HSLO - ECOLI - GREMLIN Contacts

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HSLO - 33 kDa chaperonin

UniProt:	P0A6Y5	Sequences: MPQHDQLHRYLFENFAVRGELVTVSETLQQILENHDYPQPVKNVLAELLVATSLLTATLKFDGDITVQLQGDGPMNLAVINGNNNQQMRGVARVQGEIPENADLKTLVGNGYVVITITPSEGERYQGVVGLEGDTLAACLEDYFMRSEQLPTRLFIRTGDVDGKPAAGGMLLQVMPAQNAQQDDFDHLATLTETIKTEELLTLPANEVLWRLYHEEEVTVYDPQDVEFKCTCSRERCADALKTLPDEEVDSILAEDGEIDMHCDYCGNHYLFNAMDIAEIRNNASPADPQVH	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12930
Length:	292 (277)
Sequences:	2378 (1556)
Seq/√Len:	93.5

ECOLI - HSLO
BACSU - HSLO

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
83_N	87_Q	4.631	1.00
72_D	110_N	4.428	1.00
250_D	254_A	4.122	1.00
42_K	164_K	3.843	1.00
29_Q	32_L	3.601	1.00
24_V	50_V	3.445	1.00
52_T	80_I	2.944	1.00
241_L	249_V	2.859	1.00
251_S	255_E	2.813	1.00
89_R	231_T	2.685	1.00
234_R	276_D	2.591	1.00
87_Q	227_E	2.542	1.00
22_V	50_V	2.457	1.00
246_D	250_D	2.450	1.00
274_A	278_A	2.402	1.00
262_H	269_H	2.390	1.00
36_D	95_Q	2.361	1.00
260_D	269_H	2.334	1.00
30_Q	34_N	2.290	1.00
258_E	271_L	2.238	1.00
248_E	251_S	2.236	1.00
103_D	106_T	2.157	1.00
137_A	156_I	2.128	1.00
191_L	215_E	2.085	1.00
19_G	209_L	2.044	1.00
234_R	272_F	2.012	1.00
10_Y	19_G	2.011	1.00
30_Q	33_E	1.988	1.00
75_M	92_A	1.987	1.00
237_C	261_M	1.946	1.00
48_L	78_A	1.945	1.00
31_I	49_L	1.944	1.00
257_G	274_A	1.928	1.00
34_N	268_N	1.926	1.00
19_G	213_Y	1.915	1.00
34_N	228_F	1.909	1.00
16_A	184_D	1.882	1.00
113_V	129_V	1.826	1.00
49_L	90_G	1.807	1.00
87_Q	229_K	1.805	1.00
204_P	207_E	1.801	1.00
41_V	75_M	1.786	1.00
52_T	67_V	1.766	1.00
71_G	109_G	1.751	1.00
207_E	210_W	1.751	1.00
41_V	92_A	1.744	1.00
6_Q	223_P	1.739	1.00
55_L	144_F	1.732	1.00
190_T	193_E	1.720	1.00
249_V	281_R	1.720	1.00
97_E	162_D	1.698	1.00
37_Y	42_K	1.687	1.00
242_K	245_P	1.663	1.00
260_D	271_L	1.650	1.00
203_L	211_R	1.648	1.00
187_H	216_E	1.630	1.00
182_Q	186_D	1.630	1.00
144_F	152_T	1.600	1.00
183_D	186_D	1.563	1.00
250_D	281_R	1.560	1.00
81_N	89_R	1.536	1.00
159_G	163_G	1.524	1.00
66_T	81_N	1.522	1.00
232_C	263_C	1.517	1.00
190_T	194_T	1.513	1.00
114_V	126_Q	1.509	1.00
51_A	156_I	1.508	1.00
275_M	278_A	1.469	1.00
51_A	140_L	1.460	1.00
237_C	240_A	1.454	1.00
183_D	187_H	1.435	0.99
53_S	226_V	1.426	0.99
159_G	165_P	1.424	0.99
250_D	278_A	1.413	0.99
48_L	80_I	1.410	0.99
230_C	266_C	1.409	0.99
50_V	167_A	1.408	0.99
14_N	217_E	1.406	0.99
273_N	276_D	1.396	0.99
9_R	20_E	1.383	0.99
52_T	82_G	1.356	0.99
17_V	174_V	1.335	0.99
238_A	272_F	1.332	0.99
5_D	27_T	1.320	0.99
141_E	145_M	1.313	0.99
69_L	131_L	1.289	0.99
133_G	138_A	1.281	0.99
278_A	282_N	1.259	0.99
6_Q	206_N	1.253	0.99
