GREMLIN Database
GLSA2 - Glutaminase 2
UniProt: P0A6W0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13816
Length: 308 (299)
Sequences: 1599 (1070)
Seq/√Len: 61.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
154_D199_K6.1231.00
144_G223_E4.8681.00
166_A173_W4.2961.00
40_R60_E4.1931.00
165_S193_F3.4331.00
217_K224_P3.4301.00
71_L208_T3.4291.00
46_C206_A3.3701.00
79_H137_R3.2761.00
42_G202_C3.0241.00
209_F267_V2.9821.00
16_Q298_Q2.8551.00
7_N11_E2.8361.00
12_N302_Q2.6611.00
256_L268_A2.5961.00
41_L295_V2.5921.00
25_K28_D2.5641.00
54_Q58_A2.4701.00
89_V123_V2.4441.00
246_N284_D2.3711.00
61_R204_E2.3491.00
253_R297_E2.3021.00
67_I265_G2.2371.00
20_L294_A2.2181.00
15_R18_R2.1531.00
36_V40_R2.0941.00
136_Q140_E2.0871.00
20_L23_Q2.0501.00
47_T51_Q2.0481.00
258_A268_A2.0291.00
27_A30_I1.9981.00
162_F190_Q1.9971.00
32_A35_T1.9361.00
239_A251_A1.9091.00
278_V292_G1.9021.00
44_A203_V1.8901.00
64_I68_S1.8831.00
84_E87_Q1.8781.00
139_L198_L1.8731.00
59_Q203_V1.8531.00
11_E55_A1.8361.00
46_C52_L1.8101.00
171_I175_M1.8091.00
29_Y262_V1.7941.00
218_A221_I1.7941.00
32_A160_S1.7891.00
14_L41_L1.7580.99
162_F193_F1.7560.99
43_I295_V1.7400.99
32_A156_V1.7330.99
72_S138_M1.7330.99
78_R227_T1.7290.99
68_S195_Y1.7280.99
162_F165_S1.7090.99
280_S291_A1.6890.99
94_S116_I1.6560.99
14_L55_A1.6430.99
121_L193_F1.6430.99
61_R201_S1.6290.99
43_I55_A1.6110.99
268_A296_L1.6010.99
155_T194_H1.5960.99
52_L203_V1.5940.99
155_T159_R1.5870.99
78_R230_Q1.5840.99
67_I70_V1.5550.99
44_A54_Q1.5540.99
166_A176_K1.5500.99
17_V298_Q1.4960.98
124_C191_N1.4890.98
40_R57_D1.4830.98
85_I126_M1.4770.98
74_V211_F1.4590.98
30_I33_L1.4510.98
54_Q59_Q1.4240.98
298_Q302_Q1.4230.98
36_V263_G1.4220.98
294_A297_E1.4080.97
218_A225_V1.3970.97
207_R218_A1.3900.97
270_V274_M1.3760.97
171_I174_L1.3710.97
138_M195_Y1.3670.97
243_M258_A1.3670.97
59_Q201_S1.3650.97
142_V151_I1.3430.97
37_D40_R1.3290.96
44_A202_C1.3270.96
121_L165_S1.3000.96
27_A262_V1.2930.96
35_T156_V1.2920.96
227_T230_Q1.2900.96
141_V145_L1.2900.96
73_L86_W1.2880.96
209_F275_A1.2860.96
63_S157_V1.2530.95
189_L193_F1.2450.95
122_V175_M1.2240.94
65_Q161_E1.2120.94
9_I302_Q1.2040.94
40_R279_W1.2030.94
159_R163_E1.2000.94
102_V106_M1.1760.93
48_V214_N1.1730.93
93_P241_S1.1710.93
184_D187_T1.1640.93
27_A33_L1.1640.93
26_V38_G1.1640.93
212_L234_I1.1550.92
31_P164_H1.1380.92
31_P160_S1.1380.92
