GREMLIN Database
HEM1 - Glutamyl-tRNA reductase
UniProt: P0A6X1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10427
Length: 418 (408)
Sequences: 2586 (1734)
Seq/√Len: 85.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
102_R322_E6.7541.00
276_L285_V6.5321.00
151_R155_E4.7061.00
280_A284_D4.3681.00
152_V321_A3.9531.00
248_S284_D3.7551.00
43_G135_A3.7411.00
45_V142_F3.6941.00
184_T210_I3.5841.00
208_K229_E3.2771.00
184_T208_K3.0921.00
98_S326_A3.0481.00
248_S285_V3.0211.00
317_A320_E2.9751.00
7_G89_Y2.9651.00
235_D238_E2.9091.00
356_R381_A2.8001.00
188_V257_I2.6871.00
353_E356_R2.6751.00
151_R328_E2.5891.00
212_A231_I2.5871.00
262_V276_L2.3561.00
14_P87_S2.3511.00
100_L121_V2.3351.00
174_R204_H2.3271.00
185_V206_V2.2541.00
259_K288_E2.2411.00
186_L212_A2.2241.00
151_R327_Q2.2061.00
141_M332_F2.1541.00
216_R230_V2.1221.00
239_R242_E2.1071.00
259_K263_E2.1001.00
19_E283_R2.0971.00
276_L295_A2.0701.00
216_R232_A2.0681.00
352_A388_L2.0661.00
14_P17_L2.0601.00
216_R220_Q2.0551.00
248_S280_A2.0451.00
328_E331_E2.0411.00
255_P286_E2.0341.00
359_L362_K2.0281.00
102_R108_D2.0081.00
116_Q196_L1.9681.00
94_N333_M1.9271.00
258_G261_M1.9201.00
312_A315_K1.9181.00
129_Q139_E1.9011.00
220_Q224_D1.8941.00
199_R225_E1.8811.00
57_L69_L1.8731.00
349_R393_T1.8531.00
285_V289_V1.8461.00
157_D160_A1.8231.00
349_R386_N1.7931.00
17_L87_S1.7891.00
231_I239_R1.7851.00
353_E357_D1.7421.00
250_T284_D1.7271.00
95_D98_S1.7191.00
56_Y142_F1.7051.00
190_A213_N1.6951.00
105_S152_V1.6891.00
262_V265_A1.6881.00
359_L383_K1.6591.00
260_G263_E1.6381.00
23_F31_A1.6331.00
32_L133_M1.6151.00
128_S133_M1.6071.00
43_G58_S1.5961.00
210_I231_I1.5941.00
125_F139_E1.5911.00
281_V300_V1.5761.00
148_V325_V1.5701.00
363_A376_I1.5421.00
36_L133_M1.5401.00
5_A56_Y1.5321.00
356_R378_Q1.5271.00
262_V289_V1.4990.99
97_V141_M1.4930.99
97_V329_T1.4800.99
259_K291_K1.4740.99
56_Y103_V1.4630.99
364_L374_Q1.4630.99
288_E291_K1.4620.99
58_S135_A1.4610.99
212_A233_L1.4560.99
146_F149_A1.4550.99
8_I21_V1.4530.99
103_V108_D1.4480.99
359_L387_R1.4310.99
352_A389_I1.4300.99
195_E225_E1.4250.99
332_F335_W1.4250.99
31_A46_V1.4190.99
198_A226_V1.4160.99
118_L149_A1.4050.99
185_V201_L1.4030.99
89_Y108_D1.3910.99
125_F129_Q1.3780.99
176_I296_Y1.3760.99
319_V322_E1.3740.99
70_I88_L1.3680.99
47_L121_V1.3610.99
344_T412_R1.3560.99
356_R382_W1.3500.99
240_L246_I1.3460.99
304_Q308_S1.3460.99
162_A167_F1.3440.99
105_S321_A1.3380.99
407_R414_S1.3280.99
11_K108_D1.3110.99
370_G373_A1.3060.99
237_D261_M1.3040.99
134_K139_E1.3030.99
18_R301_D1.3010.99
80_N83_D1.2940.98
