MRAY - ECOLI - GREMLIN Contacts

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MRAY - Phospho-N-acetylmuramoyl-pentapeptide-transferase

UniProt:	P0A6W3	Sequences: MLVWLAEHLVKYYSGFNVFSYLTFRAIVSLLTALFISLWMGPRMIAHLQKLSFGQVVRNDGPESHFSKRGTPTMGGIMILTAIVISVLLWAYPSNPYVWCVLVVLVGYGVIGFVDDYRKVVRKDTKGLIARWKYFWMSVIALGVAFALYLAGKDTPATQLVVPFFKDVMPQLGLFYILLAYFVIVGTGNAVNLTDGLDGLAIMPTVFVAGGFALVAWATGNMNFASYLHIPYLRHAGELVIVCTAIVGAGLGFLWFNTYPAQVFMGDVGSLALGGALGIIAVLLRQEFLLVIMGGVFVVETLSVILQVGSFKLRGQRIFRMAPIHHHYELKGWPEPRVIVRFWIISLMLVLIGLATLKVR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10604
Length:	360 (297)
Sequences:	6585 (4257)
Seq/√Len:	247.0

ECOLI - MRAY WECA
BACSU - MRAY TAGO
SULSO - GPT

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
211_G	350_V	4.066	1.00
203_M	343_W	3.911	1.00
306_L	318_I	3.770	1.00
320_R	331_K	3.523	1.00
213_A	244_T	3.355	1.00
243_C	280_I	3.247	1.00
129_I	132_W	3.206	1.00
107_G	140_I	2.674	1.00
206_V	247_V	2.658	1.00
79_I	265_M	2.506	1.00
144_V	279_I	2.500	1.00
295_G	349_L	2.454	1.00
321_M	330_L	2.451	1.00
105_L	272_A	2.448	1.00
160_L	163_P	2.404	1.00
210_G	247_V	2.348	1.00
37_S	252_G	2.329	1.00
80_L	109_G	2.322	1.00
114_V	118_R	2.290	1.00
37_S	82_A	2.237	1.00
310_S	314_R	2.203	1.00
184_I	278_G	2.170	1.00
334_P	337_R	2.118	1.00
80_L	106_V	1.999	1.00
310_S	313_L	1.996	1.00
104_V	275_G	1.971	1.00
202_I	250_G	1.970	1.00
82_A	86_S	1.940	1.00
304_V	308_V	1.914	1.00
84_V	106_V	1.885	1.00
111_I	136_W	1.868	1.00
191_V	205_T	1.862	1.00
246_I	276_A	1.830	1.00
202_I	254_L	1.777	1.00
205_T	209_A	1.776	1.00
133_K	137_M	1.755	1.00
242_V	276_A	1.751	1.00
145_A	181_Y	1.739	1.00
83_I	246_I	1.725	1.00
26_A	244_T	1.718	1.00
311_F	315_G	1.705	1.00
41_G	78_M	1.704	1.00
142_L	146_F	1.701	1.00
45_I	49_Q	1.701	1.00
36_I	82_A	1.698	1.00
246_I	273_L	1.648	1.00
138_S	181_Y	1.647	1.00
216_A	284_L	1.637	1.00
58_R	65_H	1.630	1.00
34_L	255_W	1.614	1.00
300_E	304_V	1.606	1.00
44_M	78_M	1.587	1.00
300_E	308_V	1.585	1.00
309_G	313_L	1.574	1.00
175_F	178_L	1.552	1.00
142_L	181_Y	1.549	1.00
174_L	178_L	1.547	1.00
32_T	90_W	1.539	1.00
145_A	180_A	1.529	1.00
213_A	243_C	1.527	1.00
113_F	117_Y	1.527	1.00
204_P	346_S	1.521	1.00
104_V	144_V	1.521	1.00
209_A	246_I	1.503	1.00
38_L	255_W	1.496	1.00
258_T	340_V	1.483	1.00
333_W	341_R	1.476	1.00
58_R	63_E	1.471	1.00
