GREMLIN Database
HYPA - Protein HypA
UniProt: P0A700 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10483
Length: 116 (112)
Sequences: 1452 (1134)
Seq/√Len: 107.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
28_G63_H3.1431.00
48_F62_L2.8911.00
75_T97_M2.6441.00
17_Q20_K2.4901.00
32_K65_E2.4891.00
52_C59_G2.3191.00
23_A113_I2.3141.00
28_G61_K2.3141.00
32_K107_Q2.3101.00
78_Q92_Q2.1921.00
32_K109_R2.1801.00
54_G58_E2.1461.00
70_E79_Y2.0001.00
70_E102_A1.9541.00
48_F60_C1.9371.00
72_W79_Y1.9041.00
7_C44_L1.8531.00
35_A66_E1.8351.00
30_W110_R1.8341.00
14_I26_V1.7491.00
72_W77_Q1.7381.00
18_A23_A1.6861.00
74_E99_Q1.6651.00
72_W99_Q1.6071.00
18_A56_V1.5981.00
6_L39_V1.5181.00
25_R59_G1.4881.00
13_L108_I1.4571.00
30_W63_H1.4171.00
9_R13_L1.3861.00
74_E97_M1.3691.00
43_S46_F1.3641.00
71_C98_L1.3621.00
43_S47_C1.2390.99
79_Y101_V1.2350.99
11_L57_A1.2150.99
34_G103_D1.2090.99
14_I108_I1.1980.99
10_A31_L1.1860.99
30_W65_E1.1700.99
12_E15_E1.1650.99
80_V91_P1.1580.99
8_Q51_V1.1540.98
68_E81_T1.1510.98
28_G112_E1.1460.98
14_I29_V1.1430.98
6_L38_C1.1370.98
71_C82_L1.1340.98
72_W101_V1.1270.98
18_A26_V1.1050.98
32_K67_Q1.0990.98
15_E19_A1.0910.98
67_Q105_G1.0850.98
75_T95_G1.0710.98
33_I44_L1.0660.97
71_C80_V1.0550.97
53_R58_E1.0460.97
45_A49_D1.0260.97
15_E56_V1.0190.97
10_A108_I1.0140.97
35_A68_E1.0070.96
17_Q21_H0.9750.96
65_E109_R0.9600.95
80_V98_L0.9600.95
11_L51_V0.9530.95
9_R12_E0.9440.95
70_E81_T0.9360.95
38_C47_C0.9320.94
102_A105_G0.9290.94
108_I111_I0.9180.94
7_C43_S0.9150.94
14_I23_A0.9080.94
48_F52_C0.8990.93
41_T66_E0.8840.93
30_W109_R0.8830.93
29_V62_L0.8630.92
49_D52_C0.8600.92
16_Q19_A0.8540.91
67_Q102_A0.8470.91
85_Q88_R0.8460.91
55_S58_E0.8450.91
6_L106_L0.8380.91
11_L52_C0.8340.90
26_V57_A0.8280.90
4_I47_C0.8180.90
39_V44_L0.8030.89
89_R96_D0.8000.89
8_Q12_E0.7990.89
7_C48_F0.7910.88
38_C41_T0.7910.88
41_T45_A0.7800.87
42_S45_A0.7750.87
45_A61_K0.7710.87
7_C10_A0.7660.86
7_C51_V0.7660.86
15_E55_S0.7620.86
4_I51_V0.7400.84
14_I111_I0.7300.84
29_V57_A0.7200.83
57_A60_C0.7120.82
82_L98_L0.7100.82
31_L64_L0.7020.81
45_A66_E0.7010.81
24_K56_V0.6970.81
35_A81_T0.6940.80
95_G98_L0.6900.80
16_Q20_K0.6860.80
14_I18_A0.6820.79
18_A57_A0.6800.79
6_L44_L0.6650.78
7_C47_C0.6630.77
67_Q109_R0.6580.77
15_E57_A0.6510.76
35_A69_A0.6380.75
42_S46_F0.6380.75
47_C50_L0.6310.74
82_L88_R0.6190.72
19_A92_Q0.6140.72
5_T38_C0.6120.72
18_A21_H0.6080.71
10_A14_I0.6060.71
4_I43_S0.6050.71
36_F69_A0.5980.70
7_C62_L0.5970.70
37_S43_S0.5930.69
35_A102_A0.5910.69
5_T9_R0.5900.69
48_F112_E0.5890.69
13_L17_Q0.5850.68
14_I88_R0.5830.68
24_K78_Q0.5820.68
5_T8_Q0.5820.68
69_A100_I0.5800.67
33_I106_L0.5750.67
45_A64_L0.5640.65
47_C52_C0.5620.65
26_V56_V0.5590.65
74_E96_D0.5550.64
11_L15_E0.5550.64
89_R94_H0.5530.64
52_C62_L0.5500.63
11_L55_S0.5450.63
41_T44_L0.5430.62
36_F100_I0.5420.62
47_C51_V0.5410.62
7_C37_S0.5370.62
48_F55_S0.5370.62
40_E111_I0.5370.62
25_R92_Q0.5350.61
36_F103_D0.5310.61
40_E106_L0.5260.60
23_A111_I0.5250.60
19_A22_G0.5240.60
14_I56_V0.5230.60
20_K24_K0.5220.59
38_C43_S0.5210.59
8_Q57_A0.5160.59
100_I104_D0.5140.58
31_L62_L0.5110.58
11_L29_V0.5100.58
13_L16_Q0.5070.57
71_C100_I0.5070.57
52_C60_C0.5070.57
7_C107_Q0.5060.57
40_E43_S0.5030.57
69_A102_A0.5010.56
5_T21_H0.5010.56
49_D59_G0.5000.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
5aunA 1 1 100 0.068 Contact Map
2kdxA 1 0.9914 100 0.086 Contact Map
2k2dA 1 0.3879 99 0.679 Contact Map
4qiwP 1 0.3448 97.1 0.8 Contact Map
1lkoA 3 0.8621 96.7 0.812 Contact Map
3pwfA 4 0.8103 96.5 0.815 Contact Map
1yuzA 2 0.7759 96.4 0.819 Contact Map
2lcqA 1 0.8879 95.6 0.829 Contact Map
4aybP 1 0.3448 94.4 0.842 Contact Map
3wwlA 1 0.4052 90.8 0.859 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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