299_S302_D1.2920.98
9_N108_D1.2760.98
212_A236_I1.2710.98
298_Y302_D1.2670.98
186_L243_A1.2660.98
351_Q391_A1.2600.98
229_E239_R1.2570.98
179_S182_T1.2430.98
140_R335_W1.2360.98
162_A168_A1.2340.98
186_L239_R1.2290.98
255_P287_P1.2240.98
71_R75_D1.2210.98
379_D383_K1.2150.98
210_I229_E1.2100.98
239_R243_A1.2100.98
375_A379_D1.2000.98
369_Q373_A1.1970.97
256_I284_D1.1950.97
71_R81_E1.1930.97
165_V193_T1.1880.97
385_T388_L1.1850.97
246_I276_L1.1840.97
169_A277_V1.1760.97
165_V279_I1.1710.97
42_Q60_E1.1690.97
182_T207_Q1.1670.97
101_M329_T1.1540.97
368_E374_Q1.1540.97
169_A279_I1.1500.97
148_V324_I1.1480.97
262_V274_M1.1400.97
395_S398_Q1.1390.97
177_F245_I1.1350.97
53_T106_G1.1280.96
260_G288_E1.1270.96
149_A161_S1.1250.96
4_L57_L1.1220.96
261_M286_E1.1220.96
210_I243_A1.1200.96
139_E143_Q1.1190.96
121_V142_F1.1150.96
105_S148_V1.1150.96
29_D131_G1.1100.96
231_I235_D1.1060.96
201_L206_V1.1010.96
31_A72_W1.0970.96
391_A416_G1.0930.96
184_T207_Q1.0930.96
21_V84_L1.0920.96
144_K148_V1.0880.96
184_T242_E1.0870.96
74_C79_L1.0750.95
27_K77_H1.0730.95
172_L298_Y1.0700.95
363_A380_L1.0620.95
238_E242_E1.0600.95
104_A121_V1.0520.95
97_V333_M1.0490.95
47_L124_A1.0470.95
254_L258_G1.0450.95
196_L200_H1.0430.94
271_N294_N1.0390.94
106_G112_L1.0350.94
143_Q146_F1.0330.94
286_E290_G1.0310.94
363_A381_A1.0290.94
348_Y415_L1.0270.94
405_N409_N1.0240.94
187_L201_L1.0230.94
207_Q229_E1.0220.94
348_Y389_I1.0210.94
8_I88_L1.0190.94
210_I239_R1.0140.94
217_E221_I1.0120.94
219_A223_A1.0100.93
209_M228_A1.0100.93
374_Q378_Q1.0090.93
6_L70_I1.0080.93
258_G286_E1.0070.93
403_G406_E1.0010.93
186_L231_I1.0010.93
214_R282_P0.9970.93
10_H110_L0.9900.93
110_L300_V0.9850.93
254_L260_G0.9830.92
183_V245_I0.9810.92
250_T256_I0.9790.92
126_A130_K0.9670.92
216_R233_L0.9630.92
175_Q309_H0.9630.92
46_V55_L0.9610.92
56_Y106_G0.9600.92
7_G18_R0.9570.91
30_Q33_D0.9560.91
144_K147_S0.9530.91
347_E412_R0.9480.91
257_I276_L0.9480.91
162_A171_T0.9400.91
171_T204_H0.9360.91
188_V285_V0.9340.90
36_L44_G0.9290.90
221_I224_D0.9290.90
231_I236_I0.9270.90
360_T378_Q0.9260.90
407_R411_L0.9230.90
326_A330_S0.9210.90
339_Q342_S0.9210.90
45_V134_K0.9210.90
260_G264_R0.9190.90
187_L198_A0.9180.90
372_D375_A0.9170.90
232_A235_D0.9140.89
259_K286_E0.9130.89
177_F296_Y0.9100.89
145_S149_A0.9100.89
35_L44_G0.9020.89
406_E409_N0.9010.89
98_S329_T0.9000.89
276_L297_L0.8980.89
153_R363_A0.8970.89
290_G297_L0.8960.89
118_L146_F0.8950.88
344_T347_E0.8940.88
257_I261_M0.8920.88
357_D378_Q0.8890.88
359_L379_D0.8880.88
258_G288_E0.8880.88
122_K146_F0.8860.88
111_V168_A0.8850.88