217_W	240_V	1.463	1.00
29_S	245_A	1.457	1.00
206_V	251_L	1.455	1.00
134_Y	137_M	1.455	1.00
138_S	185_V	1.453	1.00
79_I	249_A	1.440	1.00
310_S	318_I	1.427	1.00
47_H	50_K	1.417	1.00
145_A	177_I	1.414	1.00
202_I	206_V	1.387	1.00
133_K	271_L	1.381	1.00
180_A	282_V	1.366	1.00
205_T	273_L	1.360	1.00
207_F	343_W	1.348	1.00
301_T	304_V	1.319	1.00
294_G	298_V	1.317	1.00
302_L	306_L	1.310	1.00
80_L	272_A	1.302	1.00
42_P	46_A	1.277	1.00
86_S	245_A	1.271	1.00
301_T	305_I	1.271	1.00
308_V	311_F	1.269	1.00
41_G	263_V	1.261	1.00
46_A	50_K	1.257	1.00
208_V	346_S	1.254	1.00
110_V	114_V	1.249	1.00
208_V	277_L	1.233	1.00
109_G	268_V	1.225	1.00
192_N	267_D	1.221	1.00
186_G	305_I	1.219	1.00
141_A	181_Y	1.217	1.00
337_R	341_R	1.216	1.00
198_D	260_P	1.205	1.00
38_L	252_G	1.204	1.00
207_F	350_V	1.198	1.00
309_G	314_R	1.188	1.00
47_H	51_L	1.184	1.00
45_I	262_Q	1.183	1.00
183_V	187_T	1.182	1.00
196_G	325_H	1.175	1.00
138_S	142_L	1.166	1.00
188_G	271_L	1.164	1.00
33_A	248_G	1.163	1.00
84_V	102_L	1.163	1.00
259_Y	336_P	1.157	1.00
308_V	312_K	1.152	1.00
304_V	312_K	1.151	1.00
54_G	57_V	1.149	1.00
193_L	301_T	1.148	1.00
209_A	277_L	1.143	1.00
54_G	70_G	1.142	1.00
209_A	247_V	1.138	1.00
141_A	184_I	1.132	1.00
324_I	328_Y	1.131	1.00
189_N	192_N	1.119	1.00
250_G	273_L	1.117	1.00
208_V	293_M	1.117	1.00
108_Y	141_A	1.114	1.00
111_I	140_I	1.111	1.00
191_V	201_A	1.110	1.00
209_A	243_C	1.108	1.00
103_V	143_G	1.105	1.00
79_I	250_G	1.100	1.00
30_L	248_G	1.099	1.00
305_I	308_V	1.099	1.00
340_V	344_I	1.092	1.00
317_R	320_R	1.080	1.00
34_L	252_G	1.080	1.00
346_S	350_V	1.077	1.00
294_G	297_F	1.071	1.00
100_C	147_A	1.070	1.00
46_A	49_Q	1.070	1.00
162_V	165_F	1.069	1.00
137_M	271_L	1.045	1.00
55_Q	65_H	1.043	1.00
176_Y	180_A	1.042	1.00
107_G	136_W	1.035	1.00
134_Y	185_V	1.033	1.00
183_V	281_A	1.031	1.00
101_V	239_L	1.029	1.00
144_V	184_I	1.026	1.00
213_A	247_V	1.022	1.00
216_A	239_L	1.022	1.00
316_Q	320_R	1.022	1.00
297_F	301_T	1.017	1.00
71_T	264_F	1.016	1.00
252_G	256_F	1.011	1.00
184_I	279_I	1.005	1.00
272_A	276_A	1.004	1.00
36_I	86_S	1.003	1.00
67_S	264_F	0.999	1.00
301_T	308_V	0.991	1.00
43_R	46_A	0.990	1.00
30_L	244_T	0.990	1.00
328_Y	342_F	0.985	1.00
180_A	184_I	0.983	1.00
207_F	346_S	0.981	1.00
158_T	161_V	0.978	1.00
141_A	185_V	0.971	1.00
108_Y	275_G	0.969	1.00
83_I	249_A	0.964	1.00