92_D245_Q1.1330.91
205_L277_A1.1320.91
29_Y33_L1.1310.91
72_S124_C1.1260.91
52_L206_A1.1200.91
122_V180_N1.1180.91
13_I295_V1.1160.91
274_M305_R1.1150.91
72_S142_V1.1070.90
210_V219_I1.1070.90
121_L188_V1.1060.90
61_R181_F1.1050.90
211_F218_A1.1000.90
54_Q203_V1.0990.90
129_G183_H1.0960.90
138_M191_N1.0930.90
256_L269_I1.0900.90
30_I161_E1.0820.89
294_A298_Q1.0790.89
266_I289_S1.0690.89
72_S195_Y1.0560.88
121_L189_L1.0530.88
167_R177_S1.0320.87
88_R182_H1.0320.87
30_I160_S1.0220.87
48_V210_V1.0190.86
143_R146_S1.0180.86
249_E253_R1.0150.86
47_T53_F1.0130.86
79_H128_Q1.0110.86
158_A162_F1.0090.86
169_A186_T1.0090.86
129_G134_P1.0000.85
143_R149_S0.9990.85
67_I205_L0.9930.85
11_E15_R0.9860.85
208_T212_L0.9800.84
102_V175_M0.9770.84
39_S282_E0.9730.84
13_I298_Q0.9710.84
207_R211_F0.9710.84
43_I299_L0.9670.83
14_L18_R0.9600.83
88_R180_N0.9510.82
38_G282_E0.9280.81
169_A173_W0.9260.81
183_H188_V0.9240.81
93_P111_P0.9220.80
282_E291_A0.9210.80
104_L111_P0.9190.80
74_V212_L0.9190.80
258_A284_D0.9180.80
44_A52_L0.9160.80
48_V213_A0.9130.80
68_S72_S0.9070.79
52_L207_R0.9050.79
269_I275_A0.9020.79
86_W233_Q0.8950.78
132_S191_N0.8920.78
211_F225_V0.8900.78
129_G135_R0.8840.77
127_L138_M0.8770.77
139_L143_R0.8730.77
233_Q252_W0.8700.76
146_S151_I0.8700.76
143_R151_I0.8700.76
94_S112_R0.8690.76
266_I278_V0.8570.75
45_I276_I0.8560.75
17_V20_L0.8540.75
72_S127_L0.8540.75
224_P228_P0.8470.74
76_A80_Y0.8470.74
181_F188_V0.8460.74
109_G112_R0.8460.74
66_S69_K0.8320.73
170_A173_W0.8270.73
236_A306_S0.8260.73
9_I303_L0.8220.72
93_P245_Q0.8130.71
64_I263_G0.8120.71
149_S204_E0.8120.71
111_P161_E0.8080.71
187_T190_Q0.8040.70
29_Y160_S0.8040.70
42_G58_A0.8010.70
96_S103_Q0.7970.70
146_S208_T0.7970.70
57_D279_W0.7960.70
216_G219_I0.7950.70
122_V125_D0.7840.69
249_E265_G0.7830.68
93_P104_L0.7830.68
92_D241_S0.7820.68
161_E262_V0.7790.68
100_S103_Q0.7790.68
131_L134_P0.7780.68
77_M89_V0.7780.68
153_Y194_H0.7760.68
251_A270_V0.7700.67
33_L160_S0.7690.67
131_L135_R0.7690.67
226_V231_A0.7680.67
116_I241_S0.7650.67
19_P22_G0.7650.67
136_Q139_L0.7640.67
14_L295_V0.7640.67
7_N53_F0.7630.66
124_C195_Y0.7620.66
117_N168_N0.7610.66
30_I34_A0.7610.66
243_M284_D0.7590.66
239_A308_Y0.7570.66
43_I278_V0.7560.66
157_V160_S0.7560.66
130_R134_P0.7550.66
26_V34_A0.7550.66
61_R150_D0.7530.65
152_S199_K0.7530.65
92_D95_G0.7480.65
105_E109_G0.7470.65
