GLGC - ECOLI - GREMLIN Contacts

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GLGC - Glucose-1-phosphate adenylyltransferase

UniProt:	P0A6V1	Sequences: MVSLEKNDHLMLARQLPLKSVALILAGGRGTRLKDLTNKRAKPAVHFGGKFRIIDFALSNCINSGIRRMGVITQYQSHTLVQHIQRGWSFFNEEMNEFVDLLPAQQRMKGENWYRGTADAVTQNLDIIRRYKAEYVVILAGDHIYKQDYSRMLIDHVEKGARCTVACMPVPIEEASAFGVMAVDENDKIIEFVEKPANPPSMPNDPSKSLASMGIYVFDADYLYELLEEDDRDENSSHDFGKDLIPKITEAGLAYAHPFPLSCVQSDPDAEPYWRDVGTLEAYWKANLDLASVVPELDMYDRNWPIRTYNESLPPAKFVQDRSGSHGMTLNSLVSGGCVISGSVVVQSVLFSRVRVNSFCNIDSAVLLPEVWVGRSCRLRRCVIDRACVIPEGMVIGENAEEDARRFYRSEEGIVLVTREMLRKLGHKQER	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10379
Length:	431 (345)
Sequences:	7734 (4998)
Seq/√Len:	269.1

ECOLI - GLGC GLMU RMLA1
BACSU - GLGC GLMU GLGD
HALSA - Q9HSZ9 Q9HSZ8 Q9HS61
SULSO - Q97ZD1 Q980H9 Q7LXK9 Q97XG0 Q980D4 Q7LXE7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
362_I	365_A	4.480	1.00
364_S	381_R	3.645	1.00
379_L	382_C	3.629	1.00
363_D	380_R	3.522	1.00
169_P	209_S	3.314	1.00
156_H	164_T	3.134	1.00
367_L	373_V	2.986	1.00
353_R	370_E	2.982	1.00
195_K	206_P	2.831	1.00
358_S	375_R	2.799	1.00
184_D	188_K	2.793	1.00
357_N	375_R	2.509	1.00
182_A	208_K	2.492	1.00
169_P	258_P	2.484	1.00
359_F	376_S	2.449	1.00
365_A	379_L	2.397	1.00
352_S	369_P	2.379	1.00
50_K	59_S	2.288	1.00
154_I	158_E	2.285	1.00
22_A	66_I	2.260	1.00
371_V	388_C	2.259	1.00
370_E	387_A	2.235	1.00
374_G	392_E	2.231	1.00
229_E	251_A	2.220	1.00
135_Y	157_V	2.170	1.00
22_A	61_C	2.166	1.00
346_V	363_D	2.127	1.00
125_L	228_E	2.108	1.00
355_R	372_W	2.102	1.00
136_V	220_A	2.092	1.00
155_D	159_K	2.080	1.00
182_A	191_E	2.064	1.00
162_R	219_D	2.051	1.00
225_E	229_E	2.033	1.00
345_V	348_S	2.024	1.00
331_N	347_Q	2.003	1.00
152_M	166_A	1.996	1.00
40_R	46_H	1.980	1.00
351_F	369_P	1.954	1.00
384_I	388_C	1.935	1.00
350_L	354_V	1.918	1.00
375_R	392_E	1.907	1.00
189_I	256_A	1.853	1.00
367_L	371_V	1.808	1.00
167_C	256_A	1.784	1.00
55_D	83_H	1.756	1.00
58_L	69_M	1.744	1.00
350_L	356_V	1.726	1.00
225_E	251_A	1.720	1.00
360_C	377_C	1.715	1.00
384_I	390_I	1.714	1.00
152_M	217_V	1.703	1.00
135_Y	219_D	1.702	1.00
279_T	300_Y	1.696	1.00
329_T	332_S	1.659	1.00
298_D	301_D	1.655	1.00
357_N	374_G	1.648	1.00
