GREMLIN Database
GLK - Glucokinase
UniProt: P0A6V8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12957
Length: 321 (307)
Sequences: 1966 (1508)
Seq/√Len: 86.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
169_E232_R3.5431.00
180_E200_R3.0551.00
101_F134_G2.9801.00
221_R230_C2.8571.00
135_A241_M2.8181.00
128_K255_F2.8121.00
133_Y245_G2.6691.00
196_V215_P2.6611.00
162_D247_N2.6141.00
278_R282_E2.5051.00
115_H301_H2.4331.00
188_R286_R2.2731.00
168_E175_E2.2521.00
120_G278_R2.2441.00
46_R89_N2.2351.00
31_K51_E2.2301.00
269_L298_L2.1641.00
98_I312_H2.1551.00
104_V261_A2.1271.00
40_S43_A2.0831.00
196_V218_I2.0401.00
118_Q297_Y2.0371.00
246_G284_K2.0341.00
171_A178_R2.0241.00
131_A258_V2.0091.00
186_A244_F2.0081.00
260_I265_V1.9411.00
70_D83_I1.8721.00
12_G137_T1.8511.00
288_K292_H1.8481.00
112_K115_H1.8341.00
261_A264_I1.8281.00
171_A175_E1.8231.00
135_A265_V1.8221.00
38_Y47_V1.8111.00
35_G77_H1.8051.00
195_L233_A1.7861.00
45_I61_I1.7681.00
161_V251_N1.7531.00
198_L237_F1.7191.00
249_A294_I1.7041.00
198_L202_I1.6761.00
131_A248_L1.6711.00
34_S37_D1.6711.00
163_F189_V1.6441.00
57_K93_S1.6441.00
264_I267_R1.6441.00
120_G282_E1.6431.00
188_R197_N1.6381.00
185_S188_R1.6171.00
234_L271_F1.6101.00
181_I197_N1.6051.00
277_F296_V1.5921.00
84_A88_K1.5851.00
270_E273_K1.5811.00
83_I87_K1.5691.00
118_Q121_G1.5581.00
172_I205_A1.5431.00
259_F264_I1.5421.00
13_T137_T1.5311.00
163_F240_I1.5291.00
21_D26_E1.5161.00
141_V158_G1.4980.99
41_L45_I1.4980.99
41_L44_V1.4830.99
161_V186_A1.4810.99
202_I229_D1.4810.99
8_G17_L1.4800.99
234_L268_F1.4530.99
268_F271_F1.4460.99
47_V51_E1.4440.99
71_W82_S1.4340.99
239_V276_G1.4060.99
117_I273_K1.4060.99
243_R280_A1.4020.99
220_E224_A1.3990.99
163_F198_L1.3980.99
295_P298_L1.3930.99
42_E89_N1.3870.99
85_E89_N1.3830.99
143_H252_L1.3780.99
137_T192_G1.3780.99
6_L19_L1.3700.99
42_E85_E1.3660.99
17_L33_Y1.3650.99
244_F251_N1.3640.99
106_M153_S1.3610.99
139_L186_A1.3600.99
17_L44_V1.3520.99
177_L197_N1.3440.99
289_E292_H1.3390.99
227_C230_C1.3270.99
305_G309_S1.3260.99
278_R296_V1.3240.99
70_D82_S1.3150.99
179_A204_K1.3070.99
206_D232_R1.3040.99
278_R281_F1.2960.99
120_G296_V1.2950.99
269_L273_K1.2940.99
172_I175_E1.2930.99
33_Y44_V1.2900.98
141_V244_F1.2770.98
107_A304_P1.2760.98
259_F265_V1.2740.98
203_V210_P1.2700.98
245_G281_F1.2690.98
137_T263_G1.2680.98
185_S285_G1.2670.98
217_D220_E1.2610.98
176_I201_A1.2580.98
118_Q122_A1.2560.98
261_A299_I1.2460.98
