110_S	280_F	0.746	0.19
118_M	252_D	0.745	0.19
85_A	259_A	0.743	0.19
83_A	87_V	0.734	0.19
148_E	233_V	0.730	0.19
166_F	277_V	0.727	0.19
157_I	178_F	0.726	0.19
76_T	80_T	0.726	0.19
150_G	288_T	0.724	0.19
15_M	19_L	0.723	0.19
76_T	248_I	0.722	0.19
47_T	203_I	0.721	0.19
77_L	145_M	0.715	0.19
12_G	206_F	0.712	0.18
184_L	189_P	0.712	0.18
195_F	198_A	0.710	0.18
158_L	209_A	0.705	0.18
64_L	182_F	0.703	0.18
44_I	212_N	0.703	0.18
13_G	190_E	0.699	0.18
54_W	144_L	0.698	0.18
19_L	207_A	0.697	0.18
31_G	34_K	0.694	0.18
306_T	313_V	0.693	0.18
16_L	138_E	0.689	0.18
72_R	253_G	0.689	0.18
136_K	236_V	0.688	0.18
191_L	195_F	0.687	0.18
51_L	276_M	0.687	0.18
36_F	173_G	0.684	0.18
143_V	178_F	0.682	0.18
51_L	124_G	0.680	0.17
162_G	238_G	0.679	0.17
114_L	213_T	0.674	0.17
113_A	204_P	0.673	0.17
162_G	256_G	0.673	0.17
20_F	64_L	0.672	0.17
31_G	171_F	0.671	0.17
47_T	128_S	0.671	0.17
74_S	126_Y	0.671	0.17
21_L	208_F	0.670	0.17
79_V	246_K	0.669	0.17
29_S	281_K	0.668	0.17
237_T	241_L	0.666	0.17
106_F	180_V	0.666	0.17
87_V	304_I	0.665	0.17
145_M	149_S	0.662	0.17
36_F	40_T	0.661	0.17
7_I	191_L	0.661	0.17
172_V	175_V	0.658	0.17
17_V	180_V	0.657	0.17
214_I	295_V	0.657	0.17
73_K	252_D	0.656	0.17
14_M	116_A	0.654	0.17
228_L	243_I	0.651	0.17
93_S	167_E	0.650	0.17
73_K	146_S	0.649	0.17
9_K	28_F	0.649	0.17
68_G	237_T	0.647	0.17
207_A	210_L	0.645	0.16
22_G	203_I	0.645	0.16
57_C	60_A	0.643	0.16
38_S	293_T	0.643	0.16
73_K	245_D	0.642	0.16
43_M	128_S	0.641	0.16
19_L	67_T	0.641	0.16
224_L	228_L	0.638	0.16
21_L	111_T	0.637	0.16
33_G	36_F	0.635	0.16
304_I	311_R	0.635	0.16
49_P	141_A	0.634	0.16
267_V	289_S	0.634	0.16
73_K	137_E	0.634	0.16
9_K	217_T	0.633	0.16
199_V	210_L	0.628	0.16
150_G	154_T	0.627	0.16
24_L	183_A	0.627	0.16
5_R	147_L	0.625	0.16
41_N	269_T	0.622	0.16
22_G	150_G	0.621	0.16
7_I	252_D	0.620	0.16
32_A	36_F	0.620	0.16
65_S	156_I	0.618	0.16
224_L	235_I	0.618	0.16
150_G	230_G	0.616	0.16
242_I	309_W	0.616	0.16
126_Y	141_A	0.615	0.16
67_T	222_T	0.614	0.16
47_T	207_A	0.614	0.16
22_G	140_G	0.614	0.16
93_S	111_T	0.608	0.15
146_S	192_R	0.606	0.15
69_T	178_F	0.606	0.15
95_I	244_A	0.606	0.15
109_L	114_L	0.605	0.15
298_T	306_T	0.605	0.15
138_E	173_G	0.604	0.15
260_S	306_T	0.603	0.15
161_A	248_I	0.603	0.15
216_L	234_I	0.599	0.15
254_T	261_S	0.599	0.15
203_I	206_F	0.599	0.15
32_A	307_S	0.596	0.15
175_V	217_T	0.596	0.15
74_S	154_T	0.595	0.15
125_L	141_A	0.591	0.15
28_F	220_A	0.591	0.15
282_P	285_P	0.590	0.15
193_E	300_I	0.588	0.15
57_C	178_F	0.588	0.15
60_A	182_F	0.587	0.15
219_I	289_S	0.587	0.15