372_W	389_V	1.643	1.00
152_M	164_T	1.639	1.00
330_L	346_V	1.637	1.00
336_G	352_S	1.621	1.00
161_A	255_Y	1.620	1.00
277_V	286_A	1.612	1.00
349_V	366_V	1.600	1.00
162_R	253_L	1.594	1.00
184_D	190_I	1.590	1.00
188_K	255_Y	1.582	1.00
159_K	255_Y	1.581	1.00
338_C	354_V	1.566	1.00
361_N	378_R	1.559	1.00
366_V	383_V	1.543	1.00
176_S	195_K	1.529	1.00
348_S	362_I	1.515	1.00
138_I	218_F	1.488	1.00
339_V	355_R	1.488	1.00
125_L	224_Y	1.486	1.00
153_L	217_V	1.470	1.00
220_A	224_Y	1.465	1.00
129_R	224_Y	1.459	1.00
347_Q	364_S	1.452	1.00
193_V	200_P	1.450	1.00
54_I	84_I	1.448	1.00
222_Y	253_L	1.439	1.00
115_R	119_D	1.434	1.00
369_P	386_R	1.430	1.00
376_S	393_G	1.426	1.00
200_P	206_P	1.424	1.00
61_C	139_L	1.413	1.00
378_R	395_V	1.407	1.00
118_A	230_D	1.398	1.00
55_D	59_S	1.397	1.00
338_C	350_L	1.396	1.00
150_S	154_I	1.387	1.00
335_S	338_C	1.384	1.00
374_G	389_V	1.376	1.00
135_Y	217_V	1.363	1.00
155_D	257_H	1.358	1.00
53_I	277_V	1.352	1.00
334_V	338_C	1.346	1.00
371_V	384_I	1.345	1.00
77_S	81_V	1.331	1.00
163_C	248_I	1.328	1.00
368_L	386_R	1.322	1.00
354_V	371_V	1.320	1.00
362_I	367_L	1.315	1.00
335_S	352_S	1.309	1.00
182_A	193_V	1.308	1.00
77_S	105_Q	1.305	1.00
357_N	372_W	1.299	1.00
39_K	353_R	1.283	1.00
167_C	181_M	1.278	1.00
119_D	122_T	1.277	1.00
137_V	217_V	1.274	1.00
70_G	104_A	1.267	1.00
119_D	123_Q	1.266	1.00
281_E	300_Y	1.251	1.00
351_F	354_V	1.245	1.00
377_C	392_E	1.241	1.00
313_L	316_A	1.233	1.00
273_Y	289_D	1.225	1.00
68_R	100_D	1.222	1.00
73_T	77_S	1.213	1.00
229_E	247_K	1.191	1.00
48_G	290_L	1.190	1.00
380_R	397_G	1.169	1.00
368_L	383_V	1.169	1.00
227_L	230_D	1.162	1.00
327_G	340_I	1.157	1.00
174_E	195_K	1.150	1.00
151_R	154_I	1.149	1.00
275_R	289_D	1.134	1.00
46_H	52_R	1.130	1.00
275_R	285_K	1.128	1.00
87_G	90_F	1.128	1.00
377_C	394_M	1.123	1.00
296_E	300_Y	1.118	1.00
78_H	82_Q	1.113	1.00
177_A	195_K	1.110	1.00
171_P	209_S	1.100	1.00
79_T	82_Q	1.098	1.00
74_Q	114_Y	1.097	1.00
226_L	248_I	1.094	1.00
226_L	251_A	1.089	1.00
189_I	254_A	1.086	1.00
281_E	285_K	1.085	1.00
247_K	251_A	1.085	1.00
310_N	313_L	1.081	1.00
183_V	210_L	1.079	1.00
41_A	79_T	1.078	1.00
357_N	360_C	1.077	1.00
108_M	115_R	1.072	1.00
377_C	390_I	1.070	1.00
134_E	219_D	1.069	1.00
