GREMLIN Database
GLGA - Glycogen synthase
UniProt: P0A6U8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10377
Length: 477 (380)
Sequences: 25317 (19526)
Seq/√Len: 1001.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
296_A367_A4.3111.00
335_Q339_L4.1211.00
323_Q350_G3.7991.00
207_H242_S3.4121.00
134_H473_Y3.3131.00
292_V323_Q3.0581.00
312_E341_A2.9481.00
370_I386_G2.7541.00
320_Q436_R2.7381.00
33_D467_K2.6031.00
216_A220_T2.6031.00
316_G429_W2.6021.00
441_L444_R2.5821.00
453_R457_A2.5531.00
35_V470_R2.5231.00
293_P439_F2.4791.00
316_G432_L2.4191.00
38_R130_P2.3611.00
455_A459_D2.3581.00
318_L348_Q2.2531.00
297_V307_L2.2171.00
397_R424_E2.2071.00
314_L324_L2.1731.00
405_V420_G2.1411.00
329_A335_Q2.1311.00
294_L325_A2.1051.00
312_E428_A2.0741.00
397_R402_A2.0731.00
33_D470_R2.0701.00
454_Q458_M2.0441.00
444_R447_L2.0421.00
424_E430_S2.0101.00
134_H159_T2.0011.00
445_P449_R1.9721.00
437_R444_R1.9691.00
434_A437_R1.9631.00
327_L363_I1.9551.00
310_V371_L1.9381.00
406_S418_A1.9301.00
317_L436_R1.9151.00
464_V468_S1.9051.00
325_A352_Q1.8741.00
421_F434_A1.8601.00
295_F369_V1.8561.00
158_F205_A1.8561.00
343_A346_P1.8461.00
437_R441_L1.8361.00
419_S455_A1.8181.00
427_N430_S1.8161.00
29_A32_A1.7731.00
370_I391_T1.7621.00
342_A351_V1.7541.00
38_R80_Y1.7511.00
294_L323_Q1.7511.00
29_A463_Q1.7491.00
207_H472_L1.7481.00
447_L451_V1.7371.00
247_G462_W1.7331.00
295_F435_I1.7321.00
390_G453_R1.7221.00
213_P217_R1.6991.00
4_L130_P1.6911.00
3_V35_V1.6811.00
395_V422_V1.6761.00
38_R128_W1.6721.00
216_A243_G1.6691.00
301_L326_L1.6681.00
4_L40_L1.6681.00
213_P216_A1.6461.00
359_F362_R1.6441.00
314_L322_G1.6401.00
294_L366_G1.6251.00
340_A344_E1.6231.00
367_A391_T1.6121.00
295_F371_L1.6101.00
306_G309_L1.6091.00
29_A466_A1.5991.00
408_C418_A1.5961.00
336_E339_L1.5851.00
293_P368_D1.5811.00
430_S434_A1.5431.00
209_T469_Y1.5221.00
442_W445_P1.4921.00
428_A432_L1.4841.00
421_F437_R1.4771.00
436_R440_V1.4741.00
451_V454_Q1.4691.00
406_S419_S1.4611.00
449_R452_Q1.4591.00
213_P403_D1.4551.00
298_V360_S1.4471.00
468_S471_E1.4461.00
216_A241_L1.4351.00
310_V324_L1.4281.00
5_H30_Q1.4191.00
217_R221_E1.4171.00
217_R220_T1.3971.00
355_Y363_I1.3971.00
450_F454_Q1.3971.00
383_Q401_L1.3961.00
135_A156_S1.3871.00
470_R474_Y1.3861.00
355_Y359_F1.3781.00
336_E340_A1.3751.00
5_H27_P1.3671.00
315_P319_E1.3351.00
446_S450_F1.3321.00
430_S433_R1.3251.00
210_A241_L1.3211.00
24_G28_A1.3141.00
