GREMLIN Database
NIKR - Nickel-responsive regulator
UniProt: P0A6Z6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11519
Length: 133 (127)
Sequences: 685 (482)
Seq/√Len: 42.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
91_N94_D3.3161.00
56_L101_L3.0841.00
62_H76_H2.8271.00
94_D122_R2.7991.00
116_I124_G2.7851.00
76_H89_H2.7411.00
76_H95_C2.7301.00
87_H95_C2.5701.00
30_E37_R2.5401.00
104_D107_D2.4761.00
8_L36_L2.4631.00
54_A101_L2.3521.00
25_Y34_D2.2561.00
30_E33_R2.2081.00
62_H89_H2.1080.99
57_S127_Q2.0920.99
89_H95_C2.0450.99
52_G108_V2.0010.99
77_H92_H1.9170.99
56_L126_L1.8790.99
16_L31_A1.8480.98
56_L115_V1.8440.98
15_T44_A1.8290.98
49_G106_G1.7420.98
25_Y30_E1.7340.98
62_H95_C1.6930.97
53_F90_I1.5300.95
13_L17_D1.4920.94
83_V102_K1.4380.93
71_I115_V1.3500.91
30_E34_D1.3380.90
32_I98_I1.3340.90
58_Y115_V1.3290.90
33_R37_R1.2470.87
86_L100_V1.2460.87
50_T104_D1.2280.86
77_H114_D1.2130.85
63_E92_H1.1690.83
60_Y89_H1.1550.82
20_S31_A1.1540.82
72_V76_H1.1510.82
76_H87_H1.1440.82
62_H87_H1.1420.82
35_I39_A1.1290.81
72_V89_H1.1280.81
79_H111_F1.1070.80
16_L36_L1.1020.79
44_A84_A1.0930.79
123_H129_L1.0780.78
4_V7_T1.0780.78
47_Q93_D1.0770.78
38_S125_H1.0760.78
32_I77_H1.0660.77
110_H114_D1.0660.77
80_D107_D1.0520.76
68_A72_V1.0470.76
112_A124_G1.0370.75
112_A126_L1.0350.75
8_L21_Q1.0210.74
88_V96_L1.0190.74
34_D121_V1.0190.74
55_V100_V1.0120.73
15_T24_G1.0080.73
78_H110_H1.0030.73
67_L92_H0.9890.72
16_L20_S0.9840.71
7_T16_L0.9790.71
49_G105_M0.9620.69
5_T79_H0.9610.69
18_S47_Q0.9460.68
116_I123_H0.9430.68
32_I66_D0.9430.68
4_V32_I0.9340.67
6_I13_L0.9290.67
67_L118_Q0.9230.66
58_Y124_G0.9090.65
7_T12_L0.9050.65
14_E23_R0.9040.65
82_S111_F0.8950.64
19_L40_L0.8910.63
75_Q99_A0.8850.63
3_R17_D0.8770.62
4_V63_E0.8600.61
94_D108_V0.8560.60
12_L37_R0.8400.59
85_T101_L0.8390.59
10_D14_E0.8360.58
5_T119_R0.8310.58
9_D54_A0.8300.58
17_D28_R0.8290.58
13_L16_L0.8230.57
116_I125_H0.8180.57
26_N128_C0.8150.56
11_D107_D0.8080.56
86_L98_I0.7930.54
87_H97_E0.7900.54
41_A45_T0.7870.54
16_L63_E0.7780.53
3_R97_E0.7560.51
22_R47_Q0.7540.51
18_S22_R0.7490.50
20_S25_Y0.7390.49
104_D108_V0.7370.49
63_E86_L0.7320.49
97_E103_G0.7310.49
41_A129_L0.7260.48
16_L99_A0.7210.48
24_G99_A0.7190.47
3_R34_D0.7100.47
32_I44_A0.7030.46
17_D113_D0.7020.46
65_R114_D0.6970.45
31_A39_A0.6960.45
58_Y72_V0.6930.45
42_Q46_Q0.6920.45
39_A43_E0.6920.45
119_R129_L0.6900.45
108_V112_A0.6890.45
49_G54_A0.6840.44
72_V95_C0.6760.43
107_D110_H0.6740.43
45_T128_C0.6710.43
77_H107_D0.6690.43
66_D70_R0.6630.42
45_T108_V0.6620.42
60_Y87_H0.6560.42
26_N118_Q0.6520.41
58_Y67_L0.6510.41
7_T25_Y0.6510.41
50_T105_M0.6450.41
22_R49_G0.6450.41
58_Y99_A0.6440.40
40_L125_H0.6390.40
9_D43_E0.6360.40
7_T57_S0.6320.39
59_V113_D0.6310.39
78_H112_A0.6270.39
27_N123_H0.6260.39
78_H124_G0.6160.38
3_R33_R0.6140.38
88_V91_N0.6100.37
5_T68_A0.6100.37
27_N35_I0.6060.37
63_E87_H0.6040.37
26_N113_D0.6010.37
64_K119_R0.5940.36
34_D37_R0.5920.36
35_I124_G0.5920.36
27_N121_V0.5900.36
78_H104_D0.5890.36
33_R95_C0.5880.35
11_D64_K0.5840.35
69_S73_S0.5810.35
17_D33_R0.5770.34
22_R73_S0.5770.34
6_I37_R0.5770.34
27_N124_G0.5750.34
15_T18_S0.5750.34
85_T111_F0.5710.34
3_R31_A0.5660.34
32_I47_Q0.5630.33
16_L35_I0.5610.33
91_N108_V0.5540.33
59_V129_L0.5540.33
41_A94_D0.5520.32
15_T125_H0.5510.32
4_V35_I0.5510.32
12_L28_R0.5510.32
75_Q89_H0.5500.32
10_D81_L0.5470.32
27_N118_Q0.5440.32
73_S82_S0.5440.32
62_H97_E0.5390.31
109_Q113_D0.5330.31
47_Q96_L0.5320.31
52_G58_Y0.5320.31
22_R43_E0.5320.31
5_T31_A0.5270.30
35_I52_G0.5260.30
21_Q73_S0.5250.30
20_S91_N0.5230.30
3_R27_N0.5180.30
34_D91_N0.5140.29
27_N64_K0.5110.29
60_Y85_T0.5100.29
55_V98_I0.5080.29
28_R97_E0.5070.29
55_V129_L0.5040.29
53_F123_H0.5000.28
3_R35_I0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2wvfA 2 1 100 0.144 Contact Map
2hzaA 3 0.985 100 0.153 Contact Map
2bj7A 3 1 100 0.196 Contact Map
1q5yA 4 0.6316 99.9 0.486 Contact Map
2nzcA 3 0.6015 99.8 0.563 Contact Map
4me7E 2 0.594 98.9 0.754 Contact Map
3kxeC 2 0.5188 98.9 0.756 Contact Map
2k5jA 2 0.5414 98.7 0.767 Contact Map
2cpgA 2 0.3308 98.4 0.788 Contact Map
2mdvA 2 0.2857 98 0.81 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0065 seconds.