379_L	384_I	1.065	1.00
70_G	127_I	1.063	1.00
140_A	143_H	1.062	1.00
56_F	290_L	1.061	1.00
155_D	255_Y	1.060	1.00
47_F	287_N	1.057	1.00
371_V	386_R	1.051	1.00
21_V	68_R	1.045	1.00
148_D	273_Y	1.045	1.00
311_E	315_P	1.042	1.00
341_S	358_S	1.042	1.00
165_V	189_I	1.035	1.00
328_M	344_V	1.032	1.00
44_A	83_H	1.030	1.00
85_Q	90_F	1.023	1.00
122_T	125_L	1.017	1.00
246_P	250_E	1.012	1.00
54_I	71_V	1.007	1.00
179_G	194_E	1.006	1.00
230_D	236_S	0.998	1.00
327_G	330_L	0.997	1.00
148_D	151_R	0.996	1.00
43_P	141_G	0.996	1.00
121_V	138_I	0.994	1.00
237_S	243_D	0.991	1.00
40_R	79_T	0.990	1.00
226_L	247_K	0.988	1.00
371_V	385_D	0.987	1.00
218_F	244_L	0.984	1.00
333_L	349_V	0.976	1.00
145_Y	148_D	0.974	1.00
167_C	210_L	0.972	1.00
114_Y	119_D	0.971	1.00
371_V	390_I	0.970	1.00
165_V	181_M	0.970	1.00
174_E	177_A	0.965	1.00
342_G	359_F	0.965	1.00
222_Y	225_E	0.964	1.00
317_K	339_V	0.963	1.00
171_P	271_E	0.963	1.00
187_D	258_P	0.960	1.00
155_D	158_E	0.957	1.00
294_V	298_D	0.955	1.00
64_S	149_Y	0.950	1.00
52_R	83_H	0.945	1.00
373_V	379_L	0.942	1.00
133_A	221_D	0.941	1.00
311_E	314_P	0.940	1.00
55_D	87_G	0.938	1.00
73_T	103_P	0.937	1.00
212_S	216_Y	0.935	1.00
343_S	346_V	0.929	1.00
297_L	301_D	0.926	1.00
21_V	128_I	0.924	1.00
181_M	189_I	0.923	1.00
137_V	153_L	0.922	1.00
30_G	42_K	0.912	1.00
337_G	341_S	0.903	1.00
361_N	375_R	0.902	1.00
353_R	369_P	0.902	1.00
180_V	211_A	0.900	1.00
360_C	392_E	0.898	1.00
23_L	136_V	0.895	1.00
151_R	155_D	0.893	1.00
288_L	291_A	0.892	1.00
153_L	157_V	0.892	1.00
341_S	344_V	0.890	1.00
259_F	272_P	0.890	1.00
52_R	55_D	0.890	1.00
326_H	342_G	0.885	1.00
71_V	84_I	0.884	1.00
226_L	230_D	0.882	1.00
54_I	80_L	0.879	1.00
170_V	211_A	0.870	1.00
125_L	129_R	0.867	1.00
196_P	235_N	0.866	1.00
139_L	149_Y	0.864	1.00
354_V	369_P	0.861	1.00
332_S	345_V	0.858	1.00
134_E	220_A	0.856	1.00
221_D	225_E	0.854	1.00
49_G	333_L	0.852	1.00
225_E	228_E	0.845	1.00
248_I	253_L	0.844	1.00
316_A	319_V	0.844	1.00
41_A	76_Q	0.841	1.00
162_R	222_Y	0.840	1.00
319_V	326_H	0.839	1.00
222_Y	226_L	0.837	0.99
163_C	218_F	0.837	0.99
359_F	375_R	0.836	0.99
367_L	384_I	0.835	0.99
23_L	70_G	0.835	0.99
360_C	375_R	0.834	0.99
344_V	361_N	0.829	0.99
232_R	239_D	0.829	0.99
373_V	377_C	0.828	0.99
