GREMLIN Database
GLGC - Glucose-1-phosphate adenylyltransferase
UniProt: P0A6V1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10379
Length: 431 (345)
Sequences: 7734 (4998)
Seq/√Len: 269.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
362_I365_A4.4801.00
364_S381_R3.6451.00
379_L382_C3.6291.00
363_D380_R3.5221.00
169_P209_S3.3141.00
156_H164_T3.1341.00
367_L373_V2.9861.00
353_R370_E2.9821.00
195_K206_P2.8311.00
358_S375_R2.7991.00
184_D188_K2.7931.00
357_N375_R2.5091.00
182_A208_K2.4921.00
169_P258_P2.4841.00
359_F376_S2.4491.00
365_A379_L2.3971.00
352_S369_P2.3791.00
50_K59_S2.2881.00
154_I158_E2.2851.00
22_A66_I2.2601.00
371_V388_C2.2591.00
370_E387_A2.2351.00
374_G392_E2.2311.00
229_E251_A2.2201.00
135_Y157_V2.1701.00
22_A61_C2.1661.00
346_V363_D2.1271.00
125_L228_E2.1081.00
355_R372_W2.1021.00
136_V220_A2.0921.00
155_D159_K2.0801.00
182_A191_E2.0641.00
162_R219_D2.0511.00
225_E229_E2.0331.00
345_V348_S2.0241.00
331_N347_Q2.0031.00
152_M166_A1.9961.00
40_R46_H1.9801.00
351_F369_P1.9541.00
384_I388_C1.9351.00
350_L354_V1.9181.00
375_R392_E1.9071.00
189_I256_A1.8531.00
367_L371_V1.8081.00
167_C256_A1.7841.00
55_D83_H1.7561.00
58_L69_M1.7441.00
350_L356_V1.7261.00
225_E251_A1.7201.00
360_C377_C1.7151.00
384_I390_I1.7141.00
152_M217_V1.7031.00
135_Y219_D1.7021.00
279_T300_Y1.6961.00
329_T332_S1.6591.00
298_D301_D1.6551.00
357_N374_G1.6481.00
372_W389_V1.6431.00
152_M164_T1.6391.00
330_L346_V1.6371.00
336_G352_S1.6211.00
161_A255_Y1.6201.00
277_V286_A1.6121.00
349_V366_V1.6001.00
162_R253_L1.5941.00
184_D190_I1.5901.00
188_K255_Y1.5821.00
159_K255_Y1.5811.00
338_C354_V1.5661.00
361_N378_R1.5591.00
366_V383_V1.5431.00
176_S195_K1.5291.00
348_S362_I1.5151.00
138_I218_F1.4881.00
339_V355_R1.4881.00
125_L224_Y1.4861.00
153_L217_V1.4701.00
220_A224_Y1.4651.00
129_R224_Y1.4591.00
347_Q364_S1.4521.00
193_V200_P1.4501.00
54_I84_I1.4481.00
222_Y253_L1.4391.00
115_R119_D1.4341.00
369_P386_R1.4301.00
376_S393_G1.4261.00
200_P206_P1.4241.00
61_C139_L1.4131.00
378_R395_V1.4071.00
118_A230_D1.3981.00
55_D59_S1.3971.00
338_C350_L1.3961.00
150_S154_I1.3871.00
335_S338_C1.3841.00
374_G389_V1.3761.00
135_Y217_V1.3631.00
155_D257_H1.3581.00
53_I277_V1.3521.00
334_V338_C1.3461.00
371_V384_I1.3451.00
77_S81_V1.3311.00
163_C248_I1.3281.00
368_L386_R1.3221.00
354_V371_V1.3201.00
362_I367_L1.3151.00
335_S352_S1.3091.00
182_A193_V1.3081.00
77_S105_Q1.3051.00
357_N372_W1.2991.00
39_K353_R1.2831.00
167_C181_M1.2781.00
119_D122_T1.2771.00
137_V217_V1.2741.00
70_G104_A1.2671.00
119_D123_Q1.2661.00
281_E300_Y1.2511.00
351_F354_V1.2451.00
377_C392_E1.2411.00
313_L316_A1.2331.00
273_Y289_D1.2251.00
68_R100_D1.2221.00
73_T77_S1.2131.00
229_E247_K1.1911.00
48_G290_L1.1901.00
380_R397_G1.1691.00
368_L383_V1.1691.00