467_K471_E1.3101.00
293_P369_V1.2991.00
464_V467_K1.2941.00
332_P337_G1.2931.00
423_F434_A1.2921.00
356_H359_F1.2841.00
283_A362_R1.2751.00
161_H381_L1.2731.00
406_S455_A1.2731.00
292_V321_G1.2661.00
213_P243_G1.2651.00
377_E380_G1.2651.00
424_E427_N1.2651.00
418_A451_V1.2581.00
220_T238_E1.2571.00
325_A350_G1.2551.00
136_H161_H1.2541.00
297_V310_V1.2531.00
244_V472_L1.2471.00
317_L322_G1.2461.00
313_A431_L1.2411.00
444_R448_W1.2291.00
341_A344_E1.2281.00
395_V405_V1.2231.00
211_V246_N1.2121.00
308_D375_R1.2091.00
449_R453_R1.2061.00
306_G375_R1.2051.00
38_R78_G1.1981.00
316_G428_A1.1931.00
209_T472_L1.1881.00
5_H136_H1.1851.00
253_W389_Y1.1791.00
360_S364_M1.1691.00
209_T244_V1.1681.00
294_L368_D1.1671.00
327_L355_Y1.1651.00
296_A364_M1.1601.00
433_R437_R1.1551.00
327_L352_Q1.1541.00
293_P322_G1.1431.00
448_W451_V1.1351.00
27_P39_V1.1351.00
314_L317_L1.1321.00
421_F438_A1.1311.00
293_P321_G1.1281.00
245_L460_F1.1241.00
421_F448_W1.1221.00
305_K377_E1.1161.00
391_T449_R1.1161.00
316_G319_E1.1061.00
316_G320_Q1.1031.00
308_D337_G1.1001.00
315_P318_L1.0941.00
395_V401_L1.0911.00
309_L426_S1.0901.00
372_V383_Q1.0891.00
29_A33_D1.0881.00
461_S464_V1.0871.00
396_R423_F1.0821.00
298_V364_M1.0801.00
249_D253_W1.0791.00
386_G391_T1.0781.00
132_V473_Y1.0771.00
307_L326_L1.0761.00
352_Q355_Y1.0761.00
372_V382_T1.0751.00
210_A216_A1.0721.00
26_L469_Y1.0701.00
278_R282_I1.0681.00
279_Q283_A1.0661.00
342_A345_Y1.0631.00
429_W433_R1.0561.00
454_Q457_A1.0521.00
407_D434_A1.0501.00
22_V246_N1.0481.00
252_I361_H1.0341.00
156_S205_A1.0331.00
211_V378_P1.0291.00
309_L428_A1.0231.00
374_S377_E1.0221.00
296_A327_L1.0091.00
296_A363_I1.0091.00
253_W361_H1.0031.00
317_L435_I1.0001.00
308_D341_A1.0001.00
301_L335_Q0.9971.00
304_Q376_F0.9971.00
305_K374_S0.9881.00
31_I34_G0.9851.00
305_K382_T0.9801.00
22_V381_L0.9791.00
322_G439_F0.9781.00
283_A359_F0.9771.00
205_A208_I0.9751.00
432_L436_R0.9751.00
244_V469_Y0.9741.00
135_A158_F0.9721.00
210_A219_I0.9701.00
421_F444_R0.9671.00
371_L435_I0.9661.00
340_A343_A0.9651.00
369_V438_A0.9611.00
357_E360_S0.9611.00
27_P31_I0.9581.00
300_R304_Q0.9561.00
311_L342_A0.9471.00
361_H365_G0.9441.00
138_W141_G0.9421.00
471_E474_Y0.9391.00
295_F314_L0.9301.00
442_W446_S0.9291.00
408_C419_S0.9271.00
249_D252_I0.9271.00
387_L393_P0.9261.00
32_A463_Q0.9201.00
279_Q282_I0.9161.00
370_I382_T0.9111.00
339_L343_A0.9101.00
155_K206_D0.9091.00
25_A28_A0.9091.00