133_K	188_G	0.963	1.00
137_M	188_G	0.956	1.00
82_A	85_I	0.955	1.00
103_V	107_G	0.955	1.00
64_S	67_S	0.949	1.00
33_A	249_A	0.940	1.00
300_E	325_H	0.939	1.00
212_F	281_A	0.936	1.00
211_G	293_M	0.935	1.00
254_L	258_T	0.934	1.00
211_G	354_L	0.931	1.00
42_P	256_F	0.920	1.00
304_V	307_Q	0.916	1.00
73_T	268_V	0.915	1.00
307_Q	311_F	0.915	1.00
105_L	276_A	0.914	1.00
190_A	301_T	0.911	1.00
104_V	140_I	0.909	1.00
213_A	216_A	0.909	1.00
108_Y	140_I	0.909	1.00
104_V	279_I	0.909	1.00
37_S	41_G	0.907	1.00
216_A	240_V	0.901	1.00
197_L	339_I	0.899	1.00
83_I	105_L	0.897	1.00
137_M	185_V	0.892	1.00
213_A	217_W	0.890	1.00
194_T	204_P	0.889	1.00
108_Y	188_G	0.886	1.00
133_K	193_L	0.885	1.00
202_I	265_M	0.884	1.00
182_F	186_G	0.883	1.00
220_G	237_G	0.880	1.00
112_G	271_L	0.879	1.00
137_M	189_N	0.879	1.00
205_T	277_L	0.875	0.99
34_L	251_L	0.873	0.99
134_Y	138_S	0.873	0.99
213_A	240_V	0.873	0.99
205_T	250_G	0.870	0.99
333_W	337_R	0.869	0.99
248_G	252_G	0.866	0.99
80_L	105_L	0.866	0.99
39_W	43_R	0.859	0.99
87_V	98_V	0.858	0.99
320_R	330_L	0.858	0.99
133_K	136_W	0.851	0.99
41_G	252_G	0.845	0.99
146_F	150_L	0.828	0.99
245_A	248_G	0.827	0.99
251_L	255_W	0.825	0.99
71_T	261_A	0.825	0.99
43_R	47_H	0.825	0.99
259_Y	335_E	0.817	0.99
36_I	85_I	0.815	0.99
255_W	341_R	0.814	0.99
209_A	250_G	0.813	0.99
118_R	128_L	0.813	0.99
101_V	105_L	0.807	0.99
206_V	250_G	0.803	0.99
210_G	214_L	0.802	0.99
191_V	208_V	0.795	0.99
201_A	273_L	0.794	0.99
212_F	284_L	0.785	0.99
148_L	151_A	0.784	0.99
294_G	299_V	0.783	0.99
28_V	32_T	0.780	0.99
300_E	312_K	0.780	0.99
345_I	349_L	0.770	0.99
108_Y	136_W	0.769	0.99
349_L	353_G	0.764	0.99
297_F	304_V	0.764	0.99
101_V	279_I	0.764	0.99
207_F	347_L	0.763	0.99
55_Q	73_T	0.760	0.99
105_L	242_V	0.757	0.99
193_L	305_I	0.756	0.99
194_T	325_H	0.755	0.99
309_G	312_K	0.753	0.98
313_L	318_I	0.749	0.98
314_R	318_I	0.748	0.98
258_T	336_P	0.746	0.98
33_A	86_S	0.746	0.98
40_M	78_M	0.745	0.98
171_Q	175_F	0.744	0.98
63_E	66_F	0.742	0.98
37_S	79_I	0.742	0.98
173_G	178_L	0.742	0.98
118_R	129_I	0.740	0.98
83_I	272_A	0.740	0.98
131_R	135_F	0.737	0.98
290_L	294_G	0.733	0.98
141_A	145_A	0.733	0.98
38_L	256_F	0.732	0.98
40_M	82_A	0.730	0.98
101_V	276_A	0.727	0.98
208_V	350_V	0.727	0.98
321_M	326_H	0.726	0.98
208_V	294_G	0.725	0.98
144_V	148_L	0.720	0.98
55_Q	58_R	0.719	0.98
36_I	40_M	0.719	0.98