227_L230_D1.1621.00
327_G340_I1.1571.00
174_E195_K1.1501.00
151_R154_I1.1491.00
275_R289_D1.1341.00
46_H52_R1.1301.00
275_R285_K1.1281.00
87_G90_F1.1281.00
377_C394_M1.1231.00
296_E300_Y1.1181.00
78_H82_Q1.1131.00
177_A195_K1.1101.00
171_P209_S1.1001.00
79_T82_Q1.0981.00
74_Q114_Y1.0971.00
226_L248_I1.0941.00
226_L251_A1.0891.00
189_I254_A1.0861.00
281_E285_K1.0851.00
247_K251_A1.0851.00
310_N313_L1.0811.00
183_V210_L1.0791.00
41_A79_T1.0781.00
357_N360_C1.0771.00
108_M115_R1.0721.00
377_C390_I1.0701.00
134_E219_D1.0691.00
379_L384_I1.0651.00
70_G127_I1.0631.00
140_A143_H1.0621.00
56_F290_L1.0611.00
155_D255_Y1.0601.00
47_F287_N1.0571.00
371_V386_R1.0511.00
21_V68_R1.0451.00
148_D273_Y1.0451.00
311_E315_P1.0421.00
341_S358_S1.0421.00
165_V189_I1.0351.00
328_M344_V1.0321.00
44_A83_H1.0301.00
85_Q90_F1.0231.00
122_T125_L1.0171.00
246_P250_E1.0121.00
54_I71_V1.0071.00
179_G194_E1.0061.00
230_D236_S0.9981.00
327_G330_L0.9971.00
148_D151_R0.9961.00
43_P141_G0.9961.00
121_V138_I0.9941.00
237_S243_D0.9911.00
40_R79_T0.9901.00
226_L247_K0.9881.00
371_V385_D0.9871.00
218_F244_L0.9841.00
333_L349_V0.9761.00
145_Y148_D0.9741.00
167_C210_L0.9721.00
114_Y119_D0.9711.00
371_V390_I0.9701.00
165_V181_M0.9701.00
174_E177_A0.9651.00
342_G359_F0.9651.00
222_Y225_E0.9641.00
317_K339_V0.9631.00
171_P271_E0.9631.00
187_D258_P0.9601.00
155_D158_E0.9571.00
294_V298_D0.9551.00
64_S149_Y0.9501.00
52_R83_H0.9451.00
373_V379_L0.9421.00
133_A221_D0.9411.00
311_E314_P0.9401.00
55_D87_G0.9381.00
73_T103_P0.9371.00
212_S216_Y0.9351.00
343_S346_V0.9291.00
297_L301_D0.9261.00
21_V128_I0.9241.00
181_M189_I0.9231.00
137_V153_L0.9221.00
30_G42_K0.9121.00
337_G341_S0.9031.00
361_N375_R0.9021.00
353_R369_P0.9021.00
180_V211_A0.9001.00
360_C392_E0.8981.00
23_L136_V0.8951.00
151_R155_D0.8931.00
288_L291_A0.8921.00
153_L157_V0.8921.00
341_S344_V0.8901.00
259_F272_P0.8901.00
52_R55_D0.8901.00
326_H342_G0.8851.00
71_V84_I0.8841.00
226_L230_D0.8821.00
54_I80_L0.8791.00
170_V211_A0.8701.00
125_L129_R0.8671.00
196_P235_N0.8661.00
139_L149_Y0.8641.00
354_V369_P0.8611.00
332_S345_V0.8581.00
134_E220_A0.8561.00
221_D225_E0.8541.00
49_G333_L0.8521.00
225_E228_E0.8451.00
248_I253_L0.8441.00
316_A319_V0.8441.00
41_A76_Q0.8411.00
162_R222_Y0.8401.00
319_V326_H0.8391.00
222_Y226_L0.8370.99
163_C218_F0.8370.99
359_F375_R0.8360.99
367_L384_I0.8350.99
23_L70_G0.8350.99
360_C375_R0.8340.99
344_V361_N0.8290.99
232_R239_D0.8290.99
373_V377_C0.8280.99
317_K320_Q0.8280.99
129_R228_E0.8270.99
168_M274_W0.8230.99
334_V340_I0.8220.99
24_I58_L0.8190.99
188_K249_T0.8190.99
289_D292_S0.8180.99
354_V367_L0.8170.99
292_S296_E0.8150.99
314_P319_V0.8130.99
378_R393_G0.8130.99
374_G391_P0.8120.99
327_G341_S0.8100.99
318_F329_T0.8090.99
74_Q119_D0.8090.99
