GREMLIN Database
MRAY - Phospho-N-acetylmuramoyl-pentapeptide-transferase
UniProt: P0A6W3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10604
Length: 360 (297)
Sequences: 6585 (4257)
Seq/√Len: 247.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
211_G350_V4.0661.00
203_M343_W3.9111.00
306_L318_I3.7701.00
320_R331_K3.5231.00
213_A244_T3.3551.00
243_C280_I3.2471.00
129_I132_W3.2061.00
107_G140_I2.6741.00
206_V247_V2.6581.00
79_I265_M2.5061.00
144_V279_I2.5001.00
295_G349_L2.4541.00
321_M330_L2.4511.00
105_L272_A2.4481.00
160_L163_P2.4041.00
210_G247_V2.3481.00
37_S252_G2.3291.00
80_L109_G2.3221.00
114_V118_R2.2901.00
37_S82_A2.2371.00
310_S314_R2.2031.00
184_I278_G2.1701.00
334_P337_R2.1181.00
80_L106_V1.9991.00
310_S313_L1.9961.00
104_V275_G1.9711.00
202_I250_G1.9701.00
82_A86_S1.9401.00
304_V308_V1.9141.00
84_V106_V1.8851.00
111_I136_W1.8681.00
191_V205_T1.8621.00
246_I276_A1.8301.00
202_I254_L1.7771.00
205_T209_A1.7761.00
133_K137_M1.7551.00
242_V276_A1.7511.00
145_A181_Y1.7391.00
83_I246_I1.7251.00
26_A244_T1.7181.00
311_F315_G1.7051.00
41_G78_M1.7041.00
142_L146_F1.7011.00
45_I49_Q1.7011.00
36_I82_A1.6981.00
246_I273_L1.6481.00
138_S181_Y1.6471.00
216_A284_L1.6371.00
58_R65_H1.6301.00
34_L255_W1.6141.00
300_E304_V1.6061.00
44_M78_M1.5871.00
300_E308_V1.5851.00
309_G313_L1.5741.00
175_F178_L1.5521.00
142_L181_Y1.5491.00
174_L178_L1.5471.00
32_T90_W1.5391.00
145_A180_A1.5291.00
213_A243_C1.5271.00
113_F117_Y1.5271.00
204_P346_S1.5211.00
104_V144_V1.5211.00
209_A246_I1.5031.00
38_L255_W1.4961.00
258_T340_V1.4831.00
333_W341_R1.4761.00
58_R63_E1.4711.00
217_W240_V1.4631.00
29_S245_A1.4571.00
206_V251_L1.4551.00
134_Y137_M1.4551.00
138_S185_V1.4531.00
79_I249_A1.4401.00
310_S318_I1.4271.00
47_H50_K1.4171.00
145_A177_I1.4141.00
202_I206_V1.3871.00
133_K271_L1.3811.00
180_A282_V1.3661.00
205_T273_L1.3601.00
207_F343_W1.3481.00
301_T304_V1.3191.00
294_G298_V1.3171.00
302_L306_L1.3101.00
80_L272_A1.3021.00
42_P46_A1.2771.00
86_S245_A1.2711.00
301_T305_I1.2711.00
308_V311_F1.2691.00
41_G263_V1.2611.00
46_A50_K1.2571.00
208_V346_S1.2541.00
110_V114_V1.2491.00
208_V277_L1.2331.00
109_G268_V1.2251.00
192_N267_D1.2211.00
186_G305_I1.2191.00
141_A181_Y1.2171.00
337_R341_R1.2161.00
198_D260_P1.2051.00
38_L252_G1.2041.00
207_F350_V1.1981.00
309_G314_R1.1881.00
47_H51_L1.1841.00
45_I262_Q1.1831.00
183_V187_T1.1821.00
196_G325_H1.1751.00