263_C	266_C	1.251	0.99
98_I	106_T	1.251	0.99
54_L	169_G	1.245	0.99
232_C	266_C	1.242	0.99
96_G	107_L	1.240	0.99
170_M	192_T	1.235	0.98
238_A	279_E	1.234	0.98
8_H	205_A	1.230	0.98
45_L	90_G	1.230	0.98
15_F	219_T	1.227	0.98
203_L	208_V	1.206	0.98
13_E	219_T	1.198	0.98
247_E	251_S	1.196	0.98
64_D	81_N	1.196	0.98
200_L	208_V	1.186	0.98
234_R	238_A	1.183	0.98
7_L	57_A	1.169	0.98
11_L	221_Y	1.163	0.98
276_D	279_E	1.144	0.97
256_D	259_I	1.143	0.97
113_V	131_L	1.141	0.97
240_A	261_M	1.132	0.97
191_L	216_E	1.126	0.97
16_A	179_N	1.110	0.97
191_L	211_R	1.106	0.97
119_P	122_G	1.099	0.97
244_L	252_I	1.097	0.97
249_V	277_I	1.093	0.97
48_L	67_V	1.084	0.96
246_D	281_R	1.083	0.96
86_Q	226_V	1.078	0.96
53_S	88_M	1.077	0.96
26_E	30_Q	1.076	0.96
238_A	242_K	1.070	0.96
252_I	258_E	1.063	0.96
48_L	69_L	1.061	0.96
259_I	277_I	1.061	0.96
48_L	136_L	1.055	0.96
203_L	207_E	1.049	0.96
230_C	263_C	1.045	0.96
41_V	94_V	1.045	0.96
179_N	183_D	1.039	0.96
154_L	171_L	1.034	0.95
166_A	201_L	1.029	0.95
253_L	277_I	1.029	0.95
187_H	191_L	1.023	0.95
6_Q	205_A	1.016	0.95
191_L	214_H	1.012	0.95
28_L	49_L	1.007	0.95
44_V	108_V	1.003	0.95
198_E	201_L	0.999	0.94
191_L	194_T	0.988	0.94
142_D	146_R	0.982	0.94
141_E	153_R	0.974	0.94
86_Q	224_Q	0.971	0.94
245_P	248_E	0.971	0.94
279_E	282_N	0.966	0.93
29_Q	33_E	0.963	0.93
166_A	198_E	0.939	0.92
187_H	190_T	0.938	0.92
174_V	185_F	0.935	0.92
13_E	217_E	0.934	0.92
21_L	205_A	0.932	0.92
228_F	268_N	0.926	0.92
45_L	228_F	0.922	0.92
135_T	138_A	0.922	0.92
69_L	108_V	0.922	0.92
8_H	220_V	0.920	0.92
159_G	162_D	0.908	0.91
77_L	93_R	0.904	0.91
242_K	280_I	0.899	0.91
100_E	103_D	0.895	0.91
134_D	138_A	0.892	0.90
80_I	90_G	0.888	0.90
172_L	192_T	0.878	0.90
55_L	58_T	0.877	0.90
186_D	190_T	0.873	0.89
101_N	106_T	0.872	0.89
61_F	84_N	0.860	0.89
138_A	141_E	0.857	0.89
155_F	170_M	0.857	0.89
71_G	108_V	0.857	0.89
237_C	243_T	0.857	0.89
28_L	50_V	0.856	0.88
72_D	109_G	0.854	0.88
97_E	100_E	0.844	0.88
69_L	136_L	0.842	0.88
25_S	166_A	0.840	0.88
199_E	211_R	0.838	0.87
27_T	88_M	0.835	0.87
68_Q	126_Q	0.834	0.87
68_Q	114_V	0.833	0.87
58_T	171_L	0.830	0.87
196_K	219_T	0.830	0.87
160_D	163_G	0.826	0.87
99_P	103_D	0.824	0.86
30_Q	227_E	0.817	0.86
67_V	140_L	0.817	0.86
145_M	151_P	0.813	0.86
70_Q	77_L	0.812	0.86
7_L	226_V	0.809	0.85
73_G	109_G	0.804	0.85
8_H	223_P	0.803	0.85
70_Q	93_R	0.797	0.85
79_V	91_V	0.793	0.84
81_N	231_T	0.793	0.84
20_E	58_T	0.790	0.84
54_L	171_L	0.790	0.84
250_D	253_L	0.789	0.84
105_K	134_D	0.785	0.84
22_V	226_V	0.784	0.84
51_A	54_L	0.780	0.83
67_V	113_V	0.776	0.83
56_T	82_G	0.776	0.83
187_H	215_E	0.774	0.83
54_L	209_L	0.773	0.83
44_V	75_M	0.772	0.83