136_S339_Q0.8810.88
409_N413_D0.8800.88
144_K328_E0.8790.88
122_K150_K0.8770.87
33_D131_G0.8770.87
186_L233_L0.8760.87
128_S134_K0.8730.87
252_S284_D0.8700.87
3_L137_E0.8650.87
411_L414_S0.8640.87
367_L377_M0.8640.87
194_I222_L0.8630.87
91_H95_D0.8620.87
289_V292_L0.8600.86
377_M380_L0.8590.86
250_T280_A0.8580.86
276_L289_V0.8560.86
381_A384_L0.8550.86
99_H108_D0.8530.86
143_Q147_S0.8490.86
44_G55_L0.8460.86
198_A228_A0.8410.85
150_K154_T0.8400.85
217_E220_Q0.8350.85
184_T243_A0.8330.85
166_A197_V0.8320.85
12_T89_Y0.8320.85
286_E289_V0.8310.84
240_L265_A0.8300.84
244_D272_Q0.8300.84
137_E335_W0.8260.84
156_T324_I0.8240.84
173_A275_L0.8200.84
41_V59_V0.8190.84
149_A153_R0.8150.83
378_Q382_W0.8120.83
18_R281_V0.8110.83
356_R384_L0.8110.83
178_E182_T0.8090.83
15_V281_V0.8040.82
165_V300_V0.8030.82
404_D407_R0.8000.82
20_R83_D0.8000.82
115_P153_R0.7970.82
9_N89_Y0.7960.82
254_L286_E0.7950.82
35_L69_L0.7950.82
28_L127_D0.7930.82
50_C120_Q0.7920.82
125_F143_Q0.7920.82
111_V165_V0.7910.81
140_R339_Q0.7900.81
355_V380_L0.7890.81
121_V245_I0.7850.81
126_A129_Q0.7840.81
176_I245_I0.7810.81
344_T348_Y0.7790.80
398_Q402_D0.7790.80
156_T321_A0.7780.80
61_E67_E0.7760.80
348_Y392_P0.7750.80
127_D131_G0.7720.80
111_V305_S0.7720.80
173_A245_I0.7700.80
162_A318_A0.7690.80
94_N330_S0.7690.80
56_Y121_V0.7670.79
407_R410_I0.7650.79
240_L257_I0.7630.79
362_K390_H0.7620.79
380_L384_L0.7580.79
27_K30_Q0.7560.78
273_P296_Y0.7510.78
366_A371_G0.7510.78
389_I415_L0.7490.78
190_A218_R0.7480.78
400_A404_D0.7480.78
248_S289_V0.7470.78
158_I352_A0.7450.77
105_S324_I0.7450.77
171_T279_I0.7430.77
200_H321_A0.7430.77
253_P280_A0.7420.77
166_A170_C0.7420.77
32_L44_G0.7410.77
183_V244_D0.7400.77
247_I279_I0.7380.77
360_T364_L0.7380.77
152_V324_I0.7360.77
350_S354_Q0.7350.76
213_N219_A0.7350.76
188_V246_I0.7340.76
335_W338_A0.7330.76
127_D130_K0.7330.76
355_V384_L0.7320.76
45_V124_A0.7310.76
250_T282_P0.7310.76
344_T396_L0.7290.76
406_E410_I0.7270.76
367_L376_I0.7250.75
212_A232_A0.7240.75
385_T389_I0.7230.75
315_K319_V0.7230.75
246_I274_M0.7220.75
378_Q381_A0.7210.75
249_S279_I0.7200.75
23_F77_H0.7190.75
155_E324_I0.7190.75
362_K383_K0.7180.75
163_V314_R0.7140.74
100_L142_F0.7140.74
21_V79_L0.7140.74
156_T317_A0.7130.74
140_R146_F0.7080.74
236_I243_A0.7070.74
156_T173_A0.7060.74
41_V44_G0.7060.74
124_A128_S0.7050.73
116_Q283_R0.7040.73
186_L236_I0.7030.73
371_G374_Q0.7020.73
7_G150_K0.7010.73
335_W342_S0.7010.73
360_T377_M0.6990.73
206_V209_M0.6950.72
162_A310_N0.6920.72
395_S413_D0.6910.72
313_Q316_A0.6900.72
221_I225_E0.6880.72
