GREMLIN Database
IF2 - Translation initiation factor IF-2
UniProt: P0A705 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10505
Length: 890 (810)
Sequences: 2422 (1923)
Seq/√Len: 67.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
466_V548_I8.6451.00
733_A743_L6.9501.00
611_N615_Q5.1931.00
839_E880_F4.8491.00
592_H619_E4.7571.00
438_G553_E4.6771.00
802_D873_T4.5881.00
540_G543_E4.4341.00
480_I517_Y4.2991.00
803_V811_A4.0221.00
529_Q547_A3.5961.00
695_A701_V3.5741.00
821_V856_R3.5051.00
841_E866_K3.4541.00
827_P841_E3.2221.00
830_V865_V3.1441.00
413_S538_G3.1101.00
793_Q883_I3.0311.00
842_L863_I2.9671.00
823_K881_E2.9511.00
500_I539_T2.9451.00
795_I826_N2.8651.00
563_G588_E2.8461.00
410_Y538_G2.7751.00
498_N535_A2.7021.00
704_I774_L2.6661.00
136_A140_A2.6651.00
799_E874_G2.6631.00
38_S41_E2.6621.00
160_N164_D2.6611.00
434_E439_M2.6391.00
511_K532_H2.6251.00
410_Y541_I2.6181.00
602_E633_G2.6121.00
167_K171_A2.5001.00
801_R816_M2.4211.00
713_T782_M2.4211.00
515_S520_L2.4191.00
597_V628_I2.4161.00
773_N776_D2.4141.00
170_Q174_A2.4081.00
779_K783_S2.3951.00
142_R146_E2.3851.00
175_R179_E2.3851.00
715_E887_R2.3761.00
497_V530_F2.3561.00
472_D502_K2.3361.00
818_T876_V2.3321.00
388_E562_K2.2921.00
803_V812_I2.2891.00
197_E201_R2.2771.00
309_D366_I2.2721.00
171_A175_R2.2711.00
564_M645_R2.2681.00
133_E137_A2.2551.00
432_H624_I2.1971.00
461_A568_A2.1831.00
162_Q166_T2.1761.00
161_Q165_M2.1591.00
159_S163_D2.1581.00
511_K523_E2.1541.00
728_I745_G2.1391.00
191_A195_L2.1181.00
798_A822_V2.1161.00
551_Q555_L2.0631.00
758_I765_L2.0521.00
503_P506_D2.0291.00
790_L882_I2.0171.00
350_D353_T2.0101.00
174_A178_Q1.9821.00
309_D364_K1.9671.00
163_D167_K1.9631.00
756_K760_A1.9511.00
497_V532_H1.9421.00
484_Q722_G1.9271.00
480_I484_Q1.9231.00
607_R612_E1.9231.00
135_E139_Q1.9071.00
515_S524_W1.9051.00
662_R666_L1.8981.00
173_K177_E1.8781.00
198_E202_V1.8701.00
109_Q112_A1.8571.00
537_A540_G1.8551.00
112_A116_A1.8461.00
184_K188_E1.8431.00
506_D512_N1.8421.00
156_D160_N1.8301.00
199_A203_A1.8111.00
494_V548_I1.8081.00
800_V811_A1.8041.00
166_T170_Q1.7941.00
189_E192_R1.7921.00
383_T386_A1.7711.00
153_A157_K1.7671.00
509_R513_E1.7631.00
198_E201_R1.7611.00
467_L495_V1.7361.00
827_P880_F1.7211.00
135_E143_E1.7201.00
797_L819_E1.6910.99
140_A144_A1.6910.99
138_E142_R1.6900.99
317_T320_E1.6880.99
146_E150_R1.6850.99
131_K135_E1.6820.99
844_S864_G1.6750.99
822_V879_V1.6750.99
332_V357_V1.6720.99
157_K161_Q1.6670.99
283_R286_K1.6660.99
145_A149_K1.6650.99
147_Q151_E1.6610.99
388_E561_R1.6540.99
500_I540_G1.6480.99
190_E193_R1.6460.99
141_K145_A1.6290.99
532_H539_T1.6220.99
132_A136_A1.6200.99
329_G333_I1.6170.99
607_R610_R1.6170.99
