GREMLIN Database
IHFA - Integration host factor subunit alpha
UniProt: P0A6X7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10440
Length: 99 (90)
Sequences: 4896 (2786)
Seq/√Len: 293.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
55_R80_T3.2931.00
61_P70_D2.6981.00
37_A42_E2.5301.00
24_K28_E2.4841.00
56_D77_R2.4101.00
59_Q72_P2.2951.00
63_R68_G2.2281.00
61_P72_P2.1631.00
54_L77_R2.0941.00
62_G73_I2.0881.00
10_E20_K2.0121.00
22_D25_E1.9121.00
12_L27_V1.8451.00
63_R70_D1.8391.00
85_Q89_S1.8261.00
21_R25_E1.7591.00
56_D75_A1.6801.00
38_L87_L1.6121.00
30_F34_I1.6091.00
53_D82_R1.5921.00
57_K78_V1.5101.00
43_Q51_N1.5091.00
19_S22_D1.4821.00
38_L54_L1.4411.00
43_Q53_D1.4181.00
47_S84_G1.3271.00
35_R87_L1.3231.00
11_Y15_K1.3221.00
12_L30_F1.3011.00
59_Q75_A1.2601.00
23_A26_L1.2551.00
8_M46_L1.2281.00
34_I44_V1.1831.00
18_L23_A1.1551.00
76_R92_E1.1351.00
5_K28_E1.1341.00
18_L26_L1.1251.00
11_Y33_E1.1021.00
45_K51_N1.0791.00
15_K36_R1.0641.00
50_G81_F1.0431.00
11_Y14_D1.0251.00
35_R90_R0.9961.00
3_L7_E0.9931.00
31_F46_L0.9861.00
32_E35_R0.9861.00
33_E37_A0.9801.00
41_G77_R0.9801.00
15_K33_E0.9801.00
16_L23_A0.9551.00
36_R40_N0.9531.00
31_F49_F0.9461.00
64_N69_E0.9451.00
29_L33_E0.9251.00
27_V31_F0.9181.00
39_E90_R0.9101.00
53_D80_T0.8901.00
10_E14_D0.8791.00
76_R88_K0.8761.00
7_E10_E0.8551.00
36_R39_E0.8501.00
49_F52_F0.8351.00
30_F33_E0.8321.00
60_R78_V0.8271.00
18_L22_D0.8231.00
66_K69_E0.8201.00
49_F84_G0.8191.00
79_V91_V0.8161.00
15_K32_E0.7970.99
12_L16_L0.7820.99
6_A10_E0.7790.99
38_L79_V0.7710.99
51_N82_R0.7640.99
4_T7_E0.7630.99
57_K76_R0.7490.99
37_A40_N0.7460.99
79_V88_K0.7430.99
79_V87_L0.7390.99
62_G71_I0.7330.99
63_R66_K0.7330.99
19_S23_A0.7140.99
52_F81_F0.7030.99
15_K29_L0.7000.99
64_N68_G0.6960.99
13_F16_L0.6950.99
12_L26_L0.6930.99
37_A44_V0.6860.98
9_S27_V0.6840.98
45_K60_R0.6790.98
86_K89_S0.6740.98
47_S86_K0.6670.98
33_E36_R0.6660.98
9_S24_K0.6600.98
26_L33_E0.6510.98
55_R78_V0.6480.98
59_Q74_T0.6480.98
32_E36_R0.6460.98
51_N84_G0.6410.98
35_R39_E0.6400.98
62_G70_D0.6360.97
25_E29_L0.6320.97
28_E32_E0.6270.97
41_G56_D0.6150.97
31_F35_R0.6140.97
64_N67_T0.6080.97
17_G25_E0.6040.97
29_L32_E0.5970.96
24_K43_Q0.5940.96
17_G22_D0.5920.96
17_G23_A0.5810.96
40_N56_D0.5790.96
34_I52_F0.5760.95
36_R56_D0.5680.95
21_R24_K0.5660.95
86_K90_R0.5610.95
16_L29_L0.5590.95
57_K60_R0.5520.94
43_Q86_K0.5450.94
28_E31_F0.5420.94
61_P71_I0.5420.94
48_G84_G0.5390.94
11_Y37_A0.5380.94
3_L42_E0.5380.94
3_L9_S0.5360.93
87_L91_V0.5330.93
13_F20_K0.5290.93
5_K87_L0.5240.93
11_Y40_N0.5230.93
34_I49_F0.5230.93
12_L23_A0.5200.92
61_P66_K0.5170.92
35_R38_L0.5150.92
5_K24_K0.5110.92
23_A33_E0.5080.92
77_R92_E0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1owfA 1 0.9697 100 0.158 Contact Map
2iieA 1 1 100 0.188 Contact Map
4qjuA 2 0.9091 100 0.212 Contact Map
4p3vA 2 0.7273 100 0.214 Contact Map
1mulA 2 0.7677 100 0.217 Contact Map
4pt4A 2 0.9798 100 0.217 Contact Map
1exeA 2 0.9798 100 0.218 Contact Map
1b8zA 2 0.6768 100 0.219 Contact Map
1p71A 2 0.9495 100 0.22 Contact Map
1owfB 1 0.9394 100 0.224 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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