GREMLIN Database
IHFB - Integration host factor subunit beta
UniProt: P0A6Y1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10441
Length: 94 (90)
Sequences: 4704 (2672)
Seq/√Len: 281.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
54_H79_H3.3741.00
60_T69_K2.7561.00
36_T41_E2.6611.00
23_E27_K2.5761.00
55_Y76_Y2.4271.00
58_P71_E2.3601.00
62_R67_G2.2831.00
60_T71_E2.2451.00
61_G72_L2.1621.00
53_L76_Y2.1431.00
8_E19_A2.0411.00
10_L26_V1.9421.00
84_K88_D1.9381.00
21_T24_D1.9241.00
62_R69_K1.8301.00
20_K24_D1.8221.00
37_L86_L1.6921.00
55_Y74_G1.6741.00
29_M33_M1.6311.00
52_S81_K1.5741.00
42_R52_S1.4811.00
42_R50_S1.4801.00
37_L53_L1.4781.00
56_R77_V1.4531.00
34_A86_L1.3931.00
18_P21_T1.3921.00
10_L29_M1.3701.00
9_R13_Q1.3661.00
46_R83_G1.3311.00
22_V25_A1.2781.00
6_L45_I1.2631.00
17_I22_V1.1841.00
9_R32_H1.1691.00
33_M43_I1.1651.00
58_P74_G1.1561.00
75_K91_N1.1381.00
3_K27_K1.1221.00
15_S22_V1.1161.00
17_I25_A1.0941.00
13_Q35_S1.0901.00
13_Q32_H1.0781.00
44_E50_S1.0631.00
49_G80_F1.0251.00
34_A89_R1.0161.00
31_E34_A1.0091.00
35_S39_Q1.0061.00
32_H36_T1.0011.00
9_R12_T0.9961.00
26_V30_L0.9751.00
30_L48_F0.9521.00
40_G76_Y0.9491.00
30_L45_I0.9441.00
38_A89_R0.9361.00
52_S79_H0.8961.00
8_E12_T0.8941.00
28_E32_H0.8931.00
63_N68_D0.8821.00
17_I21_T0.8741.00
5_E8_E0.8741.00
65_K68_D0.8651.00
75_K87_R0.8561.00
48_F51_F0.8491.00
1_M5_E0.8441.00
35_S38_A0.8291.00
59_R77_V0.8170.99
48_F83_G0.7920.99
78_P90_A0.7780.99
29_M32_H0.7750.99
56_R75_K0.7700.99
61_G70_V0.7550.99
37_L78_P0.7440.99
10_L25_A0.7410.99
62_R65_K0.7350.99
50_S81_K0.7350.99
36_T39_Q0.7350.99
13_Q31_E0.7310.99
2_T5_E0.7290.99
85_E88_D0.7230.99
36_T43_I0.7200.99
63_N67_G0.7150.99
4_S8_E0.7040.98
78_P87_R0.7010.98
13_Q28_E0.6910.98
44_E59_R0.6690.98
25_A32_H0.6640.98
78_P86_L0.6630.98
31_E35_S0.6620.98
32_H35_S0.6620.98
61_G69_K0.6540.98
24_D28_E0.6520.98
34_A38_A0.6430.97
35_S55_Y0.6320.97
46_R85_E0.6310.97
51_F80_F0.6300.97
39_Q55_Y0.6250.97
7_I23_E0.6160.97
18_P22_V0.6090.96
23_E42_R0.6030.96
50_S83_G0.6010.96
54_H77_V0.6010.96
27_K31_E0.5990.96
16_H21_T0.5860.95
20_K23_E0.5850.95
30_L34_A0.5820.95
16_H24_D0.5790.95
63_N66_T0.5750.95
10_L22_V0.5720.95
10_L15_S0.5700.95
28_E31_E0.5660.94
58_P73_E0.5590.94
39_Q71_E0.5570.94
40_G55_Y0.5570.94
56_R59_R0.5550.94
21_T25_A0.5530.94
33_M51_F0.5480.93
7_I26_V0.5460.93
9_R36_T0.5440.93
60_T70_V0.5440.93
16_H22_V0.5420.93
11_A19_A0.5360.93
7_I15_S0.5350.93
2_T46_R0.5340.93
11_A15_S0.5330.93
33_M48_F0.5270.92
3_K23_E0.5250.92
34_A37_L0.5210.92
44_E85_E0.5180.91
9_R39_Q0.5170.91
53_L86_L0.5140.91
37_L90_A0.5120.91
4_S59_R0.5080.91
1_M41_E0.5070.91
15_S28_E0.5040.90
47_G83_G0.5020.90
4_S44_E0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qjuA 2 0.9574 100 0.185 Contact Map
4p3vA 2 0.766 100 0.203 Contact Map
1mulA 2 0.8085 100 0.206 Contact Map
1b8zA 2 0.7128 100 0.207 Contact Map
1owfB 1 1 100 0.209 Contact Map
2iieA 1 0.9894 100 0.212 Contact Map
1exeA 2 0.9894 100 0.219 Contact Map
1owfA 1 0.9894 99.9 0.224 Contact Map
2np2A 2 0.9894 99.9 0.227 Contact Map
4pt4A 2 0.9894 99.9 0.227 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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