474_G513_E1.6160.99
143_E147_Q1.6130.99
197_E200_R1.6100.99
518_G521_P1.6040.99
156_D159_S1.5950.99
172_E176_R1.5900.99
282_V285_G1.5830.99
122_E126_R1.5810.99
793_Q881_E1.5800.99
285_G289_K1.5780.99
109_Q113_E1.5770.99
359_E364_K1.5750.99
807_P864_G1.5700.99
321_L325_M1.5700.99
189_E193_R1.5660.99
119_E123_S1.5660.99
806_S809_F1.5620.99
830_V868_Y1.5580.99
609_M612_E1.5570.99
789_E887_R1.5510.99
358_A365_V1.5450.99
261_R264_K1.5380.99
168_N172_E1.5340.99
171_A179_E1.5310.99
115_Q120_A1.5290.99
676_N679_A1.5290.99
432_H439_M1.5230.99
812_I864_G1.5200.99
123_S127_E1.5180.99
63_R67_S1.5060.99
521_P530_F1.5040.99
58_K61_L1.5020.99
149_K153_A1.4970.99
373_L376_A1.4960.99
382_D560_V1.4920.99
386_A560_V1.4910.99
389_P438_G1.4850.99
768_Y777_E1.4830.99
146_E149_K1.4640.99
118_R122_E1.4590.98
37_V42_K1.4580.98
234_Q238_Q1.4580.98
285_G288_G1.4580.98
164_D168_N1.4540.98
106_E110_R1.4470.98
131_K136_A1.4450.98
570_I583_T1.4310.98
232_T239_A1.4290.98
60_T63_R1.4280.98
787_S790_L1.4220.98
197_E204_E1.4220.98
116_A120_A1.4210.98
172_E175_R1.4190.98
846_R852_V1.4180.98
396_I494_V1.4160.98
607_R611_N1.4160.98
163_D166_T1.4160.98
584_V641_V1.4110.98
434_E437_N1.4110.98
113_E117_R1.4080.98
269_A272_K1.3950.98
118_R126_R1.3930.98
76_G81_V1.3910.98
831_L836_V1.3860.98
134_R138_E1.3850.98
170_Q173_K1.3780.98
237_R241_D1.3770.98
265_G269_A1.3750.98
162_Q165_M1.3750.98
709_L720_I1.3720.98
734_T737_A1.3680.98
126_R130_Q1.3670.98
179_E183_L1.3630.98
122_E125_K1.3550.98
42_K46_I1.3500.97
193_R198_E1.3490.97
828_I865_V1.3480.97
830_V871_V1.3470.97
733_A758_I1.3450.97
522_E529_Q1.3450.97
67_S71_I1.3400.97
199_A202_V1.3340.97
188_E198_E1.3310.97
435_T438_G1.3310.97
487_K518_G1.3310.97
164_D167_K1.3240.97
737_A761_E1.3160.97
64_K67_S1.3140.97
281_A284_G1.3100.97
124_A128_A1.3060.97
532_H540_G1.3040.97
325_M363_H1.3030.97
396_I541_I1.3030.97
265_G268_H1.3010.97
111_E115_Q1.2990.97
264_K267_K1.2940.97
169_A173_K1.2940.97
161_Q169_A1.2920.97
283_R287_G1.2890.97
125_K129_Q1.2890.97
440_I494_V1.2880.97
133_E136_A1.2880.97
130_Q134_R1.2870.97
311_V366_I1.2850.97
167_K175_R1.2820.97
411_I541_I1.2810.96
230_V233_S1.2810.96
195_L199_A1.2780.96
284_G287_G1.2770.96
815_C842_L1.2760.96
76_G83_I1.2720.96
81_V91_F1.2690.96
115_Q119_E1.2690.96
839_E877_I1.2670.96
794_I819_E1.2670.96
137_A140_A1.2670.96
800_V813_A1.2640.96
134_R139_Q1.2630.96
815_C861_C1.2600.96
200_R204_E1.2560.96
284_G288_G1.2420.96
152_A156_D1.2410.96
513_E516_Q1.2360.96
822_V863_I1.2340.96
66_R70_N1.2330.96
109_Q117_R1.2320.96
237_R240_E1.2270.96
328_K331_Q1.2270.96
73_G81_V1.2260.95
141_K144_A1.2240.95
765_L846_R1.2200.95
194_K198_E1.2200.95
165_M169_A1.2180.95
236_A239_A1.2170.95
190_E194_K1.2150.95