317_K	320_Q	0.828	0.99
129_R	228_E	0.827	0.99
168_M	274_W	0.823	0.99
334_V	340_I	0.822	0.99
24_I	58_L	0.819	0.99
188_K	249_T	0.819	0.99
289_D	292_S	0.818	0.99
354_V	367_L	0.817	0.99
292_S	296_E	0.815	0.99
314_P	319_V	0.813	0.99
378_R	393_G	0.813	0.99
374_G	391_P	0.812	0.99
327_G	341_S	0.810	0.99
318_F	329_T	0.809	0.99
74_Q	119_D	0.809	0.99
42_K	142_D	0.808	0.99
219_D	222_Y	0.807	0.99
341_S	357_N	0.803	0.99
341_S	346_V	0.803	0.99
62_I	88_W	0.801	0.99
354_V	368_L	0.801	0.99
128_I	134_E	0.800	0.99
130_R	224_Y	0.800	0.99
226_L	229_E	0.800	0.99
32_R	42_K	0.798	0.99
23_L	121_V	0.789	0.99
58_L	101_L	0.788	0.99
137_V	149_Y	0.786	0.99
24_I	61_C	0.785	0.99
56_F	59_S	0.783	0.99
183_V	256_A	0.781	0.99
376_S	392_E	0.779	0.99
78_H	81_V	0.777	0.99
134_E	221_D	0.770	0.99
168_M	211_A	0.769	0.99
163_C	245_I	0.768	0.99
69_M	99_V	0.765	0.99
193_V	198_N	0.763	0.99
55_D	84_I	0.760	0.99
340_I	350_L	0.759	0.99
395_V	398_E	0.758	0.99
363_D	378_R	0.756	0.99
279_T	282_A	0.755	0.99
160_G	219_D	0.755	0.99
122_T	239_D	0.753	0.99
81_V	105_Q	0.751	0.99
249_T	254_A	0.749	0.99
108_M	114_Y	0.747	0.99
398_E	401_E	0.746	0.99
76_Q	79_T	0.746	0.99
294_V	297_L	0.746	0.99
58_L	84_I	0.744	0.99
62_I	87_G	0.742	0.99
62_I	69_M	0.740	0.99
328_M	341_S	0.739	0.99
122_T	228_E	0.739	0.99
59_S	63_N	0.736	0.99
337_G	352_S	0.736	0.99
44_A	79_T	0.733	0.99
154_I	157_V	0.733	0.99
57_A	139_L	0.731	0.99
331_N	346_V	0.727	0.99
230_D	244_L	0.726	0.99
331_N	334_V	0.725	0.99
222_Y	248_I	0.723	0.99
337_G	359_F	0.722	0.99
310_N	315_P	0.722	0.99
122_T	231_D	0.720	0.98
61_C	66_I	0.720	0.98
337_G	353_R	0.720	0.98
25_L	140_A	0.717	0.98
341_S	345_V	0.714	0.98
170_V	209_S	0.713	0.98
128_I	223_L	0.713	0.98
48_G	56_F	0.711	0.98
167_C	189_I	0.703	0.98
292_S	347_Q	0.701	0.98
334_V	345_V	0.701	0.98
34_K	38_N	0.700	0.98
40_R	385_D	0.699	0.98
272_P	289_D	0.699	0.98
328_M	343_S	0.698	0.98
360_C	376_S	0.698	0.98
66_I	153_L	0.698	0.98
362_I	379_L	0.697	0.98
185_E	190_I	0.697	0.98
319_V	341_S	0.690	0.98
60_N	64_S	0.689	0.98
218_F	223_L	0.683	0.98
233_D	236_S	0.683	0.98
70_G	124_N	0.683	0.98
175_A	199_P	0.681	0.98
310_N	314_P	0.681	0.98
358_S	361_N	0.678	0.98
380_R	395_V	0.678	0.98
86_R	90_F	0.675	0.98
275_R	286_A	0.672	0.98