138_S142_L1.1661.00
188_G271_L1.1641.00
33_A248_G1.1631.00
84_V102_L1.1631.00
259_Y336_P1.1571.00
308_V312_K1.1521.00
304_V312_K1.1511.00
54_G57_V1.1491.00
193_L301_T1.1481.00
209_A277_L1.1431.00
54_G70_G1.1421.00
209_A247_V1.1381.00
141_A184_I1.1321.00
324_I328_Y1.1311.00
189_N192_N1.1191.00
250_G273_L1.1171.00
208_V293_M1.1171.00
108_Y141_A1.1141.00
111_I140_I1.1111.00
191_V201_A1.1101.00
209_A243_C1.1081.00
103_V143_G1.1051.00
79_I250_G1.1001.00
30_L248_G1.0991.00
305_I308_V1.0991.00
340_V344_I1.0921.00
317_R320_R1.0801.00
34_L252_G1.0801.00
346_S350_V1.0771.00
294_G297_F1.0711.00
100_C147_A1.0701.00
46_A49_Q1.0701.00
162_V165_F1.0691.00
137_M271_L1.0451.00
55_Q65_H1.0431.00
176_Y180_A1.0421.00
107_G136_W1.0351.00
134_Y185_V1.0331.00
183_V281_A1.0311.00
101_V239_L1.0291.00
144_V184_I1.0261.00
213_A247_V1.0221.00
216_A239_L1.0221.00
316_Q320_R1.0221.00
297_F301_T1.0171.00
71_T264_F1.0161.00
252_G256_F1.0111.00
184_I279_I1.0051.00
272_A276_A1.0041.00
36_I86_S1.0031.00
67_S264_F0.9991.00
301_T308_V0.9911.00
43_R46_A0.9901.00
30_L244_T0.9901.00
328_Y342_F0.9851.00
180_A184_I0.9831.00
207_F346_S0.9811.00
158_T161_V0.9781.00
141_A185_V0.9711.00
108_Y275_G0.9691.00
83_I249_A0.9641.00
133_K188_G0.9631.00
137_M188_G0.9561.00
82_A85_I0.9551.00
103_V107_G0.9551.00
64_S67_S0.9491.00
33_A249_A0.9401.00
300_E325_H0.9391.00
212_F281_A0.9361.00
211_G293_M0.9351.00
254_L258_T0.9341.00
211_G354_L0.9311.00
42_P256_F0.9201.00
304_V307_Q0.9161.00
73_T268_V0.9151.00
307_Q311_F0.9151.00
105_L276_A0.9141.00
190_A301_T0.9111.00
104_V140_I0.9091.00
213_A216_A0.9091.00
108_Y140_I0.9091.00
104_V279_I0.9091.00
37_S41_G0.9071.00
216_A240_V0.9011.00
197_L339_I0.8991.00
83_I105_L0.8971.00
137_M185_V0.8921.00
213_A217_W0.8901.00
194_T204_P0.8891.00
108_Y188_G0.8861.00
133_K193_L0.8851.00
202_I265_M0.8841.00
182_F186_G0.8831.00
220_G237_G0.8801.00
112_G271_L0.8791.00
137_M189_N0.8791.00
205_T277_L0.8750.99
34_L251_L0.8730.99
134_Y138_S0.8730.99
213_A240_V0.8730.99
205_T250_G0.8700.99
333_W337_R0.8690.99
248_G252_G0.8660.99
80_L105_L0.8660.99
39_W43_R0.8590.99
87_V98_V0.8580.99
320_R330_L0.8580.99
133_K136_W0.8510.99
41_G252_G0.8450.99
146_F150_L0.8280.99
245_A248_G0.8270.99
251_L255_W0.8250.99
71_T261_A0.8250.99
43_R47_H0.8250.99
259_Y335_E0.8170.99
36_I85_I0.8150.99
255_W341_R0.8140.99
209_A250_G0.8130.99
118_R128_L0.8130.99
101_V105_L0.8070.99
206_V250_G0.8030.99
