GREMLIN Database
GLPE - Thiosulfate sulfurtransferase GlpE
UniProt: P0A6V5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10395
Length: 108 (98)
Sequences: 11233 (8197)
Seq/√Len: 828.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
60_P87_Y2.9421.00
29_P33_A2.9171.00
22_V59_T2.2381.00
13_H101_P2.1581.00
32_F36_H2.1331.00
7_I11_D2.0681.00
8_N11_D2.0001.00
11_D15_K1.9891.00
35_G97_Q1.9261.00
29_P42_H1.9221.00
95_A99_Q1.8181.00
9_V95_A1.7721.00
93_F103_E1.6881.00
63_V78_L1.6541.00
49_G53_R1.5931.00
31_S70_S1.5331.00
12_A23_L1.4941.00
56_D59_T1.4841.00
45_N49_G1.4781.00
15_K18_E1.4631.00
60_P85_V1.4411.00
48_L52_M1.4391.00
9_V99_Q1.4151.00
51_F54_D1.3931.00
75_A86_V1.3811.00
71_S88_S1.3511.00
26_I74_A1.3461.00
75_A88_S1.2671.00
12_A89_I1.2611.00
99_Q102_A1.2521.00
15_K21_A1.2481.00
15_K60_P1.2471.00
21_A62_M1.2191.00
57_F83_Y1.1971.00
12_A62_M1.1821.00
6_C90_D1.1791.00
8_N90_D1.1511.00
43_L51_F1.1411.00
23_L64_M1.1241.00
9_V89_I1.1221.00
91_G95_A1.1151.00
24_V55_N1.1121.00
7_I12_A1.1061.00
36_H64_M1.0941.00
93_F97_Q1.0891.00
22_V41_F1.0821.00
47_T51_F1.0791.00
9_V13_H1.0671.00
13_H102_A1.0611.00
64_M93_F1.0551.00
75_A79_L1.0531.00
13_H17_Q1.0471.00
37_A64_M1.0351.00
47_T50_A1.0341.00
65_C68_G1.0301.00
63_V74_A1.0301.00
27_R66_Y1.0171.00
65_C71_S1.0151.00
31_S66_Y1.0061.00
7_I87_Y0.9961.00
38_V96_W0.9931.00
94_E98_R0.9921.00
37_A40_A0.9921.00
63_V75_A0.9801.00
50_A54_D0.9771.00
78_L86_V0.9771.00
94_E97_Q0.9671.00
52_M78_L0.9501.00
79_L84_D0.9391.00
63_V86_V0.9341.00
10_A14_Q0.9101.00
28_D31_S0.9081.00
89_I92_G0.9041.00
27_R93_F0.9031.00
26_I63_V0.8961.00
62_M89_I0.8931.00
40_A64_M0.8541.00
89_I95_A0.8541.00
66_Y94_E0.8331.00
61_V78_L0.8321.00
23_L37_A0.8321.00
100_F103_E0.8281.00
77_Y81_Q0.8201.00
67_H94_E0.8111.00
65_C70_S0.8051.00
22_V61_V0.8041.00
10_A101_P0.7941.00
89_I96_W0.7901.00
7_I62_M0.7821.00
12_A16_L0.7761.00
12_A21_A0.7601.00
32_F40_A0.7591.00
9_V102_A0.7531.00
79_L86_V0.7521.00
30_Q33_A0.7471.00
31_S34_M0.7461.00
76_Q80_Q0.7441.00
72_K88_S0.7401.00
55_N61_V0.7401.00
21_A60_P0.7321.00
22_V56_D0.7291.00
10_A99_Q0.7271.00
36_H42_H0.7251.00
11_D14_Q0.7191.00
95_A98_R0.7131.00
37_A96_W0.7011.00
35_G93_F0.6931.00
12_A15_K0.6871.00
32_F42_H0.6781.00
48_L81_Q0.6741.00
13_H16_L0.6621.00
20_E60_P0.6431.00
66_Y69_N0.6421.00
9_V101_P0.6401.00
15_K62_M0.6391.00
31_S67_H0.6371.00
45_N77_Y0.6311.00
6_C88_S0.6301.00
35_G103_E0.6291.00
48_L77_Y0.6191.00
24_V41_F0.6161.00
78_L83_Y0.6111.00
55_N59_T0.6091.00
48_L51_F0.6031.00
14_Q18_E0.6001.00
72_K76_Q0.5881.00
45_N81_Q0.5691.00
67_H70_S0.5681.00
61_V86_V0.5671.00
43_L74_A0.5661.00
49_G57_F0.5621.00
27_R42_H0.5611.00
77_Y80_Q0.5561.00
67_H71_S0.5371.00
97_Q103_E0.5351.00
17_Q20_E0.5281.00
29_P44_T0.5271.00
28_D42_H0.5241.00
23_L40_A0.5221.00
76_Q79_L0.5211.00
79_L85_V0.5171.00
46_D49_G0.5131.00
83_Y86_V0.5101.00
80_Q83_Y0.5061.00
99_Q103_E0.5031.00
70_S73_G0.5031.00
52_M74_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tp9A 2 0.9722 99.9 0.17 Contact Map
1yt8A 1 1 99.9 0.173 Contact Map
1gmxA 1 1 99.9 0.186 Contact Map
3iwhA 1 0.9352 99.9 0.207 Contact Map
2hhgA 2 0.963 99.9 0.213 Contact Map
1qxnA 2 1 99.9 0.214 Contact Map
1tq1A 1 0.963 99.9 0.215 Contact Map
3hzuA 2 1 99.9 0.215 Contact Map
3fojA 1 0.9167 99.9 0.217 Contact Map
3aayA 1 1 99.9 0.218 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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