114_V	117_Y	0.719	0.98
310_S	316_Q	0.718	0.98
315_G	318_I	0.712	0.98
109_G	272_A	0.711	0.98
214_L	218_A	0.710	0.98
30_L	247_V	0.709	0.98
29_S	241_I	0.708	0.98
297_F	308_V	0.707	0.98
242_V	280_I	0.707	0.98
186_G	302_L	0.705	0.98
326_H	329_E	0.703	0.98
34_L	38_L	0.700	0.98
305_I	309_G	0.696	0.97
333_W	338_V	0.696	0.97
58_R	64_S	0.696	0.97
133_K	267_D	0.693	0.97
29_S	86_S	0.693	0.97
74_M	113_F	0.693	0.97
348_M	352_I	0.693	0.97
339_I	343_W	0.692	0.97
35_F	39_W	0.690	0.97
187_T	278_G	0.689	0.97
300_E	342_F	0.688	0.97
187_T	281_A	0.687	0.97
66_F	335_E	0.687	0.97
189_N	267_D	0.686	0.97
57_V	64_S	0.685	0.97
197_L	338_V	0.683	0.97
129_I	133_K	0.683	0.97
344_I	348_M	0.682	0.97
179_L	183_V	0.682	0.97
306_L	309_G	0.681	0.97
209_A	276_A	0.679	0.97
264_F	267_D	0.678	0.97
192_N	264_F	0.677	0.97
107_G	111_I	0.677	0.97
65_H	71_T	0.672	0.97
204_P	296_V	0.670	0.97
163_P	170_P	0.669	0.97
214_L	354_L	0.669	0.97
45_I	263_V	0.668	0.97
27_I	31_L	0.660	0.97
201_A	265_M	0.659	0.97
193_L	304_V	0.659	0.97
175_F	179_L	0.656	0.96
159_Q	171_Q	0.655	0.96
259_Y	339_I	0.652	0.96
293_M	353_G	0.649	0.96
132_W	135_F	0.644	0.96
108_Y	137_M	0.639	0.96
119_K	128_L	0.639	0.96
322_A	327_H	0.638	0.96
295_G	299_V	0.636	0.96
201_A	297_F	0.636	0.96
200_L	342_F	0.633	0.96
48_L	263_V	0.633	0.96
202_I	253_F	0.631	0.96
299_V	324_I	0.631	0.96
297_F	300_E	0.630	0.96
178_L	181_Y	0.628	0.95
83_I	209_A	0.626	0.95
328_Y	333_W	0.626	0.95
329_E	332_G	0.623	0.95
87_V	242_V	0.620	0.95
163_P	166_K	0.619	0.95
195_D	265_M	0.617	0.95
158_T	171_Q	0.615	0.95
31_L	35_F	0.613	0.95
143_G	147_A	0.613	0.95
327_H	330_L	0.609	0.95
315_G	319_F	0.608	0.95
48_L	72_P	0.608	0.95
329_E	338_V	0.606	0.94
83_I	87_V	0.606	0.94
298_V	301_T	0.605	0.94
87_V	91_A	0.604	0.94
158_T	162_V	0.604	0.94
207_F	211_G	0.604	0.94
341_R	344_I	0.602	0.94
212_F	243_C	0.601	0.94
113_F	268_V	0.600	0.94
186_G	190_A	0.600	0.94
291_V	294_G	0.599	0.94
147_A	151_A	0.599	0.94
111_I	271_L	0.598	0.94
187_T	298_V	0.598	0.94
204_P	297_F	0.597	0.94
338_V	342_F	0.595	0.94
351_L	355_A	0.595	0.94
66_F	329_E	0.594	0.94
32_T	86_S	0.593	0.94
77_I	268_V	0.592	0.94
206_V	210_G	0.591	0.94
48_L	53_F	0.590	0.94
144_V	275_G	0.589	0.94
335_E	339_I	0.588	0.94
203_M	339_I	0.587	0.94
177_I	181_Y	0.587	0.94
295_G	308_V	0.582	0.93
109_G	113_F	0.582	0.93
296_V	300_E	0.581	0.93