258_E	274_A	0.770	0.83
37_Y	92_A	0.769	0.82
253_L	258_E	0.768	0.82
210_W	214_H	0.768	0.82
127_G	143_Y	0.763	0.82
152_T	173_Q	0.763	0.82
118_T	121_E	0.763	0.82
51_A	144_F	0.762	0.82
200_L	211_R	0.761	0.82
43_N	47_E	0.754	0.81
206_N	220_V	0.752	0.81
40_P	97_E	0.750	0.81
134_D	139_C	0.748	0.81
253_L	281_R	0.745	0.80
12_F	213_Y	0.744	0.80
64_D	231_T	0.741	0.80
252_I	256_D	0.740	0.80
70_Q	112_Y	0.738	0.80
58_T	150_L	0.736	0.80
157_R	201_L	0.732	0.79
235_E	238_A	0.730	0.79
133_G	142_D	0.728	0.79
54_L	58_T	0.725	0.79
195_I	200_L	0.725	0.79
49_L	52_T	0.721	0.78
196_K	203_L	0.719	0.78
195_I	212_L	0.711	0.77
253_L	259_I	0.709	0.77
17_V	188_L	0.708	0.77
4_H	26_E	0.706	0.77
194_T	212_L	0.706	0.77
206_N	223_P	0.706	0.77
237_C	264_D	0.705	0.77
146_R	267_G	0.703	0.76
245_P	265_Y	0.703	0.76
179_N	184_D	0.701	0.76
58_T	144_F	0.699	0.76
62_D	120_S	0.699	0.76
194_T	211_R	0.692	0.75
31_I	37_Y	0.692	0.75
18_R	209_L	0.692	0.75
176_P	221_Y	0.691	0.75
9_R	222_D	0.691	0.75
116_T	126_Q	0.689	0.75
174_V	188_L	0.689	0.75
244_L	249_V	0.688	0.75
39_Q	162_D	0.687	0.75
22_V	53_S	0.686	0.75
210_W	215_E	0.685	0.75
128_V	163_G	0.684	0.74
144_F	154_L	0.684	0.74
28_L	158_T	0.683	0.74
44_V	78_A	0.679	0.74
230_C	233_S	0.678	0.74
57_A	224_Q	0.673	0.73
99_P	106_T	0.670	0.73
153_R	193_E	0.670	0.73
62_D	84_N	0.669	0.73
211_R	215_E	0.669	0.73
264_D	267_G	0.668	0.73
76_N	93_R	0.667	0.73
43_N	104_L	0.667	0.73
209_L	218_V	0.666	0.73
4_H	23_T	0.665	0.72
253_L	274_A	0.663	0.72
175_M	226_V	0.661	0.72
124_R	144_F	0.661	0.72
69_L	113_V	0.661	0.72
53_S	144_F	0.656	0.71
135_T	139_C	0.656	0.71
144_F	171_L	0.651	0.71
196_K	199_E	0.650	0.71
114_V	128_V	0.646	0.70
200_L	212_L	0.644	0.70
195_I	203_L	0.643	0.70
258_E	273_N	0.640	0.70
69_L	78_A	0.640	0.70
104_L	135_T	0.639	0.69
20_E	155_F	0.637	0.69
115_I	228_F	0.636	0.69
209_L	220_V	0.636	0.69
233_S	263_C	0.631	0.68
99_P	102_A	0.631	0.68
38_P	95_Q	0.629	0.68
256_D	274_A	0.629	0.68
23_T	205_A	0.628	0.68
55_L	171_L	0.623	0.67
193_E	282_N	0.621	0.67
183_D	275_M	0.620	0.67
219_T	222_D	0.618	0.67
77_L	80_I	0.617	0.67
195_I	211_R	0.616	0.67
102_A	106_T	0.615	0.66
10_Y	213_Y	0.615	0.66
55_L	140_L	0.614	0.66
105_K	135_T	0.614	0.66
191_L	212_L	0.613	0.66
210_W	217_E	0.612	0.66
9_R	144_F	0.612	0.66
242_K	248_E	0.610	0.66
48_L	52_T	0.610	0.66
233_S	270_Y	0.609	0.66
118_T	265_Y	0.609	0.66
32_L	42_K	0.608	0.66
39_Q	97_E	0.606	0.65
125_Y	252_I	0.605	0.65
21_L	209_L	0.603	0.65
153_R	192_T	0.601	0.65
21_L	218_V	0.600	0.65
109_G	220_V	0.600	0.65
65_I	82_G	0.598	0.64
198_E	202_T	0.597	0.64
20_E	57_A	0.596	0.64
67_V	80_I	0.591	0.63
103_D	134_D	0.586	0.63
116_T	124_R	0.585	0.63