238_H	243_D	0.671	0.98
391_P	394_M	0.671	0.98
107_R	114_Y	0.670	0.98
335_S	343_S	0.666	0.97
396_I	399_N	0.665	0.97
258_P	271_E	0.663	0.97
73_T	81_V	0.661	0.97
210_L	258_P	0.660	0.97
371_V	387_A	0.660	0.97
156_H	219_D	0.659	0.97
28_G	42_K	0.658	0.97
345_V	356_V	0.658	0.97
138_I	241_G	0.658	0.97
343_S	361_N	0.658	0.97
233_D	243_D	0.657	0.97
372_W	375_R	0.656	0.97
340_I	343_S	0.655	0.97
289_D	293_V	0.655	0.97
84_I	99_V	0.653	0.97
224_Y	227_L	0.651	0.97
247_K	250_E	0.651	0.97
319_V	336_G	0.650	0.97
343_S	358_S	0.649	0.97
330_L	344_V	0.648	0.97
308_T	315_P	0.648	0.97
329_T	334_V	0.644	0.97
70_G	128_I	0.643	0.97
117_T	142_D	0.641	0.97
281_E	296_E	0.638	0.97
126_D	129_R	0.638	0.97
340_I	344_V	0.638	0.97
146_K	273_Y	0.638	0.97
316_A	338_C	0.637	0.97
193_V	199_P	0.637	0.97
213_M	274_W	0.634	0.97
28_G	32_R	0.634	0.97
60_N	149_Y	0.633	0.97
21_V	132_K	0.631	0.97
305_P	308_T	0.630	0.96
314_P	317_K	0.626	0.96
52_R	56_F	0.625	0.96
182_A	200_P	0.623	0.96
304_W	315_P	0.623	0.96
47_F	53_I	0.621	0.96
60_N	146_K	0.620	0.96
136_V	223_L	0.620	0.96
367_L	379_L	0.620	0.96
25_L	120_A	0.617	0.96
171_P	174_E	0.617	0.96
181_M	210_L	0.615	0.96
218_F	222_Y	0.613	0.96
338_C	351_F	0.612	0.96
326_H	330_L	0.610	0.96
380_R	398_E	0.606	0.96
375_R	393_G	0.606	0.96
327_G	332_S	0.605	0.96
21_V	70_G	0.604	0.96
85_Q	103_P	0.602	0.95
25_L	72_I	0.602	0.95
73_T	80_L	0.602	0.95
283_Y	368_L	0.601	0.95
368_L	385_D	0.597	0.95
230_D	238_H	0.592	0.95
239_D	242_K	0.591	0.95
297_L	300_Y	0.588	0.95
356_V	360_C	0.587	0.95
115_R	239_D	0.587	0.95
329_T	335_S	0.587	0.95
190_I	249_T	0.585	0.95
53_I	57_A	0.584	0.95
191_E	246_P	0.584	0.95
182_A	190_I	0.583	0.95
375_R	378_R	0.581	0.95
312_S	315_P	0.581	0.95
326_H	341_S	0.581	0.95
170_V	174_E	0.581	0.95
72_I	106_Q	0.580	0.94
177_A	282_A	0.580	0.94
285_K	288_L	0.579	0.94
72_I	120_A	0.578	0.94
33_L	45_V	0.578	0.94
73_T	105_Q	0.577	0.94
30_G	43_P	0.575	0.94
166_A	215_I	0.575	0.94
60_N	63_N	0.571	0.94
139_L	215_I	0.570	0.94
230_D	247_K	0.569	0.94
63_N	146_K	0.568	0.94
377_C	391_P	0.567	0.94
370_E	386_R	0.565	0.94
26_A	80_L	0.564	0.94
285_K	289_D	0.563	0.94
285_K	296_E	0.563	0.94
338_C	352_S	0.562	0.94
361_N	376_S	0.562	0.94
342_G	346_V	0.561	0.93
37_T	45_V	0.561	0.93