210_G214_L0.8020.99
191_V208_V0.7950.99
201_A273_L0.7940.99
212_F284_L0.7850.99
148_L151_A0.7840.99
294_G299_V0.7830.99
28_V32_T0.7800.99
300_E312_K0.7800.99
345_I349_L0.7700.99
108_Y136_W0.7690.99
349_L353_G0.7640.99
297_F304_V0.7640.99
101_V279_I0.7640.99
207_F347_L0.7630.99
55_Q73_T0.7600.99
105_L242_V0.7570.99
193_L305_I0.7560.99
194_T325_H0.7550.99
309_G312_K0.7530.98
313_L318_I0.7490.98
314_R318_I0.7480.98
258_T336_P0.7460.98
33_A86_S0.7460.98
40_M78_M0.7450.98
171_Q175_F0.7440.98
63_E66_F0.7420.98
37_S79_I0.7420.98
173_G178_L0.7420.98
118_R129_I0.7400.98
83_I272_A0.7400.98
131_R135_F0.7370.98
290_L294_G0.7330.98
141_A145_A0.7330.98
38_L256_F0.7320.98
40_M82_A0.7300.98
101_V276_A0.7270.98
208_V350_V0.7270.98
321_M326_H0.7260.98
208_V294_G0.7250.98
144_V148_L0.7200.98
55_Q58_R0.7190.98
36_I40_M0.7190.98
114_V117_Y0.7190.98
310_S316_Q0.7180.98
315_G318_I0.7120.98
109_G272_A0.7110.98
214_L218_A0.7100.98
30_L247_V0.7090.98
29_S241_I0.7080.98
297_F308_V0.7070.98
242_V280_I0.7070.98
186_G302_L0.7050.98
326_H329_E0.7030.98
34_L38_L0.7000.98
305_I309_G0.6960.97
333_W338_V0.6960.97
58_R64_S0.6960.97
133_K267_D0.6930.97
29_S86_S0.6930.97
74_M113_F0.6930.97
348_M352_I0.6930.97
339_I343_W0.6920.97
35_F39_W0.6900.97
187_T278_G0.6890.97
300_E342_F0.6880.97
187_T281_A0.6870.97
66_F335_E0.6870.97
189_N267_D0.6860.97
57_V64_S0.6850.97
197_L338_V0.6830.97
129_I133_K0.6830.97
344_I348_M0.6820.97
179_L183_V0.6820.97
306_L309_G0.6810.97
209_A276_A0.6790.97
264_F267_D0.6780.97
192_N264_F0.6770.97
107_G111_I0.6770.97
65_H71_T0.6720.97
204_P296_V0.6700.97
163_P170_P0.6690.97
214_L354_L0.6690.97
45_I263_V0.6680.97
27_I31_L0.6600.97
201_A265_M0.6590.97
193_L304_V0.6590.97
175_F179_L0.6560.96
159_Q171_Q0.6550.96
259_Y339_I0.6520.96
293_M353_G0.6490.96
132_W135_F0.6440.96
108_Y137_M0.6390.96
119_K128_L0.6390.96
322_A327_H0.6380.96
295_G299_V0.6360.96
201_A297_F0.6360.96
200_L342_F0.6330.96
48_L263_V0.6330.96
202_I253_F0.6310.96
299_V324_I0.6310.96
297_F300_E0.6300.96
178_L181_Y0.6280.95
83_I209_A0.6260.95
328_Y333_W0.6260.95
329_E332_G0.6230.95
87_V242_V0.6200.95
163_P166_K0.6190.95
195_D265_M0.6170.95
158_T171_Q0.6150.95
31_L35_F0.6130.95
143_G147_A0.6130.95
327_H330_L0.6090.95
315_G319_F0.6080.95
48_L72_P0.6080.95
329_E338_V0.6060.94
83_I87_V0.6060.94
298_V301_T0.6050.94
87_V91_A0.6040.94
158_T162_V0.6040.94
207_F211_G0.6040.94
341_R344_I0.6020.94