248_E	252_I	0.585	0.63
247_E	254_A	0.583	0.62
115_I	219_T	0.582	0.62
82_G	88_M	0.582	0.62
8_H	21_L	0.580	0.62
103_D	207_E	0.578	0.62
257_G	278_A	0.577	0.62
47_E	135_T	0.576	0.61
66_T	133_G	0.576	0.61
202_T	207_E	0.575	0.61
66_T	118_T	0.574	0.61
91_V	261_M	0.574	0.61
130_G	142_D	0.572	0.61
64_D	229_K	0.571	0.61
106_T	193_E	0.570	0.61
38_P	162_D	0.570	0.61
254_A	282_N	0.569	0.61
211_R	214_H	0.568	0.60
88_M	226_V	0.568	0.60
174_V	178_Q	0.568	0.60
194_T	282_N	0.567	0.60
239_D	242_K	0.567	0.60
73_G	127_G	0.565	0.60
27_T	49_L	0.565	0.60
98_I	101_N	0.565	0.60
236_R	243_T	0.565	0.60
75_M	107_L	0.564	0.60
252_I	277_I	0.561	0.59
100_E	160_D	0.561	0.59
132_E	138_A	0.559	0.59
23_T	166_A	0.555	0.59
127_G	144_F	0.552	0.58
66_T	79_V	0.550	0.58
68_Q	116_T	0.550	0.58
146_R	150_L	0.548	0.58
62_D	85_N	0.546	0.57
9_R	122_G	0.546	0.57
172_L	188_L	0.546	0.57
56_T	83_N	0.545	0.57
241_L	280_I	0.545	0.57
22_V	153_R	0.543	0.57
9_R	19_G	0.542	0.57
241_L	272_F	0.542	0.57
49_L	53_S	0.541	0.57
15_F	175_M	0.541	0.57
6_Q	225_D	0.537	0.56
93_R	264_D	0.536	0.56
13_E	175_M	0.534	0.56
40_P	96_G	0.534	0.56
244_L	248_E	0.531	0.55
74_P	109_G	0.530	0.55
230_C	270_Y	0.530	0.55
79_V	126_Q	0.529	0.55
72_D	78_A	0.527	0.55
41_V	78_A	0.526	0.55
56_T	144_F	0.526	0.55
37_Y	41_V	0.522	0.54
174_V	182_Q	0.521	0.54
187_H	212_L	0.521	0.54
53_S	84_N	0.521	0.54
25_S	201_L	0.519	0.54
228_F	232_C	0.518	0.54
17_V	184_D	0.518	0.54
7_L	22_V	0.518	0.54
200_L	203_L	0.517	0.53
150_L	241_L	0.514	0.53
5_D	35_H	0.513	0.53
24_V	167_A	0.512	0.53
105_K	136_L	0.512	0.53
36_D	162_D	0.511	0.53
121_E	171_L	0.511	0.53
19_G	116_T	0.511	0.53
174_V	192_T	0.510	0.52
250_D	274_A	0.510	0.52
116_T	280_I	0.509	0.52
5_D	26_E	0.508	0.52
70_Q	114_V	0.508	0.52
186_D	202_T	0.508	0.52
4_H	225_D	0.507	0.52
89_R	165_P	0.507	0.52
91_V	237_C	0.506	0.52
151_P	156_I	0.505	0.52
135_T	157_R	0.505	0.52
32_L	164_K	0.504	0.52
70_Q	110_N	0.504	0.52
64_D	120_S	0.504	0.52
213_Y	216_E	0.504	0.52
245_P	281_R	0.504	0.52
50_V	53_S	0.503	0.51
82_G	86_Q	0.503	0.51
102_A	281_R	0.501	0.51
23_T	75_M	0.501	0.51
43_N	197_T	0.500	0.51
170_M	212_L	0.500	0.51

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1i7fA	2	0.7808	100	0.035	Contact Map
1vzyA	3	0.9555	100	0.077	Contact Map
1vq0A	2	0.9589	100	0.093	Contact Map
1hw7A	2	0.7842	100	0.173	Contact Map
2xigA	4	0.3904	39.8	0.96	Contact Map
2ywwA	2	0.4658	28.9	0.962	Contact Map
1cvrA	1	0.4315	18.7	0.966	Contact Map
1pg5B	2	0.476	18.6	0.966	Contact Map
1gh9A	1	0.1781	17.6	0.966	Contact Map
3t7vA	1	0.2979	17.5	0.966	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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