144_A148_A1.2140.95
705_S709_L1.2110.95
85_V89_R1.2090.95
81_V84_E1.1980.95
863_I877_I1.1970.95
79_K87_K1.1950.95
176_R179_E1.1950.95
190_E195_L1.1930.95
597_V631_L1.1920.95
415_K542_D1.1910.95
607_R614_G1.1900.95
193_R196_E1.1900.95
596_I651_R1.1900.95
88_K93_K1.1810.94
615_Q618_L1.1790.94
174_A177_E1.1770.94
230_V234_Q1.1750.94
687_H787_S1.1690.94
115_Q118_R1.1650.94
755_R759_E1.1590.94
131_K139_Q1.1590.94
190_E198_E1.1560.94
117_R121_E1.1540.94
235_H238_Q1.1520.94
67_S72_P1.1510.94
129_Q133_E1.1500.94
162_Q170_Q1.1490.94
258_K262_P1.1480.94
617_V626_V1.1450.94
117_R125_K1.1450.94
170_Q178_Q1.1450.94
121_E125_K1.1440.93
188_E197_E1.1440.93
68_T71_I1.1430.93
689_V785_M1.1420.93
523_E532_H1.1390.93
800_V871_V1.1350.93
114_E118_R1.1320.93
840_G865_V1.1300.93
149_K152_A1.1300.93
232_T236_A1.1270.93
147_Q150_R1.1220.93
806_S864_G1.1200.93
65_T68_T1.1190.93
550_L553_E1.1170.93
231_T235_H1.1150.93
811_A869_N1.1150.93
469_V500_I1.1090.92
81_V88_K1.1070.92
826_N879_V1.1060.92
130_Q137_A1.1040.92
233_S236_A1.1030.92
266_N269_A1.1030.92
118_R121_E1.1000.92
204_E208_R1.1000.92
490_Q518_G1.0990.92
166_T169_A1.0980.92
261_R267_K1.0970.92
131_K134_R1.0970.92
744_V774_L1.0950.92
85_V90_T1.0950.92
232_T235_H1.0940.92
122_E128_A1.0940.92
828_I842_L1.0930.92
190_E202_V1.0910.92
335_A338_K1.0900.92
842_L877_I1.0890.92
111_E116_A1.0890.92
167_K170_Q1.0880.92
529_Q554_V1.0860.92
131_K138_E1.0840.92
264_K269_A1.0830.91
609_M613_L1.0810.91
77_K82_Q1.0810.91
856_R859_M1.0800.91
776_D780_A1.0780.91
809_F846_R1.0770.91
65_T69_L1.0770.91
76_G80_S1.0750.91
233_S240_E1.0730.91
76_G79_K1.0700.91
475_V530_F1.0690.91
468_V533_V1.0680.91
157_K162_Q1.0680.91
163_D169_A1.0680.91
605_R612_E1.0660.91
264_K268_H1.0650.91
519_I528_S1.0640.91
143_E151_E1.0640.91
607_R613_L1.0600.91
79_K84_E1.0590.91
82_Q87_K1.0550.90
770_V774_L1.0540.90
92_V96_P1.0540.90
261_R270_E1.0540.90
137_A141_K1.0530.90
120_A124_A1.0530.90
593_K618_L1.0520.90
146_E152_A1.0510.90
266_N273_A1.0490.90
287_G290_R1.0480.90
121_E129_Q1.0470.90
843_E864_G1.0470.90
316_I320_E1.0460.90
161_Q176_R1.0450.90
115_Q121_E1.0450.90
135_E141_K1.0440.90
335_A361_M1.0400.90
41_E44_T1.0390.90
162_Q169_A1.0390.90
124_A130_Q1.0380.90
85_V88_K1.0350.90
193_R197_E1.0350.90
148_A152_A1.0340.89
750_A767_Y1.0330.89
177_E183_L1.0320.89
715_E787_S1.0320.89
153_A161_Q1.0310.89
111_E119_E1.0310.89
620_A626_V1.0310.89
343_A347_Q1.0300.89
66_R69_L1.0300.89
126_R134_R1.0290.89
815_C863_I1.0280.89
831_L834_N1.0270.89
196_E202_V1.0250.89
865_V877_I1.0240.89
789_E885_I1.0230.89
61_L67_S1.0210.89
263_K266_N1.0200.89
123_S126_R1.0200.89
646_D649_K1.0190.89
236_A241_D1.0180.89
81_V85_V1.0170.89
73_G78_S1.0170.89
798_A879_V1.0160.89
