GREMLIN Database
YCIB - Probable intracellular septation protein A
UniProt: P0A710 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11122
Length: 179 (175)
Sequences: 1009 (675)
Seq/√Len: 51.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
71_D143_Q4.7841.00
83_A131_G4.5061.00
102_Q113_Q4.3191.00
86_A128_I3.7431.00
75_K143_Q3.7281.00
41_W45_R3.2551.00
71_D75_K3.0831.00
23_Y66_L3.0371.00
12_V28_A2.8701.00
29_L58_V2.6261.00
142_P145_I2.5861.00
37_L47_V2.5121.00
30_I59_V2.4981.00
130_C154_L2.3151.00
128_I132_L2.2501.00
63_G67_F2.0221.00
86_A124_A1.9761.00
39_Y43_R1.9420.99
135_I139_F1.9350.99
10_L151_V1.9190.99
112_P172_H1.8740.99
21_D24_A1.8220.99
114_P118_K1.8080.99
136_Y141_L1.7830.99
37_L55_F1.7710.99
135_I138_A1.7530.99
16_F24_A1.7380.99
125_V129_L1.7370.99
90_L124_A1.7250.99
141_L145_I1.7170.99
91_V96_M1.6640.98
26_T62_G1.6070.98
161_F165_S1.5820.98
24_A27_A1.5720.98
17_Y143_Q1.5100.97
27_A31_V1.4990.97
14_F152_F1.4840.97
82_Y89_L1.4650.96
155_T158_T1.4650.96
23_Y68_F1.4590.96
15_A19_I1.4570.96
122_A161_F1.4170.95
90_L125_V1.4070.95
163_L166_G1.3540.94
85_F127_F1.3470.94
112_P118_K1.3430.94
102_Q106_G1.3150.93
83_A128_I1.2780.92
117_S121_L1.2620.92
90_L121_L1.2550.92
42_V45_R1.2320.91
51_A55_F1.2060.90
85_F126_F1.1970.90
65_T74_I1.1900.89
23_Y69_H1.1900.89
34_A59_V1.1880.89
159_L163_L1.1860.89
5_L39_Y1.1780.89
89_L120_N1.1740.89
132_L136_Y1.1520.88
96_M103_R1.1480.87
7_F10_L1.1430.87
133_A157_L1.1390.87
38_I42_V1.1360.87
34_A55_F1.1330.87
3_Q7_F1.1320.87
91_V124_A1.1290.87
64_L67_F1.1270.86
88_A100_L1.0990.85
139_F142_P1.0970.85
61_F85_F1.0930.85
156_A160_I1.0910.85
130_C157_L1.0850.84
105_L162_T1.0800.84
38_I41_W1.0770.84
86_A90_L1.0650.83
16_F28_A1.0550.83
72_E76_W1.0530.82
49_K53_I1.0530.82
130_C165_S1.0520.82
131_G135_I1.0290.81
101_I120_N1.0260.81
60_V63_G1.0250.81
33_T55_F1.0010.79
88_A91_V0.9970.79
35_I39_Y0.9920.78
26_T65_T0.9910.78
137_I141_L0.9880.78
84_L88_A0.9860.78
29_L33_T0.9820.78
81_I108_E0.9810.78
145_I148_N0.9770.77
41_W47_V0.9650.77
126_F161_F0.9620.76
25_A147_V0.9610.76
149_F154_L0.9600.76
126_F157_L0.9350.74
112_P115_V0.9190.73
82_Y158_T0.9190.73
30_I63_G0.9110.72
14_F18_K0.9060.72
101_I124_A0.9050.72
33_T46_K0.9030.72
71_D74_I0.9000.71
64_L68_F0.9000.71
48_E51_A0.8970.71
118_K168_Y0.8790.70
5_L43_R0.8750.69
89_L92_S0.8550.67
83_A87_G0.8520.67
61_F64_L0.8490.67
11_V69_H0.8390.66
122_A164_L0.8300.65
23_Y27_A0.8300.65
96_M99_P0.8300.65
53_I57_L0.8290.65
30_I66_L0.8290.65
83_A135_I0.8280.65
24_A41_W0.8250.65
75_K138_A0.8150.64
26_T74_I0.8030.63
49_K52_L0.8010.62
44_F98_K0.7950.62
160_I164_L0.7920.61
94_W97_K0.7920.61
30_I34_A0.7870.61
83_A132_L0.7810.60
41_W44_F0.7770.60
56_V106_G0.7680.59
152_F156_A0.7660.59
148_N152_F0.7450.57
166_G169_I0.7400.56
67_F101_I0.7390.56
81_I155_T0.7350.56
91_V125_V0.7180.54
76_W138_A0.7180.54
89_L105_L0.7140.54
91_V95_V0.7130.53