170_V	175_A	0.561	0.93
59_S	87_G	0.560	0.93
132_K	221_D	0.560	0.93
310_N	316_A	0.559	0.93
125_L	128_I	0.553	0.93
332_S	335_S	0.552	0.93
121_V	240_F	0.551	0.93
332_S	348_S	0.550	0.93
218_F	240_F	0.549	0.93
339_V	343_S	0.548	0.93
335_S	341_S	0.545	0.92
327_G	342_G	0.545	0.92
313_L	318_F	0.545	0.92
32_R	43_P	0.545	0.92
68_R	102_L	0.544	0.92
142_D	276_D	0.543	0.92
332_S	346_V	0.543	0.92
164_T	217_V	0.542	0.92
210_L	256_A	0.541	0.92
226_L	244_L	0.541	0.92
43_P	80_L	0.540	0.92
312_S	318_F	0.539	0.92
314_P	318_F	0.539	0.92
48_G	287_N	0.538	0.92
140_A	216_Y	0.538	0.92
21_V	136_V	0.537	0.92
29_R	114_Y	0.534	0.92
163_C	254_A	0.534	0.92
189_I	249_T	0.534	0.92
331_N	335_S	0.533	0.92
360_C	374_G	0.532	0.92
307_R	311_E	0.530	0.91
215_I	274_W	0.530	0.91
192_F	242_K	0.529	0.91
81_V	85_Q	0.528	0.91
170_V	271_E	0.528	0.91
82_Q	85_Q	0.528	0.91
46_H	386_R	0.527	0.91
179_G	195_K	0.527	0.91
145_Y	215_I	0.527	0.91
20_S	153_L	0.525	0.91
379_L	396_I	0.525	0.91
361_N	380_R	0.524	0.91
362_I	373_V	0.523	0.91
161_A	164_T	0.523	0.91
290_L	294_V	0.522	0.91
280_L	284_W	0.520	0.91
312_S	316_A	0.520	0.91
198_N	206_P	0.520	0.91
165_V	254_A	0.520	0.91
378_R	381_R	0.519	0.91
79_T	83_H	0.519	0.91
66_I	137_V	0.518	0.90
327_G	344_V	0.518	0.90
194_E	212_S	0.518	0.90
64_S	150_S	0.518	0.90
378_R	398_E	0.518	0.90
45_V	280_L	0.518	0.90
354_V	386_R	0.516	0.90
44_A	84_I	0.515	0.90
24_I	57_A	0.515	0.90
144_I	148_D	0.514	0.90
298_D	303_N	0.514	0.90
309_Y	312_S	0.513	0.90
310_N	318_F	0.513	0.90
86_R	89_S	0.511	0.90
166_A	213_M	0.509	0.90
308_T	314_P	0.509	0.90
140_A	214_G	0.508	0.90
350_L	367_L	0.507	0.90
383_V	401_E	0.505	0.89
195_K	278_G	0.504	0.89
168_M	213_M	0.504	0.89
237_S	242_K	0.500	0.89

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3brkX	2	0.9118	100	0.389	Contact Map
1yp2A	4	0.9002	100	0.417	Contact Map
2ggoA	3	0.8306	100	0.471	Contact Map
4g3qA	3	0.8817	100	0.473	Contact Map
1hm9A	3	0.8677	100	0.479	Contact Map
2v0hA	3	0.8515	100	0.503	Contact Map
4fceA	3	0.8445	100	0.513	Contact Map
2icyA	1	0.8167	100	0.57	Contact Map
2i5kA	5	0.8167	100	0.593	Contact Map
3jukA	3	0.5638	100	0.614	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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