158_V171_A1.0140.89
608_A612_E1.0130.88
112_A115_Q1.0130.88
58_K68_T1.0120.88
64_K71_I1.0120.88
106_E117_R1.0120.88
86_R89_R1.0110.88
83_I89_R1.0090.88
114_E122_E1.0070.88
141_K149_K1.0070.88
92_V95_D1.0070.88
531_V540_G1.0020.88
465_V551_Q0.9980.88
165_M168_N0.9970.88
89_R93_K0.9950.88
82_Q85_V0.9940.88
561_R590_T0.9930.87
268_H271_S0.9930.87
266_N270_E0.9900.87
145_A153_A0.9890.87
286_K290_R0.9860.87
265_G272_K0.9860.87
78_S84_E0.9850.87
743_L765_L0.9840.87
31_K35_D0.9820.87
138_E143_E0.9800.87
135_E142_R0.9790.87
846_R851_D0.9790.87
169_A175_R0.9770.87
823_K826_N0.9760.87
838_Y865_V0.9740.86
198_E204_E0.9740.86
601_F658_Q0.9740.86
127_E130_Q0.9730.86
56_P59_L0.9720.86
605_R609_M0.9720.86
77_K81_V0.9710.86
122_E135_E0.9700.86
110_R113_E0.9700.86
160_N168_N0.9690.86
118_R124_A0.9660.86
659_G663_E0.9640.86
269_A273_A0.9640.86
816_M859_M0.9640.86
90_T94_R0.9630.86
61_L66_R0.9630.86
286_K289_K0.9620.86
331_Q334_K0.9600.86
816_M860_E0.9570.85
79_K86_R0.9560.85
134_R140_A0.9550.85
262_P265_G0.9530.85
128_A132_A0.9530.85
169_A177_E0.9520.85
483_I517_Y0.9520.85
801_R859_M0.9510.85
129_Q137_A0.9510.85
110_R117_R0.9500.85
410_Y537_A0.9490.85
188_E194_K0.9470.85
715_E768_Y0.9460.85
171_A177_E0.9450.85
260_A263_K0.9450.85
233_S237_R0.9430.85
188_E192_R0.9420.85
194_K197_E0.9410.84
63_R69_L0.9400.84
140_A149_K0.9390.84
194_K199_A0.9390.84
153_A177_E0.9390.84
82_Q86_R0.9380.84
168_N171_A0.9370.84
27_A42_K0.9370.84
156_D161_Q0.9360.84
161_Q167_K0.9350.84
159_S167_K0.9340.84
117_R122_E0.9320.84
64_K68_T0.9310.84
374_E377_V0.9310.84
142_R150_R0.9280.84
79_K83_I0.9280.84
238_Q241_D0.9270.84
163_D170_Q0.9250.83
266_N272_K0.9230.83
610_R613_L0.9230.83
58_K69_L0.9230.83
132_A135_E0.9230.83
128_A140_A0.9220.83
798_A815_C0.9210.83
201_R204_E0.9210.83
195_L198_E0.9200.83
188_E191_A0.9200.83
133_E141_K0.9190.83
189_E200_R0.9190.83
188_E193_R0.9190.83
655_L659_G0.9180.83
267_K270_E0.9160.83
838_Y872_R0.9150.83
141_K146_E0.9140.83
80_S90_T0.9130.83
35_D42_K0.9120.83
59_L62_Q0.9100.82
259_A263_K0.9100.82
77_K84_E0.9090.82
164_D172_E0.9080.82
258_K261_R0.9080.82
159_S171_A0.9070.82
144_A157_K0.9060.82
333_I337_M0.9060.82
60_T64_K0.9060.82
144_A147_Q0.9050.82
163_D171_A0.9040.82
278_A281_A0.9040.82
275_R279_R0.9040.82
132_A138_E0.9020.82
795_I881_E0.9020.82
68_T72_P0.8980.82
139_Q144_A0.8960.81
411_I545_L0.8960.81
126_R132_A0.8950.81
344_T347_Q0.8940.81
600_G604_G0.8940.81
137_A142_R0.8940.81
231_T238_Q0.8930.81
533_V536_K0.8930.81
75_G78_S0.8910.81
61_L68_T0.8910.81
58_K63_R0.8910.81
134_R142_R0.8910.81
259_A262_P0.8890.81
139_Q143_E0.8890.81
512_N515_S0.8890.81
733_A765_L0.8890.81
159_S162_Q0.8890.81
142_R148_A0.8890.81
90_T93_K0.8880.81