161_V	164_F	0.581	0.93
334_P	338_V	0.581	0.93
239_L	283_L	0.580	0.93
350_V	353_G	0.579	0.93
221_N	238_E	0.578	0.93
44_M	53_F	0.578	0.93
134_Y	181_Y	0.577	0.93
74_M	117_Y	0.576	0.93
56_V	70_G	0.574	0.93
106_V	110_V	0.574	0.93
51_L	117_Y	0.573	0.93
65_H	329_E	0.571	0.93
296_V	304_V	0.571	0.93
265_M	273_L	0.570	0.92
96_P	147_A	0.569	0.92
158_T	163_P	0.569	0.92
316_Q	319_F	0.566	0.92
314_R	322_A	0.565	0.92
275_G	279_I	0.563	0.92
311_F	317_R	0.563	0.92
240_V	244_T	0.561	0.92
328_Y	338_V	0.560	0.92
54_G	73_T	0.559	0.92
188_G	275_G	0.559	0.92
325_H	329_E	0.559	0.92
160_L	171_Q	0.557	0.92
65_H	70_G	0.557	0.92
94_S	97_Y	0.557	0.92
57_V	65_H	0.555	0.91
187_T	290_L	0.553	0.91
82_A	249_A	0.552	0.91
146_F	177_I	0.552	0.91
290_L	297_F	0.552	0.91
323_P	327_H	0.551	0.91
75_G	253_F	0.549	0.91
130_A	134_Y	0.547	0.91
303_S	307_Q	0.543	0.91
44_M	47_H	0.541	0.90
30_L	34_L	0.541	0.90
200_L	339_I	0.538	0.90
300_E	307_Q	0.537	0.90
212_F	293_M	0.534	0.90
170_P	173_G	0.534	0.90
241_I	245_A	0.532	0.90
26_A	29_S	0.530	0.90
290_L	301_T	0.530	0.90
149_Y	177_I	0.527	0.89
195_D	201_A	0.526	0.89
295_G	304_V	0.524	0.89
161_V	166_K	0.523	0.89
33_A	82_A	0.523	0.89
309_G	322_A	0.522	0.89
188_G	278_G	0.520	0.89
208_V	297_F	0.519	0.89
151_A	176_Y	0.518	0.88
49_Q	53_F	0.518	0.88
195_D	269_G	0.518	0.88
198_D	326_H	0.517	0.88
160_L	166_K	0.516	0.88
58_R	66_F	0.516	0.88
160_L	164_F	0.515	0.88
287_E	291_V	0.510	0.88
243_C	276_A	0.510	0.88
299_V	345_I	0.510	0.88
83_I	242_V	0.509	0.88
350_V	354_L	0.509	0.88
42_P	45_I	0.508	0.88
63_E	330_L	0.508	0.88
282_V	286_Q	0.507	0.87
108_Y	272_A	0.505	0.87
77_I	109_G	0.504	0.87
48_L	54_G	0.502	0.87
203_M	207_F	0.502	0.87
73_T	335_E	0.500	0.87

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
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HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4j72A	2	0.8944	100	0.117	Contact Map
4mt1A	3	0.1417	20.7	0.963	Contact Map
3w9iA	3	0.15	11.8	0.966	Contact Map
4k0jA	3	0.1417	11.4	0.967	Contact Map
2ls4A	1	0.0667	8.7	0.968	Contact Map
4dx5A	3	0.1667	7	0.97	Contact Map
3aqpA	1	0.1306	6.9	0.97	Contact Map
4j05A	3	0.1667	6.5	0.97	Contact Map
3qnqA	2	0.1778	4.3	0.973	Contact Map
4ldsA	2	0.1333	4.2	0.973	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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