GREMLIN Database
IF3 - Translation initiation factor IF-3
UniProt: P0A707 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10506
Length: 180 (164)
Sequences: 2484 (1457)
Seq/√Len: 113.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
107_Y151_D4.0241.00
26_L37_V3.4521.00
14_R55_E3.1061.00
113_S116_R2.8511.00
104_E108_Q2.7731.00
115_I154_E2.7681.00
150_D153_Q2.6571.00
159_E175_A2.6351.00
29_L49_A2.6251.00
156_A174_L2.5181.00
44_E48_E2.2271.00
115_I155_L2.1981.00
115_I119_E2.1801.00
143_E146_N2.1541.00
41_E44_E2.1131.00
28_G32_E2.0611.00
28_G49_A2.0271.00
114_L148_V2.0111.00
38_S41_E2.0091.00
137_H140_I1.9671.00
105_G108_Q1.9651.00
55_E65_C1.9191.00
142_M146_N1.9161.00
51_V67_I1.8111.00
21_A55_E1.8041.00
23_E61_E1.7781.00
43_L47_E1.7661.00
114_L126_I1.7221.00
45_K49_A1.7071.00
73_F77_K1.7041.00
24_V65_C1.6741.00
118_L156_A1.6371.00
45_K67_I1.6201.00
111_L151_D1.6141.00
25_R33_Q1.6091.00
44_E47_E1.5521.00
111_L148_V1.5051.00
130_F141_G1.4671.00
25_R36_I1.4651.00
21_A39_L1.4631.00
130_F170_M1.4341.00
146_N161_F1.4021.00
54_V68_M1.3991.00
145_L172_M1.3921.00
109_V113_S1.3911.00
149_K172_M1.3791.00
129_R169_Q1.3641.00
146_N149_K1.3611.00
126_I148_V1.3261.00
17_G47_E1.2930.99
45_K48_E1.2810.99
158_V172_M1.2700.99
135_M138_Q1.2680.99
24_V39_L1.2610.99
108_Q111_L1.2570.99
28_G34_L1.2570.99
114_L124_A1.2560.99
77_K80_S1.2550.99
107_Y147_R1.2230.99
39_L65_C1.2200.99
97_K127_T1.2180.99
74_L78_S1.2170.99
116_R120_E1.2020.99
34_L37_V1.1980.99
147_R151_D1.1970.99
101_G134_E1.1940.99
14_R21_A1.1900.99
157_V177_K1.1680.99
128_L145_L1.1620.99
15_I70_Y1.1270.99
92_Q122_D1.1250.99
96_I114_L1.1180.98
146_N150_D1.1110.98
114_L152_L1.1020.98
119_E155_L1.0970.98
97_K129_R1.0510.98
112_R115_I1.0460.98
98_F126_I1.0440.98
142_M170_M1.0380.98
75_Y79_K1.0370.98
153_Q177_K1.0340.97
128_L138_Q1.0330.97
107_Y111_L1.0310.97
27_T33_Q1.0240.97
123_K173_V0.9960.97
102_T144_V0.9930.97
33_Q36_I0.9880.97
160_S173_V0.9730.96
55_E63_P0.9680.96
16_N52_D0.9660.96
29_L51_V0.9650.96
160_S164_K0.9520.96
140_I143_E0.9240.95
58_P62_P0.9220.95
37_V45_K0.9200.95
23_E38_S0.9110.95
27_T35_G0.8840.94
149_K161_F0.8830.94
24_V42_A0.8830.94
153_Q156_A0.8800.94
118_L152_L0.8690.93
79_K82_K0.8680.93
105_G109_V0.8580.93
146_N162_P0.8420.92
46_A52_D0.8340.92
97_K107_Y0.8340.92
99_R129_R0.8330.92
152_L156_A0.8330.92
131_R134_E0.8260.91
74_L77_K0.8260.91
149_K158_V0.8220.91
165_I169_Q0.8190.91
56_I61_E0.8170.91
144_V147_R0.8150.91
41_E45_K0.8150.91
74_L80_S0.8140.91
16_N19_I0.8050.90
84_Q88_Q0.8050.90
149_K153_Q0.7940.90
128_L144_V0.7930.90
82_K86_K0.7910.90
55_E58_P0.7880.89
39_L55_E0.7880.89
40_R44_E0.7810.89
37_V41_E0.7710.88
21_A24_V0.7540.87
93_V173_V0.7480.87
53_L65_C0.7480.87
116_R124_A0.7450.87
103_D121_G0.7420.86