42_K142_D0.8080.99
219_D222_Y0.8070.99
341_S357_N0.8030.99
341_S346_V0.8030.99
62_I88_W0.8010.99
354_V368_L0.8010.99
128_I134_E0.8000.99
130_R224_Y0.8000.99
226_L229_E0.8000.99
32_R42_K0.7980.99
23_L121_V0.7890.99
58_L101_L0.7880.99
137_V149_Y0.7860.99
24_I61_C0.7850.99
56_F59_S0.7830.99
183_V256_A0.7810.99
376_S392_E0.7790.99
78_H81_V0.7770.99
134_E221_D0.7700.99
168_M211_A0.7690.99
163_C245_I0.7680.99
69_M99_V0.7650.99
193_V198_N0.7630.99
55_D84_I0.7600.99
340_I350_L0.7590.99
395_V398_E0.7580.99
363_D378_R0.7560.99
279_T282_A0.7550.99
160_G219_D0.7550.99
122_T239_D0.7530.99
81_V105_Q0.7510.99
249_T254_A0.7490.99
108_M114_Y0.7470.99
398_E401_E0.7460.99
76_Q79_T0.7460.99
294_V297_L0.7460.99
58_L84_I0.7440.99
62_I87_G0.7420.99
62_I69_M0.7400.99
328_M341_S0.7390.99
122_T228_E0.7390.99
59_S63_N0.7360.99
337_G352_S0.7360.99
44_A79_T0.7330.99
154_I157_V0.7330.99
57_A139_L0.7310.99
331_N346_V0.7270.99
230_D244_L0.7260.99
331_N334_V0.7250.99
222_Y248_I0.7230.99
337_G359_F0.7220.99
310_N315_P0.7220.99
122_T231_D0.7200.98
61_C66_I0.7200.98
337_G353_R0.7200.98
25_L140_A0.7170.98
341_S345_V0.7140.98
170_V209_S0.7130.98
128_I223_L0.7130.98
48_G56_F0.7110.98
167_C189_I0.7030.98
292_S347_Q0.7010.98
334_V345_V0.7010.98
34_K38_N0.7000.98
40_R385_D0.6990.98
272_P289_D0.6990.98
328_M343_S0.6980.98
360_C376_S0.6980.98
66_I153_L0.6980.98
362_I379_L0.6970.98
185_E190_I0.6970.98
319_V341_S0.6900.98
60_N64_S0.6890.98
218_F223_L0.6830.98
233_D236_S0.6830.98
70_G124_N0.6830.98
175_A199_P0.6810.98
310_N314_P0.6810.98
358_S361_N0.6780.98
380_R395_V0.6780.98
86_R90_F0.6750.98
275_R286_A0.6720.98
238_H243_D0.6710.98
391_P394_M0.6710.98
107_R114_Y0.6700.98
335_S343_S0.6660.97
396_I399_N0.6650.97
258_P271_E0.6630.97
73_T81_V0.6610.97
210_L258_P0.6600.97
371_V387_A0.6600.97
156_H219_D0.6590.97
28_G42_K0.6580.97
345_V356_V0.6580.97
138_I241_G0.6580.97
343_S361_N0.6580.97
233_D243_D0.6570.97
372_W375_R0.6560.97
340_I343_S0.6550.97
289_D293_V0.6550.97
84_I99_V0.6530.97
224_Y227_L0.6510.97
247_K250_E0.6510.97
319_V336_G0.6500.97
343_S358_S0.6490.97
330_L344_V0.6480.97
308_T315_P0.6480.97
329_T334_V0.6440.97
70_G128_I0.6430.97
117_T142_D0.6410.97
281_E296_E0.6380.97
126_D129_R0.6380.97
340_I344_V0.6380.97
146_K273_Y0.6380.97
316_A338_C0.6370.97
193_V199_P0.6370.97
213_M274_W0.6340.97
28_G32_R0.6340.97
60_N149_Y0.6330.97
21_V132_K0.6310.97
305_P308_T0.6300.96
314_P317_K0.6260.96
52_R56_F0.6250.96
182_A200_P0.6230.96
304_W315_P0.6230.96
47_F53_I0.6210.96
60_N146_K0.6200.96
136_V223_L0.6200.96
367_L379_L0.6200.96
25_L120_A0.6170.96
171_P174_E0.6170.96
181_M210_L0.6150.96
218_F222_Y0.6130.96
338_C351_F0.6120.96
326_H330_L0.6100.96
380_R398_E0.6060.96
375_R393_G0.6060.96
327_G332_S0.6050.96
21_V70_G0.6040.96
