GREMLIN Database
HSLO - 33 kDa chaperonin
UniProt: P0A6Y5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12930
Length: 292 (277)
Sequences: 2378 (1556)
Seq/√Len: 93.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
83_N87_Q4.6311.00
72_D110_N4.4281.00
250_D254_A4.1221.00
42_K164_K3.8431.00
29_Q32_L3.6011.00
24_V50_V3.4451.00
52_T80_I2.9441.00
241_L249_V2.8591.00
251_S255_E2.8131.00
89_R231_T2.6851.00
234_R276_D2.5911.00
87_Q227_E2.5421.00
22_V50_V2.4571.00
246_D250_D2.4501.00
274_A278_A2.4021.00
262_H269_H2.3901.00
36_D95_Q2.3611.00
260_D269_H2.3341.00
30_Q34_N2.2901.00
258_E271_L2.2381.00
248_E251_S2.2361.00
103_D106_T2.1571.00
137_A156_I2.1281.00
191_L215_E2.0851.00
19_G209_L2.0441.00
234_R272_F2.0121.00
10_Y19_G2.0111.00
30_Q33_E1.9881.00
75_M92_A1.9871.00
237_C261_M1.9461.00
48_L78_A1.9451.00
31_I49_L1.9441.00
257_G274_A1.9281.00
34_N268_N1.9261.00
19_G213_Y1.9151.00
34_N228_F1.9091.00
16_A184_D1.8821.00
113_V129_V1.8261.00
49_L90_G1.8071.00
87_Q229_K1.8051.00
204_P207_E1.8011.00
41_V75_M1.7861.00
52_T67_V1.7661.00
71_G109_G1.7511.00
207_E210_W1.7511.00
41_V92_A1.7441.00
6_Q223_P1.7391.00
55_L144_F1.7321.00
190_T193_E1.7201.00
249_V281_R1.7201.00
97_E162_D1.6981.00
37_Y42_K1.6871.00
242_K245_P1.6631.00
260_D271_L1.6501.00
203_L211_R1.6481.00
187_H216_E1.6301.00
182_Q186_D1.6301.00
144_F152_T1.6001.00
183_D186_D1.5631.00
250_D281_R1.5601.00
81_N89_R1.5361.00
159_G163_G1.5241.00
66_T81_N1.5221.00
232_C263_C1.5171.00
190_T194_T1.5131.00
114_V126_Q1.5091.00
51_A156_I1.5081.00
275_M278_A1.4691.00
51_A140_L1.4601.00
237_C240_A1.4541.00
183_D187_H1.4350.99
53_S226_V1.4260.99
159_G165_P1.4240.99
250_D278_A1.4130.99
48_L80_I1.4100.99
230_C266_C1.4090.99
50_V167_A1.4080.99
14_N217_E1.4060.99
273_N276_D1.3960.99
9_R20_E1.3830.99
52_T82_G1.3560.99
17_V174_V1.3350.99
238_A272_F1.3320.99
5_D27_T1.3200.99
141_E145_M1.3130.99
69_L131_L1.2890.99
133_G138_A1.2810.99
278_A282_N1.2590.99
6_Q206_N1.2530.99
263_C266_C1.2510.99
98_I106_T1.2510.99
54_L169_G1.2450.99
232_C266_C1.2420.99
96_G107_L1.2400.99
170_M192_T1.2350.98
238_A279_E1.2340.98
8_H205_A1.2300.98
45_L90_G1.2300.98
15_F219_T1.2270.98
203_L208_V1.2060.98
13_E219_T1.1980.98
247_E251_S1.1960.98
64_D81_N1.1960.98
200_L208_V1.1860.98
234_R238_A1.1830.98
7_L57_A1.1690.98
11_L221_Y1.1630.98
276_D279_E1.1440.97
256_D259_I1.1430.97
113_V131_L1.1410.97
240_A261_M1.1320.97
191_L216_E1.1260.97
16_A179_N1.1100.97
191_L211_R1.1060.97
119_P122_G1.0990.97
244_L252_I1.0970.97
249_V277_I1.0930.97
48_L67_V1.0840.96
246_D281_R1.0830.96
86_Q226_V1.0780.96
53_S88_M1.0770.96
26_E30_Q1.0760.96
238_A242_K1.0700.96
252_I258_E1.0630.96
48_L69_L1.0610.96
259_I277_I1.0610.96
48_L136_L1.0550.96
203_L207_E1.0490.96
230_C263_C1.0450.96
41_V94_V1.0450.96
179_N183_D1.0390.96
154_L171_L1.0340.95
166_A201_L1.0290.95
253_L277_I1.0290.95
187_H191_L1.0230.95
6_Q205_A1.0160.95
191_L214_H1.0120.95
28_L49_L1.0070.95
44_V108_V1.0030.95
198_E201_L0.9990.94