124_A152_L0.7410.86
139_Q143_E0.7400.86
40_R43_L0.7350.86
56_I64_V0.7310.86
143_E147_R0.7300.85
28_G35_G0.7290.85
27_T31_G0.7280.85
42_A46_A0.7230.85
149_K156_A0.7210.85
123_K159_E0.7170.84
95_E127_T0.7160.84
111_L115_I0.7140.84
25_R62_P0.7140.84
23_E36_I0.7130.84
28_G33_Q0.7110.84
98_F128_L0.7110.84
80_S83_E0.7030.83
161_F164_K0.6950.83
72_K75_Y0.6940.82
145_L168_R0.6850.82
135_M168_R0.6850.82
108_Q112_R0.6840.82
149_K174_L0.6740.81
152_L174_L0.6730.80
162_P167_G0.6720.80
100_P127_T0.6700.80
98_F144_V0.6570.79
99_R134_E0.6550.79
33_Q68_M0.6520.78
103_D169_Q0.6490.78
39_L45_K0.6490.78
142_M165_I0.6470.78
29_L67_I0.6440.77
81_S85_K0.6410.77
34_L45_K0.6390.77
14_R18_E0.6380.77
76_E81_S0.6250.75
68_M102_T0.6240.75
14_R17_G0.6230.75
84_Q92_Q0.6200.75
136_A140_I0.6190.75
126_I172_M0.6180.75
80_S84_Q0.6170.74
108_Q151_D0.6170.74
159_E173_V0.6140.74
103_D113_S0.6140.74
50_G75_Y0.6130.74
58_P63_P0.6120.74
76_E129_R0.6120.74
143_E150_D0.6100.74
71_G134_E0.6090.73
83_E86_K0.6050.73
157_V175_A0.6040.73
135_M165_I0.6010.73
97_K100_P0.5980.72
99_R131_R0.5960.72
98_F107_Y0.5940.72
22_Q38_S0.5940.72
160_S174_L0.5930.72
102_T109_V0.5930.72
138_Q165_I0.5920.71
112_R116_R0.5920.71
33_Q56_I0.5840.70
165_I170_M0.5780.70
76_E82_K0.5750.69
64_V131_R0.5750.69
24_V38_S0.5730.69
25_R56_I0.5720.69
70_Y75_Y0.5710.69
29_L43_L0.5680.68
100_P128_L0.5680.68
44_E50_G0.5650.68
96_I117_F0.5640.68
85_K89_K0.5580.67
42_A52_D0.5550.67
162_P172_M0.5550.67
110_K141_G0.5510.66
101_G113_S0.5510.66
29_L76_E0.5500.66
136_A139_Q0.5500.66
142_M161_F0.5490.66
100_P130_F0.5480.66
100_P110_K0.5460.65
32_E35_G0.5460.65
76_E80_S0.5450.65
102_T160_S0.5450.65
61_E92_Q0.5440.65
112_R120_E0.5430.65
105_G113_S0.5430.65
88_Q166_E0.5420.65
131_R162_P0.5410.65
93_V177_K0.5320.63
98_F114_L0.5320.63
95_E125_K0.5270.63
109_V120_E0.5230.62
99_R107_Y0.5220.62
115_I153_Q0.5220.62
27_T66_R0.5190.61
166_E170_M0.5190.61
60_A63_P0.5190.61
97_K116_R0.5180.61
56_I66_R0.5170.61
101_G140_I0.5170.61
119_E154_E0.5160.61
36_I62_P0.5130.60
109_V112_R0.5130.60
56_I82_K0.5120.60
89_K166_E0.5090.60
145_L170_M0.5080.60
148_V169_Q0.5060.59
157_V178_K0.5050.59
107_Y138_Q0.5030.59
57_S60_A0.5030.59
56_I101_G0.5020.59
94_K106_D0.5010.59
105_G114_L0.5000.59
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ifeA 1 0.5056 100 0.486 Contact Map
1tigA 1 0.4889 99.9 0.505 Contact Map
1tifA 1 0.4222 99.9 0.513 Contact Map
1i96V 1 0.4778 99.9 0.519 Contact Map
2m71A 1 0.5056 99.9 0.52 Contact Map
2crqA 1 0.5556 99.9 0.522 Contact Map
1pbjA 2 0.25 27.7 0.938 Contact Map
3pgwS 1 0.7278 21.5 0.942 Contact Map
2rihA 2 0.2944 17.2 0.944 Contact Map
3kpbA 2 0.2556 16.2 0.945 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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