448_W452_Q0.9071.00
157_V209_T0.9061.00
211_V215_Y0.9051.00
369_V435_I0.9031.00
405_V419_S0.9011.00
250_E461_S0.9001.00
438_A448_W0.8991.00
298_V327_L0.8991.00
462_W465_A0.8991.00
308_D312_E0.8961.00
361_H389_Y0.8941.00
364_M389_Y0.8911.00
280_L284_M0.8881.00
394_L434_A0.8871.00
25_A462_W0.8791.00
71_F78_G0.8771.00
390_G450_F0.8751.00
394_L423_F0.8751.00
465_A468_S0.8741.00
365_G389_Y0.8731.00
218_E221_E0.8711.00
132_V157_V0.8671.00
447_L450_F0.8671.00
75_N78_G0.8671.00
313_A432_L0.8651.00
329_A354_G0.8631.00
310_V373_P0.8621.00
394_L435_I0.8591.00
375_R426_S0.8581.00
399_G402_A0.8571.00
120_M123_G0.8561.00
242_S472_L0.8521.00
392_L449_R0.8511.00
312_E315_P0.8491.00
22_V161_H0.8491.00
445_P448_W0.8491.00
392_L455_A0.8481.00
10_M24_G0.8471.00
300_R305_K0.8461.00
17_G20_A0.8451.00
364_M382_T0.8431.00
324_L349_V0.8421.00
148_A206_D0.8391.00
309_L396_R0.8381.00
314_L348_Q0.8371.00
22_V136_H0.8321.00
325_A363_I0.8291.00
33_D466_A0.8291.00
379_C384_L0.8241.00
31_I37_A0.8231.00
459_D468_S0.8221.00
405_V422_V0.8181.00
432_L435_I0.8171.00
337_G340_A0.8161.00
27_P37_A0.8151.00
441_L445_P0.8131.00
309_L375_R0.8071.00
407_D418_A0.8061.00
25_A29_A0.8041.00
245_L403_D0.8031.00
136_H159_T0.8011.00
295_F324_L0.7991.00
463_Q467_K0.7981.00
250_E388_K0.7961.00
159_T473_Y0.7911.00
423_F430_S0.7911.00
9_E20_A0.7871.00
21_D25_A0.7871.00
461_S465_A0.7841.00
291_K321_G0.7821.00
199_K203_Y0.7811.00
317_L439_F0.7791.00
433_R436_R0.7791.00
287_K292_V0.7781.00
121_A124_L0.7771.00
157_V473_Y0.7761.00
141_G144_P0.7761.00
352_Q363_I0.7741.00
323_Q348_Q0.7731.00
321_G348_Q0.7721.00
383_Q404_T0.7701.00
297_V373_P0.7701.00
302_T331_D0.7681.00
312_E316_G0.7641.00
113_L116_V0.7641.00
369_V394_L0.7641.00
446_S449_R0.7631.00
130_P154_A0.7631.00
296_A391_T0.7631.00
36_D78_G0.7621.00
467_K470_R0.7591.00
233_Q238_E0.7581.00
338_F351_V0.7571.00
342_A349_V0.7561.00
299_S307_L0.7551.00
280_L366_G0.7541.00
23_I136_H0.7531.00
320_Q433_R0.7531.00
363_I366_G0.7531.00
72_G81_L0.7511.00
119_E123_G0.7481.00
373_P431_L0.7481.00
407_D419_S0.7451.00
387_L452_Q0.7411.00
394_L438_A0.7401.00
387_L419_S0.7401.00
242_S468_S0.7371.00
380_G383_Q0.7371.00
338_F341_A0.7361.00
337_G341_A0.7351.00
7_C23_I0.7351.00
28_A75_N0.7351.00
469_Y473_Y0.7301.00
161_H211_V0.7301.00
362_R365_G0.7261.00
380_G401_L0.7251.00
364_M370_I0.7241.00
293_P442_W0.7231.00
317_L432_L0.7221.00
159_T209_T0.7201.00
22_V159_T0.7151.00
294_L367_A0.7091.00