229_M301_K0.7430.64
63_S158_A0.7420.64
104_L112_R0.7370.64
47_T212_L0.7370.64
140_E144_G0.7370.64
63_S279_W0.7350.64
162_F189_L0.7300.63
142_V198_L0.7300.63
101_L171_I0.7250.62
27_A164_H0.7190.62
89_V111_P0.7180.62
66_S244_Y0.7180.62
27_A161_E0.7160.62
270_V273_E0.7120.61
13_I17_V0.7120.61
221_I237_L0.7110.61
69_K244_Y0.7100.61
10_L14_L0.7100.61
65_Q197_A0.7070.61
22_G282_E0.7030.60
80_Y126_M0.6950.59
154_D157_V0.6940.59
246_N293_I0.6940.59
124_C138_M0.6900.59
26_V282_E0.6890.59
271_P280_S0.6890.59
230_Q234_I0.6860.58
239_A307_V0.6850.58
133_A194_H0.6820.58
175_M181_F0.6790.57
117_N259_K0.6780.57
250_F254_V0.6780.57
76_A254_V0.6780.57
74_V226_V0.6770.57
33_L63_S0.6770.57
295_V299_L0.6770.57
145_L226_V0.6770.57
169_A189_L0.6760.57
129_G137_R0.6730.57
139_L150_D0.6710.57
46_C50_G0.6700.56
167_R178_F0.6700.56
166_A186_T0.6680.56
13_I16_Q0.6650.56
32_A157_V0.6650.56
93_P251_A0.6640.56
158_A190_Q0.6600.55
24_G33_L0.6600.55
10_L247_A0.6590.55
164_H169_A0.6580.55
135_R187_T0.6570.55
30_I262_V0.6560.55
99_N116_I0.6550.55
254_V300_T0.6530.55
38_G280_S0.6520.54
46_C207_R0.6510.54
74_V145_L0.6500.54
94_S103_Q0.6490.54
235_N269_I0.6470.54
240_T251_A0.6470.54
18_R57_D0.6470.54
158_A197_A0.6460.54
184_D231_A0.6450.54
214_N219_I0.6440.54
147_G210_V0.6430.53
41_L291_A0.6420.53
84_E134_P0.6410.53
246_N249_E0.6410.53
108_Q234_I0.6390.53
262_V287_G0.6340.52
203_V207_R0.6290.52
138_M171_I0.6280.52
8_A15_R0.6270.52
244_Y259_K0.6250.51
159_R162_F0.6230.51
61_R199_K0.6210.51
158_A194_H0.6200.51
161_E197_A0.6180.51
96_S240_T0.6140.50
48_V215_Q0.6130.50
14_L291_A0.6110.50
70_V115_F0.6110.50
140_E150_D0.6100.50
11_E23_Q0.6100.50
76_A191_N0.6090.50
181_F195_Y0.6090.50
51_Q121_L0.6060.49
17_V294_A0.6050.49
216_G225_V0.6050.49
290_L293_I0.6050.49
209_F274_M0.6040.49
71_L142_V0.6030.49
77_M230_Q0.6030.49
123_V126_M0.6020.49
282_E290_L0.6020.49
217_K221_I0.6020.49
259_K262_V0.6010.49
10_L55_A0.5970.48
71_L212_L0.5960.48
115_F243_M0.5940.48
26_V193_F0.5930.48
46_C210_V0.5910.47
284_D288_N0.5900.47
12_N229_M0.5880.47
113_N198_L0.5850.47
95_G248_G0.5820.46
12_N19_P0.5810.46
45_I270_V0.5800.46
19_P23_Q0.5800.46
210_V213_A0.5760.46
11_E136_Q0.5760.46
30_I65_Q0.5750.46
139_L285_D0.5740.46
26_V165_S0.5740.46
113_N241_S0.5740.46
93_P116_I0.5740.46
216_G221_I0.5710.45
65_Q92_D0.5690.45
210_V214_N0.5690.45
174_L247_A0.5680.45
37_D222_D0.5660.45
