GREMLIN Database
RSMG - Ribosomal RNA small subunit methyltransferase G
UniProt: P0A6U5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10376
Length: 207 (189)
Sequences: 3955 (2912)
Seq/√Len: 211.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
98_L101_R3.0421.00
102_V119_P3.0001.00
58_I86_V2.6861.00
109_Q117_I2.6101.00
70_I136_V2.5811.00
122_S126_E2.5591.00
70_I95_L2.4031.00
93_T120_V2.3731.00
80_G94_L2.3721.00
72_V151_C2.3431.00
30_M111_E2.3201.00
34_W37_A2.2181.00
84_S116_N2.1641.00
93_T133_F2.1571.00
26_A111_E2.1181.00
91_H118_E2.0771.00
68_R91_H2.0671.00
109_Q119_P2.0631.00
45_D48_E2.0491.00
28_V49_M1.9821.00
17_T20_Q1.9561.00
61_A87_R1.9491.00
95_L127_F1.9371.00
30_M108_V1.8791.00
170_E174_A1.8741.00
134_D156_G1.8511.00
19_H23_Q1.8301.00
34_W38_Y1.8281.00
106_R119_P1.7911.00
155_P159_G1.7891.00
27_Y81_I1.7851.00
26_A29_N1.7231.00
69_F92_F1.7151.00
143_S175_L1.7111.00
30_M107_Q1.6481.00
97_S123_R1.6151.00
107_Q111_E1.6141.00
151_C161_F1.6021.00
138_S147_M1.5671.00
102_V121_Q1.5641.00
143_S146_D1.5441.00
34_W107_Q1.5411.00
70_I154_L1.5401.00
142_A146_D1.5321.00
74_T94_L1.5181.00
91_H116_N1.5161.00
28_V54_I1.4911.00
83_L92_F1.4681.00
70_I133_F1.4571.00
16_L86_V1.4461.00
107_Q110_H1.4451.00
60_V164_L1.4421.00
25_I29_N1.4041.00
20_Q23_Q1.3991.00
28_V32_H1.3661.00
94_L117_I1.3481.00
144_L163_A1.3271.00
24_L82_P1.3231.00
74_T80_G1.3211.00
99_G103_R1.3161.00
96_D102_V1.2971.00
69_F137_I1.2821.00
104_F108_V1.2801.00
103_R106_R1.2731.00
84_S117_I1.2641.00
32_H46_P1.2631.00
165_K172_E1.2301.00
136_V155_P1.1981.00
94_L105_L1.1971.00
60_V137_I1.1741.00
148_V180_Y1.1621.00
106_R110_H1.1601.00
27_Y78_L1.1521.00
87_R90_A1.1451.00
31_L49_M1.1301.00
69_F90_A1.1291.00
96_D121_Q1.1281.00
169_P198_H1.1261.00
30_M34_W1.1191.00
102_V106_R1.1181.00
59_V188_L1.1141.00
22_N26_A1.1071.00
20_Q85_I1.1021.00
66_G89_E1.1011.00
81_I117_I1.0991.00
84_S92_F1.0701.00
142_A147_M1.0681.00
23_Q88_P1.0661.00
185_V200_V1.0621.00
67_E135_G1.0561.00
145_N175_L1.0401.00
99_G121_Q1.0371.00
83_L137_I1.0361.00
171_D175_L1.0241.00
145_N149_S1.0191.00
187_K196_E1.0161.00
54_I78_L1.0121.00
23_Q85_I1.0101.00
169_P200_V0.9981.00
74_T105_L0.9861.00
135_G162_Y0.9831.00
168_M171_D0.9791.00
106_R109_Q0.9731.00
25_I50_L0.9701.00
18_D22_N0.9681.00
21_K25_I0.9681.00
19_H22_N0.9661.00
174_A177_P0.9651.00
27_Y105_L0.9621.00
30_M33_K0.9551.00
147_M163_A0.9450.99
63_Y186_V0.9370.99
187_K198_H0.9300.99
109_Q114_L0.9290.99
43_V52_R0.9290.99
27_Y108_V0.9280.99
166_G169_P0.9130.99
66_G135_G0.9120.99
50_L55_L0.9110.99
68_R93_T0.9100.99
146_D149_S0.9080.99
33_K37_A0.9050.99
76_P104_F0.8990.99
96_D119_P0.8970.99
16_L20_Q0.8970.99
61_A83_L0.8930.99
101_R105_L0.8910.99
182_V200_V0.8810.99
69_F135_G0.8760.99
127_F154_L0.8730.99
33_K36_K0.8680.99
124_V141_F0.8680.99
81_I109_Q0.8670.99
102_V105_L0.8600.99
72_V124_V0.8590.99
122_S127_F0.8500.99
144_L165_K0.8480.99
38_Y107_Q0.8450.99
93_T118_E0.8360.99
81_I114_L0.8350.99
31_L41_T0.8310.99
27_Y104_F0.8300.99
32_H49_M0.8290.99
57_S82_P0.8270.99
185_V198_H0.8250.99
51_V193_L0.8220.99
74_T102_V0.8120.98
156_G159_G0.8050.98
29_N32_H0.7980.98