443_S447_L0.7081.00
311_L349_V0.7071.00
306_G373_P0.7061.00
429_W432_L0.7051.00
81_L84_A0.7041.00
386_G393_P0.7021.00
118_A122_S0.7011.00
280_L363_I0.6991.00
455_A460_F0.6991.00
339_L351_V0.6991.00
33_D463_Q0.6981.00
314_L318_L0.6961.00
210_A215_Y0.6921.00
295_F322_G0.6921.00
287_K290_D0.6911.00
247_G465_A0.6911.00
452_Q455_A0.6881.00
200_A204_Y0.6881.00
25_A249_D0.6881.00
441_L447_L0.6871.00
31_I76_G0.6871.00
156_S206_D0.6841.00
312_E344_E0.6831.00
320_Q440_V0.6781.00
112_L116_V0.6781.00
141_G145_A0.6781.00
106_N109_R0.6781.00
309_L431_L0.6741.00
387_L455_A0.6731.00
368_D445_P0.6731.00
290_D293_P0.6731.00
397_R422_V0.6711.00
342_A346_P0.6711.00
364_M386_G0.6701.00
428_A431_L0.6701.00
110_F113_L0.6691.00
392_L438_A0.6681.00
246_N381_L0.6671.00
87_L90_R0.6651.00
308_D338_F0.6651.00
431_L435_I0.6651.00
245_L465_A0.6611.00
438_A445_P0.6601.00
325_A367_A0.6581.00
383_Q393_P0.6571.00
146_Y150_R0.6561.00
372_V401_L0.6541.00
161_H246_N0.6531.00
295_F439_F0.6521.00
443_S446_S0.6521.00
451_V455_A0.6521.00
382_T386_G0.6491.00
129_R154_A0.6461.00
371_L431_L0.6451.00
278_R290_D0.6441.00
462_W466_A0.6441.00
277_K281_Q0.6431.00
144_P148_A0.6431.00
309_L312_E0.6431.00
250_E457_A0.6421.00
5_H37_A0.6421.00
29_A462_W0.6401.00
220_T240_R0.6391.00
297_V326_L0.6381.00
253_W388_K0.6361.00
212_S215_Y0.6341.00
400_G403_D0.6321.00
438_A444_R0.6301.00
28_A32_A0.6291.00
408_C437_R0.6271.00
133_V154_A0.6261.00
196_S199_K0.6241.00
398_T401_L0.6231.00
142_L145_A0.6161.00
445_P452_Q0.6161.00
219_I241_L0.6151.00
317_L320_Q0.6141.00
372_V380_G0.6141.00
423_F431_L0.6141.00
26_L466_A0.6141.00
245_L379_C0.6141.00
313_A316_G0.6131.00
357_E361_H0.6131.00
220_T241_L0.6121.00
215_Y378_P0.6121.00
339_L342_A0.6101.00
256_E365_G0.6101.00
158_F198_L0.6091.00
303_S332_P0.6081.00
18_G22_V0.6071.00
17_G300_R0.6061.00
114_G117_G0.6061.00
450_F453_R0.6051.00
459_D464_V0.6011.00
327_L330_G0.6011.00
364_M391_T0.6001.00
419_S451_V0.5981.00
315_P344_E0.5981.00
313_A428_A0.5961.00
162_N300_R0.5961.00
160_V202_L0.5951.00
293_P445_P0.5951.00
159_T381_L0.5921.00
387_L449_R0.5921.00
113_L117_G0.5901.00
313_A317_L0.5901.00
106_N110_F0.5901.00
138_W145_A0.5891.00
301_L330_G0.5891.00
246_N380_G0.5891.00
300_R382_T0.5891.00
119_E122_S0.5881.00
377_E382_T0.5871.00
438_A441_L0.5851.00
218_E222_P0.5851.00
330_G335_Q0.5831.00
19_L137_D0.5831.00
301_L307_L0.5821.00
19_L22_V0.5821.00
437_R440_V0.5811.00
277_K362_R0.5801.00