106_G159_G0.6870.72
348_Y411_L0.6850.71
70_I85_R0.6850.71
237_D254_L0.6850.71
99_H103_V0.6840.71
253_P284_D0.6840.71
123_K246_I0.6820.71
325_V329_T0.6820.71
393_T397_Q0.6790.71
388_L393_T0.6770.70
240_L243_A0.6760.70
354_Q357_D0.6750.70
21_V77_H0.6750.70
325_V351_Q0.6740.70
352_A385_T0.6740.70
349_R390_H0.6720.70
5_A89_Y0.6710.70
198_A251_A0.6680.69
136_S139_E0.6640.69
351_Q354_Q0.6630.69
215_T219_A0.6620.69
323_T326_A0.6610.69
67_E85_R0.6590.68
3_L96_A0.6580.68
215_T218_R0.6570.68
358_E361_A0.6570.68
308_S312_A0.6560.68
190_A211_I0.6550.68
16_S19_E0.6520.68
233_L236_I0.6520.68
354_Q358_E0.6520.68
188_V236_I0.6510.67
148_V321_A0.6500.67
23_F46_V0.6470.67
166_A335_W0.6460.67
188_V197_V0.6450.67
51_N301_D0.6440.67
252_S280_A0.6430.66
3_L58_S0.6420.66
396_L411_L0.6420.66
19_E43_G0.6410.66
323_T327_Q0.6410.66
215_T397_Q0.6390.66
141_M335_W0.6390.66
110_L114_E0.6370.66
190_A222_L0.6360.66
241_R265_A0.6360.66
129_Q143_Q0.6340.65
172_L303_L0.6340.65
372_D410_I0.6330.65
219_A230_V0.6330.65
26_D29_D0.6320.65
259_K292_L0.6300.65
33_D37_A0.6300.65
395_S414_S0.6280.65
275_L296_Y0.6270.65
173_A180_L0.6250.64
235_D260_G0.6240.64
233_L254_L0.6240.64
243_A274_M0.6210.64
197_V215_T0.6210.64
27_K34_S0.6210.64
185_V275_L0.6200.64
178_E211_I0.6190.64
237_D260_G0.6170.63
405_N408_L0.6170.63
314_R317_A0.6170.63
115_P187_L0.6160.63
115_P149_A0.6140.63
41_V65_L0.6140.63
370_G374_Q0.6130.63
42_Q209_M0.6130.63
197_V247_I0.6110.63
168_A307_I0.6100.62
324_I339_Q0.6100.62
9_N344_T0.6100.62
337_R400_A0.6090.62
155_E328_E0.6070.62
231_I257_I0.6070.62
206_V245_I0.6030.62
66_Q92_Q0.6030.62
5_A96_A0.6020.61
101_M343_E0.6000.61
105_S118_L0.5970.61
213_N218_R0.5970.61
182_T185_V0.5970.61
283_R301_D0.5960.61
104_A134_K0.5940.60
309_H313_Q0.5940.60
81_E85_R0.5930.60
101_M348_Y0.5930.60
165_V324_I0.5930.60
18_R166_A0.5900.60
23_F53_T0.5880.60
101_M118_L0.5880.60
374_Q377_M0.5860.59
157_D317_A0.5850.59
222_L225_E0.5830.59
391_A395_S0.5820.59
373_A377_M0.5820.59
247_I284_D0.5790.58
349_R392_P0.5780.58
264_R288_E0.5780.58
172_L175_Q0.5770.58
50_C114_E0.5770.58
341_A397_Q0.5760.58
4_L59_V0.5750.58
38_Q75_D0.5750.58
356_R386_N0.5720.58
410_I414_S0.5720.58
95_D326_A0.5710.57
320_E323_T0.5700.57
344_T351_Q0.5690.57
201_L205_K0.5680.57
15_V19_E0.5670.57
220_Q230_V0.5660.57
203_E306_I0.5650.57
247_I277_V0.5650.57
329_T332_F0.5640.56
195_E199_R0.5620.56
28_L36_L0.5610.56
104_A145_S0.5610.56
194_I299_S0.5610.56
351_Q361_A0.5600.56
213_N222_L0.5590.56
140_R332_F0.5590.56
214_R250_T0.5590.56
361_A364_L0.5580.56
59_V65_L0.5580.56
153_R282_P0.5560.55