231_R235_S1.2440.98
13_T263_G1.2410.98
98_I103_A1.2340.98
268_F272_F1.2190.98
104_V305_G1.2120.98
96_E312_H1.2030.98
261_A265_V1.2010.98
174_L178_R1.2010.98
173_I236_L1.2010.98
223_L270_E1.1920.97
173_I201_A1.1840.97
202_I236_L1.1750.97
277_F281_F1.1690.97
33_Y51_E1.1600.97
171_A174_L1.1590.97
301_H304_P1.1540.97
13_T192_G1.1480.97
181_I188_R1.1350.97
188_R285_G1.1300.96
241_M265_V1.1260.96
7_V309_S1.1220.96
147_V152_V1.1200.96
238_C268_F1.1190.96
105_S153_S1.1190.96
253_G290_Y1.1080.96
238_C275_S1.0890.96
45_I49_L1.0870.96
238_C242_G1.0850.96
177_L189_V1.0840.96
101_F305_G1.0830.96
189_V198_L1.0780.95
239_V243_R1.0770.95
10_V61_I1.0750.95
147_V150_R1.0740.95
214_K217_D1.0730.95
104_V304_P1.0710.95
21_D24_S1.0710.95
83_I95_L1.0660.95
249_A281_F1.0630.95
58_D94_H1.0630.95
235_S271_F1.0610.95
43_A46_R1.0530.95
11_G137_T1.0500.95
203_V229_D1.0440.95
168_E172_I1.0430.94
105_S142_A1.0420.94
101_F135_A1.0370.94
63_I66_P1.0350.94
60_C312_H1.0300.94
223_L234_L1.0290.94
74_M77_H1.0280.94
87_K95_L1.0280.94
176_I204_K1.0260.94
219_T234_L1.0230.94
235_S276_G1.0220.94
215_P219_T1.0170.94
12_G192_G1.0140.94
207_N210_P1.0140.94
254_T258_V1.0110.94
195_L215_P1.0090.93
306_L309_S0.9950.93
9_D13_T0.9950.93
141_V251_N0.9860.93
143_H154_L0.9770.92
295_P299_I0.9740.92
248_L251_N0.9670.92
7_V313_L0.9630.92
202_I232_R0.9610.92
60_C309_S0.9590.92
282_E296_V0.9590.92
240_I243_R0.9580.92
192_G263_G0.9550.91
238_C271_F0.9550.91
242_G280_A0.9530.91
202_I233_A0.9530.91
73_A80_A0.9490.91
60_C98_I0.9480.91
183_H285_G0.9460.91
86_M95_L0.9450.91
261_A305_G0.9410.91
196_V200_R0.9390.91
36_L77_H0.9380.91
297_Y300_V0.9350.91
166_N283_D0.9350.91
17_L45_I0.9330.90
64_A192_G0.9320.90
63_I74_M0.9280.90
142_A155_P0.9270.90
211_E214_K0.9230.90
117_I300_V0.9210.90
76_N263_G0.9210.90
259_F266_P0.9160.90
116_L297_Y0.9130.89
294_I299_I0.9110.89
279_A283_D0.9110.89
110_M311_A0.9100.89
9_D12_G0.9080.89
104_V299_I0.9080.89
183_H188_R0.8990.89
265_V298_L0.8980.89
265_V268_F0.8910.88
199_Y233_A0.8900.88
221_R224_A0.8900.88
30_A303_N0.8890.88
104_V107_A0.8870.88
102_T153_S0.8860.88
71_W80_A0.8790.88
143_H153_S0.8770.88
130_I259_F0.8670.87
281_F291_V0.8640.87
265_V269_L0.8600.86
232_R236_L0.8600.86
222_A234_L0.8570.86
108_I132_V0.8560.86
102_T155_P0.8550.86
98_I102_T0.8540.86
218_I233_A0.8530.86
5_A313_L0.8530.86
33_Y47_V0.8520.86
189_V240_I0.8480.86
222_A231_R0.8480.86
111_L115_H0.8430.85
170_E243_R0.8420.85
84_A87_K0.8280.84