191_L194_T0.9880.94
142_D146_R0.9820.94
141_E153_R0.9740.94
86_Q224_Q0.9710.94
245_P248_E0.9710.94
279_E282_N0.9660.93
29_Q33_E0.9630.93
166_A198_E0.9390.92
187_H190_T0.9380.92
174_V185_F0.9350.92
13_E217_E0.9340.92
21_L205_A0.9320.92
228_F268_N0.9260.92
45_L228_F0.9220.92
135_T138_A0.9220.92
69_L108_V0.9220.92
8_H220_V0.9200.92
159_G162_D0.9080.91
77_L93_R0.9040.91
242_K280_I0.8990.91
100_E103_D0.8950.91
134_D138_A0.8920.90
80_I90_G0.8880.90
172_L192_T0.8780.90
55_L58_T0.8770.90
186_D190_T0.8730.89
101_N106_T0.8720.89
61_F84_N0.8600.89
138_A141_E0.8570.89
155_F170_M0.8570.89
71_G108_V0.8570.89
237_C243_T0.8570.89
28_L50_V0.8560.88
72_D109_G0.8540.88
97_E100_E0.8440.88
69_L136_L0.8420.88
25_S166_A0.8400.88
199_E211_R0.8380.87
27_T88_M0.8350.87
68_Q126_Q0.8340.87
68_Q114_V0.8330.87
58_T171_L0.8300.87
196_K219_T0.8300.87
160_D163_G0.8260.87
99_P103_D0.8240.86
30_Q227_E0.8170.86
67_V140_L0.8170.86
145_M151_P0.8130.86
70_Q77_L0.8120.86
7_L226_V0.8090.85
73_G109_G0.8040.85
8_H223_P0.8030.85
70_Q93_R0.7970.85
79_V91_V0.7930.84
81_N231_T0.7930.84
20_E58_T0.7900.84
54_L171_L0.7900.84
250_D253_L0.7890.84
105_K134_D0.7850.84
22_V226_V0.7840.84
51_A54_L0.7800.83
67_V113_V0.7760.83
56_T82_G0.7760.83
187_H215_E0.7740.83
54_L209_L0.7730.83
44_V75_M0.7720.83
258_E274_A0.7700.83
37_Y92_A0.7690.82
253_L258_E0.7680.82
210_W214_H0.7680.82
127_G143_Y0.7630.82
152_T173_Q0.7630.82
118_T121_E0.7630.82
51_A144_F0.7620.82
200_L211_R0.7610.82
43_N47_E0.7540.81
206_N220_V0.7520.81
40_P97_E0.7500.81
134_D139_C0.7480.81
253_L281_R0.7450.80
12_F213_Y0.7440.80
64_D231_T0.7410.80
252_I256_D0.7400.80
70_Q112_Y0.7380.80
58_T150_L0.7360.80
157_R201_L0.7320.79
235_E238_A0.7300.79
133_G142_D0.7280.79
54_L58_T0.7250.79
195_I200_L0.7250.79
49_L52_T0.7210.78
196_K203_L0.7190.78
195_I212_L0.7110.77
253_L259_I0.7090.77
17_V188_L0.7080.77
4_H26_E0.7060.77
194_T212_L0.7060.77
206_N223_P0.7060.77
237_C264_D0.7050.77
146_R267_G0.7030.76
245_P265_Y0.7030.76
179_N184_D0.7010.76
58_T144_F0.6990.76
62_D120_S0.6990.76
194_T211_R0.6920.75
31_I37_Y0.6920.75
18_R209_L0.6920.75
176_P221_Y0.6910.75
9_R222_D0.6910.75
116_T126_Q0.6890.75
174_V188_L0.6890.75
244_L249_V0.6880.75
39_Q162_D0.6870.75
22_V53_S0.6860.75
210_W215_E0.6850.75
128_V163_G0.6840.74
144_F154_L0.6840.74
28_L158_T0.6830.74
44_V78_A0.6790.74
230_C233_S0.6780.74
57_A224_Q0.6730.73
99_P106_T0.6700.73
153_R193_E0.6700.73
62_D84_N0.6690.73
211_R215_E0.6690.73
264_D267_G0.6680.73
76_N93_R0.6670.73
43_N104_L0.6670.73
209_L218_V0.6660.73
4_H23_T0.6650.72
253_L274_A0.6630.72
175_M226_V0.6610.72
124_R144_F0.6610.72
69_L113_V0.6610.72
53_S144_F0.6560.71
135_T139_C0.6560.71
144_F171_L0.6510.71
196_K199_E0.6500.71
114_V128_V0.6460.70
200_L212_L0.6440.70
195_I203_L0.6430.70
258_E273_N0.6400.70
69_L78_A0.6400.70
104_L135_T0.6390.69
20_E155_F0.6370.69
115_I228_F0.6360.69
209_L220_V0.6360.69
233_S263_C0.6310.68
99_P102_A0.6310.68
38_P95_Q0.6290.68
256_D274_A0.6290.68