574_L580_P0.8880.81
791_K885_I0.8870.81
465_V482_A0.8870.81
80_S86_R0.8850.81
427_H697_V0.8850.81
148_A151_E0.8850.81
511_K530_F0.8850.81
157_K163_D0.8820.80
777_E780_A0.8820.80
160_N163_D0.8810.80
355_Q365_V0.8800.80
733_A763_L0.8800.80
138_E144_A0.8780.80
437_N546_D0.8760.80
169_A172_E0.8760.80
134_R141_K0.8760.80
111_E114_E0.8760.80
687_H789_E0.8740.80
78_S82_Q0.8740.80
165_M177_E0.8730.80
566_S588_E0.8720.80
797_L876_V0.8710.80
196_E200_R0.8700.80
847_R855_V0.8680.79
79_K82_Q0.8650.79
125_K133_E0.8650.79
144_A150_R0.8630.79
120_A169_A0.8630.79
268_H272_K0.8630.79
139_Q147_Q0.8620.79
139_Q142_R0.8610.79
234_Q237_R0.8610.79
127_E134_R0.8600.79
783_S886_Q0.8570.78
749_R835_V0.8560.78
158_V170_Q0.8550.78
335_A339_L0.8550.78
91_F95_D0.8520.78
235_H241_D0.8520.78
85_V91_F0.8510.78
82_Q89_R0.8500.78
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163_D178_Q0.5210.42
120_A132_A0.5210.42
121_E141_K0.5210.42
136_A141_K0.5200.42
118_R130_Q0.5200.42
261_R266_N0.5200.42
111_E176_R0.5190.42
112_A125_K0.5190.42
144_A162_Q0.5180.42
271_S274_D0.5180.42
41_E46_I0.5170.42
641_V778_V0.5170.42
281_A291_K0.5170.42
69_L73_G0.5170.42
193_R209_M0.5170.42
576_K793_Q0.5160.42
259_A266_N0.5160.42
190_E203_A0.5160.42
779_K882_I0.5150.42
609_M614_G0.5150.42
600_G603_Y0.5150.42
646_D760_A0.5140.42
127_E157_K0.5140.42
128_A148_A0.5140.42
88_K94_R0.5130.41
850_D853_N0.5130.41
73_G109_Q0.5130.41
687_H713_T0.5130.41
289_K293_S0.5130.41
189_E209_M0.5120.41
230_V237_R0.5120.41
791_K883_I0.5120.41
220_E265_G0.5110.41
794_I831_L0.5100.41
188_E199_A0.5100.41
396_I760_A0.5090.41
136_A146_E0.5090.41
209_M221_P0.5080.41
307_N318_V0.5080.41
31_K39_A0.5080.41
73_G91_F0.5080.41
85_V93_K0.5060.41
651_R655_L0.5060.41
307_N363_H0.5060.41
130_Q144_A0.5050.41
80_S93_K0.5040.40
411_I793_Q0.5040.40
118_R129_Q0.5040.40
128_A159_S0.5040.40
293_S296_Q0.5040.40
113_E125_K0.5030.40
285_G290_R0.5030.40
515_S521_P0.5030.40
60_T69_L0.5020.40
58_K66_R0.5020.40
131_K176_R0.5020.40
184_K201_R0.5020.40
164_D170_Q0.5020.40
522_E547_A0.5010.40
311_V368_R0.5010.40
312_I358_A0.5010.40
120_A130_Q0.5010.40
137_A152_A0.5000.40
96_P115_Q0.5000.40
395_T492_P0.5000.40
47_D50_N0.5000.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1zo1I 1 0.5629 100 0.494 Contact Map
3j4jA 1 0.636 100 0.498 Contact Map
3izyP 1 0.5551 100 0.507 Contact Map
3wbiA 1 0.5247 100 0.541 Contact Map
4n3nA 2 0.5315 100 0.543 Contact Map
4upyB 1 0.564 100 0.548 Contact Map
1g7sA 1 0.5258 100 0.559 Contact Map
4kjzA 1 0.527 100 0.612 Contact Map
4n3sA 1 0.4169 100 0.639 Contact Map
4b43A 1 0.3854 100 0.776 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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