16_R192_G0.8240.84
239_V280_A0.8190.84
217_D221_R0.8150.83
165_P174_L0.8140.83
282_E292_H0.8140.83
39_P43_A0.8090.83
33_Y48_Y0.8050.83
268_F273_K0.7990.82
11_G192_G0.7990.82
83_I97_I0.7990.82
181_I185_S0.7980.82
211_E221_R0.7960.82
136_G263_G0.7940.82
110_M307_L0.7930.82
190_L240_I0.7870.81
146_H151_W0.7830.81
221_R227_C0.7830.81
209_L213_L0.7810.81
19_L56_V0.7790.81
76_N136_G0.7740.80
162_D183_H0.7730.80
9_D137_T0.7720.80
41_L47_V0.7710.80
224_A231_R0.7710.80
106_M312_H0.7680.80
185_S286_R0.7670.80
194_G215_P0.7670.80
44_V77_H0.7640.79
59_G92_F0.7620.79
76_N137_T0.7600.79
195_L218_I0.7590.79
134_G305_G0.7570.79
13_T136_G0.7540.78
176_I205_A0.7520.78
14_N192_G0.7520.78
66_P75_T0.7500.78
233_A237_F0.7490.78
162_D246_G0.7490.78
81_F97_I0.7440.77
190_L241_M0.7440.77
104_V134_G0.7440.77
281_F286_R0.7420.77
58_D93_S0.7410.77
41_L49_L0.7410.77
167_S239_V0.7360.77
62_A103_A0.7350.77
75_T160_H0.7340.76
87_K92_F0.7330.76
119_F128_K0.7320.76
174_L184_V0.7300.76
261_A266_P0.7290.76
105_S144_L0.7260.76
11_G263_G0.7250.76
139_L158_G0.7190.75
9_D192_G0.7180.75
31_K52_H0.7180.75
32_T303_N0.7180.75
76_N187_E0.7170.75
152_V253_G0.7160.75
7_V20_C0.7090.74
264_I268_F0.7090.74
76_N99_N0.7080.74
11_G136_G0.7060.74
170_E280_A0.7060.74
220_E223_L0.7030.73
280_A283_D0.7020.73
162_D243_R0.7000.73
136_G192_G0.6980.73
86_M90_L0.6980.73
102_T106_M0.6960.73
259_F299_I0.6940.72
284_K287_F0.6930.72
162_D199_Y0.6900.72
19_L54_V0.6880.72
213_L217_D0.6870.72
296_V299_I0.6820.71
82_S85_E0.6800.71
12_G263_G0.6790.71
6_L49_L0.6780.71
164_A240_I0.6770.71
98_I106_M0.6760.70
141_V161_V0.6760.70
215_P218_I0.6760.70
263_G266_P0.6720.70
276_G279_A0.6690.70
183_H284_K0.6690.70
21_D28_S0.6660.69
265_V272_F0.6630.69
30_A48_Y0.6620.69
282_E288_K0.6620.69
58_D65_C0.6610.69
18_A306_L0.6610.69
7_V48_Y0.6590.68
281_F284_K0.6590.68
209_L212_N0.6580.68
166_N170_E0.6560.68
235_S238_C0.6560.68
257_G295_P0.6530.68
243_R246_G0.6530.68
6_L52_H0.6530.68
13_T76_N0.6500.67
7_V310_G0.6490.67
62_A104_V0.6480.67
130_I260_I0.6480.67
290_Y293_D0.6460.67
258_V264_I0.6450.67
131_A245_G0.6450.67
228_T232_R0.6440.67
169_E206_D0.6440.67
187_E191_S0.6430.67
104_V108_I0.6420.66
235_S239_V0.6390.66
131_A143_H0.6380.66
143_H254_T0.6380.66
301_H307_L0.6360.66
9_D136_G0.6360.66
208_R228_T0.6360.66
269_L272_F0.6330.65
50_E53_K0.6250.64
176_I180_E0.6250.64
275_S280_A0.6220.64
182_G283_D0.6210.64
243_R284_K0.6190.64
195_L234_L0.6190.64
129_P153_S0.6180.64