16_F20_Y0.7120.53
27_A53_I0.7110.53
140_W145_I0.7110.53
125_V128_I0.7100.53
98_K103_R0.7060.53
13_F25_A0.7030.52
79_T134_N0.7000.52
99_P120_N0.7000.52
94_W121_L0.6980.52
106_G109_L0.6960.52
148_N153_G0.6880.51
34_A169_I0.6860.51
30_I127_F0.6860.51
8_L51_A0.6800.50
22_I26_T0.6780.50
21_D54_T0.6780.50
99_P102_Q0.6760.50
82_Y155_T0.6750.50
82_Y130_C0.6750.50
92_S96_M0.6730.49
9_P150_K0.6710.49
3_Q148_N0.6710.49
56_V60_V0.6690.49
11_V18_K0.6660.49
11_V15_A0.6650.48
71_D102_Q0.6630.48
25_A137_I0.6590.48
89_L101_I0.6570.48
126_F150_K0.6550.47
40_S44_F0.6540.47
8_L32_A0.6500.47
21_D41_W0.6490.47
163_L167_I0.6490.47
82_Y156_A0.6480.47
58_V78_V0.6450.46
20_Y31_V0.6430.46
43_R47_V0.6380.46
171_R174_P0.6360.46
132_L140_W0.6350.45
138_A141_L0.6350.45
28_A105_L0.6320.45
118_K121_L0.6300.45
17_Y49_K0.6250.44
80_V144_N0.6240.44
100_L103_R0.6220.44
131_G139_F0.6200.44
130_C151_V0.6190.44
6_D161_F0.6130.43
94_W103_R0.6130.43
80_V157_L0.6120.43
149_F153_G0.6080.43
18_K148_N0.6080.43
10_L71_D0.6070.43
47_V104_M0.6030.42
147_V152_F0.6020.42
134_N146_W0.5980.42
126_F169_I0.5900.41
91_V176_E0.5870.41
65_T169_I0.5850.40
109_L169_I0.5830.40
79_T107_K0.5820.40
68_F75_K0.5820.40
21_D47_V0.5820.40
24_A66_L0.5810.40
136_Y140_W0.5810.40
137_I145_I0.5780.40
124_A127_F0.5760.39
111_L119_L0.5730.39
50_M74_I0.5700.39
22_I74_I0.5690.39
89_L96_M0.5640.38
111_L170_Y0.5640.38
37_L45_R0.5620.38
144_N167_I0.5610.38
17_Y147_V0.5600.38
81_I154_L0.5600.38
133_A155_T0.5590.38
76_W167_I0.5590.38
17_Y20_Y0.5540.37
129_L133_A0.5520.37
42_V56_V0.5510.37
121_L124_A0.5510.37
92_S100_L0.5480.37
7_F11_V0.5470.37
35_I38_I0.5450.36
89_L100_L0.5450.36
15_A21_D0.5450.36
47_V52_L0.5370.36
31_V38_I0.5290.35
16_F68_F0.5280.35
39_Y44_F0.5270.35
55_F165_S0.5270.35
91_V97_K0.5260.35
99_P117_S0.5250.35
10_L89_L0.5240.34
2_K48_E0.5230.34
159_L172_H0.5230.34
51_A59_V0.5220.34
31_V162_T0.5220.34
40_S109_L0.5200.34
166_G171_R0.5190.34
25_A158_T0.5180.34
119_L165_S0.5180.34
14_F150_K0.5180.34
148_N151_V0.5170.34
53_I148_N0.5160.34
20_Y136_Y0.5150.34
105_L173_M0.5140.33
95_V114_P0.5140.33
1_M122_A0.5140.33
87_G128_I0.5110.33
99_P108_E0.5110.33
22_I69_H0.5110.33
105_L165_S0.5110.33
114_P117_S0.5100.33
35_I108_E0.5100.33
73_F134_N0.5100.33
5_L8_L0.5080.33
78_V170_Y0.5060.33
34_A53_I0.5050.33
22_I143_Q0.5050.33
50_M53_I0.5010.32
6_D32_A0.5000.32
119_L164_L0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2xq2A 2 0.905 24.4 0.951 Contact Map
3m73A 3 0.6927 3.8 0.966 Contact Map
2a65A 2 0.9162 3.2 0.967 Contact Map
2mawA 1 0.3743 2.4 0.97 Contact Map
3qrxB 2 0.1117 2.3 0.97 Contact Map
4b4aA 1 0.5084 2.2 0.97 Contact Map
3wu2Y 1 0.1229 2.1 0.97 Contact Map
4pj0Y 1 0.1229 2 0.971 Contact Map
4pgrA 1 0.7095 1.9 0.971 Contact Map
1pi7A 1 0.0894 1.9 0.971 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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