212_F243_C0.6010.94
113_F268_V0.6000.94
186_G190_A0.6000.94
291_V294_G0.5990.94
147_A151_A0.5990.94
111_I271_L0.5980.94
187_T298_V0.5980.94
204_P297_F0.5970.94
338_V342_F0.5950.94
351_L355_A0.5950.94
66_F329_E0.5940.94
32_T86_S0.5930.94
77_I268_V0.5920.94
206_V210_G0.5910.94
48_L53_F0.5900.94
144_V275_G0.5890.94
335_E339_I0.5880.94
203_M339_I0.5870.94
177_I181_Y0.5870.94
295_G308_V0.5820.93
109_G113_F0.5820.93
296_V300_E0.5810.93
161_V164_F0.5810.93
334_P338_V0.5810.93
239_L283_L0.5800.93
350_V353_G0.5790.93
221_N238_E0.5780.93
44_M53_F0.5780.93
134_Y181_Y0.5770.93
74_M117_Y0.5760.93
56_V70_G0.5740.93
106_V110_V0.5740.93
51_L117_Y0.5730.93
65_H329_E0.5710.93
296_V304_V0.5710.93
265_M273_L0.5700.92
96_P147_A0.5690.92
158_T163_P0.5690.92
316_Q319_F0.5660.92
314_R322_A0.5650.92
275_G279_I0.5630.92
311_F317_R0.5630.92
240_V244_T0.5610.92
328_Y338_V0.5600.92
54_G73_T0.5590.92
188_G275_G0.5590.92
325_H329_E0.5590.92
160_L171_Q0.5570.92
65_H70_G0.5570.92
94_S97_Y0.5570.92
57_V65_H0.5550.91
187_T290_L0.5530.91
82_A249_A0.5520.91
146_F177_I0.5520.91
290_L297_F0.5520.91
323_P327_H0.5510.91
75_G253_F0.5490.91
130_A134_Y0.5470.91
303_S307_Q0.5430.91
44_M47_H0.5410.90
30_L34_L0.5410.90
200_L339_I0.5380.90
300_E307_Q0.5370.90
212_F293_M0.5340.90
170_P173_G0.5340.90
241_I245_A0.5320.90
26_A29_S0.5300.90
290_L301_T0.5300.90
149_Y177_I0.5270.89
195_D201_A0.5260.89
295_G304_V0.5240.89
161_V166_K0.5230.89
33_A82_A0.5230.89
309_G322_A0.5220.89
188_G278_G0.5200.89
208_V297_F0.5190.89
151_A176_Y0.5180.88
49_Q53_F0.5180.88
195_D269_G0.5180.88
198_D326_H0.5170.88
160_L166_K0.5160.88
58_R66_F0.5160.88
160_L164_F0.5150.88
287_E291_V0.5100.88
243_C276_A0.5100.88
299_V345_I0.5100.88
83_I242_V0.5090.88
350_V354_L0.5090.88
42_P45_I0.5080.88
63_E330_L0.5080.88
282_V286_Q0.5070.87
108_Y272_A0.5050.87
77_I109_G0.5040.87
48_L54_G0.5020.87
203_M207_F0.5020.87
73_T335_E0.5000.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4j72A 2 0.8944 100 0.117 Contact Map
4mt1A 3 0.1417 20.7 0.963 Contact Map
3w9iA 3 0.15 11.8 0.966 Contact Map
4k0jA 3 0.1417 11.4 0.967 Contact Map
2ls4A 1 0.0667 8.7 0.968 Contact Map
4dx5A 3 0.1667 7 0.97 Contact Map
3aqpA 1 0.1306 6.9 0.97 Contact Map
4j05A 3 0.1667 6.5 0.97 Contact Map
3qnqA 2 0.1778 4.3 0.973 Contact Map
4ldsA 2 0.1333 4.2 0.973 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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