85_Q103_P0.6020.95
25_L72_I0.6020.95
73_T80_L0.6020.95
283_Y368_L0.6010.95
368_L385_D0.5970.95
230_D238_H0.5920.95
239_D242_K0.5910.95
297_L300_Y0.5880.95
356_V360_C0.5870.95
115_R239_D0.5870.95
329_T335_S0.5870.95
190_I249_T0.5850.95
53_I57_A0.5840.95
191_E246_P0.5840.95
182_A190_I0.5830.95
375_R378_R0.5810.95
312_S315_P0.5810.95
326_H341_S0.5810.95
170_V174_E0.5810.95
72_I106_Q0.5800.94
177_A282_A0.5800.94
285_K288_L0.5790.94
72_I120_A0.5780.94
33_L45_V0.5780.94
73_T105_Q0.5770.94
30_G43_P0.5750.94
166_A215_I0.5750.94
60_N63_N0.5710.94
139_L215_I0.5700.94
230_D247_K0.5690.94
63_N146_K0.5680.94
377_C391_P0.5670.94
370_E386_R0.5650.94
26_A80_L0.5640.94
285_K289_D0.5630.94
285_K296_E0.5630.94
338_C352_S0.5620.94
361_N376_S0.5620.94
342_G346_V0.5610.93
37_T45_V0.5610.93
170_V175_A0.5610.93
59_S87_G0.5600.93
132_K221_D0.5600.93
310_N316_A0.5590.93
125_L128_I0.5530.93
332_S335_S0.5520.93
121_V240_F0.5510.93
332_S348_S0.5500.93
218_F240_F0.5490.93
339_V343_S0.5480.93
335_S341_S0.5450.92
327_G342_G0.5450.92
313_L318_F0.5450.92
32_R43_P0.5450.92
68_R102_L0.5440.92
142_D276_D0.5430.92
332_S346_V0.5430.92
164_T217_V0.5420.92
210_L256_A0.5410.92
226_L244_L0.5410.92
43_P80_L0.5400.92
312_S318_F0.5390.92
314_P318_F0.5390.92
48_G287_N0.5380.92
140_A216_Y0.5380.92
21_V136_V0.5370.92
29_R114_Y0.5340.92
163_C254_A0.5340.92
189_I249_T0.5340.92
331_N335_S0.5330.92
360_C374_G0.5320.92
307_R311_E0.5300.91
215_I274_W0.5300.91
192_F242_K0.5290.91
81_V85_Q0.5280.91
170_V271_E0.5280.91
82_Q85_Q0.5280.91
46_H386_R0.5270.91
179_G195_K0.5270.91
145_Y215_I0.5270.91
20_S153_L0.5250.91
379_L396_I0.5250.91
361_N380_R0.5240.91
362_I373_V0.5230.91
161_A164_T0.5230.91
290_L294_V0.5220.91
280_L284_W0.5200.91
312_S316_A0.5200.91
198_N206_P0.5200.91
165_V254_A0.5200.91
378_R381_R0.5190.91
79_T83_H0.5190.91
66_I137_V0.5180.90
327_G344_V0.5180.90
194_E212_S0.5180.90
64_S150_S0.5180.90
378_R398_E0.5180.90
45_V280_L0.5180.90
354_V386_R0.5160.90
44_A84_I0.5150.90
24_I57_A0.5150.90
144_I148_D0.5140.90
298_D303_N0.5140.90
309_Y312_S0.5130.90
310_N318_F0.5130.90
86_R89_S0.5110.90
166_A213_M0.5090.90
308_T314_P0.5090.90
140_A214_G0.5080.90
350_L367_L0.5070.90
383_V401_E0.5050.89
195_K278_G0.5040.89
168_M213_M0.5040.89
237_S242_K0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3brkX 2 0.9118 100 0.389 Contact Map
1yp2A 4 0.9002 100 0.417 Contact Map
2ggoA 3 0.8306 100 0.471 Contact Map
4g3qA 3 0.8817 100 0.473 Contact Map
1hm9A 3 0.8677 100 0.479 Contact Map
2v0hA 3 0.8515 100 0.503 Contact Map
4fceA 3 0.8445 100 0.513 Contact Map
2icyA 1 0.8167 100 0.57 Contact Map
2i5kA 5 0.8167 100 0.593 Contact Map
3jukA 3 0.5638 100 0.614 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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