72_V136_V0.7960.98
42_S53_H0.7820.98
127_F133_F0.7800.98
43_V48_E0.7720.98
76_P101_R0.7710.98
145_N179_E0.7700.98
68_R134_D0.7700.98
31_L54_I0.7560.98
184_S187_K0.7550.98
84_S90_A0.7530.97
65_Q87_R0.7510.97
95_L122_S0.7500.97
182_V185_V0.7480.97
57_S78_L0.7470.97
39_N100_K0.7450.97
148_V152_H0.7420.97
169_P173_I0.7390.97
141_F147_M0.7360.97
72_V141_F0.7330.97
97_S121_Q0.7230.97
25_I46_P0.7230.97
80_G117_I0.7200.97
68_R132_P0.7180.97
124_V154_L0.7160.97
189_Q194_D0.7150.97
128_P154_L0.7140.97
67_E90_A0.7120.96
136_V159_G0.7110.96
148_V176_L0.7100.96
170_E187_K0.7100.96
28_V46_P0.7080.96
24_L86_V0.7030.96
183_E186_V0.7010.96
160_R183_E0.7010.96
167_Q196_E0.6930.96
17_T23_Q0.6880.96
144_L200_V0.6880.96
57_S164_L0.6870.96
51_V55_L0.6850.96
145_N176_L0.6830.96
144_L172_E0.6820.96
152_H161_F0.6780.95
59_V164_L0.6780.95
64_L69_F0.6750.95
40_L76_P0.6730.95
152_H180_Y0.6690.95
51_V190_V0.6650.95
96_D105_L0.6620.95
85_I112_L0.6580.95
190_V193_L0.6560.94
51_V192_A0.6550.94
131_P157_E0.6480.94
176_L180_Y0.6480.94
22_N25_I0.6480.94
23_Q26_A0.6470.94
152_H155_P0.6390.94
34_W103_R0.6360.94
105_L119_P0.6320.93
124_V150_W0.6320.93
49_M54_I0.6290.93
46_P49_M0.6270.93
26_A112_L0.6220.93
85_I114_L0.6200.93
81_I108_V0.6170.92
97_S125_E0.6160.92
43_V53_H0.6140.92
97_S101_R0.6120.92
34_W104_F0.6110.92
41_T49_M0.6080.92
92_F116_N0.6070.92
48_E52_R0.6060.92
106_R118_E0.6030.92
30_M104_F0.6030.92
27_Y85_I0.6020.92
59_V199_L0.6020.92
67_E87_R0.6000.91
105_L109_Q0.6000.91
72_V95_L0.5970.91
38_Y76_P0.5960.91
38_Y98_L0.5950.91
142_A150_W0.5920.91
103_R107_Q0.5870.91
190_V197_R0.5850.90
60_V83_L0.5840.90
99_G102_V0.5830.90
24_L54_I0.5800.90
28_V50_L0.5780.90
11_D189_Q0.5760.90
46_P50_L0.5750.90
137_I164_L0.5710.89
188_L199_L0.5700.89
58_I82_P0.5690.89
36_K100_K0.5660.89
67_E134_D0.5660.89
150_W153_H0.5650.89
18_D21_K0.5650.89
157_E160_R0.5630.89
68_R133_F0.5590.88
48_E51_V0.5540.88
120_V127_F0.5500.87
128_P149_S0.5480.87
33_K110_H0.5480.87
31_L76_P0.5460.87
147_M165_K0.5440.87
145_N148_V0.5410.87
69_F83_L0.5410.87
72_V147_M0.5390.86
95_L98_L0.5390.86
149_S179_E0.5340.86
41_T46_P0.5330.86
26_A30_M0.5320.86
17_T86_V0.5310.86
54_I82_P0.5300.86
42_S76_P0.5300.86
128_P153_H0.5290.85
54_I84_S0.5280.85
60_V64_L0.5230.85
196_E199_L0.5230.85
27_Y31_L0.5200.84
127_F130_E0.5190.84
167_Q198_H0.5190.84
14_I86_V0.5180.84
155_P161_F0.5140.84
19_H113_K0.5140.84
132_P156_G0.5120.84
166_G198_H0.5110.83
54_I108_V0.5100.83
188_L197_R0.5100.83
38_Y101_R0.5090.83
171_D174_A0.5070.83
136_V151_C0.5060.83
38_Y42_S0.5060.83
151_C154_L0.5030.82
61_A86_V0.5020.82
128_P131_P0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1xdzA 1 0.9952 100 0.574 Contact Map
1jsxA 1 0.9324 99.9 0.576 Contact Map
3g89A 1 0.9469 99.9 0.586 Contact Map
2b3tA 1 0.9469 99.7 0.721 Contact Map
3hp7A 1 0.9807 99.6 0.733 Contact Map
3ocjA 1 0.9807 99.6 0.741 Contact Map
4pwyA 2 0.9275 99.5 0.749 Contact Map
4p7cA 1 0.9903 99.5 0.75 Contact Map
1nv8A 1 0.9227 99.4 0.764 Contact Map
2ozvA 2 0.7246 99.3 0.774 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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