311_L341_A0.5801.00
378_P399_G0.5801.00
465_A469_Y0.5791.00
407_D421_F0.5781.00
315_P345_Y0.5771.00
112_L115_W0.5771.00
134_H469_Y0.5761.00
105_D108_L0.5761.00
214_T403_D0.5761.00
111_A114_G0.5741.00
148_A156_S0.5741.00
277_K366_G0.5741.00
379_C460_F0.5731.00
138_W144_P0.5721.00
311_L345_Y0.5711.00
35_V131_D0.5711.00
245_L468_S0.5711.00
213_P245_L0.5701.00
22_V469_Y0.5681.00
310_V314_L0.5671.00
426_S431_L0.5661.00
21_D24_G0.5661.00
160_V219_I0.5651.00
248_V388_K0.5641.00
254_S257_T0.5631.00
109_R112_L0.5621.00
4_L133_V0.5611.00
18_G305_K0.5601.00
402_A422_V0.5601.00
157_V207_H0.5601.00
162_N378_P0.5591.00
282_I290_D0.5561.00
25_A381_L0.5561.00
159_T469_Y0.5541.00
296_A325_A0.5531.00
380_G404_T0.5531.00
390_G449_R0.5521.00
4_L38_R0.5521.00
145_A148_A0.5511.00
120_M124_L0.5511.00
214_T217_R0.5511.00
145_A149_A0.5501.00
21_D357_E0.5501.00
216_A238_E0.5491.00
252_I357_E0.5491.00
306_G426_S0.5481.00
311_L338_F0.5481.00
244_V468_S0.5481.00
195_I199_K0.5461.00
293_P296_A0.5431.00
79_I85_P0.5431.00
139_H142_L0.5421.00
304_Q378_P0.5401.00
76_G79_I0.5401.00
108_L111_A0.5401.00
296_A370_I0.5391.00
383_Q395_V0.5391.00
105_D109_R0.5381.00
22_V462_W0.5381.00
144_P149_A0.5381.00
355_Y360_S0.5361.00
130_P133_V0.5351.00
5_H473_Y0.5341.00
138_W142_L0.5331.00
134_H157_V0.5331.00
111_A115_W0.5321.00
396_R425_D0.5311.00
146_Y149_A0.5291.00
436_R439_F0.5271.00
214_T218_E0.5251.00
152_R155_K0.5241.00
326_L349_V0.5231.00
207_H240_R0.5221.00
192_N195_I0.5211.00
254_S365_G0.5181.00
214_T402_A0.5181.00
303_S308_D0.5181.00
196_S200_A0.5181.00
301_L351_V0.5181.00
281_Q323_Q0.5171.00
73_H78_G0.5161.00
251_K254_S0.5161.00
8_S12_P0.5161.00
439_F442_W0.5161.00
384_L460_F0.5151.00
132_V155_K0.5151.00
431_L434_A0.5131.00
35_V474_Y0.5101.00
172_H175_N0.5071.00
211_V380_G0.5061.00
115_W119_E0.5051.00
137_D162_N0.5041.00
249_D462_W0.5041.00
138_W148_A0.5031.00
132_V206_D0.5021.00
466_A470_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qzsA 1 0.9874 100 0.196 Contact Map
1rzuA 1 0.9853 100 0.204 Contact Map
3vueA 1 0.9329 100 0.24 Contact Map
3froA 3 0.8805 100 0.293 Contact Map
4qlbA 3 0.9287 100 0.296 Contact Map
4n9wA 1 0.7254 100 0.304 Contact Map
2r60A 1 0.8616 100 0.305 Contact Map
3c48A 2 0.8008 100 0.307 Contact Map
4hlnA 1 0.9329 100 0.308 Contact Map
3s28A 4 0.9119 100 0.329 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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