193_T303_L0.5560.55
195_E249_S0.5550.55
240_L262_V0.5550.55
68_A71_R0.5550.55
177_F298_Y0.5540.55
74_C81_E0.5540.55
45_V121_V0.5540.55
170_C303_L0.5540.55
256_I280_A0.5530.55
153_R396_L0.5530.55
172_L306_I0.5520.55
229_E242_E0.5510.55
186_L246_I0.5510.55
149_A152_V0.5500.55
252_S256_I0.5500.55
67_E364_L0.5490.54
101_M148_V0.5470.54
283_R297_L0.5470.54
201_L247_I0.5470.54
132_H316_A0.5460.54
94_N388_L0.5460.54
125_F146_F0.5460.54
380_L383_K0.5450.54
49_T52_R0.5440.54
3_L97_V0.5430.54
152_V156_T0.5430.54
270_R350_S0.5420.54
121_V126_A0.5420.54
255_P289_V0.5410.53
357_D361_A0.5410.53
8_I13_A0.5400.53
25_P123_K0.5390.53
18_R335_W0.5390.53
7_G12_T0.5380.53
34_S75_D0.5370.53
349_R388_L0.5370.53
58_S137_E0.5370.53
356_R363_A0.5340.52
18_R48_S0.5340.52
55_L69_L0.5330.52
107_L322_E0.5330.52
15_V283_R0.5320.52
114_E120_Q0.5310.52
67_E242_E0.5310.52
104_A148_V0.5310.52
364_L370_G0.5290.52
166_A279_I0.5290.52
381_A387_R0.5290.52
237_D264_R0.5290.52
57_L209_M0.5280.52
39_P42_Q0.5260.51
34_S295_A0.5240.51
41_V57_L0.5240.51
115_P119_G0.5230.51
45_V100_L0.5230.51
31_A76_Y0.5230.51
163_V306_I0.5220.51
9_N162_A0.5220.51
42_Q58_S0.5220.51
363_A367_L0.5210.51
265_A274_M0.5210.51
104_A118_L0.5200.51
178_E183_V0.5200.51
178_E251_A0.5200.51
193_T197_V0.5180.50
362_K387_R0.5170.50
220_Q232_A0.5160.50
279_I306_I0.5160.50
128_S367_L0.5150.50
167_F200_H0.5150.50
100_L201_L0.5150.50
98_S102_R0.5140.50
383_K415_L0.5130.50
250_T283_R0.5130.50
55_L129_Q0.5130.50
183_V294_N0.5120.50
48_S281_V0.5110.49
148_V328_E0.5110.49
275_L298_Y0.5110.49
409_N416_G0.5100.49
103_V121_V0.5100.49
29_D127_D0.5080.49
360_T380_L0.5070.49
115_P159_G0.5070.49
187_L212_A0.5070.49
168_A301_D0.5070.49
24_S29_D0.5060.49
86_K416_G0.5050.49
187_L275_L0.5040.48
367_L373_A0.5040.48
134_K138_L0.5040.48
27_K286_E0.5040.48
318_A321_A0.5030.48
9_N112_L0.5030.48
343_E348_Y0.5030.48
167_F171_T0.5030.48
40_M65_L0.5030.48
241_R262_V0.5020.48
32_L36_L0.5020.48
200_H300_V0.5020.48
44_G57_L0.5010.48
248_S276_L0.5010.48
59_V62_Q0.5010.48
6_L69_L0.5010.48
250_T253_P0.5000.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4n7rA 2 0.9498 100 0.286 Contact Map
1gpjA 2 0.9426 100 0.396 Contact Map
4ppmA 2 0.0909 99.9 0.786 Contact Map
1edzA 2 0.6938 99.9 0.802 Contact Map
1p77A 1 0.61 99.9 0.816 Contact Map
3u62A 1 0.5574 99.9 0.817 Contact Map
1nytA 6 0.6172 99.8 0.83 Contact Map
3fbtA 2 0.6244 99.8 0.835 Contact Map
3oj0A 1 0.3301 99.8 0.836 Contact Map
2eggA 5 0.6268 99.8 0.838 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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