23_T205_A0.6280.68
55_L171_L0.6230.67
193_E282_N0.6210.67
183_D275_M0.6200.67
219_T222_D0.6180.67
77_L80_I0.6170.67
195_I211_R0.6160.67
102_A106_T0.6150.66
10_Y213_Y0.6150.66
55_L140_L0.6140.66
105_K135_T0.6140.66
191_L212_L0.6130.66
210_W217_E0.6120.66
9_R144_F0.6120.66
242_K248_E0.6100.66
48_L52_T0.6100.66
233_S270_Y0.6090.66
118_T265_Y0.6090.66
32_L42_K0.6080.66
39_Q97_E0.6060.65
125_Y252_I0.6050.65
21_L209_L0.6030.65
153_R192_T0.6010.65
21_L218_V0.6000.65
109_G220_V0.6000.65
65_I82_G0.5980.64
198_E202_T0.5970.64
20_E57_A0.5960.64
67_V80_I0.5910.63
103_D134_D0.5860.63
116_T124_R0.5850.63
248_E252_I0.5850.63
247_E254_A0.5830.62
115_I219_T0.5820.62
82_G88_M0.5820.62
8_H21_L0.5800.62
103_D207_E0.5780.62
257_G278_A0.5770.62
47_E135_T0.5760.61
66_T133_G0.5760.61
202_T207_E0.5750.61
66_T118_T0.5740.61
91_V261_M0.5740.61
130_G142_D0.5720.61
64_D229_K0.5710.61
106_T193_E0.5700.61
38_P162_D0.5700.61
254_A282_N0.5690.61
211_R214_H0.5680.60
88_M226_V0.5680.60
174_V178_Q0.5680.60
194_T282_N0.5670.60
239_D242_K0.5670.60
73_G127_G0.5650.60
27_T49_L0.5650.60
98_I101_N0.5650.60
236_R243_T0.5650.60
75_M107_L0.5640.60
252_I277_I0.5610.59
100_E160_D0.5610.59
132_E138_A0.5590.59
23_T166_A0.5550.59
127_G144_F0.5520.58
66_T79_V0.5500.58
68_Q116_T0.5500.58
146_R150_L0.5480.58
62_D85_N0.5460.57
9_R122_G0.5460.57
172_L188_L0.5460.57
56_T83_N0.5450.57
241_L280_I0.5450.57
22_V153_R0.5430.57
9_R19_G0.5420.57
241_L272_F0.5420.57
49_L53_S0.5410.57
15_F175_M0.5410.57
6_Q225_D0.5370.56
93_R264_D0.5360.56
13_E175_M0.5340.56
40_P96_G0.5340.56
244_L248_E0.5310.55
74_P109_G0.5300.55
230_C270_Y0.5300.55
79_V126_Q0.5290.55
72_D78_A0.5270.55
41_V78_A0.5260.55
56_T144_F0.5260.55
37_Y41_V0.5220.54
174_V182_Q0.5210.54
187_H212_L0.5210.54
53_S84_N0.5210.54
25_S201_L0.5190.54
228_F232_C0.5180.54
17_V184_D0.5180.54
7_L22_V0.5180.54
200_L203_L0.5170.53
150_L241_L0.5140.53
5_D35_H0.5130.53
24_V167_A0.5120.53
105_K136_L0.5120.53
36_D162_D0.5110.53
121_E171_L0.5110.53
19_G116_T0.5110.53
174_V192_T0.5100.52
250_D274_A0.5100.52
116_T280_I0.5090.52
5_D26_E0.5080.52
70_Q114_V0.5080.52
186_D202_T0.5080.52
4_H225_D0.5070.52
89_R165_P0.5070.52
91_V237_C0.5060.52
151_P156_I0.5050.52
135_T157_R0.5050.52
32_L164_K0.5040.52
70_Q110_N0.5040.52
64_D120_S0.5040.52
213_Y216_E0.5040.52
245_P281_R0.5040.52
50_V53_S0.5030.51
82_G86_Q0.5030.51
102_A281_R0.5010.51
23_T75_M0.5010.51
43_N197_T0.5000.51
170_M212_L0.5000.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1i7fA 2 0.7808 100 0.035 Contact Map
1vzyA 3 0.9555 100 0.077 Contact Map
1vq0A 2 0.9589 100 0.093 Contact Map
1hw7A 2 0.7842 100 0.173 Contact Map
2xigA 4 0.3904 39.8 0.96 Contact Map
2ywwA 2 0.4658 28.9 0.962 Contact Map
1cvrA 1 0.4315 18.7 0.966 Contact Map
1pg5B 2 0.476 18.6 0.966 Contact Map
1gh9A 1 0.1781 17.6 0.966 Contact Map
3t7vA 1 0.2979 17.5 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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