149_S	265_A	0.586	0.15
149_S	157_I	0.585	0.15
245_D	256_G	0.584	0.15
179_L	224_L	0.583	0.15
225_L	307_S	0.581	0.15
71_L	284_A	0.580	0.15
10_I	129_I	0.580	0.15
56_F	184_L	0.579	0.15
16_L	85_A	0.574	0.15
80_T	240_P	0.572	0.15
64_L	183_A	0.571	0.14
114_L	229_L	0.570	0.14
95_I	99_H	0.569	0.14
219_I	307_S	0.567	0.14
274_A	284_A	0.567	0.14
296_I	301_L	0.566	0.14
7_I	115_V	0.566	0.14
37_G	134_G	0.565	0.14
144_L	192_R	0.564	0.14
10_I	304_I	0.564	0.14
65_S	94_R	0.563	0.14
142_F	269_T	0.562	0.14
221_Q	231_V	0.562	0.14
163_I	167_E	0.562	0.14
64_L	91_I	0.562	0.14
63_K	234_I	0.562	0.14
17_V	291_V	0.560	0.14
172_V	183_A	0.559	0.14
162_G	230_G	0.558	0.14
17_V	25_C	0.558	0.14
275_E	298_T	0.558	0.14
65_S	190_E	0.557	0.14
8_E	14_M	0.557	0.14
17_V	77_L	0.556	0.14
123_G	167_E	0.554	0.14
74_S	119_D	0.553	0.14
214_I	218_V	0.552	0.14
124_G	241_L	0.552	0.14
14_M	310_S	0.552	0.14
20_F	201_T	0.552	0.14
106_F	190_E	0.551	0.14
246_K	312_K	0.551	0.14
67_T	207_A	0.549	0.14
166_F	296_I	0.548	0.14
237_T	260_S	0.544	0.14
257_I	269_T	0.544	0.14
227_I	308_I	0.543	0.14
200_Q	222_T	0.542	0.14
236_V	316_R	0.542	0.14
112_L	276_M	0.541	0.14
176_L	224_L	0.541	0.14
49_P	53_V	0.540	0.14
34_K	87_V	0.539	0.14
173_G	252_D	0.537	0.14
72_R	245_D	0.535	0.14
19_L	162_G	0.535	0.14
23_A	314_K	0.535	0.14
28_F	277_V	0.533	0.14
68_G	170_V	0.531	0.14
191_L	249_G	0.530	0.13
51_L	195_F	0.529	0.13
109_L	154_T	0.529	0.13
67_T	147_L	0.529	0.13
150_G	256_G	0.529	0.13
41_N	279_A	0.528	0.13
128_S	299_S	0.527	0.13
41_N	290_L	0.527	0.13
129_I	306_T	0.525	0.13
41_N	225_L	0.525	0.13
90_A	279_A	0.524	0.13
40_T	299_S	0.524	0.13
162_G	167_E	0.522	0.13
38_S	173_G	0.520	0.13
79_V	315_A	0.518	0.13
224_L	299_S	0.517	0.13
20_F	61_S	0.517	0.13
86_W	282_P	0.515	0.13
119_D	168_P	0.512	0.13
120_M	267_V	0.512	0.13
245_D	249_G	0.511	0.13
46_G	55_F	0.510	0.13
163_I	305_L	0.510	0.13
58_M	131_Q	0.509	0.13
79_V	193_E	0.507	0.13
112_L	268_A	0.507	0.13
172_V	316_R	0.507	0.13
230_G	293_T	0.505	0.13
174_A	291_V	0.503	0.13
133_Y	156_I	0.500	0.13

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3zuxA	1	0.8746	99.9	0.797	Contact Map
4n7wA	2	0.8807	99.6	0.868	Contact Map
4bwzA	2	0.9235	98.4	0.919	Contact Map
4czbA	2	0.9235	97.9	0.93	Contact Map
4cz8A	2	0.8991	97.3	0.938	Contact Map
1zcdA	1	0.9021	89.4	0.958	Contact Map
4huqS	1	0.4618	45.1	0.971	Contact Map
4rfsS	1	0.4832	35.5	0.972	Contact Map
3qnqA	2	0.4587	31.2	0.973	Contact Map
2kv5A	1	0.0887	27.2	0.974	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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