266_I292_G0.5660.45
138_M146_S0.5650.45
106_M174_L0.5620.44
66_S117_N0.5570.44
174_L250_F0.5570.44
16_Q302_Q0.5570.44
35_T203_V0.5560.44
65_Q167_R0.5550.43
151_I200_M0.5550.43
241_S296_L0.5530.43
25_K130_R0.5530.43
74_V234_I0.5520.43
48_V207_R0.5520.43
42_G61_R0.5510.43
68_S99_N0.5510.43
65_Q262_V0.5500.43
30_I98_F0.5500.43
217_K220_H0.5480.43
233_Q263_G0.5480.43
256_L300_T0.5470.43
128_Q181_F0.5460.42
236_A239_A0.5460.42
74_V193_F0.5450.42
75_V141_V0.5440.42
230_Q233_Q0.5440.42
211_F221_I0.5430.42
158_A297_E0.5430.42
94_S111_P0.5420.42
74_V230_Q0.5420.42
95_G245_Q0.5410.42
7_N18_R0.5400.42
117_N196_C0.5400.42
196_C262_V0.5390.42
12_N16_Q0.5390.42
103_Q112_R0.5390.42
45_I274_M0.5380.42
27_A160_S0.5370.41
70_V238_M0.5360.41
86_W263_G0.5360.41
98_F117_N0.5350.41
236_A252_W0.5340.41
91_K252_W0.5330.41
237_L245_Q0.5330.41
201_S204_E0.5320.41
25_K163_E0.5310.41
146_S149_S0.5300.41
12_N15_R0.5300.41
10_L96_S0.5300.41
151_I234_I0.5290.41
147_G150_D0.5290.41
63_S115_F0.5290.41
16_Q20_L0.5280.40
93_P240_T0.5280.40
127_L206_A0.5270.40
126_M219_I0.5260.40
65_Q113_N0.5260.40
104_L199_K0.5260.40
46_C213_A0.5250.40
23_Q282_E0.5250.40
121_L162_F0.5240.40
75_V127_L0.5240.40
69_K117_N0.5240.40
116_I180_N0.5230.40
11_E39_S0.5220.40
144_G225_V0.5220.40
173_W275_A0.5200.40
25_K285_D0.5200.40
18_R87_Q0.5200.40
267_V277_A0.5200.40
9_I13_I0.5190.39
26_V185_V0.5180.39
66_S168_N0.5180.39
172_A181_F0.5180.39
205_L265_G0.5160.39
244_Y248_G0.5150.39
36_V200_M0.5150.39
60_E279_W0.5150.39
297_E301_K0.5140.39
278_V296_L0.5120.39
73_L234_I0.5120.39
244_Y262_V0.5110.39
57_D60_E0.5110.39
98_F259_K0.5100.38
214_N301_K0.5100.38
22_G206_A0.5090.38
92_D96_S0.5090.38
103_Q106_M0.5090.38
165_S245_Q0.5070.38
151_I273_E0.5070.38
58_A61_R0.5070.38
100_S288_N0.5060.38
170_A305_R0.5040.38
88_R122_V0.5040.38
79_H129_G0.5020.38
125_D158_A0.5000.37
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2pbyA 3 0.9448 100 -0.002 Contact Map
1u60A 4 0.9935 100 0.002 Contact Map
1mkiA 3 0.9545 100 0.015 Contact Map
3uo9A 3 0.9903 100 0.021 Contact Map
4bqmA 3 0.9773 100 0.021 Contact Map
3agdA 2 0.987 100 0.051 Contact Map
1ghpA 1 0.7532 98.5 0.916 Contact Map
4m3kA 1 0.7662 98.4 0.919 Contact Map
2wuqA 2 0.8019 98.2 0.923 Contact Map
4ua6A 1 0.7792 98.1 0.925 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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