230_C261_A0.6120.63
242_G246_G0.6120.63
101_F141_V0.6110.63
65_C95_L0.6110.63
260_I264_I0.6040.62
175_E178_R0.6040.62
277_F284_K0.6040.62
118_Q123_E0.6030.62
70_D84_A0.6000.61
292_H298_L0.5990.61
59_G95_L0.5990.61
199_Y230_C0.5990.61
164_A167_S0.5950.61
69_G83_I0.5940.60
18_A310_G0.5900.60
65_C83_I0.5900.60
99_N157_E0.5890.60
14_N219_T0.5860.59
20_C307_L0.5850.59
242_G275_S0.5840.59
222_A271_F0.5830.59
164_A189_V0.5830.59
8_G280_A0.5820.59
167_S170_E0.5820.59
31_K34_S0.5810.59
19_L49_L0.5790.59
146_H150_R0.5790.59
283_D286_R0.5770.58
8_G62_A0.5760.58
165_P171_A0.5690.57
161_V247_N0.5660.57
210_P214_K0.5660.57
76_N192_G0.5660.57
54_V224_A0.5640.57
173_I202_I0.5640.57
79_W242_G0.5620.56
10_V236_L0.5600.56
210_P213_L0.5580.56
129_P146_H0.5580.56
5_A65_C0.5580.56
99_N138_G0.5570.56
127_G255_F0.5570.56
114_E235_S0.5570.56
236_L240_I0.5560.55
65_C77_H0.5560.55
139_L252_L0.5550.55
60_C306_L0.5530.55
145_V152_V0.5520.55
105_S143_H0.5510.55
10_V154_L0.5500.55
11_G76_N0.5490.55
199_Y203_V0.5490.55
207_N214_K0.5450.54
7_V28_S0.5440.54
100_D136_G0.5440.54
267_R270_E0.5420.54
106_M311_A0.5410.53
86_M245_G0.5380.53
209_L279_A0.5370.53
6_L59_G0.5360.53
174_L182_G0.5360.53
102_T142_A0.5340.53
279_A282_E0.5340.53
42_E46_R0.5320.52
168_E171_A0.5320.52
291_V294_I0.5300.52
177_L184_V0.5300.52
188_R193_P0.5300.52
142_A272_F0.5290.52
242_G284_K0.5290.52
186_A240_I0.5290.52
238_C272_F0.5290.52
302_D305_G0.5240.51
133_Y241_M0.5230.51
231_R234_L0.5220.51
258_V266_P0.5220.51
153_S254_T0.5210.51
106_M110_M0.5190.51
138_G157_E0.5170.50
157_E160_H0.5160.50
45_I90_L0.5150.50
113_K117_I0.5150.50
213_L221_R0.5130.50
161_V248_L0.5130.50
198_L240_I0.5120.50
232_R235_S0.5120.50
99_N281_F0.5110.49
105_S254_T0.5110.49
29_Q52_H0.5110.49
183_H272_F0.5110.49
9_D263_G0.5100.49
223_L268_F0.5100.49
204_K218_I0.5090.49
291_V295_P0.5070.49
264_I269_L0.5060.49
57_K224_A0.5050.49
46_R50_E0.5010.48
216_K267_R0.5000.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1sz2A 2 0.9969 100 0.429 Contact Map
3vpzA 2 0.9751 100 0.484 Contact Map
5brhA 2 0.9595 100 0.49 Contact Map
2qm1A 2 0.9159 100 0.59 Contact Map
3vglA 3 0.9034 100 0.591 Contact Map
1z05A 2 0.9221 100 0.6 Contact Map
2ap1A 2 0.9034 100 0.601 Contact Map
1z6rA 3 0.9221 100 0.603 Contact Map
3vovA 3 0.8879 100 0.604 Contact Map
3r8eA 2 0.866 100 0.606 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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